Press Release
New Clinical Data Reveals MAIA Biotechnology’s THIO Achieves High Efficacy In Advanced Non-Small Cell Lung Cancer Treatment
–News Direct–
By Mangeet Kaur Bouns
Lung cancer remains the top cause of cancer-related deaths in the U.S., accounting for approximately 20% of all cancer fatalities. The American Cancer Society's projections for 2024 highlight the gravity of this issue, with an estimated 234,580 new lung cancer cases and about 125,070 deaths anticipated in the U.S. Of these, nearly 80% to 85% are non-small cell lung cancer (NSCLC) cases, highlighting the urgent need for effective treatments.
MAIA Biotechnology, Inc. (AMEX: MAIA), a clinical-stage biopharmaceutical company focused on developing telomere-targeting immunotherapies for cancer treatment, has unveiled promising new clinical data showcasing the efficacy of its lead product candidate, THIO, in treating NSCLC. This data emerges from a phase 2 clinical trial evaluating THIO in combination with the immune checkpoint inhibitor (CPI) cemiplimab (Libtayo), targeting patients with advanced NSCLC who have not responded to at least two standard-of-care therapies.
In the context of NSCLC, where traditional treatments often fall short, THIO's potential as a first-in-class telomere-targeting agent raises hope. Its ability to disrupt cancer cell telomeres and stimulate immune responses marks a significant advancement in the fight against this devastating disease.
MAIAs Lead Candidate: THIO
THIO is a groundbreaking telomere-targeting agent, currently undergoing phase 2 clinical trials aimed at treating NSCLC with telomerase-positive cancer cells. Telomerase, present in over 85% of human cancers, plays a crucial role in the immortality and proliferation of cancer cells. THIO integrates into telomeres within these cells, disrupting their structure and function leading to rapid tumor cell death.
By inducing telomerase-dependent DNA modification and damage, THIO triggers selective cancer cell death. This process accumulates telomeric damage in cytosolic micronuclei, which then activates both innate (cGAS/STING) and adaptive (T-cell) immune responses. In in vivo cancer models, sequential treatment with THIO followed by PD-(L)1 inhibitors resulted in significant and sustained tumor regression, fostering cancer-specific immune memory.
Key Findings From The Phase 2 THIO-101 Clinical Trial
The phase 2 THIO-101 trial primarily focuses on assessing the safety and tolerability of THIO both as an anticancer agent and as an immune system activator, alongside evaluating its clinical efficacy through overall response rate (ORR).
The trial results are noteworthy. The disease control rate (DCR) for THIO in combination with CPI was 85%, far exceeding the 25-35% DCR typically seen with chemotherapy in third-line treatments. Additionally, 65% of patients surpassed the 5.8-month overall survival (OS) threshold, and 85% exceeded the 2.5-month progression-free survival (PFS) threshold, demonstrating significant clinical benefits. The median survival follow-up time stood at 9.1 months for the cohort of 20 patients.
Optimal dose selection yielded even more impressive outcomes. Patients in third-line receiving 180mg of THIO exhibited a median PFS of 5.5 months, a 75% OS rate at six months and an ORR of 38%, compared to the standard 6-10% ORR for chemotherapy. Notably, 75% of these patients crossed the 5.8-month OS threshold and 88% surpassed the 2.5-month PFS threshold, with a median survival follow-up time of 9.1 months among the eight patients assessed.
Implications And Future Directions
Dr. Vlad Vitoc, chairman and CEO of MAIA, expressed enthusiasm about the trial outcomes, noting, "All exceptional measures of efficacy in our trial to date have exceeded our own expectations and outperformed standard-of-care treatments." He emphasized THIOs potential as a robust, safe and highly effective alternative for patients who have not benefited from chemotherapy and other treatments.
The THIO-101 trial, which completed enrollment ahead of schedule in February, reached its target of 41 patients for the 180 mg dose. This data, which indicates promising disease control and overall response rates, paves the way for further investigation and potential redefinition of cancer treatment protocols.
As THIO-101 data continues to demonstrate favorable disease control and response rates, with full efficacy data anticipated in the latter half of this year, MAIA Biotechnology stands poised to redefine cancer treatment. THIOs promise to transform the standard of care in oncology offers new hope to patients with advanced NSCLC, potentially establishing a new benchmark in cancer therapy.
Featured photo by CI Photos at Shutterstock.
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United States, 29th Apr 2025, – San Francisco, CA — In a world that’s increasingly disconnected from nature, GroundingTime is proud to unveil its latest innovation: the Bamboo Grounding Fitted Sheet | 5X Grounding Power for Better Sleep Groundingtime — a wellness-forward, eco-conscious sleep essential designed to bring the science of grounding into your bedroom, without compromising on style, softness, or sustainability.
Nature-Inspired, Science-Backed
Grounding, also known as earthing, is the practice of connecting your body directly to the Earth’s natural electric charge. Studies suggest that this connection may support better sleep, reduce inflammation, and promote a greater sense of calm and balance.
Our Bamboo Grounding Fitted Sheet is designed to help facilitate this connection — effortlessly. Using a proprietary blend of conductive silver fibers woven into ultra-soft bamboo fabric, the sheet connects via a grounding cord to a grounded outlet, helping your body naturally sync with the Earth’s energy while you sleep.
“We wanted to take The Science Behind Grounding Therapy | How Earth’s Energy Heals – Groundingtime and make it easy, beautiful, and accessible for everyone,” says the GroundingTime product design team. “This sheet is as much about comfort as it is about connection.”
Why Bamboo?
Unlike traditional cotton or synthetic fabrics, bamboo is naturally breathable, hypoallergenic, and antimicrobial. It also happens to be one of the most sustainable resources on the planet.
Each GroundingTime sheet is made from certified organic bamboo sourced from responsibly managed forests, ensuring minimal environmental impact while delivering maximum comfort.
Key Benefits of Bamboo:
Thermoregulating & breathable
Incredibly soft — even after multiple washes
Naturally moisture-wicking and odor-resistant
Hypoallergenic — ideal for sensitive skin
Built-In Multi-Point
Grounding Therapy | 5X Enhanced Grounding Technology – Groundingtime
What sets this sheet apart is its integrated grounding grid of pure silver threads. These threads are seamlessly woven into the fabric, allowing for safe and effective conductivity without sacrificing comfort.
The sheet comes with a grounding cord and adapter that easily connects to a standard grounded outlet, giving you the benefits of grounding while you sleep — with no need to change your habits or routines.
Functional Design That Fits Your Life
The Bamboo Grounding Fitted Sheet is available in multiple sizes, with 15‘’ deep-pocket corners that fit even oversized mattresses. It’s machine-washable, easy to set up, and designed to integrate smoothly with any bedroom aesthetic.
Whether you’re new to grounding or a long-time believer in the benefits, this sheet is a simple yet powerful addition to your wellness routine.
What Customers Are Saying
“I’ve been using the GroundingTime bamboo sheet for just two weeks, and I’ve noticed deeper, more restful sleep. The fabric is unbelievably soft — I honestly don’t want to get out of bed.”
— Laura M., verified buyer
“I’ve struggled with chronic pain in my lower back for years. After sleeping on the GroundingTime bamboo sheet for just a few nights, I woke up with noticeably less stiffness and tension. It’s the first thing I’ve tried that’s made a real difference — naturally.”
— Daniel R., verified buyer
Sustainability at the Core
GroundingTime believes that wellness shouldn’t come at the expense of the planet. That’s why every sheet is packaged in plastic-free, recyclable materials, and a portion of each purchase goes toward reforestation and clean water initiatives.
Availability
The Bamboo Grounding Fitted Sheet is now available exclusively at www.groundingtime.com, with free U.S. shipping.
About GroundingTime
GroundingTime combines scientific research with natural therapy to offer a gentle, nature-based wellness solution for those living with chronic conditions, pain, and sleep challenges. Through grounding technology, we help users reduce stress, improve rest, and support overall health and mind-body balance in everyday life.
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United States, 29th Apr 2025, – CozyBliss, an innovator in modern home lifestyle products, is excited to announce the launch of its 2025 COOLI PRO Cooling Bedding Collection, a next-generation comfort solution designed to deliver instant cooling and long-lasting comfort throughout the night. The new collection integrates a proprietary woven pattern and Sorona® bio-based fiber technology, offering a superior sleep experience rooted in both innovation and sustainability.
Sleep Cool and Comfortable with Sorona® Fiber
At the heart of the COOLI PRO comforters is advanced Sorona® fiber technology, engineered to enhance breathability and cooling performance. Derived from 37% renewable plant-based materials, Sorona® delivers a 22% increase in loft compared to traditional polyester and improves heat dissipation by 35%. This sustainable fiber also reduces carbon emissions by up to 30% during production. Additionally, the fitted sheet fabrics include 25% GRS-certified recycled PET, further supporting CozyBliss’s commitment to environmental responsibility.
The surface of each comforter boasts a Q-Max value greater than 0.4, enabling an instant cooling effect that can reduce body temperature by 2–5°C. Crafted with precision quilting in both feathered and diamond patterns, the bedding combines tactile cooling with elevated aesthetic appeal. The 3D woven textures not only improve airflow but also provide a sleek, contemporary look that complements modern interior styles.
Stylish, Skin-Friendly, and Safe
The COOLI PRO series is available in sophisticated dual-tone colorways, including Creamy White – Misty White and Meteor Grey – Cool Grey, making it a perfect match for minimalist and modern American home décor.
Every product in the COOLI PRO collection has been independently tested and certified to meet OEKO-TEX® Standard 100, the highest safety standard. This ensures they are free from 138 potentially harmful substances, making them safe for use by all, including infants and those with sensitive skin.
Purchase Information
COOLI Series
Lightweight summer blankets with 100% poly down-alternative filling create a 3D hollow structure for enhanced elasticity and durability. Designed for summer use with excellent abrasion resistance.
COOLI PRO Series
The upgraded COOLI PRO comforter features Sorona® filling with a helical fiber structure for enhanced breathability and support. The reversible design provides both versatility and modern style.
Website: https://www.cozybliss.com/products/lightweight-natural-cooling-comforter?variant=47795869122806
The full collection is available for purchase through the CozyBliss website and Amazon CozyBliss Store.
About CozyBliss
Founded with a vision to redefine modern comfort, CozyBliss is a leading brand in American home living. The company offers an all-season, all-scene product line designed to help consumers effortlessly switch into comfort mode anytime, anywhere. By combining thoughtful design, sustainable materials, and superior craftsmanship, CozyBliss brings lasting coziness to homes around the world.
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Press Release
Blue Sky Scrubs Celebrates World Environment Day with Commitment to Sustainability and Innovation
United States, 29th Apr 2025, – Austin, TX — As the world comes together to celebrate World Environment Day on June 5, Blue Sky Scrubs is proud to spotlight its ongoing commitment to protecting the planet through thoughtful, sustainable practices. The luxury medical apparel company, known for blending style with functionality, believes that caring for the environment is a natural extension of its mission to care for healthcare professionals.
In honor of World Environment Day on June 5, Blue Sky Scrubs is proud to reaffirm its commitment to protecting the planet through sustainable business practices. As a leader in luxury medical apparel, the company believes that caring for healthcare professionals also means caring for the environment they live and work in.
Blue Sky Scrubs focuses on creating long-lasting products by using premium fabrics and expert craftsmanship, helping reduce the fast-fashion waste cycle. By designing scrubs and accessories that withstand daily wear and maintain their quality over time, the company encourages a more sustainable approach to medical workwear.
In addition, Blue Sky Scrubs minimizes the use of plastic in packaging, supports local and ethical manufacturing, and donates surplus inventory to medical missions and nonprofits, ensuring that unused items serve communities in need rather than ending up in landfills.
“We are inspired every day by healthcare workers who protect and heal,” said Shelby Marquardt, founder of Blue Sky Scrubs. “Our mission is to create products that not only serve them but also help preserve the environment for future generations.”
This World Environment Day, Blue Sky Scrubs invites the healthcare community and its supporters to reflect on the small changes that, together, can make a big difference for the planet.
For more about Blue Sky Scrubs’ sustainability efforts, visit blueskyscrubs.com.
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Country:United States
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GroundingTime Debuts Eco-Friendly Bamboo Grounding Sheet to Redefine Rest
CozyBliss Introduces 2025 COOLI PRO Cooling Comforter Featuring Sorona Technology
Blue Sky Scrubs Celebrates World Environment Day with Commitment to Sustainability and Innovation
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