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One Year Into Kabir Naths Leadership, Compass Pathways (NASDAQ: CMPS) Phase 3 Trial For Innovative Treatment Resistant Depression Progressing

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By Faith Ashmore, Benzinga

Treatment-resistant depression, also referred to as TRD, is a subset of depression that poses significant challenges for clinicians, patients and those closest to patients. It is characterized by persistent symptoms of depression that do not respond adequately to at least two different standard antidepressant treatments. This debilitating condition often leaves individuals grappling with feelings of despair, hopelessness and a diminished quality of life.

Unlike some forms of depression that may improve with pharmacological interventions or talk therapies, TRD tends to persist, leading to a multitude of negative consequences. The unyielding nature of this condition can contribute to increased rates of disability, higher suicide risk and significant financial burden due to the need for repeated treatments. Psilocybin treatment is emerging as a potentially effective approach to the treatment of TRD.

Although further research is still needed to establish its efficacy and safety, initial findings are promising. While there are a number of companies developing psilocybin treatments, Compass Pathways (NASDAQ: CMPS) is setting itself apart from its contemporaries with its phase 3 program in TRD.

The companys innovative approach has received FDA Breakthrough Therapy designation in the U.S. and Innovative Licensing and Access Pathway designation in the U.K. for their investigational COMP360 psilocybin. Moreover, in late 2021, Compass Pathways announced the completion of a randomized, controlled double-blind phase 2b study of COMP360 psilocybin treatment involving 233 patients with TRD in 22 sites across Europe and North America.

In August of 2022, Compass Pathways brought on Kabir Nath as CEO to help navigate its transition from a start-up to an established phase 3 biopharma company. Nath is a seasoned healthcare executive with over two decades of experience leading global pharmaceutical companies. He has held several leadership positions at multinational corporations, including Bristol Meyers Squibb (NYSE: BMS), GlaxoSmithKline (NYSE: GSK) and Otsuka Pharmaceutical (OTCMKTS: OTSKY).

Nath has a track record of success in developing new products and creating commercial strategies to make medicines available to patients on a global scale. He is skilled in identifying unmet patient needs and working collaboratively with stakeholders to develop targeted and effective treatment options. He also has considerable experience in psychiatric drug development.

Under Naths leadership, Compass Pathways has made significant progress in advancing the development of its investigational drug, COMP360 psilocybin. One notable accomplishment was the initiation of their phase 3 clinical trials, which are pivotal in determining the safety and efficacy of the treatment. These trials consist of two key studies: Pivotal Trial 1 (COMP005) and Pivotal Trial 2 (COMP006).

COMP005 is studying a single dose (25mg) of COMP360 psilocybin as monotherapy, comparing it with a placebo. The aim of this trial is to replicate the positive treatment response observed in the companys phase 2b study, which included 233 patients with treatment-resistant depression.

COMP006 is a fixed repeat dose monotherapy study that examines the effects of three different dose arms: 25mg, 10mg and 1mg. The objective of this trial is to investigate whether a second dose can enhance the number of responders and further improve the response observed in the phase 2b study. Additionally, this trial explores the potential for a meaningful treatment response from the repeat administration of COMP360 10mg.

Both pivotal trials have the change from baseline in MADRS (Montgomery-sberg Depression Rating Scale) total score at week six as their primary endpoint. This measure allows researchers to evaluate the effectiveness of COMP360 psilocybin in reducing depressive symptoms compared to baseline.

In addition to driving the company forward into phase 3, Nath has supported the development of the companys digital platforms that accompany its psilocybin treatment, has led a successful private placement fundraising that extends the companys runway into late 2025, and claims to have one of the most talented and experienced leadership team among psychedelic companies in the space. Nath's global experience in the pharmaceutical industry and his expertise in developing and commercializing treatments for unmet needs uniquely position him to lead Compass Pathways toward the successful development and commercialization of their investigational drug COMP360 psilocybin, subject to FDA approval.

Company BioCOMPASS Pathways plc (Nasdaq: CMPS) is a mental health care company dedicated to accelerating patient access to evidence-based innovation in mental health. Our focus is on improving the lives of those who are suffering with mental health challenges and who are not helped by current treatments. We are pioneering the development of a new model of psilocybin therapy, in which our proprietary formulation of synthetic psilocybin, COMP360, is administered in conjunction with psychological support. COMP360 has been designated a Breakthrough Therapy by the U.S. Food and Drug Administration (FDA) and has received Innovative Licensing and Access Pathway (ILAP) designation in the UK for treatment-resistant depression (TRD). We have commenced a phase 3 clinical program of COMP 360 psilocybin therapy in TRD, the largest randomised, controlled, double-blind psilocybin therapy clinical program ever conducted. Previously, we completed a phase 2b study with top line data showing a statistically significant (p<0.001) and clinically relevant improvement in depressive symptom severity after three weeks for patients who received a single high dose of COMP360 psilocybin with psychological support. We are also conducting phase 2 clinical studies of COMP360 psilocybin therapy for post-traumatic stress disorder (PTSD) and anorexia nervosa. COMPASS is headquartered in London, UK, with offices in New York and San Francisco in the United States. Our vision is a world of mental wellbeing.

This post contains sponsored content. This content is for informational purposes only and not intended to be investing advice.

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View source version on newsdirect.com: https://newsdirect.com/news/one-year-into-kabir-naths-leadership-compass-pathways-nasdaq-cmps-phase-3-trial-for-innovative-treatment-resistant-depression-progressing-838899400

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Join the E-Learning Revolution with MagnumMeta: Become Part of the Thriving Community

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Embrace the E-Learning Revolution with MagnumMeta: Join Our Expanding Community

Denver, United States, 23rd Jun 2024, King NewsWire – MagnumMeta leads the e-learning revolution with an innovative ecosystem integrating blockchain and AI technologies, enhancing educational experiences dynamically. This article offers a comprehensive guide on joining the MagnumMeta community, leveraging unique features, and becoming part of a thriving network of learners and educators.

Unleash Transformative Innate Potentials

MagnumMeta is dedicated to enriching educational journeys through advanced decentralized blockchain solutions. By joining MagnumMeta, individuals gain access to a diverse array of educational resources, participate in governance, and stake MFORGE tokens for rewards.

 Staking MFORGE Tokens

An integral part of engaging with MagnumMeta is staking MFORGE tokens, enabling community members to earn rewards while contributing to platform stability and growth.

“Staking MFORGE tokens is a powerful way to actively engage in the MagnumMeta ecosystem,” explained Ada Ego, The Chief Operating Officer and Co-founder of MagnumMeta. “It not only offers financial incentives but also supports the infrastructure driving our innovative educational platform.”

Participating in Governance

MagnumMeta values community input, allowing token holders to participate in platform governance by voting on decisions and proposing changes.

“We believe in a community-driven approach,” Ada Ego emphasized. “Empowering our users with governance rights ensures that MagnumMeta evolves in ways that benefit everyone.”

Leveraging Educational Resources

MagnumMeta offers a comprehensive suite of educational resources, including a peer-to-peer tutoring marketplace, skill-based certification programs, and an AI-powered learning management system. These resources are tailored to deliver personalized and effective learning experiences.

“MagnumMeta’s educational resources are exceptional,” remarked Jane Doe, an early adopter. “The AI-powered LMS and diverse course offerings have significantly enhanced my learning journey.”

Early Adopter Testimonials and Success Stories

Testimonials from early adopters highlight the transformative impact of MagnumMeta’s platform. Users like John Smith, a business professional, and Emily Brown, a cyber security enthusiast, have achieved career advancements and skill development through MagnumMeta’s innovative features.

“Joining MagnumMeta has transformed my career prospects,” John Smith shared. “The peer-to-peer tutoring and skill-based certifications have been instrumental in my professional growth.”

“Why MagnumMeta? Because it stands out,” noted Emily Brown. “From its extensive course library to secure blockchain credentials, MagnumMeta ensures my educational achievements are recognized and valued.”

The Inherent Network

MagnumMeta’s Affiliate Plan offers a unique opportunity for individuals to earn income while learning. Affiliates can earn referral commissions and participate in revenue-sharing initiatives, turning educational pursuits into financially rewarding ventures.

“Our affiliate program isn’t just about learning; it’s about creating financial opportunities,” Ada Ego affirmed. “It allows users to earn while enhancing their educational journey.”

 Empowering Over 500,000 Learners

MagnumMeta’s impact is felt across the education sector, boasting a community of over 500,000 learners and 100,000 graduates. This vibrant community underscores MagnumMeta’s commitment to delivering exceptional educational experiences and fostering continuous development.

Continued Commitment to Excellence

MagnumMeta remains committed to excellence by continuously expanding its course offerings and enhancing platform features. The platform’s dedication to innovation ensures that learners receive cutting-edge education aligned with industry demands.

“We are constantly evolving to meet the needs of our diverse community,” Ada Ego stated. “Our goal is to provide learners with the tools and knowledge they need to succeed in their careers and personal development.”

About MagnumMeta

MagnumMeta is an innovative educational platform integrating blockchain technology and AI to create secure, personalized learning experiences. MagnumMeta aims to transform education by making it accessible, secure, and effective. With a diverse range of courses and cutting-edge features, MagnumMeta empowers learners and educators worldwide to achieve their full potential.

Experience the future of learning with MagnumMeta and unlock your potential today. For more information, visit www.magnummeta.com or contact Rossy Redman at [email protected].

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Sustainable Countertop Solutions: The Shift from Quartz

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The Unseen Risks of Quartz CountertopsIn contemporary home design, quartz countertops are renowned for their durability and modern appeal. However, there’s a hidden danger: silica dust. When quartz is cut or sanded, it releases fine silica particles into the air. This isn’t just an annoyance—it’s a serious health threat. Both professional workers and DIY enthusiasts are at risk, with prolonged exposure potentially leading to severe lung diseases, including lung cancer.International Initiatives to Address Silica HazardsIn response to the health risks posed by silica dust, various countries have enacted stringent regulations. Australia, for example, has banned the use of quartz surfaces in new construction and renovations. This proactive measure, supported by extensive research, highlights a global effort to protect the health of construction workers and homeowners.Safer Alternatives to Quartz: A New Era of CountertopsAs restrictions on quartz surfaces become more prevalent, the search for safe, durable, and aesthetically pleasing alternatives intensifies. Innovators in the industry have developed new materials that offer the benefits of quartz without the associated health risks. These advancements mark a significant step forward in balancing beauty with safety.Promoting Eco-Friendly and Safe Countertop MaterialsThese new materials are designed with sustainability at their core, incorporating recycled elements. They not only ensure the safety of installers and users but also appeal to environmentally conscious consumers. This approach represents a significant move towards more sustainable home improvement practices.Transforming the London Worktops MarketThe objective is clear: revolutionize the London worktops market by prioritizing health and safety. These innovative products are distinguished by their quality and durability, reflecting a commitment to both human well-being and environmental stewardship. They ensure that countertops are not only functional but also beneficial for the planet and its residents.Choosing Wisely: Combining Elegance and SafetyOpting for these new materials allows homeowners to enjoy a perfect blend of style and safety. This choice underscores the industry’s dedication to offering solutions that do not compromise health or the environment.Pioneering Healthier Home ChoicesAs awareness increases about the impact of material choices on health and the environment, industry leaders are stepping up. They are guiding us towards making home decisions that prioritize both health and aesthetics. These trailblazers are leading the charge, advocating for homeowners to select surfaces like marble and safer options to quartz that ensure both elegance and peace of mind.Opt for wellness. Opt for sustainability. Opt for materials that respect your home, your health, and our planet.Discover a range of products at JR Stone and services tailored to your unique needs, contributing to a healthier, more sustainable future.

London, United Kingdom, 23rd Jun 2024 – The Unseen Risks of Quartz Countertops
In contemporary home design, quartz countertops are renowned for their durability and modern appeal. However, there’s a hidden danger: silica dust. When quartz is cut or sanded, it releases fine silica particles into the air. This isn’t just an annoyance—it’s a serious health threat. Both professional workers and DIY enthusiasts are at risk, with prolonged exposure potentially leading to severe lung diseases, including lung cancer.

International Initiatives to Address Silica Hazards
In response to the health risks posed by silica dust, various countries have enacted stringent regulations. Australia, for example, has banned the use of quartz surfaces in new construction and renovations. This proactive measure, supported by extensive research, highlights a global effort to protect the health of construction workers and homeowners.

Safer Alternatives to Quartz: A New Era of Countertops
As restrictions on quartz surfaces become more prevalent, the search for safe, durable, and aesthetically pleasing alternatives intensifies. Innovators in the industry have developed new materials that offer the benefits of quartz without the associated health risks. These advancements mark a significant step forward in balancing beauty with safety.

Promoting Eco-Friendly and Safe Countertop Materials
These new materials are designed with sustainability at their core, incorporating recycled elements. They not only ensure the safety of installers and users but also appeal to environmentally conscious consumers. This approach represents a significant move towards more sustainable home improvement practices.

Transforming the London Worktops Market
The objective is clear: revolutionize the London worktops market by prioritizing health and safety. These innovative products are distinguished by their quality and durability, reflecting a commitment to both human well-being and environmental stewardship. They ensure that countertops are not only functional but also beneficial for the planet and its residents.

Choosing Wisely: Combining Elegance and Safety
Opting for these new materials allows homeowners to enjoy a perfect blend of style and safety. This choice underscores the industry’s dedication to offering solutions that do not compromise health or the environment.

Pioneering Healthier Home Choices
As awareness increases about the impact of material choices on health and the environment, industry leaders are stepping up. They are guiding us towards making home decisions that prioritize both health and aesthetics. These trailblazers are leading the charge, advocating for homeowners to select surfaces like marble and safer options to quartz that ensure both elegance and peace of mind.

Opt for wellness. Opt for sustainability. Opt for materials that respect your home, your health, and our planet.

Discover a range of products at  JR Stone and services tailored to your unique needs, contributing to a healthier, more sustainable future.

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The post Sustainable Countertop Solutions: The Shift from Quartz appeared first on King NewsWire. It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.

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Chipmixer Backup Domain Now Available

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Chipmixer, a leading Bitcoin mixing service, announces the blocking of its primary domain. To ensure continuous service and maintain user privacy, Chipmixer is now accessible through a backup domain at Chipmixer.Online. Despite the setback, Chipmixer remains committed to providing secure and anonymous Bitcoin transactions. Users are encouraged to update their bookmarks and stay connected for the latest updates.

Vietnam, 23rd Jun 2024 – ChipMixer, a leading service in cryptocurrency mixing, announces the unfortunate blocking of its primary domain. Despite this setback, we are pleased to inform our users and the cryptocurrency community that our services remain fully operational through a backup domain.

Visit Us at Our New Domain: ChipMixer

Ensuring Continuous Service and Security

Chipmixer has been dedicated to providing top-tier privacy and security for our users’ Bitcoin transactions. The blocking of our primary domain has not deterred our commitment to maintaining these standards. By utilizing our new domain, users can continue to access our services without interruption.

Why Choose Chipmixer?

  • Anonymity: Our platform ensures that your Bitcoin transactions remain private and untraceable.
  • Reliability: With years of trusted service in the cryptocurrency community, Chipmixer stands as a reliable choice for mixing services.
  • User-Friendly: Our interface is designed for ease of use, ensuring that both new and experienced users can navigate our services effortlessly.

Call to Action

We urge all our users to update their bookmarks and spread the word about our new domain. Your privacy and the security of your transactions remain our top priority, and we will continue to provide the high-quality service you expect from Chipmixer.

Stay Connected

For the latest updates, follow us on our social media channels and visit our website regularly. Our team is available to assist with any questions or concerns you may have regarding the transition to our new domain.

About Chipmixer

Chipmixer is a premier Bitcoin mixer service designed to enhance the privacy and anonymity of cryptocurrency transactions. Our innovative approach to mixing ensures that your Bitcoin remains secure and untraceable, making Chipmixer a trusted choice in the cryptocurrency community.

 

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The post Chipmixer Backup Domain Now Available appeared first on King NewsWire. It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.

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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.

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