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One Year Into Kabir Naths Leadership, Compass Pathways (NASDAQ: CMPS) Phase 3 Trial For Innovative Treatment Resistant Depression Progressing

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–News Direct–

By Faith Ashmore, Benzinga

Treatment-resistant depression, also referred to as TRD, is a subset of depression that poses significant challenges for clinicians, patients and those closest to patients. It is characterized by persistent symptoms of depression that do not respond adequately to at least two different standard antidepressant treatments. This debilitating condition often leaves individuals grappling with feelings of despair, hopelessness and a diminished quality of life.

Unlike some forms of depression that may improve with pharmacological interventions or talk therapies, TRD tends to persist, leading to a multitude of negative consequences. The unyielding nature of this condition can contribute to increased rates of disability, higher suicide risk and significant financial burden due to the need for repeated treatments. Psilocybin treatment is emerging as a potentially effective approach to the treatment of TRD.

Although further research is still needed to establish its efficacy and safety, initial findings are promising. While there are a number of companies developing psilocybin treatments, Compass Pathways (NASDAQ: CMPS) is setting itself apart from its contemporaries with its phase 3 program in TRD.

The companys innovative approach has received FDA Breakthrough Therapy designation in the U.S. and Innovative Licensing and Access Pathway designation in the U.K. for their investigational COMP360 psilocybin. Moreover, in late 2021, Compass Pathways announced the completion of a randomized, controlled double-blind phase 2b study of COMP360 psilocybin treatment involving 233 patients with TRD in 22 sites across Europe and North America.

In August of 2022, Compass Pathways brought on Kabir Nath as CEO to help navigate its transition from a start-up to an established phase 3 biopharma company. Nath is a seasoned healthcare executive with over two decades of experience leading global pharmaceutical companies. He has held several leadership positions at multinational corporations, including Bristol Meyers Squibb (NYSE: BMS), GlaxoSmithKline (NYSE: GSK) and Otsuka Pharmaceutical (OTCMKTS: OTSKY).

Nath has a track record of success in developing new products and creating commercial strategies to make medicines available to patients on a global scale. He is skilled in identifying unmet patient needs and working collaboratively with stakeholders to develop targeted and effective treatment options. He also has considerable experience in psychiatric drug development.

Under Naths leadership, Compass Pathways has made significant progress in advancing the development of its investigational drug, COMP360 psilocybin. One notable accomplishment was the initiation of their phase 3 clinical trials, which are pivotal in determining the safety and efficacy of the treatment. These trials consist of two key studies: Pivotal Trial 1 (COMP005) and Pivotal Trial 2 (COMP006).

COMP005 is studying a single dose (25mg) of COMP360 psilocybin as monotherapy, comparing it with a placebo. The aim of this trial is to replicate the positive treatment response observed in the companys phase 2b study, which included 233 patients with treatment-resistant depression.

COMP006 is a fixed repeat dose monotherapy study that examines the effects of three different dose arms: 25mg, 10mg and 1mg. The objective of this trial is to investigate whether a second dose can enhance the number of responders and further improve the response observed in the phase 2b study. Additionally, this trial explores the potential for a meaningful treatment response from the repeat administration of COMP360 10mg.

Both pivotal trials have the change from baseline in MADRS (Montgomery-sberg Depression Rating Scale) total score at week six as their primary endpoint. This measure allows researchers to evaluate the effectiveness of COMP360 psilocybin in reducing depressive symptoms compared to baseline.

In addition to driving the company forward into phase 3, Nath has supported the development of the companys digital platforms that accompany its psilocybin treatment, has led a successful private placement fundraising that extends the companys runway into late 2025, and claims to have one of the most talented and experienced leadership team among psychedelic companies in the space. Nath's global experience in the pharmaceutical industry and his expertise in developing and commercializing treatments for unmet needs uniquely position him to lead Compass Pathways toward the successful development and commercialization of their investigational drug COMP360 psilocybin, subject to FDA approval.

Company BioCOMPASS Pathways plc (Nasdaq: CMPS) is a mental health care company dedicated to accelerating patient access to evidence-based innovation in mental health. Our focus is on improving the lives of those who are suffering with mental health challenges and who are not helped by current treatments. We are pioneering the development of a new model of psilocybin therapy, in which our proprietary formulation of synthetic psilocybin, COMP360, is administered in conjunction with psychological support. COMP360 has been designated a Breakthrough Therapy by the U.S. Food and Drug Administration (FDA) and has received Innovative Licensing and Access Pathway (ILAP) designation in the UK for treatment-resistant depression (TRD). We have commenced a phase 3 clinical program of COMP 360 psilocybin therapy in TRD, the largest randomised, controlled, double-blind psilocybin therapy clinical program ever conducted. Previously, we completed a phase 2b study with top line data showing a statistically significant (p<0.001) and clinically relevant improvement in depressive symptom severity after three weeks for patients who received a single high dose of COMP360 psilocybin with psychological support. We are also conducting phase 2 clinical studies of COMP360 psilocybin therapy for post-traumatic stress disorder (PTSD) and anorexia nervosa. COMPASS is headquartered in London, UK, with offices in New York and San Francisco in the United States. Our vision is a world of mental wellbeing.

This post contains sponsored content. This content is for informational purposes only and not intended to be investing advice.

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View source version on newsdirect.com: https://newsdirect.com/news/one-year-into-kabir-naths-leadership-compass-pathways-nasdaq-cmps-phase-3-trial-for-innovative-treatment-resistant-depression-progressing-838899400

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Bei La: A Shanghai Skylark Sings the Song of Walden.

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05a8389dc2503775a3110079eebd0fdCanadian Author Bei La

Canadian writer Bei La, born in Shanghai, recently completed a non-fiction work titled The Tears of the Skylark. This is her first work since she left Shanghai and returned to Canada two years ago. Through a skylark, a farewell song was sung about the prosperity and loneliness, brightness and darkness, disaster and redemption of Shanghai over the past hundred years.

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Mike Medavoy and Bei La

This work was completed during her travels, including the Lake Mochizuki in Hokkaido, Beverly Hills, Concord in Massachusetts, Vancouver Harbour, Niagara Town, and an isolated island on Lake Ontario. This is hertribute paid as the meditation on Henry David Thoreau’s Walden.

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The Cursed Piano

The book records the thrilling journey of her maternal grandfather as a survivor of the shocking Jiangyashipwreck in December 1948, which had a death toll even far exceeding that of the Titanic. She describes her father, who was a military doctor, taking the risk of hiding more than ten ancestral gold bars and jewelry in the soil of his own iron tree during the Cultural Revolution, avoiding the fate of being confiscated but enduring the hardships brought by wealth. She also depicts the extraordinary significance of the Christian faith of her parents’ family to their lives. And she looksback at the distorted era when she was criticized for peeking at world classics in her youth. She witnesses the human nature revealed by the COVID-19 epidemic around the world……

What made Bei La decide to give up her luxurious life in Shanghai was not her experiences during the quarantine hotel and lockdown period, but rather, as a human being, everything she experienced during those special times has passed away with the wind. She left because she was called and pulled by a free soul. When a writer sees desolation amidst the hustle and bustle, yearning for tranquility amidst the clamor, and seeking her own “Walden”in the endless wilderness, she is awakened by literature.

“The farther away from one’s hometown in terms of geographical location, the closer the hometown in literature,” said Bei La.

She wrote in this book: Humans are immersed in a large sphere, gradually shrouded in anxiety, fear, absurdity, nothingness, and despair. In the ever-changing world, the unpredictability of fate has become a human destiny. This is an era that has become indifferent to tragedy. Any pain is futile. When a person is far away from the hustle and bustle, you will hear your own voice, and your soul will return to the wilderness of freedom.

The girl doesn’t speak

But it tells of sadness;

The silence of the river

Only records the years;

Time daydreaming

But it answered everything

This is the skylark singing: “Please give me the freedom to fall deeply in love with someone, give me the courage to embrace you tightly. Please give me a path to explore truth, and give me the power to find light in darkness,even if it requires sacrificing my life.”

“No matter what she has experienced or is currently experiencing,Bei La can always extract beneficial nutrients from hardships and transform them into valuable literary wealth. The light of brightness and hope has not disappeared in her eyes for a second. She stands at the spiritual pole and her thoughts far exceed those of contemporary writers. This is the best annotation that Shanghai Bei La can become the world’s Bei La,” said her literary agent An Boshun.

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French Opera:The Lover of Shanghai

The French opera Shanghai Lovers adapted from Bei La’ novel was accomplished on May 24th at the Fontainebleau Theater. This opera has 13 scenes and is expected to be performed in 2 hours and 10 minutes. The lineup is very strong, reproducing the bustling modernity and true love of Shanghai a century ago. The rivers of this Far Eastern city are full of her spirit of embracing all rivers.

This French opera that reproduces Bei La’s hometown will premiere in Paris and tour the world.

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Bei La

Bei La is a Canadian citizen born in Shanghai. As a contemporary writer of romanticism and humanitarianism, she also serves as a Visiting Researcher for the Institute of Arts and Humanities in Shanghaijiao Tong University. She has published over a dozen novels, including “The Cursed Piano”, “Song of Survivors”, “Sentimental Casablanca”, etc. Over the years, Bei La has focused her literary creation and researches on “Jews in Shanghai”. During the past two decades, she has visited Jews across the world who lived or were born in Shanghai, gathering a large number of first-hand historical materials. The “Jews in Shanghai” series is designed to include ten books. Howard Goldblatt, a renowned Jewish American sinologist, is the English translator of her works. “The Cursed Piano”, the last work of British playwright Ronald Harwood who is the Oscar Winner of Best Screenplay for “The Pianist”, is based on Bei La’s novel of the same name, also known as the companion piece of “The Pianist”. Bei La’s work “Song of the Survivors” is regarded as the Shanghai version of “Gone with the Wind”. “Song of Survivors” is based on the experience of Mike Medavoy’s parents in Shanghai during World War II. Mike grew up and became a top Hollywood producer who is an eight-time Oscar Winner of Best Picture with films such as “One Flew over the Cuckoo’s Nest”. With love and faith as the main thread, Bei La’s works portray the humanitarian spirit of her hometown Shanghai by demonstrating the shared emotions and destiny of human beings, and fleshing out the wisdom and humor of the Jews, who showed tremendous optimism and resilience in the face of misery and uprooted existence. With an eye for love and beauty, Bei La tells the stories of Jews related to Shanghai, spreading the seed of love and faith to the world. In addition to her literary creation, as a music and art lover, Bei La also performed the piano solo “Butterfly lovers“ in a concert of the Israeli pianist Yaron Kolberg, and she once gave a concert at the Shanghai Concert Hall as well.

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Revolutionising Insect Repellents: BiteRepel’s Commitment to Safety, Efficacy and Sustainability

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California, USA – In a world where the threat of mosquito-borne viruses is ever-present, the need for effective protection is paramount. Enter BiteRepel, a game-changing product in the crowded market of insect repellents, known for its unparalleled commitment to safety, efficacy and environmental consciousness. BiteRepel’s unique formula targets mosquitoes’ specific genetic makeup, ensuring that even the newest variants are kept at bay.

Unmatched Safety and Environmental Consciousness

BiteRepel is the first of its kind, meticulously formulated to be both pet-safe and reef-friendly. The unique formula effectively reduces the risk of contracting mosquito-borne viruses while ensuring a healthier ecosystem for all. With the rise of new variants of mosquitoes since mid-2022, traditional repellents like DEET and Citronella have shown limited effectiveness. This is where BiteRepel steps in as your ultimate solution.

“BiteRepel stands out because it addresses the evolving nature of mosquito threats with a focus on both human and environmental health,” says Serene Johnson, Sales and Service Lead at BiteRepel. “Our products are not only effective but also align with the values of eco-conscious consumers.”

Natural and Organic Ingredients

Free from harmful chemicals, BiteRepel is completely natural and organic. The brand offers peace of mind to families and eco-conscious consumers alike. By choosing BiteRepel, you not only protect yourself from mosquito-borne viruses but also safeguard the well-being of your furry companions and the environment. BiteRepel is dedicated to combining safety, effectiveness, and sustainability without compromise.

Rigorous Testing and Proven Effectiveness

BiteRepel’s range of insect sprays and recommended insect repellents are formulated to provide unparalleled protection against relentless pests. Their products have undergone rigorous testing to ensure their effectiveness against the latest mosquito strains, giving you peace of mind in any situation.

“Our commitment to quality is reflected in the thorough testing each product undergoes,” states Drew Carlyle, Quality Assurance Manager at BiteRepel. “We ensure that our repellents are effective against all types of mosquitoes, including genetically modified strains.”

Sustainability Commitment

BiteRepel is dedicated to environmental sustainability. The formula’s eco-friendly and biodegradable nature ensures it leaves no harmful residue, making it a sustainable choice for the environmentally conscious. BiteRepel’s non-toxic, natural, vegan, and 100% organic composition is crafted without harmful chemicals like Picaridin, DEET, IR3535, and Citronella, as well as parabens and gluten. This dedication to purity ensures the product is safe for users and the planet alike.

Innovative Origins

The journey of BiteRepel began with a mission to transform outdoor enjoyment by providing effective protection against biting insects. Driven by a clear objective to create a reliable solution, BiteRepel underwent extensive research and numerous trials. This process led to the development of a groundbreaking formula that sets a new standard in insect repellents. BiteRepel not only repels all mosquito types, including genetically modified strains, but also deters a wide range of other insects and pests. The brand’s focus on innovation, natural ingredients, and user well-being has resulted in a product that ensures a comfortable and safe outdoor experience.

We believe in responsible innovation, which is why our product is not only highly effective but also ethical and safe for the environment, pets, and marine life,” says Jesse Neimus, Assistant Manager at BiteRepel. “It’s a game-changer in the fight against mosquito-borne diseases and a testament to what can be achieved when science and nature work in harmony.”

The Conscientious Choice

BiteRepel is the conscientious choice for modern, eco-conscious consumers who value both personal and environmental health. It’s not just about keeping bugs at bay; it’s about fostering a safer, harmonious and healthier world for all. With BiteRepel, you can finally reclaim your outdoor spaces and enjoy peace of mind knowing that you’re protected against mosquitoes and the diseases they spread.

Perfect for All Outdoor Activities

BiteRepel is the perfect solution for outdoor enthusiasts. Whether you’re hunting, fishing, golfing, camping, off-roading, swimming, backpacking, walking, running, jogging, hiking or participating in other sporting activities, BiteRepel has you covered. It’s also ideal for outdoor events like parties, BBQs, and gardening. Their products work great on flying and crawling insects, including fleas, ticks, gnats, flies, spiders, ants, and other bugs.

A Message from Our Founder

“Our journey started with a personal need and evolved into a mission to protect people and the environment,” says the founder of BiteRepel. “We’re proud to offer a product that not only protects against mosquito bites but does so in a way that’s safe for our families, pets and the planet.”

Join the BiteRepel Movement

Join BiteRepel in embracing the great outdoors with confidence and comfort. Say goodbye to ineffective repellents and hello to BiteRepel – your ultimate defence against mosquito-borne viruses. Don’t wait until it’s too late; make BiteRepel a staple in your home and outdoor adventures. BiteRepel offers affordable, accessible protection that everyone can benefit from. Don’t let mosquitoes dictate your life – take control with BiteRepel and enjoy the outdoors without worry.

Connect with Us

For more information, visit BiteRepel. Follow us on Twitter, Facebook, and Instagram.

About BiteRepel

At BiteRepel, the mission is to revolutionize outdoor protection with effective, easy-to-use insect repellents. Harnessing the power of science and nature, innovative formulas are developed that set a new standard for safety and efficacy. With a relentless commitment to quality, BiteRepel delivers unparalleled protection against mosquitoes, ticks, and other biting insects. This pioneering approach empowers a life unrestricted by nuisance bites, making the outdoors more accessible and enjoyable.

Our formula is a testament to our values of responsible innovation, combining effectiveness with ethical considerations. By choosing BiteRepel, you are not only protecting yourself from mosquito-borne viruses but also contributing to a healthier planet. Join us in embracing the great outdoors with confidence and comfort, knowing nature’s best defence safeguards you. Choose BiteRepel for peace of mind and unparalleled protection.

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Organization: BiteRepel

Contact Person: Jesse Neimus

Website: https://www.biterepel.com/

Email: Send Email

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Country: United States

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Press Release

OPTRAFFIC: Revolutionizing Traffic Safety Equipment with Technology and Innovation

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China, 27th Jul 2024, King NewsWire – OPTRAFFIC, a premier manufacturer of traffic safety equipment since 2008, is at the forefront of creating innovative solutions for road safety and traffic management. With an extensive range of products, including variable message signs, arrow boards, light towers, radar speed signs, and portable traffic signals, OPTRAFFIC continues to lead the industry by enhancing the quality, durability, and adaptability of its offerings.

Innovative Traffic Safety Solutions

OPTRAFFIC’s product line is designed to meet the diverse needs of traffic management professionals. Key products include:

  • Variable Message Signs: These signs provide dynamic and customizable messaging to motorists, ensuring clear communication of important traffic information. Products such as portable changeable message signs and portable traffic message boards are integral for real-time traffic management and emergency situations. For more details, visit Variable Message Signs.
  • Arrow Boards: Essential for directing traffic, OPTRAFFIC’s arrow boards come in various configurations, including arrow board trailers and solar arrow boards. These are crucial for managing road closures and diversions efficiently. Explore our range here: Arrow Boards.
  • Light Towers: OPTRAFFIC offers a selection of light towers, including portable light towers, LED light towers, and solar light towers, ensuring optimal visibility in low-light conditions for roadworks and events. Learn more at Lighting Towers.
  • Traffic Signals: Portable traffic signal lights, LED traffic signal lights, and portable signal lights from OPTRAFFIC provide reliable and flexible solutions for temporary traffic control. More information can be found here: Traffic Signals.
  • Variable Speed Limit Signs: To enhance speed regulation and safety, OPTRAFFIC’s variable speed limit signs, including speed limit signs with radar and solar speed limit signs, offer precise and adaptable speed control measures. Discover our products at Variable Speed Limit Signs.
  • Boom Gates: For parking management and access control, OPTRAFFIC provides robust solutions such as parking boom gates and portable boom gates, designed to ensure efficient vehicle movement and security. Explore our options at Boom Gate.

Future-Focused Innovation

Looking ahead, OPTRAFFIC is committed to leveraging cutting-edge technology and big data analytics to develop smarter, more adaptable, and more durable traffic management equipment. This strategic approach aims to enhance road safety and traffic efficiency significantly. By integrating advanced technologies, OPTRAFFIC envisions a future where traffic management systems are more responsive and efficient, ultimately reducing traffic congestion and improving safety for all road users.

Global Reach and Commitment

While OPTRAFFIC serves a global market, it remains focused on delivering exceptional quality and service to its customers in the United States. The company’s dedication to innovation and excellence ensures that its products meet the highest standards of reliability and performance.

For more information about Optraffic and its range of traffic safety equipment, please visit https://optraffic.com/ or contact Yolanda Chen at [email protected].

About OPTRAFFIC:

Optraffic is a leading manufacturer of traffic safety equipment, established in 2008. The company specializes in the production and supply of high-quality products such as variable message signs, arrow boards, light towers, radar speed signs, and portable traffic signals. With a focus on innovation and technology, Optraffic aims to create smarter, more adaptable, and more durable traffic management solutions. By leveraging big data analytics and advanced technologies, Optraffic is dedicated to improving road safety and traffic efficiency worldwide.

Media Contact

Organization: OPTRAFFIC

Contact Person: Yolanda Chen

Website: https://optraffic.com/

Email: Send Email

Country: China

Release Id: 27072414833

The post OPTRAFFIC: Revolutionizing Traffic Safety Equipment with Technology and Innovation appeared first on King NewsWire. It is provided by a third-party content provider. King Newswire makes no warranties or representations in connection with it.

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