Press Release
CMS’s (867.HK/8A8.SG) Self-developed Innovative INHBE-Targeting siRNA Drug CMS-D008 Presents Its Preclinical Results at the ADA Scientific Sessions
SHENZHEN, CHINA – China Medical System Holdings Limited (“CMS” or the “Group”) is pleased to announce that the preclinical results of its self-developed innovative INHBE-targeting small nucleic acid drug CMS-D008 injection (“CMS-D008”), have been presented in a poster at the American Diabetes Association (ADA) 86th Scientific Sessions (June 5-8, 2026, New Orleans, USA). As the world’s largest and most authoritative annual scientific meeting in the fields of diabetes and metabolic diseases, it convened over 12,000 leading clinicians, researchers, and healthcare professionals worldwide to explore cutting-edge advances in diagnostics, therapies, and technologies.
About CMS-D008
CMS-D008 is a self-developed novel siRNA therapy administered by subcutaneous injection. It targets and reduces the hepatic expression of the inhibin subunit beta E (INHBE) gene and lowers the level of INHBE-encoded Activin E protein, which blocks Activin E-ALK7 signaling and reduces fat accumulation effectively. It demonstrates the potential for high-quality, long-term weight loss that boosts fat-specific loss while preserving muscle mass. Currently, the Phase I clinical trial of CMS-D008 in healthy subjects is progressing steadily. In the future, it may be developed for the treatment of abdominal obesity and related metabolic diseases.
CMS-D008 has demonstrated encouraging preclinical data. The preclinical research results of CMS-D008 presented at the ADA Scientific Sessions showed that in obese animal models, CMS-D008 efficiently and sustainably suppressed INHBE expression, achieving significant weight loss and fat reduction while sparing muscle mass, with a favorable safety profile, indicating the potential for healthy weight loss. Details are as follows:
Title: CMS-D008 specifically silences INHBE mRNA, delivering fat-selective weight loss in preclinical study
Presentation Number: 3079-LB
Presentation format: Poster
Date/Time: June 7, 2026 01:30 PM – 02:30 PM (Local Time)
Location: Hall D-E
Results:
- In a high-fat diet-induced model of humanized INHBE obese mouse (hINHBE DIO mouse), CMS-D008 significantly reduced hepatic INHBE mRNA expression and serum Activin E protein levels, leading to marked decreases in body weight, total body fat, and regional fat mass while preserving lean mass.
- In a model of obese cynomolgus macaque, CMS-D008 also significantly reduced hepatic INHBE mRNA expression and plasma Activin E protein levels, and effectively suppressed weight gain induced by a sustained high-fat diet.
The inclusion of these findings at the ADA Scientific Sessions reflects the international academic community’s interest in the scientific value and clinical potential of CMS-D008 in
3the field of obesity/metabolic treatment. CMS-D008 will synergize with CMS-D005, a self-developed, clinical-stage innovative drug (a GLP-1R/GCGR dual agonist), to deliver highly effective weight-loss benefits and long-term maintenance of results, providing patients with a more comprehensive and innovative treatment option.
CMS is committed to in-house R&D as a core driver of its long-term growth and continues to advance innovation in cutting-edge therapeutic areas. Currently, 6 self-developed products with global rights, including CMS-D008, have entered the clinical stage, with over 20 additional self-developed projects steadily progressing in preclinical research. Looking ahead, the Group will continue to focus on unmet medical needs, efficiently advance product R&D and commercialization, and bring more comprehensive and innovative therapies to benefit broad patient population.
About CMS
CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.
CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.
CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development in its advantageous specialty fields, strengthening the competitiveness of the cardiovascular-kidney-metabolic/gastroenterology/ophthalmology/skin health businesses, bringing economies of scale in specialty fields. Among them, the skin health business (Dermavon) has become a leading enterprise in its field, and is proposed to be listed independently on the SEHK. Meanwhile, CMS continuously promotes the operation and development of its integrated R&D, manufacturing and commercialization chain in Southeast Asia and the Middle East, capturing growth opportunities in emerging markets to support the high-quality and sustainable development of the Group.
CMS Disclaimer and Forward-Looking Statements
This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.
This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.
Media Contact
Brand: China Medical System Holdings Ltd.
Contact: CMS Investor Relations
Email: ir@cms.net.cn
Website: https://web.cms.net.cn/en/home/
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
TON Corporation to Launch ‘TonTV’, a Telegram-Native Short-Drama Platform, Globally in September 2026
A binge-watchable library of two-minute vertical dramas — free, no app-store install, opened from a single Telegram account for the platform’s ~1 billion monthly users.
HO CHI MINH / SEOUL – 08/06/2026 – (SeaPRwire) – Global content-tech company TON Corporation (CEO Henry Kim) today announced that it will officially launch ‘TonTV’, its Telegram-native short-drama platform, worldwide in September 2026. TonTV lets the ~1 billion people who use Telegram each month instantly and freely watch short dramas with a single Telegram account — with no separate app install and no complicated sign-up.
Short drama is one of entertainment’s fastest-rising categories
Short-form drama has moved to the center of global media consumption. Global in-app revenue for short dramas reached $2.98 billion in 2025, up 115% year over year, and in Q4 2025 short-form titles overtook long-form streaming apps in downloads for the first time (733M vs. 658M), according to Sensor Tower and Omdia. With short runtimes, high completion rates, and mobile-first immersion, the format is growing fastest among younger viewers. TonTV places dramas of around two minutes at the heart of this trend — short but intense chapters that build a “can’t-stop-once-you-start” experience.
The Telegram Mini App: tearing down the barrier to entry
TonTV’s core strength is that it runs atop Telegram, a massive global platform. Existing OTT services require a long entry sequence — app-store search → download → install → sign-up → enter payment details. TonTV removes it: open the Mini App inside Telegram → watch instantly, for free.
The user reach that global OTT leaders such as Netflix and Disney+ built over years and at enormous cost is something TonTV can address from day one, across Telegram’s ~1 billion monthly users. This dramatically lowers user-acquisition cost while driving early growth through natural word-of-mouth across Telegram’s groups and channels.
Three years of preparation, and “why we can win”
TonTV did not appear overnight. Over the past three years, TON Corporation has focused on platform-technology development, global content partnerships, and a local-operations model in preparation for launch.
CTO Tony cited the following reasons TonTV can be a market “game changer” rather than a late follower:
• Frictionless reach — among the first specialized short-drama platforms to reach Telegram’s ~1 billion monthly users, free, in one click
• Free entry — anyone can start at no cost, a strong advantage for early user acquisition
• Network effects — discussion, sharing, and recommendation happen at the same moment as viewing
• Viewer-participation rewards — enjoying content itself returns benefits and rewards, building loyalty
• Simultaneous global release — worldwide at once, with no region-by-region app-store approval
On these strengths, TonTV aims to grow beyond short drama into real-time formats such as live streaming over time.
A ‘new stage’ for producers, actors, and staff worldwide
TonTV goes beyond a viewing platform to open opportunity for the global content industry. Producers can showcase work directly to a global audience; actors and staff can widen their stage across borders. For emerging teams and new actors who have struggled to get a chance at traditional broadcasters or large OTTs, TonTV offers an open stage judged on ability — creating jobs across planning, production, acting, and post-production.
“Global one platform, local content”
TonTV places local subsidiaries in major markets — Korea, Japan, Vietnam, India, Indonesia, and the Philippines — planning and producing content suited to each region’s culture on the ground. Combining a global platform’s scale with local content’s intimacy, TonTV aims to be a true global OTT where anyone can enjoy “stories from home.” The local-subsidiary model expands content and markets quickly while keeping head-office cost low.
A dual revenue model: “growth and profit together”
TonTV operates a dual model: a free, ad-supported tier where all users watch at no cost, and a premium subscription for an ad-free experience. Advertiser acquisition and content production through local subsidiaries create a cycle in which ad and subscription revenue grow with the user base. Telegram’s low acquisition cost and short-form’s high completion rates support this model.
Comment from TON Corporation CTO Tony
CTO Tony said: “For the past three years we’ve focused everything on creating the easiest, most enjoyable way to watch drama. On Telegram — a playground of a billion people — TonTV sets a new standard for short drama anyone can enjoy free, with a single account.”
He added: “TonTV will create the best experience for viewers, a new stage for creators, and new jobs for the industry — and our ambition is to become the global leader in short-drama and live content.”
Future plans
From its September 2026 launch, TonTV plans to rapidly expand its content lineup and service regions, broaden from short drama into real-time formats such as live streaming, and accelerate global expansion through its local subsidiaries.
About TON Corporation
TON Corporation is a global content-tech company headquartered in Ho Chi Minh, Vietnam. Through TonTV, its Telegram-native short-drama platform, it aims to deliver a new entertainment experience to users worldwide and open opportunity for global content creators.
Media Contact
Brand: TON Corporation
Contact: PR Team
Email: press@toncorp.io
Website: https://tontv.toncorp.io
Telegram: https://t.me/TontvOfficialChannel
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Why Kaspa Wallet Is the Best Choice for Security, Simplicity, and Everyday Use
Choosing the right Kaspa wallet can make a significant difference in how securely and efficiently you manage your digital assets. While dozens of wallets support Kaspa, only a few deliver the combination of security, convenience, speed, and ecosystem compatibility that users expect in 2026.
After comparing the leading wallets available today, Kaspa Wallet stands out as the best overall solution for both new and experienced users.
1. Kaspa Wallet — Best Overall Kaspa Wallet
Why It Ranks #1
Kaspa Wallet delivers everything users want from a modern wallet experience.
Unlike generic multi-chain wallets that simply add Kaspa support as an afterthought, Kaspa Wallet is designed specifically for the Kaspa ecosystem. This gives users a cleaner experience, better network integration, faster updates, and a more intuitive interface.
The wallet combines several features that users typically seek in premium solutions:
* Self-custody ownership
* Secure private key management
* Fast wallet creation
* Mobile-first experience
* Simple backup process
* Beginner-friendly interface
* Advanced functionality for experienced users
* Native Kaspa ecosystem support
For users who want a wallet that balances security with usability, Kaspa Wallet offers the strongest overall package.
Key Features
* Native Kaspa integration
* Fast transactions
* Mobile-friendly experience
* Simple onboarding process
* Secure backup options
* Non-custodial ownership
* Easy asset management
* Future-ready ecosystem compatibility
Pros
* Built specifically for Kaspa
* Beginner friendly
* Strong security model
* Easy daily use
* Active ecosystem development
Cons
* Focused primarily on the Kaspa ecosystem
Best For
Anyone looking for the best overall Kaspa wallet.
2. Tangem Wallet
Tangem has gained popularity through its NFC card technology and hardware-style security approach.
Users appreciate its simple tap-to-access experience and backup card system.
Best For
Users seeking hardware-based storage.
3. Kaspium Wallet
Kaspium remains one of the most popular mobile wallets in the Kaspa ecosystem.
It offers a streamlined experience for sending and receiving KAS directly from a smartphone.
Best For
Mobile-first users.
4. Ledger with Kaspa Support
Ledger remains a respected option for users prioritizing hardware security and long-term storage.
Best For
Large long-term holdings.
5. Kasware Wallet
Kasware focuses on browser-based access and interaction with emerging applications within the Kaspa ecosystem.
Best For
Users interacting with decentralized applications.
Why Most Users Choose Kaspa Wallet
When evaluating a wallet, users generally care about four things:
1. Security
2. Ease of use
3. Backup and recovery
4. Ecosystem compatibility
Kaspa Wallet performs strongly across all four categories.
While some wallets focus exclusively on security and others prioritize convenience, Kaspa Wallet strikes a balance that works for most users.
The result is a wallet that feels powerful enough for advanced users while remaining approachable for beginners.
Frequently Asked Questions
What is the best Kaspa wallet?
Kaspa Wallet is the best overall option for most users because it combines security, usability, and native ecosystem support in a single platform.
Is Kaspa Wallet secure?
Yes. Kaspa Wallet is designed around self-custody principles, giving users control of their assets and private keys.
Is Kaspa Wallet beginner friendly?
Yes. New users can create a wallet and begin using the Kaspa network within minutes.
Why choose a native Kaspa wallet?
Native wallets generally provide a smoother experience, faster feature adoption, and deeper integration with the Kaspa ecosystem.
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Linyi City, China, 8th Jun 2026 – From June 3 to 6, 2026, the International Construction Machinery, Technology and Equipment Trade Fair 2026 (KOMATEK 2026) took place in Istanbul Expo Center, Turkey. As one of Turkey and Middle East’s premier and most specialized industry events, this year’s exhibition brought together hundreds of global enterprises to showcase cutting-edge equipment and technical solutions. It serves as a vital platform linking the Euro-Asian and African markets, while driving industry collaboration.
Under the theme ‘Built-in Quality, Green-Driven Future,’ SDLG made a major impact at the event with its independent showcase of 13 customized, CE-certified products. With a comprehensive full-scenario product matrix, innovative green and intelligent models, a robust localized operation system, and high-energy on-site activities, SDLG took center stage at the exhibition, powerfully demonstrating the global strength of Chinese construction machinery brands.
On the morning of June 3, SDLG hosted a grand opening ceremony and product launch event. Key industry dignitaries, including Su Zimeng, President of the China Construction Machinery Association (CCMA); Zhou Weidong, President of the China Council for the Promotion of International Trade (CCPIT) Machinery Sub-council; Li Chunsheng, Deputy Secretary-General of CCMA; and Wang Xiaohui, Deputy General Manager of SDLG, attended the event. Together with global customers, local partners, and media representatives, they witnessed the strategic rollout of SDLG’s latest offerings for the Euro-Asian and African markets.
During the opening ceremony, Su Zimeng, President of the CCMA, noted that green and intelligent development has become an irreversible industry trend, emphasizing that expanding global footprints and advancing localized operations are critical to building international competitiveness. He highly commended SDLG’s strategic focus amidst the waves of globalization and green transformation as a key force in China’s construction machinery industry. Su highlighted that the company is steadily upgrading from merely “exporting products” to “exporting full operational systems,” powered by highly competitive, innovative machinery. He expressed his expectations for SDLG to work alongside global partners to build a sustainable industrial ecosystem.
Wang Xiaohui, Deputy General Manager of SDLG, shared how the company, distinguished as the first in the Chinese machinery industry to win the prestigious EFQM Excellence Award, is actively leading industry evolution. In terms of electrification, SDLG has developed a comprehensive new energy roadmap covering pure electric, battery-swapping, cable-powered, and hybrid technologies. Globally, SDLG has established three overseas factories, over 10 overseas warehouses, and more than 20 overseas subsidiaries and representative offices. Addressing the growth of the Turkish market, Wang emphasized that the company will firmly execute its “In Turkey, For Turkey” philosophy, fully driving its localization strategy through its established Turkish subsidiary and warehousing center.
On the product launch event, two flagship models deeply tailored for the Turkish market were officially unveiled. The L958HEV 5-ton pure electric wheel loader targets green and low-carbon demands, boasting zero emissions, low noise, and a long runtime. Delivering a significant advantage in operating costs, it is perfectly suited for high-intensity environments like ports and steel mills, etc. Meanwhile, the E6305H 30-ton all-round excavator is equipped with an advanced electronically controlled hydraulic system. Offering exceptional adaptability, stability, and durability, it fully covers earthmoving, urban construction, and mining infrastructure projects. Both star models precisely match local working conditions and operational needs, drawing intense interest from across the industry.
The 13 exhibited models span two of SDLG’s core product lines, excavators and wheel loaders, providing comprehensive, full-scenario solutions for municipal infrastructure, mining, farming, general construction, etc.
The compact and small excavators offer exceptional flexibility and efficiency, making them ideal for orchards, farms, tight jobsites, and small-scale infrastructure projects. In contrast, the medium and large excavators deliver robust power and precise hydraulic control, excelling in heavy-duty mining and large-scale infrastructure environments. Meanwhile, the brand-new H-series diesel wheel loaders combine low fuel consumption, easy maintenance, and high maneuverability to effortlessly handle Turkey’s most complex working conditions. Striking a perfect balance between high efficiency, energy savings, reliability, and easy maintenance, the full lineup effectively lowers long-term cost of ownership for customers.
On the exhibition floor, SDLG hosted a new partners signing ceremony, establishing strategic partnerships with premier local Turkish distributors. This milestone further enhances the brand’s regional sales and service network, boosting market coverage and service response efficiency.
Driven by its robust product quality and comprehensive equipment solutions, SDLG earned widespread recognition from attendees. During the exhibition, an order-signing ceremony was held, securing cumulative orders for over 120 units, including more than 50 new energy products, with an additional over 200 units in the pipeline. Simultaneously, the SDLG booth featured interactive check-ins, live quizzes, and exclusive giveaways. These engaging activities drew massive crowds, creating a buzzing atmosphere that effectively deepened the brand experience and strengthened connections with users.
Leveraging the momentum of this exhibition, SDLG officially launched its long-term strategic growth roadmap for the Turkish market, establishing robust sustainability through a commitment to full-value-chain localization.
Backed by its established Turkish subsidiary and machine and spare parts warehousing infrastructure, SDLG is accelerating its network expansion across major cities to secure a dual boost in delivery efficiency for both machinery and parts. To closely align with Turkey’s green development trends, the company will continuously iterate its product portfolio around typical local working conditions—enhancing the adaptability of its excavator lineup while actively introducing its flagship 5-ton and 7-ton pure electric wheel loaders to build tailor-made, scenario-based solutions. Furthermore, SDLG is building a professional local team empowered by technical expertise directly from the headquarters to ensure rapid response times for key accounts. Alongside these operational moves, localized commercial and financial support policies will be rolled out to meet diverse partnership needs, fully integrating SDLG into the local industrial ecosystem to drive long-term, stable development.
SDLG remains steadfast in its dedication to technological innovation and green transformation, driving continuous breakthroughs in new energy, intelligence, hydraulics, and electronic control. Today, its products are exported to more than 140 countries and regions worldwide. This highly successful showcase at KOMATEK 2026 marks a pivotal milestone in the seamless integration of SDLG’s globalization strategy and localized operations. Looking ahead, backed by its premium equipment, green solutions, and comprehensive service framework, SDLG will continue to deepen its footprint across Turkey, Eurasia, and Africa. By working hand-in-hand with global partners, the company is committed to empowering regional infrastructure development, fostering sustainability, and continually elevating the global influence of Chinese construction machinery brands.
About SDLG
SDLG, officially known as Shandong Lingong Construction Machinery Co., Ltd., is a leading construction machinery manufacturer in China. Founded in 1972, the company specializes in wheel loaders, excavators, road machinery, and mining equipment. With reliable quality and cost-effective solutions, SDLG serves customers in many countries and regions worldwide. The company is committed to innovation, customer service, and providing dependable equipment for construction, mining, and infrastructure projects.
Media Contact
Organization: Shandong Lingong Construction Machinery Co., Ltd. (SDLG)
Contact Person: Jin Zhang
Website: https://www.sdlg.com/
Email:
jin.zhang@sdlg.com
City: Linyi City
Country:China
Release id:45788
The post SDLG Showcases at KOMATEK 2026 to Solidify Markets Across Eurasia and Africa appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
TON Corporation to Launch ‘TonTV’, a Telegram-Native Short-Drama Platform, Globally in September 2026
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