Press Release
CMS (867/8A8): NDA of Innovative Drug Y-3 for Injection for Acute Ischemic Stroke Accepted in China
SHENZHEN, CHINA – China Medical System Holdings Limited (the “Group” or “CMS”) is pleased to announce that on 11 December 2025, the New Drug Application (NDA) of Class 1 Innovative Drug Y-3 for Injection (proposed English generic name: Loberamisal for Injection) (“Y-3 for Injection” or the “Product”) has been accepted by National Medical Products Administration of the People’s Republic of China (NMPA). The Product is a brain cytoprotectant indicated for the treatment of acute ischemic stroke.
With well-defined targets and clear mechanism of action, Y-3 for Injection is able to exert multiple therapeutic effects. As the world’s first brain cytoprotectant developed based on the important targets PSD95-nNOS and MPO, in the pathological processes of stroke, Y-3 for Injection acts on multiple key pathological processes of the ischemic cascade in ischemic stroke. Through multi-target, highly selective synergy, it is more conducive to exerting brain cytoprotective effects. The Product has an excellent therapeutic effect on ischemic stroke and the potential to prevent post-stroke depression and anxiety symptoms.
Y-3 for Injection demonstrates excellent clinical data with excellent efficacy and a favorable safety profile. The results of Phase II clinical trial of the Product in China indicated that among patients with ischemic stroke within 48 hours of onset, patients in the Y-3 group (40mg, qd) demonstrated a significantly higher proportion of patients achieving an excellent functional outcome (mRS of 0-1) at 90 days than those in the placebo group, with a rate difference of 16%. The Phase III clinical trial of the Product in China was conducted by Beijing Tiantan Hospital, Capital Medical University as the leading site. It has enrolled nearly 1,000 patients with acute ischemic stroke within 48 hours of onset across approximately 40 research centers nationwide, aiming to evaluate the efficacy and safety of Y-3 for Injection in treating patients with acute ischemic stroke within 48 hours of onset. The Phase III clinical study met the primary efficacy endpoint, with patients achieving significant clinical benefits and an overall favorable safety profile. The key study results are planned to be presented at international academic conferences, and the full study will be published in international academic journals.
The Central Nervous System (CNS) is one of the core advantageous fields of CMS, where a deeply integrated layout has been progressively established. The product portfolio has solidified the market foundation, including the marketed innovative drug VALTOCO (Diazepam Nasal Spray), the original brand drug Deanxit (Flupentixol and Melitracen Tablets), and the improved new drug ZUNVEYL (Benzgalantamine Gluconate Enteric-coated Tablets), which is currently under NDA review. The addition of Y-3 for Injection will further strengthen the product portfolio, generating highly efficient synergies in terms of expert networks and market resources. It is expected that if approved for marketing, Y-3 for Injection will bring a new generation of brain cytoprotectant with excellent efficacy and more comprehensive therapeutic effects to Chinese patients with ischemic stroke. Leveraging the successful commercialization experience and compliant and efficient operation system, the Group will accelerate the accessibility of innovative therapies to benefit more patients.
More Information about Y-3 for Injection
The pathological processes of acute ischemic stroke are highly complex and interconnected. There is an urgent clinical need for multi-target, multi-mechanism coordinated interventions to achieve more effective regulation of the complex ischemic cascade, thereby improving treatment outcomes and enhancing patients’ quality of life. Y-3 for Injection is able to uncouple PSD95-nNOS, inhibit MPO activity, and enhance the activity of α2-GABAA receptor (a subtype of GABAA receptor with antidepressant and anxiolytic effects). With this multi-target, highly selective synergistic mechanism, it is expected to achieve a technological breakthrough in the simultaneous intervention of “stroke treatment and prevention of post-stroke depression and anxiety”, making Y-3 for Injection a promising novel brain cytoprotectant with excellent efficacy and more comprehensive therapeutic effects.
The results of Phase II clinical trial of Y-3 for Injection for the treatment of acute ischemic stroke were presented as an oral poster at the 10th European Stroke Organisation Conference in 2024 (ESOC 2024). It indicated that among patients with ischemic stroke within 48 hours of onset, patients in the Y-3 group (20mg, 40mg, 60mg, qd) demonstrated a significantly higher proportion of patients achieving an excellent functional outcome (mRS of 0-1) at 90 days than those in the placebo group (20mg: 67.8% vs 60.7%, 40mg: 76.7% vs 60.7%, 60mg: 70.0% vs 60.7%). Moreover, the Product showed comparable safety to placebo in acute ischemic stroke patients, exhibiting good tolerability.
On 24 August 2023, the Group through its wholly-owned subsidiary entered into a Collaboration Agreement (the “Agreement”) with Neurodawn Pharmaceutical Co., Ltd. (“NeuroDawn”), a clinical needs-oriented pharmaceutical company driven by innovation and R&D. In accordance with the Agreement, the Group obtains an exclusive promotion right in mainland China, the Hong Kong Special Administrative Region, and the Macau Special Administrative Region. The term of the Agreement is permanent.
About Stroke
According to the Guideline for Prevention and Treatment of Cerebrovascular Disease (2024 Edition) issued by the National Health Commission, approximately 3.94 million new stroke cases occur in China each year, accounting for one-third of the global new cases[1]. Among these, ischemic stroke accounts for about 72%, with over 2.8 million new cases annually; the number of existing stroke patients in China has exceeded 28 million[1]. Data from China’s cause-of-death monitoring in 2021 shows that stroke-related deaths accounted for 23% of the national total deaths[1]. Over the past three decades, the disease burden of stroke-related disabilities in China has continued to increase[1]. Coupled with factors such as the accelerating aging of the population, the pressure of stroke prevention and control will further intensify in the future, posing enormous challenges to patients’ families and society[1]. In addition, post-stroke depression and anxiety are common complications of stroke, with incidence rates of approximately 30% and 25% respectively[2]. They can hinder the recovery of patients’ neurological functions, even increase the risk of death, and severely affect patients’ prognosis. Y-3 for Injection holds significant potential value for the long-term neurological function improvement and overall prognosis of a vast number of stroke patients, indicating broad market prospects.
About CMS
CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.
CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.
CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development in its advantageous specialty fields, strengthening the competitiveness of the cardio-cerebrovascular/ gastroenterology/ ophthalmology/ skin health businesses, bringing economies of scale in specialty fields. Among them, the skin health business (Dermavon) has become a leading enterprise in its field, and is proposed to be listed independently on the SEHK. Meanwhile, CMS continuously promotes the operation and development of its integrated R&D, manufacturing and commercialization chain in Southeast Asia and the Middle East, capturing growth opportunities in emerging markets to support the high-quality and sustainable development of the Group.
Reference
- National Health Commission of the People’s Republic of China. Guideline for Prevention and Treatment of Cerebrovascular Disease (2024 Edition) [J]. Chinese Journal of Magnetic Resonance Imaging, 2025, 16(1): 1-8. DOI: 10.12015/issn.1674-8034.2025.01.001.
- Chen Xinyu, Lyu Xiaohan, Li Ruina, et al. Post-Stroke Anxiety [J]. International Journal of Cerebrovascular Disease, 2022, 30(2): 129-133. DOI: 10.3760/cma.j.issn.1673-4165.2022.02.010.
CMS Disclaimer and Forward-Looking Statements
This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.
This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.
Media Contact
Brand: China Medical System Holdings Ltd.
Contact: CMS Investor Relations
Email: ir@cms.net.cn
Website: https://web.cms.net.cn/en/home/
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
MARS Umzuge Enhances Europe-Wide Operations to Meet Growing Demand for International Relocation
In order to meet the increasing demand for international moving services and ease the customers’ experience of cross-border moves, MARS Umzuge has decided to extend its services throughout Europe. Berlin-based relocation company strengthens its operations across Europe to support smooth and reliable international moves.
Berlin, Germany, 21st Apr 2026 – MARS Umzuge, a relocation company based in Berlin has today announced a Europe expansion of its operations covering more countries to address increasing demands in international relocation services. The European region has been increasing mobility from country to country, necessitating an improved infrastructure, logistics coordination and service capability for maximum effectiveness, safety and customer-orientation in their relocation experiences.
Growing Demand for International Moving
In recent years a number of people and businesses are now moving between various European countries. This has created high demand for reliable removal services. MARS Umzuge, a trusted moving company in Berlin, has observed a steady increase in inquiries about international relocation services.
The company already offers structured and well-planned Removals Berlin services. With this expansion, it aims to improve its ability to handle moves across different countries in Europe. The goal is to make the moving process easier more predictable and less stressful for customers.
Focus on Better Planning and Coordination
The major areas to be addressed are logistics and coordination. MARS Umzuge Berlin is known for its full planning, proper handling of consignments and immediate services of deliveries.
International operations demand multi-layered coordination across borders with a central hub linking each participating site. To conduct all this firm has been enhancing its transport planning and route management. This ensures no more delays and assures the timely arrival of the goods, safely. The company reaches its peak status because the Removals Berlin service is carefully planned, ensuring every step is transparent for clients.
Simple and Transparent Moving Process
MARS Umzuge also worked to keep our services simple and easy to understand. Customers were guided throughout the entire moving process right from planning to packing, transportation and delivery. Being a Moving company Berlin has to focus on good communication skills with its clients, which helps prevent confusion and builds trust during the moving phase. Its Removals Berlin services are structured in a way that customers can stay informed and feel more confident about their relocation.
Flexible Services for Different Needs
MARS Umzuge perceives the diversity in each move as its solution to provide a wide range of services for every relocation. In Germany or throughout Europe, a move will always be treated with one and the same level of services. Being an adversity-resilient Moving company Berlin has carried MARS Umzuge seamlessly through the line with small and big moves. Combining the company’s resources has proven beneficial in consistently achieving the aim of assisting individuals, families and enterprises. Further expansions in its Removals Berlin services have given the company a way to handle any number of moving problems elsewhere in Europe.
Maintaining Quality and Reliability
Reliability and Quality, being the primary focus for MARS Umzuge, serve for practicality in all dealings. Their contract establishes a systematic strategy that emphasizes careful management and prompt delivery of products. As Berlin’s most dependable moving company demonstrates careful attention to essential tasks like packing, loading and transportation all of which are crucial for ensuring safety during the lengthy and challenging journey. The entire procedure is regularly reviewed to improve service standards ensuring that all goods and relocation services are provided through our trusted Removals Berlin network everywhere.
Future Plans
As international moves become more frequent, a foreign moving company might find it beneficial to further familiarize itself with the process, reflecting an ongoing industry trend. And recognizing this, the organized and reliant presence of an international moving company has its reason. And MARS Umzuge, the company puts in work towards enhancing operations, preparing to make moves easier for helpful clients. The moving company, gaining popularity in Berlin, is broadening its reach throughout Europe to promote seamless and efficient relocations. In Removals Berlin, simple processes and trustworthiness will undoubtedly remain the cornerstone.
About MARS Umzuge
MARS Umzuge is a Berlin-based moving company that undertakes moves on behalf of people and companies. They’ve always closed the sale off at the highest level of organizational skills service you can rely on and straightforward communication. They are the masters at providing a professional removals company Berlin facility to their clients to make moving precious stuff easy and efficient. Indeed MARS Umzuge gives world citizens help at moving quite around in Europe for internal and outside movers.
Media Contact
Website: https://www.mars-umzuege.de/
Email: info@mars-umzuege.de
Contact No: +49 30 12021901
WhatsApp: 0163 62 49 365
Waldstraße 71, 13403 Berlin, Germany
Media Contact
Organization: Mars Umzüge
Contact Person: Mars Umzüge
Website: https://www.mars-umzuege.de/
Email: Send Email
Contact Number: +493012021901
Address:Waldstraße 71, 13403
City: Berlin
Country:Germany
Release id:44193
The post MARS Umzuge Enhances Europe-Wide Operations to Meet Growing Demand for International Relocation appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
MARS Umzuge Enhances Europe-Wide Operations to Meet Growing Demand for International Relocation
In order to meet the increasing demand for international moving services and ease the customers’ experience of cross-border moves, MARS Umzuge has decided to extend its services throughout Europe. Berlin-based relocation company strengthens its operations across Europe to support smooth and reliable international moves.
Berlin, Germany, 21st Apr 2026 – MARS Umzuge, a relocation company based in Berlin has today announced a Europe expansion of its operations covering more countries to address increasing demands in international relocation services. The European region has been increasing mobility from country to country, necessitating an improved infrastructure, logistics coordination and service capability for maximum effectiveness, safety and customer-orientation in their relocation experiences.
Growing Demand for International Moving
In recent years a number of people and businesses are now moving between various European countries. This has created high demand for reliable removal services. MARS Umzuge, a trusted moving company in Berlin, has observed a steady increase in inquiries about international relocation services.
The company already offers structured and well-planned Removals Berlin services. With this expansion, it aims to improve its ability to handle moves across different countries in Europe. The goal is to make the moving process easier more predictable and less stressful for customers.
Focus on Better Planning and Coordination
The major areas to be addressed are logistics and coordination. MARS Umzuge Berlin is known for its full planning, proper handling of consignments and immediate services of deliveries.
International operations demand multi-layered coordination across borders with a central hub linking each participating site. To conduct all this firm has been enhancing its transport planning and route management. This ensures no more delays and assures the timely arrival of the goods, safely. The company reaches its peak status because the Removals Berlin service is carefully planned, ensuring every step is transparent for clients.
Simple and Transparent Moving Process
MARS Umzuge also worked to keep our services simple and easy to understand. Customers were guided throughout the entire moving process right from planning to packing, transportation and delivery. Being a Moving company Berlin has to focus on good communication skills with its clients, which helps prevent confusion and builds trust during the moving phase. Its Removals Berlin services are structured in a way that customers can stay informed and feel more confident about their relocation.
Flexible Services for Different Needs
MARS Umzuge perceives the diversity in each move as its solution to provide a wide range of services for every relocation. In Germany or throughout Europe, a move will always be treated with one and the same level of services. Being an adversity-resilient Moving company Berlin has carried MARS Umzuge seamlessly through the line with small and big moves. Combining the company’s resources has proven beneficial in consistently achieving the aim of assisting individuals, families and enterprises. Further expansions in its Removals Berlin services have given the company a way to handle any number of moving problems elsewhere in Europe.
Maintaining Quality and Reliability
Reliability and Quality, being the primary focus for MARS Umzuge, serve for practicality in all dealings. Their contract establishes a systematic strategy that emphasizes careful management and prompt delivery of products. As Berlin’s most dependable moving company demonstrates careful attention to essential tasks like packing, loading and transportation all of which are crucial for ensuring safety during the lengthy and challenging journey. The entire procedure is regularly reviewed to improve service standards ensuring that all goods and relocation services are provided through our trusted Removals Berlin network everywhere.
Future Plans
As international moves become more frequent, a foreign moving company might find it beneficial to further familiarize itself with the process, reflecting an ongoing industry trend. And recognizing this, the organized and reliant presence of an international moving company has its reason. And MARS Umzuge, the company puts in work towards enhancing operations, preparing to make moves easier for helpful clients. The moving company, gaining popularity in Berlin, is broadening its reach throughout Europe to promote seamless and efficient relocations. In Removals Berlin, simple processes and trustworthiness will undoubtedly remain the cornerstone.
About MARS Umzuge
MARS Umzuge is a Berlin-based moving company that undertakes moves on behalf of people and companies. They’ve always closed the sale off at the highest level of organizational skills service you can rely on and straightforward communication. They are the masters at providing a professional removals company Berlin facility to their clients to make moving precious stuff easy and efficient. Indeed MARS Umzuge gives world citizens help at moving quite around in Europe for internal and outside movers.
Media Contact
Website: https://www.mars-umzuege.de/
Email: info@mars-umzuege.de
Contact No: +49 30 12021901
WhatsApp: 0163 62 49 365
Waldstraße 71, 13403 Berlin, Germany
Media Contact
Organization: Mars Umzüge
Contact Person: Mars Umzüge
Website: https://www.mars-umzuege.de/
Email: Send Email
Contact Number: +493012021901
Address:Waldstraße 71, 13403
City: Berlin
Country:Germany
Release id:44193
The post MARS Umzuge Enhances Europe-Wide Operations to Meet Growing Demand for International Relocation appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Post Oak Group, recently named the Best Middle-Market Investment Bank in Texas, is expanding its cross-border M&A capabilities to meet this demand, reinforcing its position as a premier advisor to founders, shareholders, and institutional investors pursuing international transactions.
Houston, Texas, United States, 21st Apr 2026 – As middle-market companies increasingly look beyond U.S. borders for growth, strategic partnerships, and capital, the demand for investment banks equipped to navigate cross-border complexity has never been greater. Post Oak Group, recently named the Best Middle-Market Investment Bank in Texas, is expanding its cross-border M&A capabilities to meet this demand, reinforcing its position as a premier advisor to founders, shareholders, and institutional investors pursuing international transactions.
The firm’s cross-border platform is built to address the unique challenges of international dealmaking: differing regulatory frameworks, currency exposure, tax structuring, cultural nuances in negotiation, and the coordination of buyers, investors, and counsel across multiple jurisdictions. With a track record spanning 12 countries and more than $82 billion in completed transactions, Post Oak Group has developed an execution framework designed specifically for the middle market, one that delivers institutional-grade advisory without the bureaucracy and inefficiency often associated with larger global banks.
A Differentiated Approach to International Dealmaking
Middle-market companies pursuing cross-border transactions have historically faced a difficult choice: engage a bulge-bracket bank where their deal risks being deprioritized, or work with a regional advisor lacking true international reach. Post Oak Group was built to eliminate that tradeoff.
“Middle-market founders and shareholders deserve the same caliber of cross-border execution that larger companies receive from global banks,” said Alex Treistman, Managing Partner of the Capital Markets practice at Post Oak Group. “Our platform is designed to deliver that level of sophistication while maintaining the senior-led attention and agility that defines how we operate.”
The firm’s recognition as the Best Middle-Market Investment Bank in Texas reflects this differentiated positioning, a testament to the firm’s ability to combine institutional-grade execution with the responsiveness and customization that middle-market clients require.
Senior-Led Execution Across Every Engagement
A defining feature of Post Oak Group’s cross-border model is the direct involvement of senior bankers throughout the lifecycle of every transaction. The firm’s leadership team brings more than 250 years of combined experience across capital markets, mergers and acquisitions, and a wide range of industry specializations.
Rather than delegating execution to junior staff once a mandate is won, a common dynamic at larger institutions, Post Oak Group’s senior professionals remain deeply engaged from initial strategy through closing. This partner-led model is particularly critical in cross-border engagements, where judgment, relationships, and real-time decision-making often determine the outcome of a transaction.
Global Reach, Integrated Platform
Post Oak Group operates a fully integrated investment banking platform spanning capital markets and M&A advisory, with approximately 300 professionals across advisory, execution, research, operations, and support functions. This integration allows the firm to seamlessly coordinate capital raises, recapitalizations, and buy-side or sell-side M&A mandates across jurisdictions, a capability that is increasingly important as middle-market companies pursue hybrid transactions combining capital infusion with strategic partnership or acquisition.
The firm’s international reach spans North America, Europe, Australia, Latin America, and select markets in Asia, supported by long-standing relationships with institutional investors, family offices, strategic acquirers, and private equity sponsors across the globe.
Meeting a Growing Need in the Middle Market
Cross-border M&A activity in the middle market has accelerated meaningfully in recent years, driven by supply chain realignment, the globalization of founder-owned businesses, and increased appetite from international strategic acquirers and institutional investors for U.S.-based middle-market assets. Post Oak Group’s expansion of its cross-border capabilities is designed to meet this demand head-on.
About Post Oak Group
Post Oak Group is a leading middle-market investment bank headquartered in Houston, Texas, recently recognized as the Best Middle-Market Investment Bank in Texas. The firm operates a fully integrated platform spanning capital markets and M&A advisory, with a track record of more than $82 billion in transactions across 12 countries. Post Oak Group serves founders, shareholders, and institutional investors through senior-led, partner-driven engagements designed to deliver institutional-grade execution with boutique-level attention.
For more information, visit postoakgroup.co
Media Contact
Organization: Post Oak Group
Contact Person: Alexander Treistman
Website: https://www.postoakgroup.co/
Email:
info@postoakgroup.co
City: Houston
State: Texas
Country:United States
Release id:44181
The post Post Oak Group Strengthens Cross-Border M&A Capabilities for Middle-Market Clients appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
MARS Umzuge Enhances Europe-Wide Operations to Meet Growing Demand for International Relocation
MARS Umzuge Enhances Europe-Wide Operations to Meet Growing Demand for International Relocation
Post Oak Group Strengthens Cross-Border M&A Capabilities for Middle-Market Clients
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