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Five New Side Chains Of CTC Travel Service Chain Have Been Officially Added

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5 years ago

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On November 11, Daniel Smith, CEO of Singapore Dorn Fund Management Agency and CEO of CTC, and heads of five new side chains officially reached strategic consensus after long-term friendly communication, and announced that five new side chains under CTC Global Travel Chain, including DRN, SPO, REK, EDR and TBL, were officially connected to the chain. Due to the global COVID-19 outbreak, the strategic press conference scheduled for Singapore was not held as scheduled. This multi-party strategic cooperation was finally concluded in the form of electronic contract.

Singapore donne the fund management organ CEO, the chief executive of CTC, Daniel Smith, of five new side chain anchor spots (durban, South Africa, Sao Paulo, Brazil, reykjavik, Edinburgh, Istanbul, Turkey) the characteristics of human geography environment and beautiful landscapes, said after the outbreak must personally go to feel the unique local customs. It is reported that the operation centers of the five new side chains are set up in local business centers in the five cities, and have reached strategic cooperation with the famous local travel companies.

Durban is a beautiful coastal city in Kwazulu-Natal province, South Africa’s second largest city, known as the “best managed City in Africa”, is also a famous international conference capital. Golden beaches, lush palm trees, a warm subtropical climate and the blue waters of the Indian Ocean make Durban an international tourist destination.

Sao Paulo is located in the southeastern state of Sao Paulo, Brazil, is the largest city in Brazil, South America’s largest and most prosperous city, the world’s famous international metropolis. There are many famous buildings in downtown Sao Paulo, the most remarkable of which is the Catholic Cathedral, one of the largest churches in South America. Built in the 1930s and on The 400th anniversary of Sao Paulo’s founding in 1954, it is a classic Gothic edifice.

Five attractions anchored by five new side chains

Reykjavik, the capital of the republic of Iceland, is Iceland’s largest city and a big port, due to its excellent geographical location as northern European main ports, reykjavik city layout is symmetrical, few tall buildings, the main buildings and the residents of the small and exquisite housing paint red and green more, under the sun, colorful, colorful; With the north and east of the city covered by the snow-capped peaks, particularly beautiful.

Edinburgh is the capital of Scotland in the United Kingdom, located on the south bank of the Gulf of Forth in the central lowlands of Scotland. Edinburgh is the city that best reflects the Scottish style, and was listed as a World Heritage Site by UNESCO in 1995. Edinburgh has many ancient churches and gorgeous Victorian buildings.

Istanbul is the economic, cultural and transportation center of Turkey. It is the only city across Asia and Europe in the world and a world famous tourist resort. Located at the eastern end of the Balkan Peninsula and west of the south mouth of the Bosphorus Strait, it dominates the entrance of the Black Sea and is the key point of the Eurasian transportation. It has a very important strategic position and is a modern city across The Two continents of Europe and Asia.

Tourism has always been an important source of economic growth for major countries in the world. Especially since the beginning of the 21st century, tourism demand has been developing towards multiple levels. The boundary of the traditional cultural and tourism industry is gradually blurred, and the development model based on offline consumption will gradually transform to the combination of online and offline. Digital cultural innovation will accelerate a new round of cross-boundary integration of cultural tourism industry and give birth to new forms of business.

CTC and the directors of five new side chains are optimistic about the future prospects of the digital travel industry. With the gradual expansion of scientific and technological reform to various industries, the cultural and tourism industry will also usher in a peak of development. It will be closely integrated with block chain technology, artificial intelligence, big data and other technologies to stimulate the vitality of the cultural and tourism industry, promote the upgrading of the cultural and tourism industry, and empower the digital transformation of the cultural and tourism industry.

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Press Release

Roofer Booker Revolutionizes Lead Generation for Contractors with Verified Exclusive Appointments and Smart Digital Tools

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16 minutes ago

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March 5, 2026

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United States, 5th Mar 2026 – Roofer Booker, the company behind RooferBooker.com, is transforming the contractor marketing landscape with a performance-driven, pay-per-verified-lead system built specifically for roofers and remodelers. With more than 1,700 homeowner appointments booked in 2026 alone and over 45 contractors partnering with the platform this year, Roofer Booker is redefining how local contractors secure high-intent projects without retainers or long-term commitments.

Changing the Lead Generation Industry for Contractors

For years, contractors have relied on expensive third-party platforms and shared lead systems where multiple companies compete for the same homeowner inquiry. Roofer Booker disrupts that model by offering exclusive, high-intent leads that are shared with only one contractor—unless the contractor opts otherwise.

Each verified lead includes the homeowner’s name, phone number, project timeline, type of project, home address, and homeowner status. All phone numbers are verified before delivery, ensuring quality and reducing wasted follow-up time.

At $95 per qualified lead and a one-time $500 setup fee, the company’s “Pay as You Grow” structure allows contractors to scale predictably. There are no monthly retainers, giving small and mid-sized roofing and remodeling businesses a more controlled and transparent marketing investment.

Connecting Homeowners with Local Verified Contractors

Roofer Booker is not only supporting contractors—it is simplifying the process for homeowners seeking reliable services.

Through targeted digital campaigns, including social media outreach, email marketing, and strategic prospecting methods, Roofer Booker identifies homeowners actively searching for remodeling or roofing services. Instead of homeowners navigating multiple directories or dealing with aggressive sales calls from competing contractors, the platform connects them directly with a vetted local professional.

This streamlined connection creates a win-win ecosystem:

  • Homeowners receive faster responses from qualified contractors.
  • Contractors engage with homeowners who are already interested and prepared to move forward.

By focusing on high-intent prospects rather than cold traffic, Roofer Booker increases booking efficiency and improves close rates for its contractor partners.

Data-Driven Marketing Backed by 22 Years of Combined Experience

With a combined 22 years of digital marketing experience—specializing in construction and roofing—Roofer Booker applies a structured, research-first approach to every campaign.

The process includes:

  • Market Research: Analyzing local service areas and identifying target demographics.
  • Campaign Launch: Deploying customized advertising campaigns tailored to roofing and remodeling services.
  • Instant Lead Delivery: Sending real-time email and text notifications to sales representatives the moment a homeowner submits a form.
  • Live Tracking: Providing contractors with access to a personalized lead management portal to track performance metrics in real time.

This transparent tracking system allows contractors to monitor which leads are called, booked, or sold, while also managing billing and payments within their dedicated portal.

Introducing Digital Project Cost Calculators for Homeowners

A major innovation setting Roofer Booker apart is the introduction of digital project cost calculators designed for homeowners.

These tools allow homeowners to estimate potential roofing or remodeling costs before committing to a consultation. By offering upfront budgeting guidance, Roofer Booker increases homeowner confidence and filters inquiries to ensure contractors receive leads from individuals who understand realistic project ranges.

This added layer of pre-qualification strengthens the quality of every appointment, benefiting both parties in the transaction.

Dedicated Support and Certified Systems

Every contractor partner is assigned a dedicated account representative to answer questions, resolve concerns, or review disputed leads. This personalized support system reinforces the company’s commitment to accountability and long-term partnerships.

Once approved, contractors can typically go live within 3–4 days, accelerating the path from onboarding to booked appointments.

The company’s structured backend automations, campaign frameworks, and verification processes are designed to eliminate inefficiencies often found in traditional lead platforms.

A Scalable Growth Model for Modern Contractors

Roofer Booker’s model is built around scalability. Contractors can determine how many leads they are prepared to handle—whether 20+ per month or more—and expand as their team grows.

The platform specifically partners with businesses that:

  • Operate in roofing or remodeling
  • Have at least one full-time sales representative (excluding owners)
  • Have experience purchasing leads
  • Are ready to scale operations strategically

By focusing on serious contractors prepared for growth, Roofer Booker maintains quality control and ensures strong campaign performance.

About Roofer Booker

Roofer Booker is a United States-based lead generation company specializing in roofing and remodeling contractors. Through exclusive verified leads, real-time CRM integration, digital cost calculators, and transparent pay-per-lead pricing, Roofer Booker is reshaping how contractors connect with homeowners.

Roofer Booker continues to expand its network of contractor partners while advancing technology-driven solutions that simplify the connection between homeowners and trusted local professionals.

Media Contact

Organization: Roofer Booker

Contact Person: Raz

Website: https://rooferbooker.com/get-leads/

Email: Send Email

Country:United States

Release id:42207

The post Roofer Booker Revolutionizes Lead Generation for Contractors with Verified Exclusive Appointments and Smart Digital Tools appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section

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CMS(867.HK/8A8.SG): Self-Developed INHBE-Targeting siRNA Drug Received IND Approval for Overweight/Obesity

Published

1 hour ago

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March 5, 2026

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SHENZHEN, CHINA – China Medical System Holdings Limited (“CMS” or the “Group”) is pleased to announce that self-developed innovative drug INHBE-targeting small nucleic acid drug CMS-D008 injection (“CMS-D008”) received the Drug Clinical Trial Approval Notice issued by National Medical Products Administration (“NMPA”) on 4 March 2026. The NMPA has approved the conduct of clinical trials of CMS-D008 injection for overweight or obese individuals.

About CMS-D008

CMS-D008 is a novel siRNA therapy administered by subcutaneous injection. CMS-D008 targets and reduces the hepatic expression of the inhibin subunit beta E (INHBE) gene and lowers the level of Activin E protein encoded by INHBE, which blocks Activin E-ALK7 signaling and reduces fat accumulation effectively. Preclinical studies suggested that CMS-D008 efficiently and sustainably suppressed INHBE expression. In the diet-induced obesity model, CMS-D008 enhanced weight loss by reducing fat mass while retaining lean mass with a good safety profile. It demonstrates potentially better prospects for high-quality, long-term weight loss that boosts fat-specific loss while preserving muscle mass. In the future, it may be developed for the treatment of overweight/obesity, abdominal obesity, and related metabolic diseases.

Fat Loss, muscle preserved: a potentially better therapeutic option for overweight/obesity

Overweight or obesity is a chronic, progressive, relapsing disease characterized by excessive accumulation or abnormal distribution or function of body fat[1]. World Obesity Atlas 2025 Report projected that the global proportion of overweight and obese adults will rise to 50%, with nearly 3 billion adults impacted by high body mass index (BMI), and the population of adults who are overweight or obese in China is projected to reach 515 million by 2030[2]. Existing GLP-1RAs have been proven to be effective for the treatment of overweight and obesity. The main actions of GLP-1RAs are to suppress appetite by acting on the central nervous system and to delay gastric emptying[3]. INHBE’s novel mechanism of action differs from GLP-1RAs. INHBE is identified through genome-wide association studies. Populations with loss of function in INHBE are associated with favorable fat distribution and beneficial metabolic characteristics[4]. Targeted inhibition of INHBE might be more conducive for long-term weight management at the genetic level with precisely lower visceral fat and favorable metabolic profiles.

CMS-D008 teams up with CMS-D005: highly effective weight loss plus long-term maintenance, building a more comprehensive weight-loss solution

CMS-D008 will synergize with CMS-D005, a self-developed innovative drug currently in clinical development. CMS-D008 reduces fat without sacrificing muscle mass by precisely inhibiting INHBE gene expression; while CMS-D005, as a GLP-1R/GCGR dual agonist, can effectively reduce liver fat while losing weight. The synergy between these two drugs will achieve highly effective weight loss benefits and long-term maintenance of results, jointly enhancing the Group’s R&D capabilities and product competitiveness in the field of obesity/metabolic treatment. Furthermore, leveraging the Group’s mature network resources in the field of cardiovascular and metabolic diseases, the drug’s R&D and commercialization process will be accelerated, providing patients with more comprehensive and innovative treatment options.

The Group is actively preparing to initiate relevant clinical trials and strives to launch the Product as soon as possible.

About CMS

CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.

CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.

CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development in its advantageous specialty fields, strengthening the competitiveness of the cardiovascular-kidney-metabolic/ gastroenterology/ ophthalmology/ skin health businesses, bringing economies of scale in specialty fields. Among them, the skin health business (Dermavon) has become a leading enterprise in its field, and is proposed to be listed independently on the SEHK. Meanwhile, CMS continuously promotes the operation and development of its integrated R&D, manufacturing and commercialization chain in Southeast Asia and the Middle East, capturing growth opportunities in emerging markets to support the high-quality and sustainable development of the Group.

Reference:

  1. Chinese Society of Endocrinology. Guideline for chronic weight management and clinical practice of anti-obesity medications(2024 version). Chinese Journal of Endocrinology and Metabolism. 2024,40(7):545-564.
  2. World Obesity Federation. World Obesity Atlas 2025. London: World Obesity Federation, 2025. https://data.worldobesity.org/publications/?cat=23
  3. Zhikai Zheng, Yao Zong, Yiyang Ma, Yucheng Tian, Yidan Pang, Changqing Zhang, Junjie Gao. Glucagon-like peptide-1 receptor: mechanisms and advances in therapy. Sig Transduct Target Ther 9, 234 (2024). doi: 10.1038/s41392-024-01931-z
  4. Parsa Akbari, Olukayode A Sosina, Jonas Bovijn, et al. Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes. Nat Commun.2022 Aug 23;13(1):4844. doi: 10.1038/s41467-022-32398-7.

CMS Disclaimer and Forward-Looking Statements

This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.

This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.

Media Contact

Brand: China Medical System Holdings Ltd.

Contact: CMS Investor Relations

Email: ir@cms.net.cn

Website: https://web.cms.net.cn/en/home/

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Press Release

Oberheiden P.C. Now Offering Nevada Asset Protection Trusts

Published

1 hour ago

on

March 5, 2026

By

United States, 5th Mar 2026 – Oberheiden P.C. is pleased to announce that the firm’s asset protection attorneys are now offering Nevada asset protection trusts to clients nationwide. Nevada asset protection trusts are unique among domestic asset protection trusts (DAPTs) for their flexibility, and they can be powerful tools for insulating high-net-worth individuals’ assets from creditor claims both in and out of court.

According to the firm’s founding attorney, Dr. Nick Oberheiden, “While many high-net-worth individuals are familiar with the benefits afforded by offshore asset protection trusts, far fewer are familiar with the domestic options that are available. The Nevada asset protection trust can be a particularly good option for individuals who want to protect their assets within the United States while also taking advantage of the estate planning, tax planning, and other benefits that domestic trusts can afford.”

Dr. Oberheiden says that forming Nevada asset protection trust can be a particularly good option for several reasons. For example, while a Nevada asset protection trust is a type of irrevocable trust, a grantor (the individual who forms a trust) still has the ability to modify how they hold their assets over time. This distinguishes Nevada law from the laws of many other states. Nevada also has a shorter statute of limitations for creditor claims than most other states (two years in most cases), and Nevada law does not recognize any exception creditors.

“These factors, combined with the relative ease of forming a Nevada domestic asset protection trust, make using a Nevada DAPT a desirable option in a wide range of circumstances—including circumstances in which high-net-worth individuals might otherwise be looking at transferring assets into an offshore trust established in the Cook Islands or another foreign jurisdiction.” Dr. Oberheiden continues, “If you are interested in learning about your options for protecting your wealth from both known and unknown creditors, it will be worth talking to an attorney about whether a Nevada DAPT is a good option for your individual circumstances.”

While forming a Nevada DAPT involves leveraging the benefits afforded under the state’s trust laws, Dr. Oberheiden emphasizes that this is not solely an option for Nevada residents. “When the Nevada legislature adopted the state’s asset protection trust laws, it specifically opened up the possibility of forming a Nevada DAPT to individuals residing across the country. Although there are certain statutory requirements that make it important to work with a Nevada trust company, individuals nationwide can form statutory trusts in Nevada for asset protection purposes.”

Dr. Oberheiden is also quick to emphasize that while forming a Nevada DAPT is a desirable option in many cases, it is important for all high-net-worth individuals to make informed decisions about their asset protection needs based on their individual circumstances. “While forming a Nevada DAPT to protect real property and other assets will make sense for many individuals, it is important to consider the other options that are available as well. A few states offer self-settled spendthrift trust options that will meet individuals’ needs in some cases; and, in other cases, forming an offshore asset protection trust may be necessary to protect assets located around the world.”

“Additionally,” he continues, “limited liability companies and other vehicles can be used for asset protection as well. Purchasing liability insurance can be a cost-effective means of limiting high-net-worth individuals’ personal liability exposure as well. Ultimately, while we are now offering Nevada asset protection trusts, we are still focused on ensuring that we provide each of our clients with a custom-tailored solution focused on their specific risks and needs.”

Dr. Oberheiden says that high-net-worth individuals who are interested in learning about the options for safeguarding their assets in the U.S. and abroad are encouraged to contact the firm for a complimentary initial consultation. “We have a team of highly skilled asset protection attorneys who are committed to helping our clients protect their assets not only in the short term, but also for future generations.” He continues, “If you have questions, one of our attorneys will be more than happy to schedule a call to begin talking through your options in strict confidence.”

Nick Oberheiden, Founding Attorney, 888-680-1745 (Office)

Attorney Advertising – Oberheiden, P.C., is an asset protection law firm headquartered in Houston, TX with a nationwide network of senior attorneys and consultants. The firm’s asset protection attorneys are available to assist clients with Nevada asset protection trusts and other asset protection strategies throughout the United States. The firm’s addresses and contact information can be found at www.federal-lawyer.com/our-locations.

 

Media Contact

Organization: Oberheiden, P.C.

Contact Person: Nick Oberheiden, Founding Attorney

Website: https://federal-lawyer.com/asset-protection/

Email: Send Email

Contact Number: +18886801745

Country:United States

Release id:42208

Disclaimer: This press release is provided for general informational purposes only and does not constitute legal, financial, or professional advice.

The post Oberheiden P.C. Now Offering Nevada Asset Protection Trusts appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section

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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.

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