Connect with us

Press Release

The 25-30 side chain of CTC Civil travel service chain is officially on the chain

Published

6 years ago

on

On December 23, Daniel Smith, CEO of Singapore Done Fund Management Institution and CEO of CTC, reached a strategic consensus with the heads of the six new side chains after in-depth communication and discussion for many times, and announced that the six side chains of CTC Global Cultural Travel Chain (VEA, LMA, HVA, MCO, WAS and VNC) were officially linked up. Due to the impact of the global COVID-19 epidemic, the strategic press conference that was scheduled to be held in Singapore was not held as scheduled. This multi-party strategic cooperation was finally reached in the form of electronic agreement.

Singapore Done the fund management organ CEO, the chief executive of CTC, Daniel Smith, for six side chain fixed anchor (Vienna, Austria, Lima, Peru, Havana, Cuba, Mexico City, Warsaw, Poland, Venice, Italy), the characteristics of human geography environment and beautiful landscape, said after the outbreak must personally go to feel the unique local customs. It is reported that six new side chain operation centers are set up in the business centers of six cities, and reached strategic consensus with the famous local travel companies.

Vienna, on the Danube river in northeastern Austria, is known as the “capital of music” in the world. Stopping on this city street full of musical notes is always a romantic scene, which makes people easily fall in love unawares, just like the nature of romance in Vienna. Most of Vienna’s tourist attractions are open all year round, such as The Schonbrunn Palace, hofburg Palace, Belfort Palace and the Vienna Museum, of which the Schonbrunn Palace is a UNESCO World Heritage Site.

Lima is the capital of Peru and the largest economic and cultural center in the country. It is located on the coastal irrigation oasis. In Lima is always most of the colonial period, South America is the most important political and commercial centers of power, therefore retained a large number of colonial buildings, such as large monasteries catacombs Francis, the central plaza, SAN street plaza and the buildings also earned Lima, scientific and cultural organization UNESCO awarded the “world cultural heritage” of reputation.

Located on the northwest coast of The Island of Cuba, Havana is the capital of the Republic of Cuba. It is located in the tropics, with a mild climate and pleasant seasons. It is known as the “Pearl of the Caribbean”, with many ancient churches, castles, squares, museums, monuments, parks, libraries and so on. The port city of distinctive and lasting appeal, classical and modern, the new world and old world, white and black, high culture and the lowbrow, all elements full of collision, there are telltale signs here, all seemingly independent individuals, together in the sunshine and the vibrant tropical port harmonious unify.

Mexico City is not only the capital of Mexico, but also the largest city in Mexico. Architectural buildings, historical sites, museums, palaces, monuments, shopping malls, government buildings, everything in Mexico City. The water garden on the Hochmirco Canal is the city’s largest tourist attraction, as well as landmark buildings such as the El Angel Daily Independent newspaper and the Angel of Independence Victory Column. Mexico City is the headquarters of many large media companies and Spanish newspapers. About 20% of the Mexican population lives in Mexico City, so this city is also known as the city that never sleeps.

Warsaw is the capital of the Republic of Poland, and the famous Warsaw Convention was signed here. Today, Warsaw still maintains the layout of the old and new cities. Various historical monuments and places of interest are mostly concentrated in the old city, attracting a large number of tourists from abroad every year. The Old Town is located on the west bank of the Vistula River. It is a cluster of majestic and majestic red spire buildings in the Middle Ages. The famous ancient buildings include the former Royal Palace known as the “Polish National Cultural Monument” and the most beautiful and magnificent Baroque building in Warsaw. Base Palace, Lazienki Palace, an outstanding representative of Polish classical architecture, etc.

Venice is the capital of the Veneto region in northern Italy, a world-famous historical and cultural city, and the birthplace of the Venetian school of painting. Its architecture, paintings, sculptures, operas, etc. have an extremely important position and influence in the world. The water city of Venice is the essence of the Renaissance, and it is also the only city in the world without cars. God shed tears here, but made it more crystal clear and tender, just like a romantic dream floating on the blue waves, enjoying “because of water There is the reputation of life, beautiful because of water, and prosperity because of water, and the reputation of “water city”.

In the context of the global epidemic situation is not optimistic and the economy is complex and changeable, the tourism industry is still an industry with stable market demand and a good development momentum in recent years. It has exceeded the global economic average growth rate for 7 consecutive years and has become the fastest growing industry one. With the integration of the global tourism industry and digitalization, the future will gradually achieve leapfrog development, bringing new horizons to the holiday economy and new development opportunities for the digital cultural tourism industry.

The so-called hero sees the same. The heads of CTC and the six new side chains agreed that the future development trend of the cultural and tourism industry will be to integrate blockchain technology into it, which is the need for the in-depth development of the integration of culture and tourism in the new economic environment. By building a new industrial ecological application system through blockchain technology, the cultural tourism industry will accelerate the circulation of assets, empower the growth of the digital economy, and promote the sustainable development of the cultural tourism industry’s digitization, capitalization, and ecologicalization.

About Author

Alex Jacob

Alex Jacob is a literature author. He was born in Chicago. Alex passion is writing news articles. He writes number of articles and published it.

See author's posts

Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.

Related Topics:
Continue Reading

Press Release

Quoin Pharmaceuticals Announces FDA Fast Track Designation for QRX003 for the Treatment of Peeling Skin Syndrome

Published

5 hours ago

on

September 22, 2026

By

Ashburn, Virginia, September 22nd, 2026, FinanceWire

– First-Ever Fast Track Designation Granted for a Peeling Skin Syndrome Therapy

– Second Fast Track Designation Granted to QRX003, in Addition to Netherton Syndrome

– Fast Track Designation Facilitates Development and Expedites Regulatory Review of Therapies Addressing Serious Conditions with Significant Unmet Medical Need

– Follows July 2026 FDA Clearance of the First-Ever IND Submitted for Peeling Skin Syndrome

– Phase 2/3 Study Expected to Initiate in 2H 2026, Enrolling up to 12 Pediatric and Adult Patients in the U.S. and Europe

– Peeling Skin Syndrome Currently Has No Approved Treatment

Quoin Pharmaceuticals Ltd. (NASDAQ: QNRX) (“Quoin” or the “Company”), a late clinical-stage specialty pharmaceutical company focused on rare and orphan diseases, today announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track Designation to QRX003 for the treatment of Peeling Skin Syndrome (PSS). QRX003 is an investigational topical serine protease inhibitor lotion. Peeling Skin Syndrome is a rare genetic skin disease for which there is currently no approved treatment.

Key Facts

  • Fast Track Designation applies to QRX003 for the treatment of Peeling Skin Syndrome.
  • This is the first ever Fast Track Designation granted for a Peeling Skin Syndrome therapy.
  • Peeling Skin Syndrome is the second indication for which QRX003 has received Fast Track Designation. The FDA granted Fast Track Designation to QRX003 lotion (4%) for the treatment of Netherton Syndrome on March 11, 2026.
  • The designation follows FDA clearance in July 2026 of Quoin’s Investigational New Drug (IND) application for QRX003 in Peeling Skin Syndrome. Quoin submitted that IND on June 2, 2026, and it was the first IND ever submitted to the FDA for the disease.
  • Quoin expects to initiate a Phase 2/3 clinical study of QRX003 in Peeling Skin Syndrome in the second half of 2026.
  • The IND submission was supported by clinical observations from an ongoing investigator-led pediatric study in a single subject. Significant improvements in skin appearance along with positive changes in pruritus and a number of quality-of-life measures have been recorded. Treatment is ongoing and has continued for more than 15 months, with no adverse events reported.
  • There is currently no approved treatment for Peeling Skin Syndrome.

“This is an important regulatory milestone for QRX003 and for a community that today has no approved treatment,” said Dr. Michael Myers, CEO and Co-Founder of Quoin Pharmaceuticals. “Quoin submitted the first IND ever filed with the FDA for Peeling Skin Syndrome, that IND was cleared in July, and QRX003 has now been granted Fast Track Designation for the disease. We expect to initiate our Phase 2/3 study in the second half of 2026, and we believe Fast Track status will allow us to work closely with the agency as we advance the first company-sponsored clinical study in this disease.”

Peeling Skin Syndrome Development Program

The planned Phase 2/3 study is expected to enroll up to 12 pediatric and adult patients with Peeling Skin Syndrome in the United States and Europe. In the study, QRX003 will be applied twice-daily to greater than 80% of patients’ body surface area (BSA) over a 48-week period, with an interim data review at 24 weeks. Quoin is targeting approval of QRX003 as a potential treatment for Peeling Skin Syndrome in 2028.

The IND submission was supported by clinical observations from an ongoing investigator-led pediatric study. The subject has achieved improvements across key objective severity endpoints, including the Modified Ichthyosis Area Severity Index (M-IASI), Investigator’s Global Assessment (IGA) as well as pruritus and a pediatric dermatology-specific quality-of-life measure (CDLQI). Treatment is ongoing, and after continued dosing with QRX003 for over 15 months, no adverse events have been reported.

About Fast Track Designation

The FDA’s Fast Track program is designed to facilitate the development and expedite the review of drugs that treat serious conditions and fill an unmet medical need. A therapy granted Fast Track Designation may benefit from more frequent interactions with the FDA, eligibility for rolling review of regulatory submissions, and potential qualification for Accelerated Approval and Priority Review, if relevant criteria are met.

About Peeling Skin Syndrome (PSS)

Generalized inflammatory peeling skin syndrome (PSS) is a rare autosomal recessive genodermatosis caused by loss-of-function disease-causing variants of the corneodesmosin gene (CDSN), resulting in excessive shedding of the superficial layers of the epidermis. Patients generally suffer from a variety of conditions including severe pain and chronic pruritus (itch). There is currently no approved treatment for PSS.

About QRX003

QRX003 is an investigational topical serine protease inhibitor lotion in late-stage development for Netherton Syndrome and other orphan skin diseases. QRX003 has been granted Orphan Drug, Rare Pediatric Disease, and Fast Track designations by the U.S. Food and Drug Administration, and Orphan Drug Designation in the European Union and Japan for Netherton Syndrome. QRX003 has also been granted Rare Pediatric Disease and Fast Track Designation by the FDA for Peeling Skin Syndrome. QRX003 lotion (4%) is currently being evaluated in Phase 2/3 whole-body clinical trials in patients with Netherton Syndrome. Quoin expects to initiate a Phase 2/3 clinical study of QRX003 in Peeling Skin Syndrome in the second half of 2026.

About Quoin Pharmaceuticals Ltd

Quoin Pharmaceuticals Ltd. is a late clinical-stage specialty pharmaceutical company focused on developing and commercializing therapeutic products that treat rare and orphan diseases. We are committed to addressing unmet medical needs for patients, their families, communities, and care teams. Quoin’s innovative pipeline is focused on two key platform products, QRX003 and QRX009, that collectively have the potential to target a broad number of rare and orphan indications, including Netherton Syndrome, Peeling Skin Syndrome, Palmoplantar Keratoderma, Pachyonychia Congenita, Gorlin Syndrome and Tuberous Sclerosis Complex, Microcystic Lymphatic Malformations, Venous Malformations, Angiofibromas and others.

For more information, visit: www.quoinpharma.com or LinkedIn for updates.

Forward-Looking Statements

The Company cautions that statements in this press release that are not descriptions of historical facts are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements may be identified by the use of words referencing future events or circumstances, such as “expect,” “intend,” “hope,” “plan,” “potential,” “anticipate,” “look forward,” “believe,” “may,” and “will,” among others. This press release contains forward-looking statements. All statements that reflect the Company’s expectations, assumptions, projections, beliefs, or opinions about the future, other than statements of historical fact, are forward-looking statements, including, without limitation, statements relating to: Fast Track Designation facilitating development and expediting regulatory review of therapies addressing serious conditions with significant unmet medical need; plans to initiate a Phase 2/3 clinical study of QRX003 in Peeling Skin Syndrome in the second half of 2026; Fast Track status allowing Quoin to work closely with the FDA to advance the first company-sponsored clinical study in Peeling Skin Syndrome; the study expecting to enroll up to 12 pediatric and adult patients with Peeling Skin Syndrome in the United States and Europe; QRX003 expected to be applied twice-daily to greater than 80% of a patients’ body surface area over a 48-week period, with an interim data review at 24 weeks; targeting approval of QRX003 as a potential treatment for Peeling Skin Syndrome in 2028; therapies granted Fast Track Designation benefiting from more frequent interactions with the FDA, eligibility for rolling review of regulatory submissions, and potential qualification for Accelerated Approval and Priority Review, if relevant criteria are met; and Quoin’s products in development collectively having the potential to target a broad number of rare and orphan indications, including Netherton Syndrome, Peeling Skin Syndrome, Palmoplantar Keratoderma, Pachyonychia Congenita, Gorlin Syndrome, Tuberous Sclerosis Complex, Microcystic Lymphatic Malformations, Venous Malformations, Angiofibroma and others. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based upon the Company’s current expectations and involve assumptions that may never materialize or may prove to be incorrect. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties including, but not limited to, the Company’s ability to pursue its regulatory strategy; the Company’s ability to obtain regulatory approvals for commercialization of product candidates or to comply with ongoing regulatory requirements; the Company’s ability to complete clinical trials on time and achieve desired results and benefits as expected; and other factors discussed in the Company’s Annual Report on Form 10-K for the year ended December 31, 2025 and in other filings the Company has made and may make with the SEC in the future. One should not place undue reliance on these forward-looking statements, which speak only as of the date on which they were made. The Company undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as may be required by law.

Contacts

Jeff Ramson
jramson@pcgadvisory.com
Michael Myers
mmyers@quoinpharma.com

About Author

Cloud PR Wire

See author's posts

Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.

Continue Reading

Press Release

Why Starting Work at 14 Prepared William Stapleton to Sell a Company for $300 Million

Published

6 hours ago

on

September 22, 2026

By

  • William Stapleton, President and CEO of Iron Rock Payments in Frisco, Texas, shares how early work shaped his path from private banking to entrepreneurship.

How did working from age 14 influence your career?

Texas, USA, Sep 22, 2026, ZEX PR WIRE — “I have worked since I was 14 years old to support myself and used this work ethic into college,” Stapleton says. He grew up in a working-class household in Long Beach, California. His mother is from Ecuador and his father is of German and Polish descent. Starting work young built financial responsibility and shaped his approach to business.

He played varsity baseball and water polo while working through high school. He graduated with honors from Long Beach Wilson Classical High School near the top of his class. In college, he took an unpaid internship at Salomon Brothers while balancing his studies. “I graduated college with full honors, top of my class academically,” he says. He earned a double major in Rhetorical Theory and Global Economics from California State University, Long Beach in 2006.

What did you learn in private banking that helped you as an entrepreneur?

After graduation, Morgan Stanley Private Bank recruited Stapleton to work in New York. He later joined JPMorgan Chase, where he contributed to building what is now known as the Chase Private Client program. He spent approximately seven years in private banking and advisory roles.

Working with high-net-worth clients taught him how to manage relationships, assess risk, and structure solutions. Those skills transferred directly to running a business. Understanding client needs and delivering value became the foundation of his entrepreneurial approach.

How did you transition from banking to payments?

Stapleton founded PayFacto, a credit card processing company based in Montreal. He built the company from the ground up and grew it until Visa acquired it in 2019. The sale carried an estimated valuation of $300 million.

He did not wait long to start again. In 2012, he founded Iron Rock Payments, a credit card processing company based in Frisco, Texas. The company has been recognized as an Inc. 5000 company and employs 15 people. Stapleton serves as President and CEO.

What do businesses get wrong about payment processing?

Many businesses treat payment processing as a commodity. They focus only on rates and miss the bigger picture. The right processor can improve cash flow, reduce chargebacks, and provide data that drives decisions.

Stapleton emphasizes that service matters as much as price. Businesses need a partner who understands their industry and responds quickly when issues arise. A few basis points saved on fees mean nothing if downtime costs thousands in lost sales.

What lessons from your first exit did you apply to Iron Rock Payments?

Selling PayFacto taught Stapleton the importance of building systems that scale. He learned to hire people who are better than him in specific areas and to trust them. He also realized that culture drives retention and retention drives growth.

At Iron Rock Payments, he focused on creating processes that work whether the company has 5 employees or 50. He invests in technology that automates repetitive tasks so his team can focus on client relationships. He also prioritizes transparency with clients and employees.

What advice do you give to people thinking about starting a business?

Start before you feel ready. Waiting for the perfect moment means you will never start. Stapleton began working at 14 and took an unpaid internship in college because he wanted experience more than money.

He also advises entrepreneurs to stay close to their customers. The best product ideas come from listening to what clients actually need, not from guessing. Finally, he says to protect your reputation. Trust takes years to build and seconds to destroy.

If you do nothing else

  1. Start working as early as you can to build a strong work ethic and financial discipline.

  2. Take internships or entry-level roles that teach you skills, even if the pay is low or nonexistent.

  3. Spend time in an industry before you try to disrupt it so you understand how it really works.

  4. Build systems and processes that can scale as your business grows.

  5. Hire people who are stronger than you in areas where you are weak and trust them to do their jobs.

  6. Listen to your clients and let their needs guide your product and service decisions.

  7. Protect your reputation by delivering on promises and treating people with respect.

Share this Q&A with someone who is thinking about making the leap from employee to entrepreneur or who wants to understand how early work experience shapes long-term success.

About William Stapleton

William Stapleton is President and CEO of Iron Rock Payments, a credit card processing company based in Frisco, Texas. He founded the company in 2012 after selling his previous venture, PayFacto, to Visa in 2019 at an estimated valuation of $300 million. Before entering entrepreneurship, he worked in private banking at Morgan Stanley and JPMorgan Chase, where he contributed to creating the Chase Private Client program. He graduated with full honors from California State University, Long Beach with a double major in Rhetorical Theory and Global Economics.

About Author

Cloud PR Wire

See author's posts

Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.

Continue Reading

Press Release

David Wayne Fish makes a personal pledge: one season, one sport, no missed games

Published

6 hours ago

on

September 22, 2026

By

California, USA, Sep 22, 2026, ZEX PR WIRE — David Wayne Fish is putting a specific commitment on the record. With six kids moving through baseball, football, and tennis across overlapping seasons, he says the easiest thing to let slip is presence. So he is naming the standard out loud.

“If one of my kids has a game or a practice, someone from this family is there,” Fish says. “That’s the whole pledge. It sounds simple because it should be simple. The hard part is building a life where you can actually keep it.”

Fish runs healthcare and wellness companies as a consultant and CEO, work that does not pause for a Tuesday scrimmage. He is not pretending otherwise. The pledge is not about having endless free time. It is about deciding in advance what wins when a calendar conflict shows up.

Why he is saying it publicly

Fish has coached football, baseball, and helped organize tennis for years. He says most parents do not fail their kids through some dramatic absence. They fail them through a hundred small ones that never get flagged as decisions at all.

“Nobody skips a game and thinks of it as a broken promise,” he says. “It just looks like a scheduling problem. I wanted to write my own rule down so it stops being negotiable case by case.”

He credits his own father, and the model of family life he grew up with in Michigan, for the instinct behind this. Fish says he was raised around the idea that a father’s job includes showing up, not just providing.

What the commitment actually covers

The pledge Fish is making has a few concrete parts:

Every game gets a family face in the stands. Not every game gets David personally, with six kids and overlapping seasons that is not realistic, but every game gets someone: him, his wife, or another family member who can stand in.

Coaching commitments get finished, not started. Fish says he does not sign up to coach a season and then quietly hand it off when work gets busy. If he takes a team, he finishes the season.

Conflicts get resolved before the week starts, not during it. Fish says he sits down weekly and maps which kid has what, so trade-offs get made on a Sunday with a clear head instead of on a Wednesday in a parking lot.

“I’d rather lose an hour on Sunday mapping the week than lose a moment at my kid’s game because I’m distracted by something I should have planned around,” he says.

What he is asking of himself, not other parents

Fish is careful to frame this as his own standard, not a lecture. He is not telling other families how to run their weeks.

“I’m not in a position to tell another parent what their life allows,” he says. “I know what mine allows, and I know where I’ve cut corners before without meaning to. This is me closing that gap for myself.”

He says the pledge will get tested immediately, since his kids’ seasons rarely line up cleanly. Two games at the same hour, in two different towns, is not a hypothetical for his family. It happens.

“When that comes up, the answer isn’t ‘we’ll figure it out.’ The answer is already written down: someone from this family goes to each one,” Fish says. “I’d rather have made that call in October than try to make it in the car in March.”

Holding himself to it

Fish says he plans to track the pledge the same plain way he tracks anything else he takes seriously: a simple log of games, and who from the family was there. No app, no public scoreboard, just a habit he intends to keep himself honest about.

“If I say I’m going to do something for my kids, I want a way to check whether I actually did it,” he says. “That’s the only accountability that’s ever mattered to me.”

To read more, visit the website here.

About David Wayne Fish

David Wayne Fish is an entrepreneur based in Laguna Niguel, California. He works as a CEO and consultant to healthcare and wellness companies. Outside that work, he coaches youth football and baseball, helps organize tennis programs, and is the father of six children active in sports.

About Author

Cloud PR Wire

See author's posts

Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.

Continue Reading

LATEST POST

Like Us
Follow Us
Subscribe Us
Follow Us