Press Release
Candel Therapeutics (NASDAQ: CADL) Lead Candidate CAN-2409 Combats Lung, Pancreatic And Prostate Cancers With Fast Track Designation For Three Cancers
–News Direct–
By Jeremy Golden, Benzinga
Immunotherapy has transformed the way cancer is treated, but just 20% to 40% of patients typically respond to FDA-approved immune checkpoint inhibitor (ICI) treatments.
Poor ICI treatment response has been linked to the tumors ability to disguise antigen presentation and generate an immunosuppressive microenvironment. In addition, most conventional immunotherapies are not designed to educate the patients immune system on how to recognize a variety of tumor antigens and neoantigens.
Amid this landscape, a clinical-stage biopharmaceutical company has developed a new multimodal biological approach that leverages the ability of viral gene constructs to activate cancer-killing mechanisms, exposing multiple tumor antigens to the immune system, resulting in vaccination against the tumor while inhibiting the immunosuppressive tumor microenvironment.
Candel Therapeutics, Inc. (NASDAQ: CADL) is developing a product candidate that is being studied in lung, pancreatic and prostate cancers. Candels most advanced viral immunotherapy candidate, CAN-2409, is an investigational off-the-shelf replication-defective adenovirus designed to induce an individualized, systemic immune response against the patients own tumor.
Part of the companys adenovirus platform, CAN-2409 is injected directly into the tumor or target tissue using a localized injection, akin to the standard approach for vaccination.
CAN-2409's adenoviral construct serves as a vector to transport the HSV-thymidine kinase gene into tumor cells at the site of injection. These tumor cells can then express HSV-thymidine kinase, which converts generic, FDA-approved anti-herpes drugs such as ganciclovir, acyclovir and valacyclovir into a toxic nucleotide analog that blocks DNA synthesis in dividing cells.
Cancer cells exposed to the toxic nucleotide analog in the tumor microenvironment have been observed to undergo immunogenic cell death. Simultaneously, the adenoviral serotype 5 capsid protein elicits a strong pro-inflammatory signal in the tumor microenvironment, creating the optimal conditions to induce a specific CD8+ T cell-mediated response against the injected tumor and uninjected distant metastases for broad and systemic anti-tumor activity.
CAN-2409 is currently being studied in an open-label, phase 2 clinical trial in non-small cell lung cancer (NSCLC) and in randomized, controlled, blinded phase 2b and phase 3 clinical trials in prostate cancer. The company has recently released very encouraging data for CAN-2409s ability to improve overall survival in non-metastatic pancreatic cancer, with topline overall survival data in non-small cell lung cancer planned for this quarter (Q2 2024) and results from the prostate clinical trials later this year (Q4 2024).
When it comes to NSCLC, the company previously presented data from the phase 2 clinical trial in which patients received two administrations of CAN-2409 plus prodrug. Those patients demonstrated the following:
1) Increased infiltration of CD8+ cytotoxic T cells in the tumor microenvironment, systemic expansion of effector T cells and increased soluble granzyme B levels in peripheral blood;
2) Favorable changes in the trajectory of tumor progression;
3) Decreased tumor size of target lesions in most patients; and
4) Reduced size of uninjected tumor lesions.
The CAN-2409 immunotherapy antitumor strategy aims to increase the number of long survivors beyond 10 to 13 months.
As previous work has shown that progressive disease could be converted into stable disease in most patients with non-small cell lung cancer after CAN-2409 treatment, the hypothesis is that this will translate into improved survival.
When it comes to pancreatic cancer, the company reported notable improvements in patients with borderline resectable pancreatic ductal adenocarcinoma (PDAC) after experimental treatment with CAN-2409. The estimated overall survival rate was 71.4% at 24 months in CAN-2409-treated patients versus only 16.7% in the control arm after chemoradiation.
In 2023, CAN-2409 received Fast Track Designation for both non-small cell lung cancer and pancreatic cancer, a validation from the FDA on its potential. CAN-2409 plus valacyclovir in combination with continued PD-1/PD-L1 agents is being evaluated in an ongoing, open-label phase 2 clinical trial in patients with late-stage NSCLC and an inadequate response to anti-PD(L)-1 therapy. In 2024, CAN-2409 also received Orphan Drug Designation from the FDA for CAN-2409 in borderline resectable pancreatic cancer.
In the upcoming year, Candel plans to announce data readouts for the following:
1) Phase 2 topline overall survival (OS) data for CAN-2409 in NSCLC, expected in Q2 2024;
2) Phase 2 topline data for CAN-2409 in low-to-intermediate-risk, localized, non-metastatic prostate cancer, expected in Q4 2024;
3) Phase 3 topline data for CAN-2409 in localized intermediate/high-risk prostate cancer, expected in Q4 2024.
Featured photo by National Cancer Institute on Unsplash.
Candel is a clinical stage biopharmaceutical company focused on developing off-the-shelf multimodal biological immunotherapies that elicit an individualized, systemic anti-tumor immune response to help patients fight cancer. Candel has established two clinical stage multimodal biological immunotherapy platforms based on novel, genetically modified adenovirus and herpes simplex virus (HSV) gene constructs, respectively. CAN-2409 is the lead product candidate from the adenovirus platform and is currently in ongoing clinical trials in non-small cell lung cancer (NSCLC) (phase 2), borderline resectable pancreatic cancer (phase 2), and localized, non-metastatic prostate cancer (phase 2 and phase 3). CAN-3110 is the lead product candidate from the HSV platform and is currently in an ongoing investigator-sponsored phase 1 clinical trial in recurrent high-grade glioma (HGG). Finally, Candels enLIGHTEN Discovery Platform is a systematic, iterative HSV-based discovery platform leveraging human biology and advanced analytics to create new viral immunotherapies for solid tumors.
This article includes certain disclosures that contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding the timing and advancement of development programs, including the timing and availability of additional data, key data readout milestones, including CAN-3110 in HGG; expectations regarding the potential benefits conferred by Fast Track Designation; expectations regarding the therapeutic benefit of its programs, including the potential for its programs to extend patient survival; and expectations regarding cash runway and expenditures. The words may, will, could, would, should, expect, plan, anticipate, intend, believe, estimate, predict, project, potential, continue, target and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on managements current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, those risks and uncertainties related to the timing and advancement of development programs; expectations regarding the therapeutic benefit of the Companys programs; that final data from our pre-clinical studies and completed clinical trials may differ materially from reported interim data from ongoing studies and trials; the Companys ability to efficiently discover and develop product candidates; the Companys ability to obtain and maintain regulatory approval of product candidates; the Companys ability to maintain its intellectual property; the implementation of the Companys business model, and strategic plans for the Companys business and product candidates, and other risks identified in the Companys SEC filings, including the Companys most recent Quarterly Report on Form 10-Q filed with the SEC, and subsequent filings with the SEC. The Company cautions you not to place undue reliance on any forward-looking statements, which speak only as of the date they are made. The Company disclaims any obligation to publicly update or revise any such statements to reflect any change in expectations or in events, conditions or circumstances on which any such statements may be based, or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements. Any forward-looking statements contained in this press release represent the Companys views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date.
This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice.
Contact Details
Aljanae Reynolds
+1 617-916-5445
Company Website
View source version on newsdirect.com: https://newsdirect.com/news/candel-therapeutics-nasdaq-cadl-lead-candidate-can-2409-combats-lung-pancreatic-and-prostate-cancers-with-fast-track-designation-for-three-cancers-458506267
Candel Therapeutics
COMTEX_453480918/2655/2024-06-07T08:28:02
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Press Release
KeyCrew Media Selects ACME Real Estate as Verified Expert for Boutique Brokerage Operations, and LA Market Expertise
KeyCrew Media, a real estate analytics and media network, has selected Courtney Poulos and her team at ACME Real Estate as a KeyCrew Verified Expert.
LOS ANGELES, CA, December 12, 2025 — KeyCrew Media, a real estate analytics and media network, has selected Courtney Poulos and her team at ACME Real Estate as a KeyCrew Verified Expert. The boutique Los Angeles brokerage will contribute specialized insights on renovation-resale strategy, boutique brokerage operations, and LA market dynamics.
KeyCrew Verified Experts are carefully selected as prolific market trend authorities who demonstrate exceptional insight and expertise in their fields. These distinguished professionals and companies regularly contribute market insights, expert perspectives, and forward-looking analysis to help audiences navigate complex industry landscapes.
Founded in 2011 by Broker/Owner Courtney Poulos, ACME Real Estate has established itself as a premier boutique brokerage specializing in renovation-resale projects across Los Angeles. Operating in what Poulos calls “the NFL of real estate,” ACME has built its reputation on comprehensive agent training, ethical accountability, and exceptional client experiences without the backing of international capital funding.
ACME Real Estate offers a distinctive “one-stop shop” approach for real estate investors and renovation-resale specialists. The brokerage provides full-spectrum support from acquisition—including deal analysis and cost-benefit evaluation—through in-house design services at any price point, sophisticated appraisal packaging, and premium marketing. With 35 agents completing 178 transaction sides totaling $155 million in sales volume over the past 12 months, ACME has proven that boutique brokerages can compete against corporate giants through superior training and service.
“We’re honored that ACME Real Estate has been selected as a KeyCrew Verified Expert,” said Courtney Poulos, Broker/Owner. “We built ACME to fill a gap in the market—highly trained agents who the public can trust, comprehensive support for renovation-resale investors, and a commitment to quality over scale. This recognition validates what our clients already know: sometimes the underdogs deliver the highest quality service.”
ACME Real Estate’s areas of expertise include:
- Renovation-Resale Strategy – Comprehensive acquisition analysis, cost estimation, design consultation, and resale marketing for investors
- Boutique Brokerage Operations – Building and scaling quality-focused independent brokerages in competitive markets
- Los Angeles Market Dynamics – Deep expertise in LA neighborhoods, market trends, and investment opportunities
- Agent Training & Development – Mastery-based training programs emphasizing contract expertise and client psychology
- Premium Property Marketing – High-end photography, printed materials, and strategic positioning for maximum market performance
About ACME Real Estate
ACME Real Estate is a boutique independent brokerage founded in 2011 and based in Los Angeles. With 35 agents and 178 transaction sides totaling $155 million in sales volume over the past 12 months, ACME specializes in renovation-resale projects and provides comprehensive support from acquisition through marketing and sale. The brokerage offers in-house design services at any price point, sophisticated appraisal packaging, and premium marketing execution. ACME serves both real estate investors and traditional buyers and sellers with what Broker/Owner Courtney Poulos describes as “the most concierge, attentive, well-trained group of underdogs you could ever have behind you.” Website: https://acmeflorida.com/
About KeyCrew Media
KeyCrew Media is the next generation real estate intelligence platform that leverages AI-powered analytics and first-person reporting from verified experts to produce forward-looking insights across local markets and niche asset classes. Proprietary market reporting is delivered through KeyCrew’s growing portfolio of niche media properties—including KeyCrew Journal, NextAsset News, and other specialized publications—as well as selectively syndicated to media partners that influence industry decision-makers. Learn more at keycrew.co
Media Contact
Organization: KeyCrew Media
Contact Person: Heather Hook
Website: https://www.keycrew.co
Email: Send Email
City: Baltimore
State: Maryland
Country:United States
Release id:39011
The post KeyCrew Media Selects ACME Real Estate as Verified Expert for Boutique Brokerage Operations, and LA Market Expertise appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
KeyCrew Media Selects Brooke Pfautz as Verified Expert for Vacation Rental Management and Property Technology
KeyCrew Media, a real estate analytics and media network, has selected Brooke Pfautz, CEO and Founder of Vintory, as a KeyCrew Verified Expert.
NATIONWIDE, December 12, 2025 — KeyCrew Media, a real estate analytics and media network, has selected Brooke Pfautz, CEO and Founder of Vintory, as a KeyCrew Verified Expert. Pfautz will contribute data-driven analysis on vacation rental management, property technology innovation, and industry consolidation trends.
KeyCrew Verified Experts are carefully selected as prolific market trend authorities who demonstrate exceptional insight and expertise in their fields. These distinguished professionals regularly contribute market insights, expert perspectives, and forward-looking analysis to help audiences navigate complex industry landscapes.
Brooke Pfautz brings unparalleled expertise to the vacation rental management sector, having helped over 950 companies scale their portfolios through strategic growth initiatives. As founder of both Vintory and Comparent, Pfautz has established herself as a leading voice on data-driven property acquisition, AI integration in hospitality operations, and market consolidation dynamics. Her work encompasses the largest database of vacation rental homeowners globally and the industry’s first comprehensive ranking system through the Comparent 100.
With 18 years of experience in the short-term rental industry, Pfautz successfully scaled Vantage Realty to over 500 properties before its acquisition. She has since focused on revolutionizing how professional vacation rental managers approach growth through Vintory’s data and marketing platform, which aggregates information from over 10 sources to create what she calls “stacked data architecture” — a proprietary approach that provides unprecedented accuracy in homeowner targeting.
Pfautz’s insights on artificial intelligence adoption have positioned her as a forward-thinking industry authority. She advocates that property managers not implementing AI-native tools by 2026 risk competitive obsolescence, emphasizing that data capture — particularly call recordings and guest communications — represents the critical intellectual property that will differentiate winners in an increasingly AI-driven marketplace.
“I’m honored to be selected as a KeyCrew Verified Expert,” said Brooke Pfautz. “The vacation rental management industry is at a pivotal moment where data quality and AI adoption will separate thriving companies from those left behind. Having helped nearly 1,000 companies with their growth strategies, I’ve seen firsthand how the right data and technology stack can transform a mid-sized operator into a market leader. I’m excited to share insights that help property managers navigate consolidation pressures, leverage their unique data assets, and position themselves strategically whether they’re scaling independently or preparing for acquisition.”
Pfautz’s areas of expertise include:
- Vacation Rental Management Growth Strategies — Proven frameworks for inventory acquisition and scaling beyond 10 million in gross bookings
- Property Technology & AI Integration — Strategic guidance on AI-native tools, data architecture, and competitive positioning
- Market Consolidation & M&A Dynamics — Insights on institutional capital trends, acquisition metrics, and positioning for exit
- Homeowner Data & Marketing Analytics — Expertise in multi-source data aggregation, targeting precision, and marketing ROI optimization
About Vintory
Vintory is a data, sales, and marketing platform that helps professional vacation rental managers grow their inventory through the world’s largest database of vacation rental homeowners. The platform combines proprietary stacked data architecture with tech-enabled marketing services, building targeted campaigns that drive qualified leads through custom CRM and automation systems. Vintory has supported over 950 property management companies with strategic growth initiatives. Website: www.vintory.com
About KeyCrew Media
KeyCrew Media is the next generation real estate intelligence platform that leverages AI-powered analytics and first-person reporting from verified experts to produce forward-looking insights across local markets and niche asset classes. Proprietary market reporting is delivered through KeyCrew’s growing portfolio of niche media properties — including KeyCrew Journal, NextAsset News, and other specialized publications — as well as selectively syndicated to media partners that influence industry decision-makers. Learn more at keycrew.co
Media Contact
Organization: KeyCrew Media
Contact Person: Heather Hook
Website: https://www.keycrew.co
Email: Send Email
City: Baltimore
State: Maryland
Country:United States
Release id:39013
The post KeyCrew Media Selects Brooke Pfautz as Verified Expert for Vacation Rental Management and Property Technology appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
KLOTA Launches Two Free Analysis Tools to Help E-Commerce Brands Improve Search and AI Visibility
Sweden, 13th Dec 2025 – KLOTA AB, a Sweden-based digital performance and SEO consultancy, has announced the launch of two new free analysis tools designed specifically for serious e-commerce companies seeking stronger visibility, better performance, and clearer insights across search engines and AI-driven platforms. The newly released tools—the AI Visibility Analyzer and the Shopping Feed Analyzer—are currently available as free BETA services and deliver actionable results within approximately 10 minutes via email.
As search behavior rapidly evolves, e-commerce brands are no longer competing only for traditional Google rankings. Increasingly, consumers are discovering products and brands through AI-powered assistants such as ChatGPT, Claude, Perplexity, and Gemini. KLOTA’s new tools are built to address this shift, providing practical diagnostics that help online retailers understand where they stand and what to fix.
The AI Visibility Analyzer focuses on how well a website is seen, accessed, and understood by modern AI search engines and large language models. The tool evaluates critical factors such as AI-bot accessibility (including robots.txt and llms.txt), content clarity and readability, structured data, and core technical SEO elements. Based on this analysis, it generates an easy-to-understand AI Visibility Score ranging from 0 to 100, along with clear, prioritized recommendations that highlight the most impactful improvements.
“This is about helping companies prepare for the next generation of search,” said Anders Karlsson, Contact at KLOTA AB. “Many e-commerce brands are still optimizing only for classic search results, while AI assistants are already shaping how users discover information and products. The AI Visibility Analyzer makes this new landscape measurable and actionable.”
The second tool, the Shopping Feed Analyzer (Google Shopping Feed Analyzer ), is designed for e-commerce businesses actively running Google Shopping and Performance Max (PMax) campaigns. Poor feed quality is a common reason for disapproved products, limited reach, and underperforming ads. KLOTA’s tool performs an automated quality audit of a Google Shopping product feed , reviewing required attributes, product titles and descriptions, pricing accuracy, images, Google product categories, and overall compliance with Google’s specifications.
After the audit, users receive a detailed PDF report that includes an executive summary and a prioritized action list. This enables marketing and e-commerce teams to quickly identify errors, resolve disapprovals, and systematically improve feed quality for better campaign performance.
“Most feed issues are not strategic—they’re technical and fixable,” Karlsson added. “The challenge is knowing exactly where the problems are and what to address first. The Shopping Feed Analyzer removes that guesswork and gives teams a clear roadmap.”
Both tools are offered as free BETA services, reflecting KLOTA’s commitment to sharing expertise and helping e-commerce brands adapt to a more complex digital ecosystem. Once a website URL or product feed is submitted, the analysis is processed automatically and sent by email in about 10 minutes, making the tools accessible even for busy teams with limited technical resources.
While some information within the tools may be presented in English, the insights are designed to be universally applicable for international e-commerce brands aiming to compete more effectively in search, paid media, and AI-driven discovery.
With the launch of these tools, KLOTA reinforces its position as a forward-looking partner for e-commerce growth—bridging traditional SEO, paid shopping performance, and the emerging world of AI visibility.
For more information visit https://www.klota.se .
About KLOTA AB
KLOTA AB is a Sweden-based digital consultancy specializing in SEO, e-commerce optimization, and data-driven performance strategies. The company works with ambitious brands that want to improve visibility, traffic quality, and revenue across search engines, advertising platforms, and AI-powered discovery channels.
Media Contact
Organization: KLOTA AB
Contact Person: Anders Karlsson
Website: https://www.klota.se/
Email: Send Email
Address:Katrinedalsgatan 13A 504 51 BORÅS Sweden
Country:Sweden
Release id:39023
The post KLOTA Launches Two Free Analysis Tools to Help E-Commerce Brands Improve Search and AI Visibility appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
KeyCrew Media Selects ACME Real Estate as Verified Expert for Boutique Brokerage Operations, and LA Market Expertise
KeyCrew Media Selects Brooke Pfautz as Verified Expert for Vacation Rental Management and Property Technology
KLOTA Launches Two Free Analysis Tools to Help E-Commerce Brands Improve Search and AI Visibility
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