Press Release
X-tosis Receives Grant from The Michael J. Fox Foundation to Advance Novel Parkinson’s Disease Therapy
Gainesville, United States, June 23rd, 2026, FinanceWire
X-tosis Receives Grant from The Michael J. Fox Foundation for Parkinson’s Research to Advance Novel Parkinson’s Disease Therapy. The ward supports advancement of X-tosis’s mitochondrial approach and accelerates development of its lead Parkinson’s candidate toward the clinic.
X-tosis, Inc., a precision-medicine biotechnology company founded in 2024 and dedicated to developing novel mitochondrial therapeutics for neurodegenerative diseases, today announced it has been awarded a $2.74 million grant from The Michael J. Fox Foundation for Parkinson’s Research (MJFF) through its Parkinson’s Disease Therapeutics Pipeline Program. The funding will support advancement of XTS001, the lead candidate from the company’s MitoXTS platform, a patented family of small-molecule inhibitors of voltage-dependent anion channel 1 (VDAC1) oligomerization, toward clinical development for the treatment of Parkinson’s disease (PD). The grant was awarded following a competitive peer-review process evaluating scientific innovation and translational potential.
The MJFF Parkinson’s Disease Therapeutics Pipeline Program accelerates promising PD therapies from preclinical to clinical stages by supporting innovative approaches that address core disease mechanisms.
XTS001 is a brain-penetrant, orally available small molecule designed to selectively inhibit VDAC1 oligomerization, a pathological process increasingly recognized as a central driver of mitochondrial failure, neuroinflammation, and neuronal loss in PD. Preclinical studies in animal models of PD and AD across the MitoXTS platform have demonstrated reduced dopaminergic neuron loss, restoration of dopamine levels, and protection against key PD-associated pathologies through preservation of mitochondrial function and prevention of apoptosis triggered by cellular stressors.
“This grant from MJFF is a major milestone for X-tosis and represents a strong validation of our MitoXTS approach to addressing unmet needs in Parkinson’s and other neurodegenerative diseases,” said Yotam Nisemblat, Chief Scientific Officer of X-tosis and Principal Investigator on the project. “By preserving mitochondrial integrity upstream in the neurodegeneration cascade, we aim to shift treatment from symptomatic relief to targeting underlying disease biology. We are grateful for MJFF’s support to advance confirmatory studies, biomarker development, and IND-enabling work.”
“This award from The Michael J. Fox Foundation is more than funding; it is support for further investigation of our scientific approach that mitochondrial dysfunction is a central addressable driver of Parkinson’s disease,” said Erin Henderson, CEO of X-tosis, Inc. “We believe XTS-001 represents a first-in-class opportunity to intervene upstream in the neurodegenerative cascade, potentially transforming the treatment paradigm from symptomatic management to targeting disease biology.. With MJFF’s support, we are accelerating toward IND-enabling studies and positioning XTS001 as a potential therapeutic approach for Parkinson’s disease and beyond.”
X-tosis’s MitoXTSTM platform is built upon more than five decades of pioneering research by Professor Varda Shoshan-Barmatz, PhD, a global leader in mitochondrial biology and VDAC1 specifically. Her groundbreaking work established VDAC1 as a central regulator of mitochondrial function and apoptosis, with direct implications for neurodegenerative diseases. With over 225 publications, more than 14,000 citations, and multiple patents covering VDAC1-targeted therapeutics, her discoveries form the scientific foundation of X-tosis’s pipeline.
X-tosis plans to leverage the grant to achieve key development milestones and position XTS001 for clinical trials. If successful, this work could contribute to the development of therapies with the potential to slow disease progression and improve outcomes for millions worldwide. Beyond Parkinson’s disease, the MitoXTS platform is being advanced across multiple neurodegenerative indications, positioning X-tosis with a diversified pipeline of precision mitochondrial therapeutics.
About Parkinson’s Disease
Parkinson’s disease affects more than 10 million people globally and currently lacks approved disease-modifying therapies.
About X-tosis, Inc.
X-tosis, Inc. is a Gainesville, FL-based biotechnology company developing first-in-class mitochondrial therapeutics via the patented MitoXTS platform. By modulating VDAC1 oligomerization to restore mitochondrial health, reduce inflammation, and prevent neuronal death, X-tosis aims to transform treatment for Alzheimer’s, Parkinson’s, ALS, and related conditions. For more information, visit www.x-tosis.com.
Contact
CEO
Erin Henderson
X-tosis
info@x-tosis.com
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
San Jose, California, Aug 25, 2026, ZEX PR WIRE — For Robert Clamon, motorcycle racing has never been about taking unnecessary chances. It has been about preparation, judgement, and knowing how to make decisions when there isn’t much time to hesitate.
Those lessons have followed him into his professional life.
Clamon, an Area Fleet Operations Supervisor with PG&E in San Jose, began his career as a mechanic at San Jose BMW before moving into management roles at Weston’s Auto Body and Monterey-Salinas Transit. Across each stage of his career, he has found that managing risk is less about avoiding uncertainty and more about being prepared for it.
“People hear motorcycle racing and think it’s all about speed,” Clamon said. “But if you’re not prepared, speed doesn’t help you. You need to understand the machine, pay attention to what’s happening around you, and know when to push and when to back off.”
That mindset has influenced how Clamon approaches decisions at work.
In racing, conditions can change quickly. A rider has to respond without losing focus. In operations, the details are different, but Clamon sees a similar need for calm thinking and situational awareness.
“You’re rarely going to have perfect information,” he said. “At some point, you have to make the best decision you can with what you know, then be willing to adjust if something changes.”
Preparation Before Pressure
Clamon’s mechanical background gave him an early appreciation for preparation. At San Jose BMW, he learned that problems often begin with details that are easy to overlook.
That lesson became even more important as he moved into leadership.
“When you’ve worked on the equipment yourself, you understand that small things matter,” he said. “You don’t want the first time you notice a problem to be when everything has already gone wrong.”
Rather than viewing preparation as a way to eliminate all risk, Clamon sees it as a way to create better options when something unexpected happens.
He carries the same philosophy into motorcycle racing. Proper maintenance, knowing the bike, understanding conditions, and staying mentally focused all help a rider make better decisions once the race begins.
A Serious Accident Changed His View of Risk
Clamon’s relationship with risk became more personal after he was involved in a serious motorcycle accident.
Recovery forced him to slow down and reconsider what progress looked like. It also challenged the idea that determination always means pushing harder.
“There were times when I wanted things to move faster than they were going to,” Clamon said. “You learn that sometimes the right decision is to be patient. That was a difficult lesson, but it’s one I’ve carried with me.”
The experience changed how he handles pressure. When a situation starts to feel overwhelming, he tries to avoid reacting to everything at once.
His approach is simple: take a breath, identify what matters most, and deal with the next problem in front of him.
“That doesn’t mean ignoring the bigger picture,” he said. “It means not letting the bigger picture stop you from making the next good decision.”
Why Good Risk-Taking Isn’t Reckless
Clamon believes people sometimes confuse confidence with certainty.
Whether someone is moving into management, suggesting a new idea, or taking on an unfamiliar responsibility, there’s rarely a guarantee that everything will work exactly as planned.
For Clamon, confidence comes from preparation and experience rather than pretending uncertainty doesn’t exist.
“Taking a risk doesn’t mean you stop thinking about the consequences,” he said. “You should understand what can go wrong, prepare for what you can, and then decide whether the risk makes sense.”
That perspective has shaped a career that moved from hands-on mechanical work into increasingly complex management responsibilities.
Clamon doesn’t see those earlier roles as separate from the work he does today. Instead, he views them as part of the experience that taught him how to judge problems, listen to people, and make decisions without overcomplicating them.
Motorcycle racing may seem far removed from fleet leadership, but for Clamon, the connection is clear.
Preparation matters before pressure arrives. Details matter when the stakes rise. And sometimes the most important skill isn’t knowing how fast to move, but knowing when to slow down.
About Robert Clamon
Robert Clamon is an Area Fleet Operations Supervisor with PG&E in San Jose, California. His career has included roles as a mechanic at San Jose BMW, General Manager at Weston’s Auto Body, and Fleet Supervisor at Monterey-Salinas Transit. His background combines hands-on automotive experience with years of management and fleet operations work.
Outside of his career, Clamon is interested in motorcycle racing, fosters miniature pigs, and is an avid dog lover. He values integrity, dependability, continuous learning, and practical problem-solving, and he credits both his professional experience and recovery from a serious motorcycle accident with shaping the way he approaches leadership and decision-making.
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Port Louis, Mauritius, August 25th, 2026, FinanceWire
24 August 2026 launch expands access to quantum computing, cybersecurity, space, nuclear energy, AI and robotics.
STARTRADER evolves alongside global markets, expanding its product range to reflect client interests and trading habits. On 24 August, the company will add 30 new U.S. stock and ETF CFDs to MT5, expanding its range of CFD exposure to companies and themes across technology, infrastructure and innovation.
The expansion spans eight areas. Quantum computing additions include IONQ, QBTS, QUBT, ARQQ and QMCO; software infrastructure includes ZS, S, RBRK and GTLB; space and defence includes LUNR, PL, RCAT and BKSY; while XE and NNE expand the range of CFDs linked to nuclear and energy themes.
The launch also adds SERV and POET across AI and semiconductors; VCX across asset management; DOCN and FROG across cloud and DevOps; and FUTU, ONDS, OUST, VSAT, LASR, AEHR, UCTT and GSAT across fintech, communications and advanced technology. Thematic ETFs DXYZ and NASA complete the release.
The addition caps STARTRADER’s most active year of product development. In 2026, the company announced 330+ instruments, extended trading hours across selected stock and ETF instruments, and launched XAUUSD247, its 24/7 gold CFD, all driven by one goal: giving clients greater choice as markets evolve.
“Traders should not need multiple places to follow the markets that matter. As industries emerge and attention shifts, we keep expanding access with purpose, giving clients the markets, products and flexibility they need, their way.”
Peter Karsten, CEO of STARTRADER
The new instruments will be available on MT5 with 1:5 leverage, trade sizes from 0.1 to 1,000 lots, and trading hours from Monday to Friday, 16:30–23:00 GMT+3. Availability depends on account type, client classification and jurisdiction; the instrument is not available to clients in all countries.
The latest release reflects STARTRADER’s pillars of Strength, Trust, Ambition and Resilience through broader choice, continuous innovation and an offering designed to adapt with clients and markets.
Risk Warning: CFDs are complex instruments and carry a high risk of losing money rapidly due to leverage. Ensure you understand the risks before trading.
Disclaimer: This content is for informational purposes only and does not constitute financial or investment advice or a recommendation to trade. It is not intended for distribution or use in any jurisdiction where such distribution would be contrary to local laws or regulations.
About STARTRADER
STARTRADER is a global multi-asset broker empowering retail and institutional partners to access global markets through a range of platforms, including MetaTrader, STARTRADER APP, and STAR Copy.
STARTRADER operates through entities licensed and regulated by authorities including CMA, ASIC, FSCA, FSA and FSC, combining strong governance with a client-first approach, serving both retail clients and partners with a commitment to transparency, reliability, and long-term growth.
Contact
Janna.magabilen
Janna.magabilen@startrader.com
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
Coinbunch Launches Specialist Crypto Tax Reporting and Accounting Service for Individuals and Institutions
United Arab Emirates, 25th Aug 2026 — Coinbunch, a licensed and registered financial institution, today announced the launch of its crypto tax reporting, transaction reconciliation, and accounting service for individuals and institutions whose digital asset holdings are too fragmented, technical, or spread across jurisdictions for conventional tax preparers and generic tax software to handle correctly.
Crypto holders with activity spanning multiple exchanges, wallets, and chains routinely run into the same problem: cost basis is fragmented or missing, some exchanges have closed or stopped providing records, and on-chain activity such as staking, lending, liquidity provision, and bridging falls outside what most preparers can interpret. Generic tax software compounds the issue by frequently misreading transfers between a client’s own wallets and exchanges as taxable disposals, inflating reported gains and producing schedules that do not reflect what actually happened.
Coinbunch’s service is built specifically around these failure points. The desk reconstructs cost basis from on-chain data, partial exports, and bank records; identifies and reconciles self-transfers so they are removed from the disposal schedule; classifies DeFi and on-chain income into the correct tax treatment; and prepares multi-year catch-up filings for clients whose earlier returns were never filed or were filed incompletely. Every filing-ready schedule is delivered with supporting working papers that trace each figure back to its source records. A parallel accounting line of service provides bookkeeping and financial statement preparation for individuals, funds, and entities holding digital assets, built from the same reconciled data where clients engage the desk for both.
Every engagement follows the same structure: a confidential scoping call to assess the client’s holdings, jurisdictions, and entity type; a written scope of work and a fixed fee delivered before any work begins; and execution in which transactions are matched, cost basis is rebuilt, and gaps are flagged for the client’s review before any figure is finalized. Data collection is read-only throughout — Coinbunch never requests private keys, seed phrases, or transfer authority.
The firm reports a track record spanning more than 30 jurisdictions and hundreds of engagements, all delivered on a fixed-fee basis with no hourly billing. Clients range from individual traders and long-term holders with years of complex or unfiled history, to family offices, funds, corporate treasuries, and DeFi participants whose on-chain activity requires specialist classification.
“I have spent the past 12 years practicing tax law and the past eight working in cybersecurity. Both fields reward the same habits: precision, patience, and a willingness to sit with a problem until it is properly understood. That is the mindset we brought to Coinbunch,” said Joachim, Founder and CEO of Coinbunch.
Coinbunch confirms client eligibility before any onboarding begins, assessing jurisdiction, entity type, source of funds, and identity verification. The firm does not serve every country and directs prospective clients to confirm coverage before starting a scoping call. Coinbunch does not hold, move, or transact client assets, and has warned that any party claiming to recover blockchain funds on the firm’s behalf is fraudulent.
Coinbunch is available now for scoping calls at coinbunch.com, with a written scope of work and fixed fee provided after each confidential consultation.
About Coinbunch
Coinbunch Inc. is a licensed and registered financial institution and a Domestic Business Corporation registered in Albany, New York. The firm provides crypto tax reporting, transaction reconciliation, tax advice, bookkeeping, and financial statement preparation for private and institutional holders of digital assets, with services covering cost basis reconstruction, transfer reconciliation, multi-year catch-up filings, and filing-ready reporting backed by traceable working papers. Coinbunch is led by Founder and CEO Joachim, who brings 12 years of tax law practice and 8 years in cybersecurity, including prior roles at Microsoft, Barclays, and Cisco. More information is available at coinbunch.com.
Media Contact
Organization: Coinbunch Inc
Contact Person: Joachim Holdinghausen
Website: https://coinbunch.com/
Email: Send Email
Country:United Arab Emirates
Release id:48373
The post Coinbunch Launches Specialist Crypto Tax Reporting and Accounting Service for Individuals and Institutions appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Robert Clamon on What Motorcycle Racing Taught Him About Risk and Decision-Making
STARTRADER Adds 30 U.S. Stock and ETF CFDs as 2026 Product Expansion Accelerates
Coinbunch Launches Specialist Crypto Tax Reporting and Accounting Service for Individuals and Institutions
Benzinga Money Article Discusses How to Become Part of the 12% of Retirees Who Have Achieved the Recommended $550,000 Minimum Retirement Savings Threshold
Apu Apustaja Conquers New York with Lively Street Ads, Including Times Square Billboard
Bay Smokes Maintains Quality Amid Legislative Changes in the Hemp Industry
-
Press Release1 week ago
Meet the Surgeon Behind the Billboard Turning Heads Across Long Island: Dr. David Pincus of Pincus Plastic Surgery
-
Press Release3 days ago
MTLI Group Advances Canada’s Industrial Infrastructure With Integrated Automation, Construction and Facility Solutions
-
Press Release3 days ago
Way.com Expands Auto Repair Marketplace to Simplify Car Care for Drivers Nationwide
-
Press Release1 week ago
New Self-Help Book Reveals a Powerful Journey of Healing from Childhood Abuse
-
Press Release1 week ago
TripleDart tops $7 million ARR with AI-led growth, reports 50 per cent EBIT margin
-
Press Release1 week ago
Lontto Outlines Clay Brick Production Equipment Range for Construction Suppliers
-
Press Release1 week ago
Pullner Reports Sustained Demand for Filtration Cartridges Across Power Generation Sector
-
Press Release3 days ago
MTLI Group Connects Construction, Automation and Facility Operations Across U.S. Markets