Press Release
Candel Therapeutics (NASDAQ: CADL) Lead Candidate CAN-2409 Combats Lung, Pancreatic And Prostate Cancers With Fast Track Designation For Three Cancers
–News Direct–
By Jeremy Golden, Benzinga
Immunotherapy has transformed the way cancer is treated, but just 20% to 40% of patients typically respond to FDA-approved immune checkpoint inhibitor (ICI) treatments.
Poor ICI treatment response has been linked to the tumors ability to disguise antigen presentation and generate an immunosuppressive microenvironment. In addition, most conventional immunotherapies are not designed to educate the patients immune system on how to recognize a variety of tumor antigens and neoantigens.
Amid this landscape, a clinical-stage biopharmaceutical company has developed a new multimodal biological approach that leverages the ability of viral gene constructs to activate cancer-killing mechanisms, exposing multiple tumor antigens to the immune system, resulting in vaccination against the tumor while inhibiting the immunosuppressive tumor microenvironment.
Candel Therapeutics, Inc. (NASDAQ: CADL) is developing a product candidate that is being studied in lung, pancreatic and prostate cancers. Candels most advanced viral immunotherapy candidate, CAN-2409, is an investigational off-the-shelf replication-defective adenovirus designed to induce an individualized, systemic immune response against the patients own tumor.
Part of the companys adenovirus platform, CAN-2409 is injected directly into the tumor or target tissue using a localized injection, akin to the standard approach for vaccination.
CAN-2409's adenoviral construct serves as a vector to transport the HSV-thymidine kinase gene into tumor cells at the site of injection. These tumor cells can then express HSV-thymidine kinase, which converts generic, FDA-approved anti-herpes drugs such as ganciclovir, acyclovir and valacyclovir into a toxic nucleotide analog that blocks DNA synthesis in dividing cells.
Cancer cells exposed to the toxic nucleotide analog in the tumor microenvironment have been observed to undergo immunogenic cell death. Simultaneously, the adenoviral serotype 5 capsid protein elicits a strong pro-inflammatory signal in the tumor microenvironment, creating the optimal conditions to induce a specific CD8+ T cell-mediated response against the injected tumor and uninjected distant metastases for broad and systemic anti-tumor activity.
CAN-2409 is currently being studied in an open-label, phase 2 clinical trial in non-small cell lung cancer (NSCLC) and in randomized, controlled, blinded phase 2b and phase 3 clinical trials in prostate cancer. The company has recently released very encouraging data for CAN-2409s ability to improve overall survival in non-metastatic pancreatic cancer, with topline overall survival data in non-small cell lung cancer planned for this quarter (Q2 2024) and results from the prostate clinical trials later this year (Q4 2024).
When it comes to NSCLC, the company previously presented data from the phase 2 clinical trial in which patients received two administrations of CAN-2409 plus prodrug. Those patients demonstrated the following:
1) Increased infiltration of CD8+ cytotoxic T cells in the tumor microenvironment, systemic expansion of effector T cells and increased soluble granzyme B levels in peripheral blood;
2) Favorable changes in the trajectory of tumor progression;
3) Decreased tumor size of target lesions in most patients; and
4) Reduced size of uninjected tumor lesions.
The CAN-2409 immunotherapy antitumor strategy aims to increase the number of long survivors beyond 10 to 13 months.
As previous work has shown that progressive disease could be converted into stable disease in most patients with non-small cell lung cancer after CAN-2409 treatment, the hypothesis is that this will translate into improved survival.
When it comes to pancreatic cancer, the company reported notable improvements in patients with borderline resectable pancreatic ductal adenocarcinoma (PDAC) after experimental treatment with CAN-2409. The estimated overall survival rate was 71.4% at 24 months in CAN-2409-treated patients versus only 16.7% in the control arm after chemoradiation.
In 2023, CAN-2409 received Fast Track Designation for both non-small cell lung cancer and pancreatic cancer, a validation from the FDA on its potential. CAN-2409 plus valacyclovir in combination with continued PD-1/PD-L1 agents is being evaluated in an ongoing, open-label phase 2 clinical trial in patients with late-stage NSCLC and an inadequate response to anti-PD(L)-1 therapy. In 2024, CAN-2409 also received Orphan Drug Designation from the FDA for CAN-2409 in borderline resectable pancreatic cancer.
In the upcoming year, Candel plans to announce data readouts for the following:
1) Phase 2 topline overall survival (OS) data for CAN-2409 in NSCLC, expected in Q2 2024;
2) Phase 2 topline data for CAN-2409 in low-to-intermediate-risk, localized, non-metastatic prostate cancer, expected in Q4 2024;
3) Phase 3 topline data for CAN-2409 in localized intermediate/high-risk prostate cancer, expected in Q4 2024.
Featured photo by National Cancer Institute on Unsplash.
Candel is a clinical stage biopharmaceutical company focused on developing off-the-shelf multimodal biological immunotherapies that elicit an individualized, systemic anti-tumor immune response to help patients fight cancer. Candel has established two clinical stage multimodal biological immunotherapy platforms based on novel, genetically modified adenovirus and herpes simplex virus (HSV) gene constructs, respectively. CAN-2409 is the lead product candidate from the adenovirus platform and is currently in ongoing clinical trials in non-small cell lung cancer (NSCLC) (phase 2), borderline resectable pancreatic cancer (phase 2), and localized, non-metastatic prostate cancer (phase 2 and phase 3). CAN-3110 is the lead product candidate from the HSV platform and is currently in an ongoing investigator-sponsored phase 1 clinical trial in recurrent high-grade glioma (HGG). Finally, Candels enLIGHTEN Discovery Platform is a systematic, iterative HSV-based discovery platform leveraging human biology and advanced analytics to create new viral immunotherapies for solid tumors.
This article includes certain disclosures that contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding the timing and advancement of development programs, including the timing and availability of additional data, key data readout milestones, including CAN-3110 in HGG; expectations regarding the potential benefits conferred by Fast Track Designation; expectations regarding the therapeutic benefit of its programs, including the potential for its programs to extend patient survival; and expectations regarding cash runway and expenditures. The words may, will, could, would, should, expect, plan, anticipate, intend, believe, estimate, predict, project, potential, continue, target and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on managements current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, those risks and uncertainties related to the timing and advancement of development programs; expectations regarding the therapeutic benefit of the Companys programs; that final data from our pre-clinical studies and completed clinical trials may differ materially from reported interim data from ongoing studies and trials; the Companys ability to efficiently discover and develop product candidates; the Companys ability to obtain and maintain regulatory approval of product candidates; the Companys ability to maintain its intellectual property; the implementation of the Companys business model, and strategic plans for the Companys business and product candidates, and other risks identified in the Companys SEC filings, including the Companys most recent Quarterly Report on Form 10-Q filed with the SEC, and subsequent filings with the SEC. The Company cautions you not to place undue reliance on any forward-looking statements, which speak only as of the date they are made. The Company disclaims any obligation to publicly update or revise any such statements to reflect any change in expectations or in events, conditions or circumstances on which any such statements may be based, or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements. Any forward-looking statements contained in this press release represent the Companys views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date.
This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice.
Contact Details
Aljanae Reynolds
+1 617-916-5445
Company Website
View source version on newsdirect.com: https://newsdirect.com/news/candel-therapeutics-nasdaq-cadl-lead-candidate-can-2409-combats-lung-pancreatic-and-prostate-cancers-with-fast-track-designation-for-three-cancers-458506267
Candel Therapeutics
COMTEX_453480918/2655/2024-06-07T08:28:02
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New Media FF & Emmy Nominee David Leon Launch Music Curation for Media—Driving Growth & Engagement Across High-Impact Creative Segments
Los Angeles, CA — Crafting the Score of Tomorrow: Emmy Nominee David Leon & New Media Film Festival Launch Music Curation for Media. In a dynamic new collaboration, New Media Film Festival® and EMMY®-nominated music supervisor David Leon unveil Music Curation for Media—a category dedicated to the power of sound in storytelling. This initiative is designed to support creators in finding the perfect musical match for their projects, from short films to branded content.
New Media Film Festival® has long been a champion of innovation and empowerment, spotlighting creators working in classic media and being the forefront of technology in media. Now with music curation added to its roster, the festival continues its mission to elevate emerging formats and visionary voices.
“Brief. Curate. Review. Sync. Done.” Your soundtrack to storytelling starts here. newmediafestival.gumroad.com/l/mediacuration
Jamie Adler, Nagin Cox, Ava Della Pietra, Pam Hurst Della Pietra, 2 X Emmy Winner Doug Leighton, Travis Gemoets, Media Futurist Susan Johnston, Emmy Nominee & CEO David Leon, 10 X Telly Winner Randy Bellous & Int’l Jazz Artist Irina Maleeva. Credit Jomel Fragante.
Hear the perfect match
The Music Curation Workflow
Submit Brief – Share your project’s vision and musical needs.
Curate Music – EMMY Nominee David Leon identifies tracks that align creatively and financially.
Discover the true connection
Review & Budget Match – Collaborate to finalize selections and negotiate licensing.
Formalize Licensing – Sync license templates and expert support ensure smooth execution.
Why Music Curation for Media Matters
In today’s content-saturated world, music isn’t just background—it’s narrative. The right track can elevate emotion, define brand identity, and transform a scene from forgettable to unforgettable. Music curation for media ensures that every beat is intentional, every transition seamless, and every story amplified through sound. It’s a creative discipline that blends instinct, strategy, and deep musical knowledge—especially vital for filmmakers, advertisers, and digital storytellers navigating tight timelines and complex licensing landscapes. This isn’t playlist-making—it’s precision storytelling through sound. David’s deep experience in score production, rights and clearances, and the festival’s extensive music capabilities ensures that every beat serves the story.
“With experience in rights and clearances, score production, and festival navigation, David brings both creative and strategic firepower to our team. We’re proud to partner with David in this exciting new chapter.” Susan Johnston – Founder/Director New Media Film Festival®
David Leon: The Force Behind the Sound
In his music career, David has held senior leadership roles across top-tier organizations in aerospace, entertainment, and broadcast music—bringing a wealth of experience from globally recognized institutions., David Leon brings unmatched creative and strategic firepower to this initiative. His work has shaped iconic media moments, and now he’s helping creators do the same.Beyond the studio, David is a sought-after speaker and educator, with appearances at TEDx, San Diego Comic-Con, and major industry panels. His passion for empowering storytellers through music makes him the ideal partner for this visionary collaboration.
About New Media Film Festival®: Since the festivals 2009 inception, Honoring Stories worth Telling has been New Media Film Festival® s mandate. As the 1st Major Festival celebrating innovation, story, mediums & platforms, New Media Film Festival® has led the way in the pursuit of stories worth telling, the exploration of new media technologies, boundary pushing resulting in new distribution models and creating and establishing new methodologies in the global monetization of content. The New Media Film Festival® embodies the transformative power of the cinematic arts and it reaches across cultural bridges to wed story and technology for everyone.
The festival is designed to both discover and cultivate highly creative work from emerging and seasoned content creators. Judges at the New Media Film Festival® include representatives from HBO, BBC, PBS, Marvel, the Academy of Motion Picture Arts and Sciences, the Television Academy, and other pioneers in the entertainment industry. Filmmakers vie for a chance at priceless awards. including a one on one meeting with Marvel or HBO, Studio time, Post and more. Accepted Filmmakers will benefit from a Red Carpet Press Junket, VIP Soiree, networking, international art exhibit, Q&A’s, and much more. www.newmediafilmfestival.com
Media Contact
Organization: New Media Film Festival®
Contact Person: Crystal
Website: https://www.newmediafilmfestival.com
Email: Send Email
Contact Number: +13102881100
Address:2355 Westwood Blvd.
Address 2: 381
City: Los Angeles
State: CA
Country:United States
Release id:31703
The post Strategic Alliance Targets Growth in Audio-Driven Media appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
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Press Release
Emerging Base Ecosystem Token MONK Gains Traction with Community-Led Airdrops and Staking
A new memecoin titled MONK, built on the Base network, is quickly gaining momentum through an ecosystem that merges meme culture with active utility. The token, themed around a blue monkey character, has generated attention through consistent airdrop programs, staking incentives, and a growing cross-project strategy involving its partner token, DORGO.
Unlike many ephemeral meme tokens, MONK is structured with an emphasis on user participation. It features:
- 3% buy/sell fees directed toward sustainability
- Liquidity staking rewards via a custom LP farm
- Airdrops to token holders and ecosystem participants
- A future roadmap involving NFT integrations and Base-native collaborations
The project has positioned itself as part of a broader narrative on Base, embracing memetic storytelling while introducing on-chain mechanics typically seen in more utility-based assets.
Recent activity includes:
- Weekly airdrop campaigns distributed to LP stakers and holders
- A meme contest designed to expand social visibility across platforms like X (Twitter) and Telegram
- A DAO structure planned under its partner project DORGO, with future governance tie-ins anticipated
With consistent on-chain volume, organic community engagement, and integrations into Base’s growing DeFi landscape, MONK is beginning to establish itself as more than a typical meme token instead acting as a social anchor in a developing network of interlinked projects.
For media inquiries or listing-related questions, the team can be reached via their official site: www.monkisbased.com or contact@monkisbased.com via email.
Marketing Partner: crmoonboy (crmoon)
Socials:
Telegram: https://t.me/monkisbased
X/Twitter: https://x.com/monkisbased
Media Contact
Organization: Monk
Contact Person: Alex
Website: https://monkisbased.com
Email: Send Email
City: Miami
State: Florida
Country:United States
Release id:31832
The post Emerging Base Ecosystem Token MONK Gains Traction with Community-Led Airdrops and Staking appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
BoostARA Transforming the Global Sports Industry Through Web3 and Computing Power Incentives
BoostARA: Transforming the Global Sports Industry Through Web3 and Computing Power Incentives
With the global sports industry valued at over USD 600 billion and rapidly shifting toward digital and decentralized models, the market is entering a historic window for disruption and value creation.
As global audiences accelerate their migration to Web3, the sports industry is undergoing an unprecedented digital transformation. BoostARA emerges as the world’s first protocol to integrate “Web3 Sports × Computing Power Incentives,” reshaping the perception of sports value and establishing a new, on-chain sports economy.
Zoom image will be displayed
Guided by its core philosophy — “Exercise as Rights, Data as Assets, Participation as Value” — BoostARA is building a Web3-powered network defined by multi-dimensional participation, decentralized governance, and continuous community-driven incentives.
A. Dual Growth Engines: Technology and Mechanism Innovation
Unlike traditional Move-to-Earn (M2E) models, BoostARA introduces an innovative combination of on-chain incentives and computing power economics. Through mechanisms such as Base Computing Power + Referral Incentives + Tiered Team Computing Power, the platform achieves viral user growth and optimized reward distribution.
Leveraging AI recognition, oracle verification, and smart contracts, sports activities — including running, cycling, and ball games — are verified in real time and converted into on-chain assets, creating a closed-loop value cycle where exercise becomes assets.
BoostARA also implements a dual-layer DAO governance model, giving users direct influence over ecosystem development — from operational decisions and event arrangements to NFT issuance and virtual club management — ensuring a decentralized, community-built sports economy.
B. Multi-Layered Incentives Driving Sustainable Growth
To drive adoption and long-term engagement, BoostARA has designed a comprehensive reward framework covering:
– Static computing power mining
– Dynamic referral incentives
– Node dividends
– Tiered team-based bonuses
The platform’s native token, ARA, underpins this incentive model. Its economic framework incorporates:
– Daily emission reduction
– Transaction slippage control
– Liquidity pool dividends
– Token burning mechanisms
This model ensures healthy token circulation and a long-term deflationary trend.
Token Economics (Total Supply: 300 billion ARA):
– Mining Output: 295 billion
– Market Incentives: 3 billion
– Market Control: 1 billion
– Initial Liquidity: 1 billion
C. An Integrated Web3 Sports Ecosystem
Built on four core pillars — On-chain Sports × NFTs × Community Governance × Token Incentives — BoostARA’s ecosystem includes:
– BoostMove — On-chain sports data recognition
– BoostCard — NFT sports star cards
– BoostDAO — Governance and voting infrastructure
– BoostVault — Computing power incentive pool
Together, these components form a complete value chain, from activity tracking and asset creation to governance participation and reward distribution.
Zoom image will be displayed
D. Strategic Partnerships
BoostARA collaborates with:
– Global sports organizations and clubs from Europe’s top five leagues
– BOOSTARA Investment Group
– Sports platforms such as 188 Sports and SABA Sports
– Web3 infrastructure and AI providers including BSC, TokenPocket, Feixiaohao, MetaMask, DeepSeek, Chainlink, and OpenAI API partners.
E. A New Paradigm for Sports Value
BoostARA is more than a technological innovation — it is a digital renaissance of sportsmanship. Through blockchain and decentralized governance, BoostARA ensures that the passion and dedication of every athlete and fan are recognized and rewarded.
As the global sports industry enters a new era of digitization, tokenization, and collaborative governance, BoostARA — powered by technology and community — aims to redefine sports value and co-create the future of the digital sports economy.
Media Contact
Organization: BoostARA Public Relations
Contact Person: Lukas Wike
Website: https://www.boostara.io
Email: Send Email
Country:United States
Release id:31800
The post BoostARA Transforming the Global Sports Industry Through Web3 and Computing Power Incentives appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
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