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New Clinical Data Reveals MAIA Biotechnology’s THIO Achieves High Efficacy In Advanced Non-Small Cell Lung Cancer Treatment

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2 years ago

on

–News Direct–

By Mangeet Kaur Bouns

Lung cancer remains the top cause of cancer-related deaths in the U.S., accounting for approximately 20% of all cancer fatalities. The American Cancer Society's projections for 2024 highlight the gravity of this issue, with an estimated 234,580 new lung cancer cases and about 125,070 deaths anticipated in the U.S. Of these, nearly 80% to 85% are non-small cell lung cancer (NSCLC) cases, highlighting the urgent need for effective treatments.

MAIA Biotechnology, Inc. (AMEX: MAIA), a clinical-stage biopharmaceutical company focused on developing telomere-targeting immunotherapies for cancer treatment, has unveiled promising new clinical data showcasing the efficacy of its lead product candidate, THIO, in treating NSCLC. This data emerges from a phase 2 clinical trial evaluating THIO in combination with the immune checkpoint inhibitor (CPI) cemiplimab (Libtayo), targeting patients with advanced NSCLC who have not responded to at least two standard-of-care therapies.

In the context of NSCLC, where traditional treatments often fall short, THIO's potential as a first-in-class telomere-targeting agent raises hope. Its ability to disrupt cancer cell telomeres and stimulate immune responses marks a significant advancement in the fight against this devastating disease.

MAIAs Lead Candidate: THIO

THIO is a groundbreaking telomere-targeting agent, currently undergoing phase 2 clinical trials aimed at treating NSCLC with telomerase-positive cancer cells. Telomerase, present in over 85% of human cancers, plays a crucial role in the immortality and proliferation of cancer cells. THIO integrates into telomeres within these cells, disrupting their structure and function leading to rapid tumor cell death.

By inducing telomerase-dependent DNA modification and damage, THIO triggers selective cancer cell death. This process accumulates telomeric damage in cytosolic micronuclei, which then activates both innate (cGAS/STING) and adaptive (T-cell) immune responses. In in vivo cancer models, sequential treatment with THIO followed by PD-(L)1 inhibitors resulted in significant and sustained tumor regression, fostering cancer-specific immune memory.

Key Findings From The Phase 2 THIO-101 Clinical Trial

The phase 2 THIO-101 trial primarily focuses on assessing the safety and tolerability of THIO both as an anticancer agent and as an immune system activator, alongside evaluating its clinical efficacy through overall response rate (ORR).

The trial results are noteworthy. The disease control rate (DCR) for THIO in combination with CPI was 85%, far exceeding the 25-35% DCR typically seen with chemotherapy in third-line treatments. Additionally, 65% of patients surpassed the 5.8-month overall survival (OS) threshold, and 85% exceeded the 2.5-month progression-free survival (PFS) threshold, demonstrating significant clinical benefits. The median survival follow-up time stood at 9.1 months for the cohort of 20 patients.

Optimal dose selection yielded even more impressive outcomes. Patients in third-line receiving 180mg of THIO exhibited a median PFS of 5.5 months, a 75% OS rate at six months and an ORR of 38%, compared to the standard 6-10% ORR for chemotherapy. Notably, 75% of these patients crossed the 5.8-month OS threshold and 88% surpassed the 2.5-month PFS threshold, with a median survival follow-up time of 9.1 months among the eight patients assessed.

Implications And Future Directions

Dr. Vlad Vitoc, chairman and CEO of MAIA, expressed enthusiasm about the trial outcomes, noting, "All exceptional measures of efficacy in our trial to date have exceeded our own expectations and outperformed standard-of-care treatments." He emphasized THIOs potential as a robust, safe and highly effective alternative for patients who have not benefited from chemotherapy and other treatments.

The THIO-101 trial, which completed enrollment ahead of schedule in February, reached its target of 41 patients for the 180 mg dose. This data, which indicates promising disease control and overall response rates, paves the way for further investigation and potential redefinition of cancer treatment protocols.

As THIO-101 data continues to demonstrate favorable disease control and response rates, with full efficacy data anticipated in the latter half of this year, MAIA Biotechnology stands poised to redefine cancer treatment. THIOs promise to transform the standard of care in oncology offers new hope to patients with advanced NSCLC, potentially establishing a new benchmark in cancer therapy.

Featured photo by CI Photos at Shutterstock.

Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders.

This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice.

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View source version on newsdirect.com: https://newsdirect.com/news/new-clinical-data-reveals-maia-biotechnologys-thio-achieves-high-efficacy-in-advanced-non-small-cell-lung-cancer-treatment-599831106

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CoinRabbit Wins “Best Crypto Lending Platform 2026” Award from International Business Magazine

Published

18 minutes ago

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September 4, 2026

By

Toronto, Canada, September 4th, 2026, Chainwire

CoinRabbit has been named Best Crypto Lending Platform 2026 by International Business Magazine, highlighting a lending product that has issued more than $1.45 billion in loans since 2020.

About the International Business Magazine Award

The International Business Magazine Awards recognize companies and executives making a significant impact across global industries. The selection process combines public nominations with jury review, with nominees assessed on their work, progress, and contribution to their respective industries.

For CoinRabbit, the award comes at an important stage in the company’s development. It is moving beyond borrowing against crypto and building a broader ecosystem for managing digital-asset capital.

Why CoinRabbit Was Named the Best Crypto Lending Platform

The Best Crypto Lending Platform 2026 award recognizes the work CoinRabbit has put into its ecosystem. The platform provides borrowers with fast access to liquidity and confidence that their funds remain secure. CoinRabbit maintains a clear no-rehypothecation policy, giving clients greater certainty that their collateral is not being reused or lent out elsewhere.

That focus on a predictable borrowing experience has remained central as CoinRabbit has expanded the product. There is no traditional credit check because crypto collateral does the underwriting, and the lending process takes about 10 minutes whether a client is borrowing a few hundred dollars or managing a six-figure position.

The award jury also highlighted CoinRabbit’s Private Program as a high-touch approach for clients with significant balances. Designed for portfolios of $500,000 and above, it offers a more personalized way to manage assets around each client’s financial goals, liquidity needs, and timing. As part of CoinRabbit’s broader digital-asset ecosystem, the program gives clients a more private banking-style experience.

Capital Preservation at the Core

CoinRabbit is expanding into capital management, but lending remains at the core of the business. By giving clients access to liquidity without a need to sell their crypto, it helps preserve capital and keep assets invested for the long term.

Walter Barrett, Chief Strategy & Growth Officer at CoinRabbit, commented:

“We’ve spent years building and refining the product, and it’s rewarding to see that work recognized. At the same time, CoinRabbit is becoming more than just a lending platform. With the Private Program, we’re bringing a private credit approach to managing crypto. Clients can work directly with a success manager to find the right strategy for their needs, with a more tailored way to build crypto capital. We also continue to improve the core lending product, keeping it simple. For us, the goal is to make both sides of the business stronger as we grow.”

As CoinRabbit evolves, capital preservation remains a central idea behind the company’s products and services.

About CoinRabbit

CoinRabbit is a crypto asset management platform built for long-term capital preservation. It provides flexible liquidity management across multiple environments. Instant payments and lending, yield and trading products, and also the Private Program are available from a single platform. Since 2020, CoinRabbit has maintained a 100% capital reserve model, ensuring that client assets are fully reserved and never rehypothecated.

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Press Release

Liquid Mercury Announces Initial Closing of ACQUA1 Offering

Published

3 hours ago

on

September 4, 2026

By

Chicago, United States, September 4th, 2026, Chainwire

Liquid Mercury today announced that ACQUA1, LLC completed the initial closing of its MERC exchange offering on September 1, 2026.

ACQUA1 is a Liquid Mercury subsidiary that operates Liquid Mercury’s Lab Company program, licensing Liquid Mercury technology to companies primarily tokenizing real-world assets and receiving fees plus a minority equity stake in return. Liquid Mercury is the majority holder and Manager.

“Over the past 18 months, dozens of companies have approached Liquid Mercury seeking to tokenize their assets,” said Tony Saliba, CEO and founder of Liquid Mercury. “Many assumed they would need to raise capital and build this infrastructure from scratch. Licensing Mercury RWA lets them launch on systems that were already live and proven, at a fraction of the time and cost. ACQUA1 token holders now own a slice of the business that earns equity, plus fees from the companies in the Lab Company program.”

Verified accredited investors subscribed by exchanging MERC for non-voting Class B units of ACQUA1 at the initial conversion rate of 10 MERC per unit. Under its operating agreement, ACQUA1 must burn 100% of the MERC it receives at each closing within five business days and may not transfer, trade, lend, stake, pledge, or otherwise deploy it. 

On September 2, all 563,230,000 MERC received at the initial closing were burned via a transfer to the dead address, as the offering documents require.

Initial Closing Highlights

  • Initial closing: September 1, 2026
  • MERC burned: 563,230,000
  • Transferred to the dead address September 2, 2026
  • Units issued: 56,323,000
  • Non-voting Class B units of ACQUA1, LLC under Rule 506(c) of Regulation D
  • 10 MERC per unit
  • Evidenced on-chain by ACQUA1-C tokens
  • ACQUA1-C tokens convert one-for-one into ACQUA1 tokens upon issuance
  • Remaining closings: On or about October 30 and December 31, 2026
  • ACQUA1 may skip or terminate at its discretion
  • The conversion rate at subsequent closings may differ

Verification Links

Burn transaction

ACQUA1-C contract

Verified accredited investors can request full terms at acqua1.liquidmercury.com/contact.

About Liquid Mercury

Liquid Mercury powers professional crypto trading and digital asset marketplaces. The company delivers institutional-grade infrastructure, access to deep liquidity, and best-in-class trading tools and workflow automation across its Pro, OTC, and RWA platforms. Through Mercury RWA, Liquid Mercury is extending that infrastructure into tokenized real-world assets, with $MERC serving as the access and platform layer token. For more information, visit www.liquidmercury.com.

Investor Notice

This press release does not constitute an offer to sell or the solicitation of an offer to buy any securities. Class B units of ACQUA1, LLC and the ACQUA1 tokens representing them are offered and sold in reliance on the exemption from registration provided by Rule 506(c) of Regulation D under the Securities Act of 1933, solely to verified accredited investors as defined in Rule 501(a) of Regulation D, and solely pursuant to ACQUA1’s confidential private placement memorandum, as supplemented, and definitive subscription documents, which contain important information, including risk factors. ACQUA1 tokens are restricted securities, are subject to transfer restrictions under ACQUA1’s operating agreement and may remain illiquid indefinitely; investors should not assume that Rule 144 will be available. Statements regarding future revenues, valuations, portfolio performance, and subsequent closings are forward-looking and subject to risks and uncertainties; actual results may differ materially. The MERC contract has no burn function; tokens are removed from circulation by transferring to the dead address. Supply outstanding excluding the dead address is 5,436,770,000 MERC, as of the date of publication.

Contacts

Director
Kent Egan
Liquid Mercury
ke@liquidmercury.com
Director
Ryan Hansen
Liquid Mercury
hansenr@liquidmercury.com

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Press Release

Cracking 1.33 Trillion Daily Tokens: B.AI Powers the “AI Grid” with Full-Stack Infrastructure to Fuel the Agentic Era

Published

4 hours ago

on

September 4, 2026

By

Singapore – B.AI, a next-generation AI infrastructure platform, recently set off a developer frenzy by offering free access to top-tier models. Within days, daily token throughput across the platform crossed 1.33 trillion—a historic milestone. 

The record-breaking figure underscores the campaign’s explosive rollout, but it marks only the first step in B.AI’s broader strategic roadmap. Moving beyond traditional compute distribution pipelines, B.AI aims to build the global settlement layer for intelligence: a core infrastructure hub engineered to power cross-node collaboration, orchestration, and value distribution for AI agents across complex business workflows. 

Positioning itself strategically above all models, below all agents, B.AI deeply integrates a diverse range of top-tier models with full-stack components, laying an unshakable, irreplaceable foundation for the mass adoption of autonomous agents and the productivity boom that follows.

Daily Token Throughput Tops 1.33 Trillion: B.AI’s Free Access Rollout Fuels Usage Boom

B.AI’s recent move to open free access to premium AI models has captivated developers and quickly taken over industry conversations. The push for accessible compute has not only fueled a surge in platform activity but also shattered usage records. 

In a matter of days, soaring API demand pushed the platform’s daily token throughput past a staggering 1.33 trillion. Over a 15-day window, cumulative volume reached 8.19 trillion tokens, drawing in more than 220,000 new API users. As of September 3, B.AI’s total user base had officially surpassed 2.3 million. 

That massive adoption traces directly to the platform’s zero-cost model lineup, a strategic rollout built to erase developers’ cost concerns. With every barrier removed, B.AI now offers unlimited free access to six leading frontier models: DeepSeek-V4-Flash, DeepSeek-V4-Flash-Vision-Exp, Tencent Hy3, Xiaomi MiMo-V2.5, GLM-5.3-Flash (Ox Alpha), and Qwen3.8-Flash. 

Notably, on September 3, B.AI rolled out a new pricing structure for DeepSeek-V4-Flash and DeepSeek-V4-Flash-Vision-Exp, introducing tiered discounts. Developers now receive a 50% discount during peak hours, with off-peak rates dropping to just 25% of standard peak pricing. At the same time, the platform has kept zero-cost access in place for GLM-5.3-Flash (Ox Alpha), Qwen3.8-Flash, Tencent Hy3, and Xiaomi MiMo-V2.5. Despite the shift toward commercialization, developer momentum hasn’t wavered, with platform-wide token throughput continuing its steady climb.

This sustained momentum proves the campaign was far more than a short-term compute giveaway—it is a bellwether for the broader evolution of AI infrastructure. Cracking 1.33 trillion daily tokens makes one thing clear: AI applications are moving past basic chatbots. Powered by a high-performance technical stack and flexible service mechanics, B.AI is laying the groundwork for the next frontier—autonomous AI agents operating at scale. 

Powering the “AI Grid”: B.AI Anchors the Global Settlement Layer for the Agent Economy

For B.AI, democratizing compute is only the prelude. Looking further ahead, the platform is committed to building full-stack infrastructure for the agentic era, cementing its position as the global settlement layer for intelligence.

In the agent era, a typical agent task calls for constant switching between models. No single provider can power a complete workflow on its own, so developers are left juggling fragmented API protocols, disjointed billing systems, and conflicting rate limits. 

B.AI’s settlement layer bridges this exact gap. Positioned strategically “above all models, below all agents,” B.AI abstracts models across different providers, capabilities, and cost structures into a unified pool of schedulable resources.

Powered by a dual-tier API structure offering official-route reliability alongside lowest-cost custom channels, developers can choose between guaranteed direct connections and deeply discounted options across a broad lineup of models. Combined with smart routing on the Chat interface, B.AI operates as a full-stack “AI grid,” ensuring every agent request lands on the optimal model to deliver reliable performance at maximum cost-efficiency. 

On the settlement front, this power grid seamlessly bridges both Web2 and Web3 models. For Web2, developers can rely on familiar traditional payment methods to top up with minimal friction. For Web3, B.AI leverages on-chain payment rails to offer global developers decentralized, verifiable, and low-friction payment options.

With dual payment systems running in parallel, B.AI enables developers and agent applications across any infrastructure setup to find their optimal settlement path on the grid, providing single-point integration with borderless global reach. 

Driving Core Productivity: B.AI Reshapes Agent Collaboration

Beyond building a foundation for compute routing and global settlement, B.AI is moving past base infrastructure to power real-world productivity. By enabling seamless agent collaboration across complex workflows, it delivers the missing execution layer for the agent economy. 

At the heart of this execution layer is native Codex integration. Full compatibility with the Responses API means developers can now use a single B.AI key inside Codex to run flagship GPT models and DeepSeek favorites side by side. 

Engineers can now bring these powerhouse models straight into their daily dev stack. From code generation and reasoning to debugging and refactoring, B.AI unifies the entire workflow under one roof—delivering a direct line from model selection to shipped code. 

Beyond coding, to keep agents running reliably in real-world production at scale, B.AI has built a full-stack infrastructure powered by five core components, equipping agents with a fine-tuned operational engine:

  • x402 Payment Protocol: Introduces an innovative “pay-before-response” model that executes high-frequency, on-chain micro-settlements in the background during cross-agent API calls and compute orchestration.
  • 8004 Identity Protocol: Issues verifiable on-chain credentials for every agent, logging execution history and credit scores to establish a reliable layer of trust for cross-node collaboration.
  • Skills Matrix: Plug-and-play, standardized building blocks that interface directly with MCP servers to equip agents with instant, modular tool-calling capabilities.
  • BAIclaw and BAIcode: Built-in platform assistants engineered for end-to-end execution. BAIclaw manages all-in-one terminal operations and multi-agent workflows, while BAIcode serves as an advanced developer engine that streamlines the full pipeline from task analysis and architecture design to coding and testing.

From the token surge sparked by zero-cost model access to its positioning as the global settlement layer for intelligence; from seamless Codex integration to full-stack infrastructure powered by x402, 8004, Skills, and native assistants—B.AI delivers far more than a battle-tested technical stack; it unveils a clear blueprint for what lies ahead. B.AI is building not just accessible compute today, but the definitive launchpad for a thriving agent economy. The future is here—and this is only the beginning.

B.AI Team
support@b.ai

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