Press Release
X-tosis Receives Grant from The Michael J. Fox Foundation to Advance Novel Parkinson’s Disease Therapy
Gainesville, United States, June 23rd, 2026, FinanceWire
X-tosis Receives Grant from The Michael J. Fox Foundation for Parkinson’s Research to Advance Novel Parkinson’s Disease Therapy. The ward supports advancement of X-tosis’s mitochondrial approach and accelerates development of its lead Parkinson’s candidate toward the clinic.
X-tosis, Inc., a precision-medicine biotechnology company founded in 2024 and dedicated to developing novel mitochondrial therapeutics for neurodegenerative diseases, today announced it has been awarded a $2.74 million grant from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) through its Parkinson’s Disease Therapeutics Pipeline Program. The funding will support advancement of XTS001, the lead candidate from the company’s MitoXTS platform, a patented family of small-molecule inhibitors of voltage-dependent anion channel 1 (VDAC1) oligomerization, toward clinical development for the treatment of Parkinson’s disease (PD). The grant was awarded following a competitive peer-review process evaluating scientific innovation and translational potential.
The MJFF Parkinson’s Disease Therapeutics Pipeline Program accelerates promising PD therapies from preclinical to clinical stages by supporting innovative approaches that address core disease mechanisms.
XTS001 is a brain-penetrant, orally available small molecule designed to selectively inhibit VDAC1 oligomerization, a pathological process increasingly recognized as a central driver of mitochondrial failure, neuroinflammation, and neuronal loss in PD. Preclinical studies in animal models of PD and AD across the MitoXTS platform have demonstrated reduced dopaminergic neuron loss, restoration of dopamine levels, and protection against key PD-associated pathologies through preservation of mitochondrial function and prevention of apoptosis triggered by cellular stressors.
“This grant from MJFF is a major milestone for X-tosis and represents a strong validation of our MitoXTS approach to addressing unmet needs in Parkinson’s and other neurodegenerative diseases,” said Yotam Nisemblat, Chief Scientific Officer of X-tosis and Principal Investigator on the project. “By preserving mitochondrial integrity upstream in the neurodegeneration cascade, we aim to shift treatment from symptomatic relief to targeting underlying disease biology. We are grateful for MJFF’s support to advance confirmatory studies, biomarker development, and IND-enabling work.”
“This award from The Michael J. Fox Foundation is more than funding; it is support for further investigation of our scientific approach that mitochondrial dysfunction is a central addressable driver of Parkinson’s disease,” said Erin Henderson, CEO of X-tosis, Inc. “We believe XTS-001 represents a first-in-class opportunity to intervene upstream in the neurodegenerative cascade, potentially transforming the treatment paradigm from symptomatic management to targeting disease biology.. With MJFF’s support, we are accelerating toward IND-enabling studies and positioning XTS001 as a potential therapeutic approach for Parkinson’s disease and beyond.”
X-tosis’s MitoXTSTM platform is built upon more than five decades of pioneering research by Professor Varda Shoshan-Barmatz, PhD, a global leader in mitochondrial biology and VDAC1 specifically. Her groundbreaking work established VDAC1 as a central regulator of mitochondrial function and apoptosis, with direct implications for neurodegenerative diseases. With over 225 publications, more than 14,000 citations, and multiple patents covering VDAC1-targeted therapeutics, her discoveries form the scientific foundation of X-tosis’s pipeline.
X-tosis plans to leverage the grant to achieve key development milestones and position XTS001 for clinical trials. If successful, this work could contribute to the development of therapies with the potential to slow disease progression and improve outcomes for millions worldwide. Beyond Parkinson’s disease, the MitoXTS platform is being advanced across multiple neurodegenerative indications, positioning X-tosis with a diversified pipeline of precision mitochondrial therapeutics.
About Parkinson’s Disease
Parkinson’s disease affects more than 10 million people globally and currently lacks approved disease-modifying therapies.
About X-tosis, Inc.
X-tosis, Inc. is a Gainesville, FL-based biotechnology company developing first-in-class mitochondrial therapeutics via the patented MitoXTS platform. By modulating VDAC1 oligomerization to restore mitochondrial health, reduce inflammation, and prevent neuronal death, X-tosis aims to transform treatment for Alzheimer’s, Parkinson’s, ALS, and related conditions. For more information, visit www.x-tosis.com.
Contact
CEO
Erin Henderson
X-tosis
info@x-tosis.com
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
Dental.me Publishes First-Ever Fully-Verified List of Florida Dentists
10,800+ dental practice listings will help members of underserved communities find trustworthy dental services while providing an efficient, accurate information source for insurers, employers, and state-level access programs
United States, 29th Jun 2026 — Dental.me, the independent dentist directory, today announced the publication of the first-ever fully verified list of dentists in the state of Florida. The list, which contains detailed information on 10,807 dental practices in 247 Florida cities, will help members of underserved communities find trustworthy dental services while providing an efficient, accurate information source for insurers, employers, and state-level access programs.
“Until now, there was no single resource that covered every dental practice in every Florida city,” explained Spencer Whiteclaw, CEO of Dental.me. “The information that was available tended to be incomplete, out of date, or inaccurate. Online listings are often opaque. A practice that’s been shuttered for two years still shows up at the top of search rankings, and so forth. That’s the problem we’re solving with this new list.”
The list organizes dental practices by city and specialty so potential patients can compare them on the details that matter, e.g., location, services, hours, public ratings, and the completeness of listings. Dental.me makes practice verification an essential element of its listings. “Patients get the truth. Practices get a clean lane to claim their own listings,” Whiteclaw added. The verification process is manual and painstaking.
The company invested effort and resources in developing a comprehensive list of dental practices covering smaller towns and urban neighborhoods where high-integrity data on dental services has traditionally been in short supply. The listings cover dental practices from Pensacola in the Panhandle to Key West, and from Belle Glade and Clewiston in the agricultural interior to the dense urban corridors of South Florida.
To access the list, visit https://dental.me
About Dental.me
Dental.me is an independent dentist directory built to help people find and compare dental practices using clear, factual, sourced information. The company is currently focused on Florida, with plans for a nationwide expansion.
Media Contact
Organization: Dental.me
Contact Person: Spencer Whiteclaw
Website: https://dental.me
Email: Send Email
Country:United States
Release id:46583
The post Dental.me Publishes First-Ever Fully-Verified List of Florida Dentists appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
Coffee Journal Publishes 50-Stop South Africa Coffee Shop Guide
Coffee Journal, an independent South African specialty coffee publication founded by Bibi Burness
Randvaal Meyerton, Gauteng, South Africa, 29th Jun 2026 – Coffee Journal, an independent South African specialty coffee publication founded by Bibi Burness, announced the publication of its new 50-stop South Africa coffee shop guide, a nationwide editorial feature that spotlights specialty cafes, roasteries and coffee-growing estates across all nine provinces. First published June 18 and presented as a living resource for coffee travelers and local readers, the feature is designed to widen the conversation beyond the country’s largest coffee hubs and toward a more geographically representative view of South African specialty coffee.
The article frames the project as a bucket-list style guide rather than a leaderboard. According to the published methodology inside the feature, every province receives a place on the list, while the country’s biggest coffee cities are capped to make room for smaller towns, regional roasteries and farm destinations. The article states that Cape Town entries were capped at five, Johannesburg at five and Durban at three, a structure intended to create room for coffee destinations in places such as the Karoo, the Midlands, the Soutpansberg and the Port Edward area.
That editorial choice gives the release a clear news angle: a new national coffee guide that deliberately shifts attention away from metro-heavy ranking formats. In practice, the list becomes part travel guide, part editorial map and part discovery tool for readers who want to understand how specialty coffee is distributed across the country. By treating coffee as both a hospitality category and a regional culture story, Coffee Journal positions the feature as relevant to consumers, tourism stakeholders, roasters and destination businesses alike.
The feature also sets out defined selection criteria. The article says the list favors specialty over chains and story over hype, with priority given to venues that offer a compelling reason to travel, including working roasteries, award-winning baristas, distinctive cafe environments and coffee farms where visitors can engage with production more directly. The guide highlights three coffee-growing estates in particular — Beaver Creek in Port Edward, Sabie Valley in White River and Citimba in Louis Trichardt — presenting them as rare opportunities to experience South African coffee from the tree rather than only in the cup.
The guide is not presented as a closed editorial product. Instead, Coffee Journal invites readers to leave Traveller Notes, submit Go or Don’t-go verdicts and suggest shops that deserve inclusion in future updates. That built-in feedback layer gives the article continuing editorial relevance after publication and creates a transparent mechanism for expansion. It also supports return visits by encouraging readers to contribute practical details such as what to order, what to expect and which overlooked destinations should move into the next round of coverage.
Coffee Journal’s broader editorial platform strengthens the release’s credibility. The publication describes itself as independent, South Africa-based and not funded by roasters or brand partnerships, while its site includes consumer education tools such as the grind guide, city-based coffee coverage including Cape Town coffee roasters, and a published explanation of how Coffee Journal scores SA specialty roasters. Together, those resources position the new list inside a wider editorial ecosystem focused on coffee discovery, home brewing and transparency.
The article also includes a statement from Burness that captures the editorial rationale behind the project: “Every province in this country has someone quietly roasting extraordinary coffee. You just have to go looking.” That line gives the release a concise, fact-based quote already published on the site and ties the guide to a broader message about under-recognized regional talent in South African coffee.
For the specialty coffee sector, the list may be significant because it organizes discovery around national spread rather than density in a handful of cities. Many coffee roundups concentrate heavily on Cape Town and Johannesburg. Coffee Journal’s structure takes a different approach by making provincial representation part of the editorial rule itself. That approach can improve visibility for smaller operators and lesser-covered areas while also giving travelers a clearer sense of how coffee culture appears across multiple regions, not just established urban centers.
The release also aligns with Coffee Journal’s identity as a specialty coffee publication that combines editorial curation with practical user participation. Its homepage presents the brand as a place to track espresso, discover South African roasters and learn the craft, while the about page says the publication was founded in 2026 to create a central home for the country’s specialty coffee scene. In that context, the 50-stop guide functions as both a standalone article and a strategic content asset that complements the site’s directories, brew guides and transparency-based reporting.
The new feature is now available on the Coffee Journal website, where readers can browse the full list, review province-by-province selections and contribute notes for future updates. Additional coverage of South African roasters, brewing resources and editorial coffee guides is available through Coffee Journal.
Media Contact
Organization: Coffee Journal
Contact Person: Bibi Burness
Website: https://coffeejournal.co.za/
Email: Send Email
Contact Number: +27729850426
Address:52 The Avenue, Henley on Klip
City: Randvaal Meyerton
State: Gauteng
Country:South Africa
Release id:46582
The post Coffee Journal Publishes 50-Stop South Africa Coffee Shop Guide appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
Dental.me Publishes First-Ever Fully-Verified List of Florida Dentists
10,800+ dental practice listings will help members of underserved communities find trustworthy dental services while providing an efficient, accurate information source for insurers, employers, and state-level access programs
United States, 29th Jun 2026 — Dental.me, the independent dentist directory, today announced the publication of the first-ever fully verified list of dentists in the state of Florida. The list, which contains detailed information on 10,807 dental practices in 247 Florida cities, will help members of underserved communities find trustworthy dental services while providing an efficient, accurate information source for insurers, employers, and state-level access programs.
“Until now, there was no single resource that covered every dental practice in every Florida city,” explained Spencer Whiteclaw, CEO of Dental.me. “The information that was available tended to be incomplete, out of date, or inaccurate. Online listings are often opaque. A practice that’s been shuttered for two years still shows up at the top of search rankings, and so forth. That’s the problem we’re solving with this new list.”
The list organizes dental practices by city and specialty so potential patients can compare them on the details that matter, e.g., location, services, hours, public ratings, and the completeness of listings. Dental.me makes practice verification an essential element of its listings. “Patients get the truth. Practices get a clean lane to claim their own listings,” Whiteclaw added. The verification process is manual and painstaking.
The company invested effort and resources in developing a comprehensive list of dental practices covering smaller towns and urban neighborhoods where high-integrity data on dental services has traditionally been in short supply. The listings cover dental practices from Pensacola in the Panhandle to Key West, and from Belle Glade and Clewiston in the agricultural interior to the dense urban corridors of South Florida.
To access the list, visit https://dental.me
About Dental.me
Dental.me is an independent dentist directory built to help people find and compare dental practices using clear, factual, sourced information. The company is currently focused on Florida, with plans for a nationwide expansion.
Media Contact
Organization: Dental.me
Contact Person: Spencer Whiteclaw
Website: https://dental.me
Email: Send Email
Country:United States
Release id:46583
The post Dental.me Publishes First-Ever Fully-Verified List of Florida Dentists appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
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