Press Release
Macao Blusea Digital Asset Exchange—Exploring the Ocean of the Digital Economy
The Macao International Brand Exchange is licensed by the Macao government. Besides being a market maker for tangible assets like traditional centralized exchanges, it has also founded Blusea Digital Asset Exchange, a next-generation decentralized platform where people trade NFTs, metaverse items, derivatives etc., digitalize real-world assets, as well as benefit from various DeFi services.
In 2009, China approved the Hengqin Overall Development Plan to incorporate Hengqin into Zhuhai Special Economic Zone with a view to gradually building the island into a demonstration zone for the new collaborative relationship among Guangdong, Hong Kong and Macao under One Country Two Systems. Coincidentally, it was also in 2009 that Satoshi Nakamoto invented Bitcoin and opened the Pandora Box of the digital economy.
On the wings of China’s Reform and Opening-up, the Macau International Brand Exchange stumbled upon this Pandora Box and decided to seize the opportunity.
Macao Blusea Digital Asset Exchange
BluSea’s Core Business
As a next-generation metaverse exchange, BluSea is not only involved in NFT and DeFi, but also supports the digitalization of assets. Not restricting its business to digital artworks or game NFTs, BluSea understands the game-changing potential of real-world asset digitalization. Blusea’s introduction of DeFi is also expected to boost the value of users’ metaverse assets.
Digitalization of Real-world Assets
BluSea’s Technological Advantage and Security System
Both NFT and DeFi need to be supported by powerful technologies and a trustworthy security system. BluSea has adopted AI-powered formal verification to safeguard assets and smart contracts. BluSea boasts Nasdaq-level concurrency thanks to its AI-optimized network environment. AI quantitative transaction, smart financing as well as transaction route optimization will lower the barrier to trading assets in the metaverse.
When it comes to security, BluSea uses cutting-edge multi-level protection strategies for the front and back ends to safeguard the user terminal for asset safety.
BluSea’s Diverse Use Scenarios
BLUS is the only official token on BluSea. Besides paying transaction fees, granting voting power, minting NFTs and other conventional uses, BLUS also supports cross-border payment and free exchange into foreign currencies through Paypal thanks to One Country Two Systems.
Cross-border Payment
BluSea and OpenSea
In contrast to OpenSea’s sole focus on NFT trading, BluSea integrates NFT, DeFi and the AI-powered self-improving IPFS public chain—BLUS Chain.
BLUS Chain is a powerful next-generation public chain designed specifically for the metaverse. It uses IPFS for its basic data storage layer to provide distributed storage for metaverse assets and AI technologies to achieve high efficiency and security. Meanwhile, thanks to BluSea’s own cross-chain bridge Maelstrom, NFT assets can freely flow to and from mainstream public chains such as Ethereum, BSC, HECO, etc, which helps boost the liquidity of NFT and attract more users and investments to BluSea.
The integration of blockchain and semiconductor technologies will enable BluSea to build a platform for digital mirroring, which will allow users to bring their real-world assets into the virtual world and become the first people to witness the era of the metaverse.
Digital Mirroring
A New Chapter for the Digital Economy
Into the era of the digital economy, countries around the world are competing for an early lead. Europe, Canada, Australia and other developed countries have all launched Bitcoin ETFs. El Salvador went one step ahead and made Bitcoin its fiat currency.
The Digital Economy
In the meanwhile, in the 2021 CIFTIS—Global Trade in Services Summit, Chinese president Xi Jinping said, “We will join hands with all parties, continue to open up and cooperate for mutual benefit and share opportunities in service trading for the recovery and sustained growth of the world economy. We will build a mature system of rules for the service industry, and start by testing international free trade agreement rules in Beijing and other cities, building pilot zones for digital trade. We will continue to support the development of SMEs, deepen the reform of the OTC market, establish the Beijing Stock Exchange and develop SMEs into the main force for innovation in the service sector.
The Greater Bay Area is China’s primary window to the global economy. In Outline Development Plan for the Guangdong-Hong Kong-Macao Greater Bay Area issued by the State Council in 2019, it was clearly stated that building a stock market with RMB-based settlement in Macao is being studied. Now China’s national cryptocurrency DCEP has been launched in several cities, and BluSea as a digital token platform will not only help SMEs to get on the fast track of digitalization but also play an exemplary role as a pioneer in digital trade.
With support from the state, BluSea Exchange as well as the Macau International Brand Exchange will continue to focus on developing the digital economy to empower the real economy. Together they will explore new business models, facilitate the development of new economies, help build China’s influence in the international financial sector. Eventually, the Greater Bay Area will welcome a new chapter of the international digital economy with Hengqin as its center.
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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
Cloudbet Academy Launches World Cup 2026 Betting Guide: Crypto Strategies and Tournament Insights
Willemstad, Curaçao – Cloudbet, a leading crypto sportsbook and casino, today announces the release of the World Cup 2026 Betting Guide, a new free course in its Cloudbet Academy platform. Designed specifically for crypto users, this 35-minute open-access guide delivers targeted strategies and practical insights to help bettors navigate the expanded 48-team FIFA World Cup 2026, scheduled for June 11 to July 19, 2026.
The FIFA World Cup consistently ranks as one of the most heavily bet-on sporting events globally, attracting billions in wagers each edition due to its massive scale, international reach, and cultural impact. Industry estimates for recent tournaments place global betting turnover in the tens of billions of dollars, with projections for 2026 suggesting even higher volumes given the tournament’s unprecedented 48-team format and 104 matches.
A Cloudbet spokesperson says, “The 2026 World Cup is a prime moment for crypto bettors. On Cloudbet, with instant deposits and payouts in over 40 cryptocurrencies, you’re in the game within minutes. Stablecoins like USDT let you ride out volatility through the tournament, and low gas fees mean you can move fast when the odds shift. Want to back your country? Your club hero? You can, and with no red tape.”
Hundreds of outrights, player props, team specials, group winners, and other futures markets are already live on Cloudbet. These cover everything from tournament winner and top goalscorer to assists leader and match-specific propositions, giving users immediate access to a broad spectrum of options. For high-stakes bettors, Cloudbet’s Whale Mode—launched just in time for the Super Bowl—enables VIP traders to automate large positions with precision, making it ideal for high-profile tournaments like the World Cup.
The Academy, launched in late 2025, features three core tracks—Crypto Betting Basics, Sports Betting Fundamentals, and Betting Strategies & Analytics—that include interactive quizzes and rewards upon completion. The World Cup 2026 Betting Guide stands apart as the first tournament-specific course. It provides a focused, standalone deep dive that equips crypto users with crypto-optimized approaches to futures positioning, match betting, in-play tactics, and more.
World Cup 2026 Betting Guide: 7 Key Modules
The guide is structured across seven concise modules:
- World Cup 2026 basics and tournament format
Breaks down the expanded 48-team format and how it creates inefficiencies across early group pricing, qualification paths, and futures markets.
- World Cup outright & futures betting
Covers early positioning tactics, how to track odds shifts during qualification and the tournament, and how to use stablecoins to manage long-term volatility.
- How to place World Cup match bets
Introduces group-stage vs knockout-stage dynamics and teaches contextual analysis beyond surface-level rankings.
- World Cup props, specials & group-based markets
Focuses on Golden Boot, assist leaders, group winners, and other specials—plus how to adjust for neutral-venue effects.
- World Cup vs club football: What’s the difference?
Explains key differences in tempo, tactics, pressure, and bankroll management between international and club football.
- World Cup live betting strategies
Explores how to spot momentum swings in real time and use on-chain sentiment indicators to find edge in fast-moving markets.
- Advanced World Cup betting strategies & common mistakes (Advanced)
Covers sharp techniques like futures hedging, accumulator timing, and how to avoid common pitfalls like public sentiment chasing and overconfidence.
World Cup 2026 Qualification Snapshot
As of January 2026, 42 nations have qualified, including co-hosts USA, Canada, and Mexico, plus major teams from every confederation such as Spain, England, France, Argentina, Brazil, Japan, and Morocco. The December 2025 draw has set the groups, and six final spots will be decided in March 2026 through UEFA play-offs and the inter-confederation tournament in Mexico.
The Academy’s ‘World Cup Outright & Futures Betting‘ module covers more on this, including strategies for betting on group qualification, interpreting odds movements during play-offs, and positioning early in long-term markets amid uncertainty.
A Cloudbet spokesperson noted, “With groups locked in and just a few spots left, now’s the window where early odds still reflect uncertainty. This is when sharp bettors get in—before pricing tightens after March and public money floods the markets in June.”
Current World Cup 2026 Outright Odds on Cloudbet (as of January 2026)
● Spain: 5.55 odds
● England: 6.64 odds
● France: 8.99 odds
● Brazil: 9.11 odds
● Argentina: 9.13 odds
For the latest odds, visit Cloudbet.com.
Access the World Cup 2026 Betting Guide now at cloudbet.com/en/academy/world-cup-2026-betting-guide
About Cloudbet
Founded in 2013, Cloudbet is the world’s longest-running crypto sportsbook and casino. Players can bet with over 40 cryptocurrencies across thousands of sports markets and a full portfolio of casino games, including slots, live dealers, and provably fair crypto titles.
Cloudbet has processed millions of bets securely, offering sharp odds, high limits, instant crypto payouts, and 24/7 customer support.
In 2024, Cloudbet introduced a welcome offer and loyalty program built for serious players—real cash rewards, daily cash drops, and 10% rakeback with no wagering requirements.
From Premier League and NFL props to esports, tennis, and basketball, Cloudbet delivers the sharp action crypto bettors expect.
Find us at Cloudbet.com, on Instagram @cloudbetofficial, and Twitter/X @Cloudbet.
Media Contact
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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
CMS (867.HK/8A8.SG): Ruxolitinib Phosphate Cream Obtained China NDA Approval, Becoming The First and Only Targeted Drug for Vitiligo in China
SHENZHEN, CHINA – China Medical System Holdings Limited (“CMS” or the “Group”) is pleased to announce that its subsidiary, Dermavon Holdings Limited (“Dermavon”, an innovative pharmaceutical company specialized in skin health which is applying for a separate listing on the Main Board of The Stock Exchange of Hong Kong Limited, please refer to the announcement published by the Group on 22 April 2025 for details) received approval from the National Medical Products Administration of China (NMPA) on 30 January 2026 for the New Drug Application (NDA) of ruxolitinib phosphate cream (the “Product”) for the treatment of non-segmental vitiligo with facial involvement in children aged 12 years and older and adult patients. It is the first and only targeted drug approved in China for vitiligo, addressing a significant unmet clinical need.
Ruxolitinib phosphate cream is the first and only drug approved by the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for repigmentation in nonsegmental vitiligo[1,2]. Prior to receiving formal NDA approval, the Group benefited from the “Early and Pilot Implementation” policy granted to the Hainan Free Trade Port and Lecheng Pilot Zone (“Lecheng Pilot Zone”), the “Hong Kong and Macau Medicine and Equipment Connect” policy, and the clinically urgently needed imported drug policies of the Beijing and Tianjin Free Trade Zones, and had already initiated the pilot application of ruxolitinib phosphate cream. Currently, Boao Super Hospital has prescribed ruxolitinib phosphate cream to over 7,000 patients with non-segmental vitiligo, and more than twenty hospitals in Guangzhou, Shenzhen, Dongguan, Foshan, Zhongshan, Zhuhai, Jiangmen, Huizhou, Beijing and Tianjin have provided prescription services for the Product, demonstrating its clinical potential.
The product has shown positive results in both overseas clinical studies and the real-world study in China: in two identical Phase III double-blind, randomized, placebo-controlled studies (TRuE-V1 and TRuE-V2) conducted overseas, the proportion of patients achieving the primary efficacy endpoint of at least 75% improvement in the Facial Vitiligo Area Score Index (F-VASI 75) after 24 weeks of treatment with ruxolitinib phosphate cream was 29.9% in both studies, significantly higher than the 7.5% and 12.9% in the placebo groups, respectively. Continued use up to 52 weeks showed sustained repigmentation[3]. In accordance with the relevant regulations of the Lecheng Pilot Zone’s real-world data application pilot project, ruxolitinib phosphate cream underwent real-world study in China, demonstrating positive efficacy consistent with the results of overseas pivotal clinical studies. All secondary efficacy endpoints in both domestic and overseas clinical studies showed a benefit trend consistent with the primary efficacy endpoint, and the treatment effect for vitiligo continued to improve with prolonged treatment. Furthermore, according to safety monitoring data from the Lecheng Pilot Zone, no new safety event was identified, no adverse event (AE) leading to discontinuation or withdrawal of treatment occurred, and no study drug-related serious adverse event (SAE) occurred.
This approval in vitiligo brings new hope for treatment to over 10 million vitiligo patients in China, addressing urgent clinical needs. At the same time, it will add to Dermavon’s product portfolio in the field of skin treatment, potentially synergizing with Dermavon’s commercialized innovative drug ILUMETRI (tildrakizumab injection), commercialized exclusive drug Hirudoid (mucopolysaccharide polysulfate cream), and a series of innovative drugs under development and dermatological skin care products, in terms of expert network and market resources, thereby potentially enhancing Dermavon’s position in the field of skin health.
Furthermore, the Phase III clinical trial in China of ruxolitinib phosphate cream for the treatment of mild to moderate atopic dermatitis (AD) has achieved positive results. Currently, the Group is actively advancing the NDA for ruxolitinib phosphate cream for the treatment of AD in China, which, if approved, will provide a new treatment option for a broader patient population with AD in China.
About Vitiligo
Vitiligo is a chronic autoimmune disease characterized by depigmentation of the skin, which results from the loss of pigment-producing cells known as melanocytes. It is estimated that there are approximately 10.3 million vitiligo patients in China and non-segmental vitiligo patients account for approximately 8.2 million[4]. Existing therapies, such as topical corticosteroids (TCS) and topical calcineurin inhibitors (TCIs), have clinical limitations, with adverse reactions or limited efficacy with long-term use. The NDA approval of ruxolitinib phosphate cream successfully fills the gap in targeted drug treatment for vitiligo and is of great landmark significance.
More About Ruxolitinib Phosphate Cream
Ruxolitinib phosphate cream (Opzelura®), a novel cream formulation of the selective JAK1/JAK2 inhibitor ruxolitinib developed by Incyte, is approved for the topical treatment of nonsegmental vitiligo in adult and patients aged 12 years and older, and for the short-term and non-continuous chronic treatment of mild to moderate AD in patients aged 2 years and older without immunodeficiency in the U.S. In Europe, ruxolitinib phosphate cream is approved for the treatment of non-segmental vitiligo with facial involvement in adults and adolescents from 12 years of age.
The Group, through a subsidiary of Dermavon entered into a Collaboration and License Agreement with Incyte for ruxolitinib phosphate cream on 2 December 2022, obtaining an exclusive license to develop, register and commercialize the Product in Mainland China, Hong Kong Special Administrative Region, Macau Special Administrative Region, Taiwan Region and eleven Southeast Asian countries (the “Territory”) and a non-exclusive license to manufacture the Product in the Territory. The subsidiary of Dermavon has sublicensed the relevant rights for the Product outside Mainland China to the Group (excluding Dermavon and its subsidiary).
Incyte has worldwide rights for the development and commercialization of ruxolitinib phosphate cream, marketed in the United States and Europe as Opzelura®. Opzelura® and the Opzelura® logo are registered trademarks of Incyte.
About CMS
CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.
CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.
CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development in its advantageous specialty fields, strengthening the competitiveness of the cardio-cerebrovascular/ gastroenterology/ ophthalmology/ skin health businesses, bringing economies of scale in specialty fields. Among them, the skin health business (Dermavon) has become a leading enterprise in its field, and is proposed to be listed independently on the SEHK. Meanwhile, CMS continuously promotes the operation and development of its integrated R&D, manufacturing and commercialization chain in Southeast Asia and the Middle East, capturing growth opportunities in emerging markets to support the high-quality and sustainable development of the Group.
Reference:
- The U.S. FDA approval information can be found on the Incyte official website, as follows:
- The EMA approval information can be found on the Incyte official website, as follows:
- The clinical studies information can be found on the Opzelura® official website, as follows:
https://www.opzelura.com/opzelura-prescribing-information
- China Insights Consultancy’s industrial report
CMS Disclaimer and Forward-Looking Statements
This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.
This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.
Media Contact
Brand: China Medical System Holdings Ltd.
Contact: CMS Investor Relations
Email: ir@cms.net.cn
Website: https://web.cms.net.cn/en/home/
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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
Gabriel Malkin Florida Completes 120-Mile Camino Walk with Focus, Patience, and Preparation
Florida, US, 30th January 2026, ZEX PR WIRE, Most students don’t spend the start of summer walking across northern Spain. Gabriel Malkin did. In June 2025, the Florida high school graduate completed a 120-mile stretch of the Camino de Santiago, one of the world’s oldest pilgrimage routes. It wasn’t a last-minute idea. It was a goal he had planned for, trained for, and quietly worked toward for months.
This wasn’t about adventure or social media. For Gabriel, it was about setting a physical goal and showing up for it every day.
“I didn’t want to wing it,” he said. “It was important to take it seriously.”
Gabriel’s prep started long before his flight to Europe. He built up mileage slowly, starting with short daily walks in South Florida. As the months went on, he added distance, tested gear, and paid attention to recovery. Blisters, sore muscles, and weather were all part of the process. So was building patience.
“The Camino isn’t just hard because it’s long,” Gabriel said. “It’s hard because you have to get up and do it again every day. Even when you’re tired. Even when nothing hurts and you feel fine—you still have to walk.”
The daily rhythm became its own challenge. Mornings often started before sunrise, with quiet stretches of trail through farmland, hills, and towns. Gabriel carried a small pack with essentials. Water, snacks, extra socks. No Wi-Fi. No schedule beyond the day’s distance. Just a clear goal and a few hours of steady effort.
That focus and consistency mirrors how Gabriel approaches most things. Whether he’s in class, on the tennis court, or working on saxophone tone, he tends to favor structure and repetition over shortcuts. It’s not about perfection. It’s about showing up, improving slowly, and staying with it.
“I’ve never been the fastest or the strongest at anything,” he said. “But I like knowing I’m getting better, even if it’s slow.”
Gabriel grew up in South Florida and attended Virginia Shuman Young Elementary, Pine Crest in Fort Lauderdale, and NSU University School in Davie. He played tennis, baseball, and football through different stages of school. He also spent time hiking local trails and practicing saxophone, two interests he says helped him train for the Camino more than people might expect.
“Hiking helped with endurance, obviously,” he said. “But playing music teaches you a lot about repetition and listening to your body. You learn when to push and when to pause.”
For Gabriel, the Camino wasn’t a performance or a competition. It was a quiet personal test. He kept notes during the walk, not for a blog, but to track how each day felt. When he crossed the finish line in Santiago, there was no big moment. Just a quiet sense of completion.
Now back home, Gabriel hasn’t stopped walking. He’s back to local trails, early mornings, and training logs. He’s also thinking about what comes next—college, travel, more endurance goals—but isn’t rushing anything.
“There’s no rush,” he said. “The Camino reminded me that showing up every day matters more than trying to get somewhere fast.”
Gabriel Malkin Florida continues to build habits rooted in preparation, consistency, and follow-through. Whether through athletics, academics, or music, his focus remains steady: stay curious, stay active, and finish what you start.
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Cloudbet Academy Launches World Cup 2026 Betting Guide: Crypto Strategies and Tournament Insights
CMS (867.HK/8A8.SG): Ruxolitinib Phosphate Cream Obtained China NDA Approval, Becoming The First and Only Targeted Drug for Vitiligo in China
Gabriel Malkin Florida Completes 120-Mile Camino Walk with Focus, Patience, and Preparation
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