Press Release
New Clinical Data Reveals MAIA Biotechnology’s THIO Achieves High Efficacy In Advanced Non-Small Cell Lung Cancer Treatment
–News Direct–
By Mangeet Kaur Bouns

Lung cancer remains the top cause of cancer-related deaths in the U.S., accounting for approximately 20% of all cancer fatalities. The American Cancer Society's projections for 2024 highlight the gravity of this issue, with an estimated 234,580 new lung cancer cases and about 125,070 deaths anticipated in the U.S. Of these, nearly 80% to 85% are non-small cell lung cancer (NSCLC) cases, highlighting the urgent need for effective treatments.
MAIA Biotechnology, Inc. (AMEX: MAIA), a clinical-stage biopharmaceutical company focused on developing telomere-targeting immunotherapies for cancer treatment, has unveiled promising new clinical data showcasing the efficacy of its lead product candidate, THIO, in treating NSCLC. This data emerges from a phase 2 clinical trial evaluating THIO in combination with the immune checkpoint inhibitor (CPI) cemiplimab (Libtayo), targeting patients with advanced NSCLC who have not responded to at least two standard-of-care therapies.
In the context of NSCLC, where traditional treatments often fall short, THIO's potential as a first-in-class telomere-targeting agent raises hope. Its ability to disrupt cancer cell telomeres and stimulate immune responses marks a significant advancement in the fight against this devastating disease.
MAIAs Lead Candidate: THIO
THIO is a groundbreaking telomere-targeting agent, currently undergoing phase 2 clinical trials aimed at treating NSCLC with telomerase-positive cancer cells. Telomerase, present in over 85% of human cancers, plays a crucial role in the immortality and proliferation of cancer cells. THIO integrates into telomeres within these cells, disrupting their structure and function leading to rapid tumor cell death.
By inducing telomerase-dependent DNA modification and damage, THIO triggers selective cancer cell death. This process accumulates telomeric damage in cytosolic micronuclei, which then activates both innate (cGAS/STING) and adaptive (T-cell) immune responses. In in vivo cancer models, sequential treatment with THIO followed by PD-(L)1 inhibitors resulted in significant and sustained tumor regression, fostering cancer-specific immune memory.
Key Findings From The Phase 2 THIO-101 Clinical Trial
The phase 2 THIO-101 trial primarily focuses on assessing the safety and tolerability of THIO both as an anticancer agent and as an immune system activator, alongside evaluating its clinical efficacy through overall response rate (ORR).
The trial results are noteworthy. The disease control rate (DCR) for THIO in combination with CPI was 85%, far exceeding the 25-35% DCR typically seen with chemotherapy in third-line treatments. Additionally, 65% of patients surpassed the 5.8-month overall survival (OS) threshold, and 85% exceeded the 2.5-month progression-free survival (PFS) threshold, demonstrating significant clinical benefits. The median survival follow-up time stood at 9.1 months for the cohort of 20 patients.
Optimal dose selection yielded even more impressive outcomes. Patients in third-line receiving 180mg of THIO exhibited a median PFS of 5.5 months, a 75% OS rate at six months and an ORR of 38%, compared to the standard 6-10% ORR for chemotherapy. Notably, 75% of these patients crossed the 5.8-month OS threshold and 88% surpassed the 2.5-month PFS threshold, with a median survival follow-up time of 9.1 months among the eight patients assessed.
Implications And Future Directions
Dr. Vlad Vitoc, chairman and CEO of MAIA, expressed enthusiasm about the trial outcomes, noting, "All exceptional measures of efficacy in our trial to date have exceeded our own expectations and outperformed standard-of-care treatments." He emphasized THIOs potential as a robust, safe and highly effective alternative for patients who have not benefited from chemotherapy and other treatments.
The THIO-101 trial, which completed enrollment ahead of schedule in February, reached its target of 41 patients for the 180 mg dose. This data, which indicates promising disease control and overall response rates, paves the way for further investigation and potential redefinition of cancer treatment protocols.
As THIO-101 data continues to demonstrate favorable disease control and response rates, with full efficacy data anticipated in the latter half of this year, MAIA Biotechnology stands poised to redefine cancer treatment. THIOs promise to transform the standard of care in oncology offers new hope to patients with advanced NSCLC, potentially establishing a new benchmark in cancer therapy.
Featured photo by CI Photos at Shutterstock.
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Press Release
KeyCrew Media Selects ACME Real Estate as Verified Expert for Boutique Brokerage Operations, and LA Market Expertise
KeyCrew Media, a real estate analytics and media network, has selected Courtney Poulos and her team at ACME Real Estate as a KeyCrew Verified Expert.
LOS ANGELES, CA, December 12, 2025 — KeyCrew Media, a real estate analytics and media network, has selected Courtney Poulos and her team at ACME Real Estate as a KeyCrew Verified Expert. The boutique Los Angeles brokerage will contribute specialized insights on renovation-resale strategy, boutique brokerage operations, and LA market dynamics.

KeyCrew Verified Experts are carefully selected as prolific market trend authorities who demonstrate exceptional insight and expertise in their fields. These distinguished professionals and companies regularly contribute market insights, expert perspectives, and forward-looking analysis to help audiences navigate complex industry landscapes.
Founded in 2011 by Broker/Owner Courtney Poulos, ACME Real Estate has established itself as a premier boutique brokerage specializing in renovation-resale projects across Los Angeles. Operating in what Poulos calls “the NFL of real estate,” ACME has built its reputation on comprehensive agent training, ethical accountability, and exceptional client experiences without the backing of international capital funding.
ACME Real Estate offers a distinctive “one-stop shop” approach for real estate investors and renovation-resale specialists. The brokerage provides full-spectrum support from acquisition—including deal analysis and cost-benefit evaluation—through in-house design services at any price point, sophisticated appraisal packaging, and premium marketing. With 35 agents completing 178 transaction sides totaling $155 million in sales volume over the past 12 months, ACME has proven that boutique brokerages can compete against corporate giants through superior training and service.
“We’re honored that ACME Real Estate has been selected as a KeyCrew Verified Expert,” said Courtney Poulos, Broker/Owner. “We built ACME to fill a gap in the market—highly trained agents who the public can trust, comprehensive support for renovation-resale investors, and a commitment to quality over scale. This recognition validates what our clients already know: sometimes the underdogs deliver the highest quality service.”
ACME Real Estate’s areas of expertise include:
- Renovation-Resale Strategy – Comprehensive acquisition analysis, cost estimation, design consultation, and resale marketing for investors
- Boutique Brokerage Operations – Building and scaling quality-focused independent brokerages in competitive markets
- Los Angeles Market Dynamics – Deep expertise in LA neighborhoods, market trends, and investment opportunities
- Agent Training & Development – Mastery-based training programs emphasizing contract expertise and client psychology
- Premium Property Marketing – High-end photography, printed materials, and strategic positioning for maximum market performance
About ACME Real Estate
ACME Real Estate is a boutique independent brokerage founded in 2011 and based in Los Angeles. With 35 agents and 178 transaction sides totaling $155 million in sales volume over the past 12 months, ACME specializes in renovation-resale projects and provides comprehensive support from acquisition through marketing and sale. The brokerage offers in-house design services at any price point, sophisticated appraisal packaging, and premium marketing execution. ACME serves both real estate investors and traditional buyers and sellers with what Broker/Owner Courtney Poulos describes as “the most concierge, attentive, well-trained group of underdogs you could ever have behind you.” Website: https://acmeflorida.com/
About KeyCrew Media
KeyCrew Media is the next generation real estate intelligence platform that leverages AI-powered analytics and first-person reporting from verified experts to produce forward-looking insights across local markets and niche asset classes. Proprietary market reporting is delivered through KeyCrew’s growing portfolio of niche media properties—including KeyCrew Journal, NextAsset News, and other specialized publications—as well as selectively syndicated to media partners that influence industry decision-makers. Learn more at keycrew.co
Media Contact
Organization: KeyCrew Media
Contact Person: Heather Hook
Website: https://www.keycrew.co
Email: Send Email
City: Baltimore
State: Maryland
Country:United States
Release id:39011
The post KeyCrew Media Selects ACME Real Estate as Verified Expert for Boutique Brokerage Operations, and LA Market Expertise appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
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Press Release
KeyCrew Media Selects Brooke Pfautz as Verified Expert for Vacation Rental Management and Property Technology
KeyCrew Media, a real estate analytics and media network, has selected Brooke Pfautz, CEO and Founder of Vintory, as a KeyCrew Verified Expert.
NATIONWIDE, December 12, 2025 — KeyCrew Media, a real estate analytics and media network, has selected Brooke Pfautz, CEO and Founder of Vintory, as a KeyCrew Verified Expert. Pfautz will contribute data-driven analysis on vacation rental management, property technology innovation, and industry consolidation trends.

KeyCrew Verified Experts are carefully selected as prolific market trend authorities who demonstrate exceptional insight and expertise in their fields. These distinguished professionals regularly contribute market insights, expert perspectives, and forward-looking analysis to help audiences navigate complex industry landscapes.
Brooke Pfautz brings unparalleled expertise to the vacation rental management sector, having helped over 950 companies scale their portfolios through strategic growth initiatives. As founder of both Vintory and Comparent, Pfautz has established herself as a leading voice on data-driven property acquisition, AI integration in hospitality operations, and market consolidation dynamics. Her work encompasses the largest database of vacation rental homeowners globally and the industry’s first comprehensive ranking system through the Comparent 100.
With 18 years of experience in the short-term rental industry, Pfautz successfully scaled Vantage Realty to over 500 properties before its acquisition. She has since focused on revolutionizing how professional vacation rental managers approach growth through Vintory’s data and marketing platform, which aggregates information from over 10 sources to create what she calls “stacked data architecture” — a proprietary approach that provides unprecedented accuracy in homeowner targeting.
Pfautz’s insights on artificial intelligence adoption have positioned her as a forward-thinking industry authority. She advocates that property managers not implementing AI-native tools by 2026 risk competitive obsolescence, emphasizing that data capture — particularly call recordings and guest communications — represents the critical intellectual property that will differentiate winners in an increasingly AI-driven marketplace.
“I’m honored to be selected as a KeyCrew Verified Expert,” said Brooke Pfautz. “The vacation rental management industry is at a pivotal moment where data quality and AI adoption will separate thriving companies from those left behind. Having helped nearly 1,000 companies with their growth strategies, I’ve seen firsthand how the right data and technology stack can transform a mid-sized operator into a market leader. I’m excited to share insights that help property managers navigate consolidation pressures, leverage their unique data assets, and position themselves strategically whether they’re scaling independently or preparing for acquisition.”
Pfautz’s areas of expertise include:
- Vacation Rental Management Growth Strategies — Proven frameworks for inventory acquisition and scaling beyond 10 million in gross bookings
- Property Technology & AI Integration — Strategic guidance on AI-native tools, data architecture, and competitive positioning
- Market Consolidation & M&A Dynamics — Insights on institutional capital trends, acquisition metrics, and positioning for exit
- Homeowner Data & Marketing Analytics — Expertise in multi-source data aggregation, targeting precision, and marketing ROI optimization
About Vintory
Vintory is a data, sales, and marketing platform that helps professional vacation rental managers grow their inventory through the world’s largest database of vacation rental homeowners. The platform combines proprietary stacked data architecture with tech-enabled marketing services, building targeted campaigns that drive qualified leads through custom CRM and automation systems. Vintory has supported over 950 property management companies with strategic growth initiatives. Website: www.vintory.com
About KeyCrew Media
KeyCrew Media is the next generation real estate intelligence platform that leverages AI-powered analytics and first-person reporting from verified experts to produce forward-looking insights across local markets and niche asset classes. Proprietary market reporting is delivered through KeyCrew’s growing portfolio of niche media properties — including KeyCrew Journal, NextAsset News, and other specialized publications — as well as selectively syndicated to media partners that influence industry decision-makers. Learn more at keycrew.co
Media Contact
Organization: KeyCrew Media
Contact Person: Heather Hook
Website: https://www.keycrew.co
Email: Send Email
City: Baltimore
State: Maryland
Country:United States
Release id:39013
The post KeyCrew Media Selects Brooke Pfautz as Verified Expert for Vacation Rental Management and Property Technology appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
KLOTA Launches Two Free Analysis Tools to Help E-Commerce Brands Improve Search and AI Visibility
Sweden, 13th Dec 2025 – KLOTA AB, a Sweden-based digital performance and SEO consultancy, has announced the launch of two new free analysis tools designed specifically for serious e-commerce companies seeking stronger visibility, better performance, and clearer insights across search engines and AI-driven platforms. The newly released tools—the AI Visibility Analyzer and the Shopping Feed Analyzer—are currently available as free BETA services and deliver actionable results within approximately 10 minutes via email.
As search behavior rapidly evolves, e-commerce brands are no longer competing only for traditional Google rankings. Increasingly, consumers are discovering products and brands through AI-powered assistants such as ChatGPT, Claude, Perplexity, and Gemini. KLOTA’s new tools are built to address this shift, providing practical diagnostics that help online retailers understand where they stand and what to fix.
The AI Visibility Analyzer focuses on how well a website is seen, accessed, and understood by modern AI search engines and large language models. The tool evaluates critical factors such as AI-bot accessibility (including robots.txt and llms.txt), content clarity and readability, structured data, and core technical SEO elements. Based on this analysis, it generates an easy-to-understand AI Visibility Score ranging from 0 to 100, along with clear, prioritized recommendations that highlight the most impactful improvements.
“This is about helping companies prepare for the next generation of search,” said Anders Karlsson, Contact at KLOTA AB. “Many e-commerce brands are still optimizing only for classic search results, while AI assistants are already shaping how users discover information and products. The AI Visibility Analyzer makes this new landscape measurable and actionable.”
The second tool, the Shopping Feed Analyzer (Google Shopping Feed Analyzer ), is designed for e-commerce businesses actively running Google Shopping and Performance Max (PMax) campaigns. Poor feed quality is a common reason for disapproved products, limited reach, and underperforming ads. KLOTA’s tool performs an automated quality audit of a Google Shopping product feed , reviewing required attributes, product titles and descriptions, pricing accuracy, images, Google product categories, and overall compliance with Google’s specifications.
After the audit, users receive a detailed PDF report that includes an executive summary and a prioritized action list. This enables marketing and e-commerce teams to quickly identify errors, resolve disapprovals, and systematically improve feed quality for better campaign performance.
“Most feed issues are not strategic—they’re technical and fixable,” Karlsson added. “The challenge is knowing exactly where the problems are and what to address first. The Shopping Feed Analyzer removes that guesswork and gives teams a clear roadmap.”
Both tools are offered as free BETA services, reflecting KLOTA’s commitment to sharing expertise and helping e-commerce brands adapt to a more complex digital ecosystem. Once a website URL or product feed is submitted, the analysis is processed automatically and sent by email in about 10 minutes, making the tools accessible even for busy teams with limited technical resources.
While some information within the tools may be presented in English, the insights are designed to be universally applicable for international e-commerce brands aiming to compete more effectively in search, paid media, and AI-driven discovery.
With the launch of these tools, KLOTA reinforces its position as a forward-looking partner for e-commerce growth—bridging traditional SEO, paid shopping performance, and the emerging world of AI visibility.
For more information visit https://www.klota.se .
About KLOTA AB
KLOTA AB is a Sweden-based digital consultancy specializing in SEO, e-commerce optimization, and data-driven performance strategies. The company works with ambitious brands that want to improve visibility, traffic quality, and revenue across search engines, advertising platforms, and AI-powered discovery channels.
Media Contact
Organization: KLOTA AB
Contact Person: Anders Karlsson
Website: https://www.klota.se/
Email: Send Email
Address:Katrinedalsgatan 13A 504 51 BORÅS Sweden
Country:Sweden
Release id:39023
The post KLOTA Launches Two Free Analysis Tools to Help E-Commerce Brands Improve Search and AI Visibility appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
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