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CMS’s (867.HK/8A8.SG) Self-developed Innovative INHBE-Targeting siRNA Drug CMS-D008 Presents Its Preclinical Results at the ADA Scientific Sessions

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3 months ago

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SHENZHEN, CHINA – China Medical System Holdings Limited (“CMS” or the “Group”) is pleased to announce that the preclinical results of its self-developed innovative INHBE-targeting small nucleic acid drug CMS-D008 injection (“CMS-D008”), have been presented in a poster at the American Diabetes Association (ADA) 86th Scientific Sessions (June 5-8, 2026, New Orleans, USA). As the world’s largest and most authoritative annual scientific meeting in the fields of diabetes and metabolic diseases, it convened over 12,000 leading clinicians, researchers, and healthcare professionals worldwide to explore cutting-edge advances in diagnostics, therapies, and technologies.

 

About CMS-D008

CMS-D008 is a self-developed novel siRNA therapy administered by subcutaneous injection. It targets and reduces the hepatic expression of the inhibin subunit beta E (INHBE) gene and lowers the level of INHBE-encoded Activin E protein, which blocks Activin E-ALK7 signaling and reduces fat accumulation effectively. It demonstrates the potential for high-quality, long-term weight loss that boosts fat-specific loss while preserving muscle mass. Currently, the Phase I clinical trial of CMS-D008 in healthy subjects is progressing steadily. In the future, it may be developed for the treatment of abdominal obesity and related metabolic diseases.

 

CMS-D008 has demonstrated encouraging preclinical data. The preclinical research results of CMS-D008 presented at the ADA Scientific Sessions showed that in obese animal models, CMS-D008 efficiently and sustainably suppressed INHBE expression, achieving significant weight loss and fat reduction while sparing muscle mass, with a favorable safety profile, indicating the potential for healthy weight loss. Details are as follows:

Title: CMS-D008 specifically silences INHBE mRNA, delivering fat-selective weight loss in preclinical study

Presentation Number: 3079-LB

Presentation format: Poster

Date/Time: June 7, 2026 01:30 PM – 02:30 PM (Local Time)

Location: Hall D-E

Results:

  1. In a high-fat diet-induced model of humanized INHBE obese mouse (hINHBE DIO mouse), CMS-D008 significantly reduced hepatic INHBE mRNA expression and serum Activin E protein levels, leading to marked decreases in body weight, total body fat, and regional fat mass while preserving lean mass.
  2. In a model of obese cynomolgus macaque, CMS-D008 also significantly reduced hepatic INHBE mRNA expression and plasma Activin E protein levels, and effectively suppressed weight gain induced by a sustained high-fat diet.

 

The inclusion of these findings at the ADA Scientific Sessions reflects the international academic community’s interest in the scientific value and clinical potential of CMS-D008 in

3the field of obesity/metabolic treatment. CMS-D008 will synergize with CMS-D005, a self-developed, clinical-stage innovative drug (a GLP-1R/GCGR dual agonist), to deliver highly effective weight-loss benefits and long-term maintenance of results, providing patients with a more comprehensive and innovative treatment option.

 

CMS is committed to in-house R&D as a core driver of its long-term growth and continues to advance innovation in cutting-edge therapeutic areas. Currently, 6 self-developed products with global rights, including CMS-D008, have entered the clinical stage, with over 20 additional self-developed projects steadily progressing in preclinical research. Looking ahead, the Group will continue to focus on unmet medical needs, efficiently advance product R&D and commercialization, and bring more comprehensive and innovative therapies to benefit broad patient population.

 

About CMS

CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.

 

CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.

 

CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development in its advantageous specialty fields, strengthening the competitiveness of the cardiovascular-kidney-metabolic/gastroenterology/ophthalmology/skin health businesses, bringing economies of scale in specialty fields. Among them, the skin health business (Dermavon) has become a leading enterprise in its field, and is proposed to be listed independently on the SEHK. Meanwhile, CMS continuously promotes the operation and development of its integrated R&D, manufacturing and commercialization chain in Southeast Asia and the Middle East, capturing growth opportunities in emerging markets to support the high-quality and sustainable development of the Group.

 

CMS Disclaimer and Forward-Looking Statements

This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.

This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.

 

Media Contact

Brand: China Medical System Holdings Ltd.

Contact: CMS Investor Relations

Email: ir@cms.net.cn

Website: https://web.cms.net.cn/en/home/

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Press Release

Amboss and Aureo Connect the Lightning Network to Mexico’s Banking System

Published

7 hours ago

on

September 9, 2026

By

Mexico City, Mexico, September 9th, 2026, FinanceWire

Businesses and individuals anywhere in the world can now send payments that arrive as pesos in a Mexican bank account in seconds

Amboss Technologies, the payments platform that connects businesses to instant, global payments, and Aureo, the Mexican platform that converts Lightning payments directly into peso bank deposits, today announced an integration that links the global Lightning Network to Mexico’s banking system end to end.

Until now, the Lightning Network’s instant settlement stopped at the edge of Mexico’s financial system. With this integration, any business using Amboss Payments can route funds to an Aureo Lightning address and have them arrive as Mexican pesos in a bank account via SPEI, Mexico’s interbank transfer system, in seconds. A customer pays in bitcoin over the Lightning Network, and the recipient in Mexico receives pesos in their bank account without touching an exchange.

Lightning payments have become increasingly popular, with a reach of more than 900 million users globally through exchange apps including Coinbase, Binance, and Cash App. For businesses, Lightning payments cost less than traditional payment cards and settle instantly and finally, with no chargeback risk, making them an attractive supplement to card processing.

The timing reflects a large and underserved market. The United States and Mexico traded an estimated $872 billion in goods in 2025, making Mexico America’s largest trading partner, yet most cross-border business payments still move on slow and costly correspondent banking rails.

With Amboss and Aureo connected, a Mexican business can accept Lightning payments from customers across the United States and globally, hold balances in bitcoin, USDT, or USDC to manage treasury, and move funds to their Mexican bank account whenever they choose.

“Payment rails between the US and Mexico were designed decades ago, and businesses on both sides of the border pay for that every day,” said Jesse Shrader, CEO and Co-Founder of Amboss Technologies.

With Aureo, a Mexican business can accept payments from more than 900 million people through the apps they already use, at a lower cost than card processing, with no chargebacks, and receive pesos in its bank account within seconds. But the opportunity goes beyond accepting payments: Mexican and international businesses can also use the same infrastructure to send pesos to suppliers, contractors, workers, or any other recipient with a Mexican bank account. That is what modern cross-border settlement should look like.

Mexican businesses have always been ready to sell to the world. What they lacked was a payment rail that matched their ambition,” said Gustavo Flores, CEO and Founder of Aureo. “By connecting to Amboss, we make it possible for any business in Mexico to accept instant payments from customers anywhere and receive pesos directly in its bank account, fully compliant with Mexican regulations. Through Aureo’s Direct to Bank feature, a business only needs to set up an Aureo Lightning address once and link it to its Mexican bank account. From that point on, incoming Lightning payments are automatically converted and deposited as pesos, removing the complexity of creating and paying individual Lightning invoices. This is the missing link between the global economy and the Mexican banking system.

The integration is live today. Aureo appears in the Destinations and Integrations sections of the Amboss Payments app, where users can direct incoming payments to any Aureo Lightning address. Aureo operates in full compliance with Mexican regulatory requirements, including KYC verification for all users.

About Amboss Technologies

Amboss connects businesses to instant, global payments with stable money. Businesses send and receive bitcoin with instant conversion to USDT or USDC for no volatility into self-custody. Learn more about reaching 900M+ compatible customers at amboss.tech or meet here.

About Aureo

Aureo is a Mexican platform that connects the Lightning Network to the Mexican banking system. With an Aureo Lightning address, incoming payments are automatically converted to pesos and deposited directly into a Mexican bank account via SPEI. Learn more at aureobitcoin.com.

If interested in exploring how to integrate Bitcoin infrastructure into business in Mexico, users can book a free call with one of Aureo’s founders here.

 Media Contacts

Aureo: maciej@aureobitcoin.com

Contact

Founder
Phil
21M Communications
phil@21mcommunications.com

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Press Release

Global Multi-Asset Broker FP Markets Secures UAE CMA Category 5 Licence

Published

8 hours ago

on

September 9, 2026

By

Limassol, Cyprus, September 9th, 2026, FinanceWire

Global multi-asset Forex and CFD broker FP Markets has been granted a Category 5 Licence by the UAE’s Capital Market Authority (CMA), formerly the Securities and Commodities Authority (SCA), adding to the Australian-founded broker’s global regulatory footprint and marking a strategic step into the UAE market. 

The licence, held by group entity FP Markets MENA Securities L.L.C. S.O.C., permits the broker to carry out marketing, promotional, and client introduction activities in Dubai and across the Emirates. In recent years, the UAE has drawn growing numbers of brokers, fintechs, and financial services providers looking to operate on more solid regulatory ground as they build out their regional client base. 

John Lewis, FP Markets Chief Marketing Officer, stated: ‘Securing a CMA licence is part of FP Markets’ longer-term approach to regulation. Over the past 20 years, each licence we’ve added has built toward the multi-regulated presence we operate today, and the UAE is a natural next step in that. For our clients and partners, this means added security, transparency, and quality of service.’   

The licence also underpins a more direct regulatory relationship within the UAE market, on top of FP Markets’ existing multi-jurisdictional oversight. FP Markets holds licences across multiple leading jurisdictions including: the Australian Securities and Investments Commission (ASIC), the Financial Services Authority (FSA) in Seychelles, the Financial Sector Conduct Authority (FSCA) of South Africa, and the Capital Markets Authority (CMA) of Kenya.

FP Markets will continue to expand its regulatory coverage across markets, in conjunction with ongoing investment in its trading infrastructure, technology, and support functions, ensuring that the pace of regulatory growth is matched by the award-winning quality of service the broker offers to clients and partners alike. 

About FP Markets

FP Markets is a global, multi-regulated, award-winning broker established in Sydney, Australia in 2005. The broker offers 10,000+ CFD instruments across seven asset classes, available on industry-leading platforms including MetaTrader 4/5, TradingView, and cTrader. 

FP Markets’ regulatory presence includes the Australian Securities and Investments Commission (ASIC), the Financial Services Authority (FSA) in Seychelles, the Financial Sector Conduct Authority (FSCA) of South Africa, and the Capital Markets Authority (CMA) of Kenya.

For more information, users can visit www.fpmarkets.com

Contact

CMO
John Lewis
FP Markets
j.lewis@fpmarkets.com

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Spyder Moving and Storage launches a 30-day challenge for stress-free relocations

Published

9 hours ago

on

September 9, 2026

By

Mississippi, USA, Sep 09, 2026, ZEX PR WIRE — Most people wait too long to start packing. Spyder Moving and Storage, based in Oxford, Mississippi, says the biggest source of moving day stress is not the move itself. It is the four weeks before it.

Vladyslav Ladygin, owner of Spyder Moving and Storage, built the company around the idea that a move goes smoothly when the plan is broken into small pieces instead of one big weekend scramble. The 30-day challenge is the company’s attempt to put that thinking into a format anyone can follow, whether they hire movers or not.

“A move feels overwhelming when it’s one giant task,” Ladygin said. “It stops feeling that way once you break it into thirty small ones.”

What the challenge covers

The plan runs in four blocks, each covering about a week:

Days 1 to 7: Sort and decide. Go room by room and separate items into keep, donate, and toss. Spyder Moving and Storage recommends starting with closets and garages, since those tend to hold the most items nobody has touched in a year.

Days 8 to 14: Gather supplies and set a budget. This includes boxes, tape, and padding, along with a firm number for what the move should cost. The company suggests getting a written estimate early so there are no surprises later.

Days 15 to 21: Pack the rooms used least. Guest rooms, storage areas, and seasonal items go first. Kitchens and bedrooms wait until closer to moving day, since those stay in use the longest.

Days 22 to 30: Confirm logistics and pack the essentials. This is the week to confirm the moving date, arrange parking or elevator access, and pack a separate bag with the things needed for the first night in the new place.

Built from the company’s own jobs

Spyder Moving and Storage says the plan reflects patterns the company sees on actual moves, not a generic template. Every step in the plan maps to a problem the company has run into on jobs: families who packed the kitchen too early and had nowhere to cook, or households that waited until the last week to start and ran out of boxes.

The company plans to publish the full day-by-day checklist through its channels so households can follow along without needing to hire a mover first. Ladygin said the goal is for the plan to work whether Spyder handles the move or a family does it themselves.

“We built this company to make moving less stressful,” Ladygin said. “That doesn’t have to depend on whether someone books us.”

A plan for local families too

Spyder Moving and Storage works with households across Oxford and the surrounding area, and the company says the same 30-day approach applies to local moves as well as longer ones. A move across town still benefits from the same early sorting and early packing, even if the truck ride is short.

The company also supports several local and regional causes, including Move for Hunger, pet shelters, and the Denver Children’s Foundation, and treats the 30-day plan as part of the same idea: give people a clear, usable resource rather than a vague promise.

How to follow along

Spyder Moving and Storage will share the checklist in stages over the next month, timed to match the four blocks of the plan. Households that want to start now can begin with the sort-and-decide phase, since that step works no matter when moving day falls.

The company said it built the plan to be simple enough to start today and specific enough to actually follow through day 30.

To read more, visit the website here.

About Spyder Moving and Storage

Spyder Moving and Storage is a moving and storage company based in Oxford, Mississippi. It was founded and is owned by Vladyslav Ladygin, a graduate of William Carey University in Hattiesburg, Mississippi. The company serves local and long-distance moves and supports several community and charitable organizations, including Move for Hunger and the Denver Children’s Foundation.

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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.

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