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CMS(867.HK/8A8.SG): Self-Developed INHBE-Targeting siRNA Drug Received IND Approval for Overweight/Obesity

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SHENZHEN, CHINA China Medical System Holdings Limited (“CMS” or the “Group”) is pleased to announce that self-developed innovative drug INHBE-targeting small nucleic acid drug CMS-D008 injection (“CMS-D008”) received the Drug Clinical Trial Approval Notice issued by National Medical Products Administration (“NMPA”) on 4 March 2026. The NMPA has approved the conduct of clinical trials of CMS-D008 injection for overweight or obese individuals.

About CMS-D008

CMS-D008 is a novel siRNA therapy administered by subcutaneous injection. CMS-D008 targets and reduces the hepatic expression of the inhibin subunit beta E (INHBE) gene and lowers the level of Activin E protein encoded by INHBE, which blocks Activin E-ALK7 signaling and reduces fat accumulation effectively. Preclinical studies suggested that CMS-D008 efficiently and sustainably suppressed INHBE expression. In the diet-induced obesity model, CMS-D008 enhanced weight loss by reducing fat mass while retaining lean mass with a good safety profile. It demonstrates potentially better prospects for high-quality, long-term weight loss that boosts fat-specific loss while preserving muscle mass. In the future, it may be developed for the treatment of overweight/obesity, abdominal obesity, and related metabolic diseases.

Fat Loss, muscle preserved: a potentially better therapeutic option for overweight/obesity

Overweight or obesity is a chronic, progressive, relapsing disease characterized by excessive accumulation or abnormal distribution or function of body fat[1]. World Obesity Atlas 2025 Report projected that the global proportion of overweight and obese adults will rise to 50%, with nearly 3 billion adults impacted by high body mass index (BMI), and the population of adults who are overweight or obese in China is projected to reach 515 million by 2030[2]. Existing GLP-1RAs have been proven to be effective for the treatment of overweight and obesity. The main actions of GLP-1RAs are to suppress appetite by acting on the central nervous system and to delay gastric emptying[3]. INHBE’s novel mechanism of action differs from GLP-1RAs. INHBE is identified through genome-wide association studies. Populations with loss of function in INHBE are associated with favorable fat distribution and beneficial metabolic characteristics[4]. Targeted inhibition of INHBE might be more conducive for long-term weight management at the genetic level with precisely lower visceral fat and favorable metabolic profiles.

CMS-D008 teams up with CMS-D005: highly effective weight loss plus long-term maintenance, building a more comprehensive weight-loss solution

CMS-D008 will synergize with CMS-D005, a self-developed innovative drug currently in clinical development. CMS-D008 reduces fat without sacrificing muscle mass by precisely inhibiting INHBE gene expression; while CMS-D005, as a GLP-1R/GCGR dual agonist, can effectively reduce liver fat while losing weight. The synergy between these two drugs will achieve highly effective weight loss benefits and long-term maintenance of results, jointly enhancing the Group’s R&D capabilities and product competitiveness in the field of obesity/metabolic treatment. Furthermore, leveraging the Group’s mature network resources in the field of cardiovascular and metabolic diseases, the drug’s R&D and commercialization process will be accelerated, providing patients with more comprehensive and innovative treatment options.

The Group is actively preparing to initiate relevant clinical trials and strives to launch the Product as soon as possible.

About CMS

CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.

CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.

CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development in its advantageous specialty fields, strengthening the competitiveness of the cardiovascular-kidney-metabolic/ gastroenterology/ ophthalmology/ skin health businesses, bringing economies of scale in specialty fields. Among them, the skin health business (Dermavon) has become a leading enterprise in its field, and is proposed to be listed independently on the SEHK. Meanwhile, CMS continuously promotes the operation and development of its integrated R&D, manufacturing and commercialization chain in Southeast Asia and the Middle East, capturing growth opportunities in emerging markets to support the high-quality and sustainable development of the Group.

Reference:

  1. Chinese Society of Endocrinology. Guideline for chronic weight management and clinical practice of anti-obesity medications(2024 version). Chinese Journal of Endocrinology and Metabolism. 2024,40(7):545-564.
  2. World Obesity Federation. World Obesity Atlas 2025. London: World Obesity Federation, 2025. https://data.worldobesity.org/publications/?cat=23
  3. Zhikai Zheng, Yao Zong, Yiyang Ma, Yucheng Tian, Yidan Pang, Changqing Zhang, Junjie Gao. Glucagon-like peptide-1 receptor: mechanisms and advances in therapy. Sig Transduct Target Ther 9, 234 (2024). doi: 10.1038/s41392-024-01931-z
  4. Parsa Akbari, Olukayode A Sosina, Jonas Bovijn, et al. Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes. Nat Commun.2022 Aug 23;13(1):4844. doi: 10.1038/s41467-022-32398-7.

CMS Disclaimer and Forward-Looking Statements

This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.

This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.

Media Contact

Brand: China Medical System Holdings Ltd.

Contact: CMS Investor Relations

Email: ir@cms.net.cn

Website: https://web.cms.net.cn/en/home/

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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.

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Press Release

WellPCB Expands Wire Harness Capacity for Growing EV and Medical Device Demand

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China, 16th Apr 2026 – WellPCB, a leading manufacturer of printed circuit boards and electronic interconnect solutions, has announced the expansion of its global wire harness manufacturing capacity in response to increasing demand from the electric vehicle and medical device sectors. The development reflects broader industry trends toward electrification, advanced medical technologies, and the need for reliable interconnect solutions across critical applications.

The expansion includes upgraded production lines, enhanced automation capabilities, and increased output capacity across existing facilities. These improvements are intended to support manufacturers requiring custom-engineered wire harnesses and cable assemblies. WellPCB continues to focus on precision manufacturing, rapid prototyping, and adherence to internationally recognized quality standards.

Demand for wire harnesses has increased alongside the growth of electric vehicles and ongoing innovation in medical device manufacturing. Electric vehicles rely on complex wiring systems to manage battery performance, sensors, and onboard electronics. Medical devices also require precise and reliable cable assemblies to ensure operational accuracy and patient safety. These factors have contributed to sustained global demand for specialized manufacturing capabilities.

Company representatives indicated that the expansion improves responsiveness to customer requirements while maintaining strict quality assurance processes. WellPCB operates under ISO 9001 and IATF 16949 certifications, ensuring that production processes align with international standards for quality management and automotive manufacturing.

Abby, Operations Specialist at WellPCB, commented on the development, stating, “The expansion of manufacturing capacity addresses the evolving needs of industries that depend on high-performance wire harness solutions. Electric vehicle manufacturers and medical device producers require consistent quality, precision engineering, and timely delivery. The upgraded facilities are intended to support these expectations while maintaining established production standards.”

The investment also strengthens rapid prototyping capabilities. Faster turnaround times for prototypes are increasingly important for companies developing new technologies, particularly in sectors with accelerated product cycles. Improved prototyping efficiency supports innovation and helps reduce development timelines.

In addition to increased production output, the expansion incorporates advanced quality control systems to ensure product consistency. Automated inspection processes and enhanced testing protocols have been introduced to reduce variability and maintain compliance with industry requirements. These measures support long-term reliability in applications where performance and safety remain essential.

Industry analysts have observed continued growth in the wire harness market as electrification trends expand globally. Electric vehicles are expected to represent a larger share of the automotive sector, while medical technology continues to advance through increased integration of electronic components. Manufacturers capable of scaling production while maintaining quality standards are positioned to support these developments.

The company’s location in Shijiazhuang, Hebei, provides access to established supply chains and logistics networks, supporting efficient distribution to international markets. The expanded capacity strengthens the ability to serve customers across multiple regions while maintaining consistent delivery timelines.

Abby also addressed the future outlook, stating, “Ongoing investment in manufacturing capabilities and process optimization remains a priority as industry requirements continue to evolve. Future efforts will focus on enhancing technological integration within production systems and expanding support for emerging applications in both electric mobility and healthcare technologies.”

The expansion reflects a broader commitment to adapting manufacturing operations to meet changing industry demands. As the complexity of electronic systems increases across multiple sectors, the importance of reliable interconnect solutions continues to grow. By scaling production capacity and refining processes, WellPCB aligns its operations with these evolving requirements.

For further information on Custom Wire Harness Manufacturing, contact WellPCB at sales@wellpcb.net or visit the company at 3rd Floor, Nanhai Plaza, No. 505 Xinhua Road, Xinhua District, Shijiazhuang, Hebei, China.

Media Contact

Organization: WellPCB

Contact Person: Abby

Website: https://wireharnessproduction.com/

Email: Send Email

Address:3rd Floor, Nanhai Plaza, No. 505 Xinhua Road, Xinhua District, Shijiazhuang, Hebei, China

Country:China

Release id:44037

The post WellPCB Expands Wire Harness Capacity for Growing EV and Medical Device Demand appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section

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Press Release

WellPCB Launches High-Reliability Custom Cable Assemblies for Automation and Robotics

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China, 16th Apr 2026 – WellPCB, a respected manufacturer of custom-engineered wire harnesses and cable assemblies, has announced the launch of a new line of high-reliability custom cable assemblies designed to support the evolving demands of industrial automation and robotics applications. The development reflects increasing requirements across industries for durable, precision-engineered connectivity solutions in complex and high-performance environments.

The newly introduced cable assemblies are engineered to meet stringent performance and safety standards required in automated manufacturing systems, robotic platforms, and industrial control operations. These assemblies are designed to maintain stability under challenging conditions, including vibration, temperature fluctuations, and continuous mechanical stress. The design framework emphasizes flexibility, allowing configurations tailored to specific operational and environmental requirements.

The product line incorporates materials and production processes aligned with recognized international quality standards, including ISO 9001 and IATF 16949 certifications. Each assembly is developed with attention to consistency, traceability, and compliance with industry regulations. Rapid prototyping capabilities are also included, enabling efficient design validation and refinement within shortened development timelines.

Abby, Operations Specialist at WellPCB, commented on the announcement: “The introduction of this new line of custom cable assemblies reflects a response to the technical demands observed in industrial automation and robotics sectors. Emphasis has been placed on reliability, adaptability, and adherence to established quality standards to ensure performance in critical applications.”

The launch coincides with continued expansion in automation technologies across multiple sectors, including manufacturing, medical equipment, and logistics systems. As robotic systems become increasingly complex, stable and high-performance electrical connectivity has become essential. Cable assemblies play a critical role in transmitting power and data between components, making reliability a key factor in maintaining system efficiency and operational continuity.

Engineering efforts behind the new product line have focused on enhancing shielding, insulation, and connector durability. These improvements are intended to reduce signal interference, support long-term use, and ensure consistent performance across demanding applications. The assemblies are also designed for modular integration, enabling compatibility with a wide range of automation and robotic systems without requiring extensive system modifications.

In addition to product development, internal production processes have been refined to support the efficient handling of customized orders. Manufacturing workflows incorporate multi-stage testing procedures to verify electrical performance and mechanical resilience. These measures contribute to maintaining quality standards while supporting varied application requirements.

Industry trends indicate increasing reliance on interconnected systems and advanced automation technologies, often associated with Industry 4.0 initiatives. Within this context, dependable components such as cable assemblies are essential to minimizing system downtime and maintaining consistent operational performance.

The company operates from its facility located at 3rd Floor, Nanhai Plaza, No. 505 Xinhua Road, Xinhua District, Shijiazhuang, Hebei, China. This location serves as a central hub for engineering, production, and quality assurance activities.

Abby also addressed the company’s perspective on future developments: “Ongoing advancements in automation and robotics are expected to introduce new technical challenges and requirements. Continued investment in engineering capabilities and process improvements will remain a priority to support evolving industry needs and maintain alignment with global standards.”

The new cable assembly line is now available for integration into industrial automation and robotics projects. Engagement with partners across automotive, medical, and industrial sectors continues to support application-specific development and long-term collaboration.

For additional information regarding Custom Cable Assembly Manufacturing, inquiries may be directed to sales@wellpcb.net.

Media Contact

Organization: WellPCB

Contact Person: Abby

Website: https://wireharnessproduction.com/

Email: Send Email

Address:3rd Floor, Nanhai Plaza, No. 505 Xinhua Road, Xinhua District, Shijiazhuang, Hebei, China

Country:China

Release id:44039

The post WellPCB Launches High-Reliability Custom Cable Assemblies for Automation and Robotics appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section

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Press Release

Hometown Introduces a Cooperative Game That Transforms Screen Time Into Shared Family Experience

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A new city building experience encourages families to reconnect through collaborative gameplay, turning individual screen use into meaningful shared moments across generations.

United States, 16th Apr 2026 – In homes across the world, a quiet shift has taken place. It is rarely discussed openly, yet widely felt. Families continue to live under the same roofs, share the same spaces, and follow familiar routines. But increasingly, they are no longer sharing the same moments. Evenings that once held conversation, laughter, or simple presence have gradually been replaced by parallel experiences, where each individual is engaged in a separate digital world despite being physically together.

Hometown cooperative family game logo and city building experience

This change is not the result of neglect. In most cases, it reflects how technology has evolved. Devices designed for personalization have reshaped interaction in subtle but significant ways, making it easier for individuals to focus on their own content rather than a shared experience. As a result, meaningful interaction within families has quietly diminished, even as connectivity through devices has increased.

Hometown, a newly introduced cooperative city building game, has been developed in response to this reality. Instead of attempting to remove screens from everyday life, the experience redefines how they can be used. The goal is not to reduce screen time, but to transform it into something shared, something that brings people back into the same moment.

At its core, the game is built on a simple but deliberate idea. Meaningful interaction happens when people are engaged together with a shared purpose. Hometown introduces a cooperative structure requiring two participants, where each role is essential to progress. One participant plans and builds, shaping the layout and long term development of the city, while the other explores the environment, interacting with the world and unlocking new elements. Neither role can move forward independently, making collaboration a natural part of the experience.

By making cooperation essential, the game encourages communication without forcing it. Players naturally begin to talk, coordinate, and respond to one another, shifting from passive co presence to active engagement. Unlike many digital experiences driven by urgency and competition, Hometown removes elements that disrupt interaction. There are no advertisements competing for attention, no countdown timers creating pressure, and no leaderboards introducing comparison. The experience unfolds at a calm and flexible pace, allowing players to focus on each other rather than the screen itself.

During development, early testing revealed an outcome that extended beyond gameplay. Families did not simply play the game. They began to talk. Conversations emerged naturally, often moving beyond the game itself into personal memories, shared experiences, and cultural identity. What started as a digital activity became a bridge for real world connection.

As players progress, they unlock cultural heritage inspired landmarks, including elements influenced by Chinese traditions and real world history. These include gateways, pavilions, and historically influenced environments that add depth to the experience. While visually engaging, these elements often serve a deeper purpose. They prompt reflection. Players frequently pause not to advance in the game, but to recall stories, share memories, and ask questions that may not have surfaced otherwise.

In one instance, a grandparent spent over an hour describing a location that an in game structure resembled. What began as a simple observation developed into a meaningful conversation about family history, migration, and lived experience. For the younger participant, it became more than a story. It was a connection to something previously unknown, something personal and lasting.

These moments were not designed as features. They emerged naturally from the environment the game creates. By offering a shared experience without distraction, Hometown provides space for conversations that often go unspoken in everyday life. It demonstrates that connection does not always require more time or effort, but rather the right context.

A short brand video illustrating this experience is available here:
https://youtu.be/FZ2tPgtxtO8?si=UpcJ24w5R1ZJPvju

The video reflects a simple yet powerful moment, where a family shares a single experience, focused on the same thing without distraction. It captures the essence of what Hometown is designed to achieve.

The game is designed to be accessible and easy to adopt. It is free to play and requires two devices connected via Bluetooth, allowing for local cooperative interaction. Sessions are recommended at approximately 30 minutes, though early observations suggest many families continue playing beyond that. The flexibility of the experience allows it to fit naturally into daily routines without requiring significant planning or commitment.

While the experience is accessible to all, it holds particular relevance for multicultural families. For those navigating multiple identities and balancing heritage with modern life, Hometown offers a space where both can coexist naturally. Culture is not presented as instruction, but as interaction. Players discover, build, and discuss together, allowing conversations about identity and belonging to emerge organically.

In a digital landscape where most experiences are designed for individual consumption, Hometown offers a different perspective. It does not compete for attention. It reshapes it. The experience reflects a simple truth. Connection does not require more tools or more time. It requires a shared moment, a common focus, and a reason to stay present.

Hometown aims to provide that reason.

About Hometown

Hometown is a cooperative, family focused city building game designed to bring people together through shared interaction, cultural storytelling, and calm, collaborative gameplay. The platform emphasizes connection across generations in a digital first world.

For more information, visit:
Website:https://www.hometowngames.app/
Facebook:https://www.facebook.com/hometowngameofficial
Instagram:https://www.instagram.com/home.town.official/
X:https://x.com/gamehometow/
Threads:https://www.threads.com/@home.town.official/
Youtube:https://www.youtube.com/@Hometown_game

Media Contact

Organization: PR Media House

Contact Person: Jake Parker

Website: https://prmediahouse.com/

Email: Send Email

Country:United States

Release id:44074

The post Hometown Introduces a Cooperative Game That Transforms Screen Time Into Shared Family Experience appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section

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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.

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