Press Release
CMS(867.HK/8A8.SG): Ruxolitinib Phosphate Cream (Lumirix®) Achieves Initial Prescriptions in Multiple Regions in China for Patients with Vitiligo
SHENZHEN, CHINA – On 12 March 2026, China Medical System Holdings Limited (“CMS” or the “Group”) is pleased to announce that its subsidiary, Dermavon Holdings Limited (“Dermavon”, an innovative pharmaceutical company specialized in skin health, which is applying for a separate listing on the Main Board of The Stock Exchange of Hong Kong Limited) has its innovative prescription medicine ruxolitinib phosphate cream (Lumirix®) (the “Product”, marketed as Opzelura® in the U.S., Europe and Canada) recorded the initial prescriptions for vitiligo patients across 30 provincial-level regions. The prescriptions cover approximately a thousand influential public and private medical institutions in the field of skin health and disease management, including Huashan Hospital, Fudan University, Shanghai Skin Disease Hospital, Dermatology Hospital of Southern Medical University, Second People’s Hospital of Chengdu, The First Bethune Hospital of Jilin University, The Second Xiangya Hospital of Central South University, United Family Healthcare Group, among others*. Meanwhile, the Product has become concurrently accessible via over 1,300 offline drugstores as well as JD.com e-commerce platform. *Hospital rankings are listed in no particular order.
As the first topical JAK inhibitor approved in China for the treatment of vitiligo, ruxolitinib phosphate cream has officially launched its large-scale clinical application today, marking a breakthrough in China’s vitiligo treatment landscape and ushering in a new era of precision targeted therapy for vitiligo. Supported by safety and efficacy fully demonstrated in clinical studies, the Product is expected to bring new hope for repigmentation to millions of vitiligo patients.
The rapid commercialization progress of ruxolitinib phosphate cream underscores strong product operation capabilities of CMS (including Dermavon), while also reflecting the robust supports from China’s regulatory reforms in accelerating patient access to clinically urgently needed innovative drugs. Benefiting from the integrated healthcare ecosystem of the Hainan Free Trade Port and the “Urgently Needed Imported Drugs for Clinical Use” policy, the Product initiated pilot clinical use in August 2023 at Boao Super Hospital within the Boao Lecheng International Medical Tourism Pilot Zone. Pilot usage subsequently expanded to designated medical institutions across the Guangdong–Hong Kong–Macao Greater Bay Area, Beijing-Tianjin region and other regions. In accordance with the relevant regulations of China’s real-world data application pilot project, as well as supported by the Hainan Provincial Medical Products Administration and the Administration of the Boao Lecheng International Medical Tourism Pilot Zone, the Product has accumulated real-world clinical data in China under pilot application, significantly accelerating its clinical, registration and approval timelines. The Product received its Drug Registration Certificate on January 30, 2026 (approval date: January 27, 2026).
Following its approval, in less than 1.5 months (including the Chinese New Year holiday), the initial prescriptions for ruxolitinib phosphate cream have been issued across multiple regions and hospitals, reflecting the highly efficient collaboration and concerted efforts among CMS teams, regulatory authorities and business partners. With robust support from the cross-departmental coordination mechanism of the Beijing Daxing Airport Economic Zone Joint Administrative Committee, once import conditions were met, the Product completed customs clearance approval, sampling and related customs procedures within 24 hours, and obtained the drug testing report within 7 working days, representing efficient execution and acceleration for the innovative drugs in China. During this process, the Beijing Municipal Medical Products Administration proactively provided end-to-end policy guidance; the government service center has efficiently completed customs clearance filing; the Beijing Institute for Drug Control has conducted methodological pre-testing to accelerate timelines for innovative drug, and continuous worked during the Chinese Spring Festival; and Daxing Airport Customs provided specialized pre-guidance on declaration and swiftly completed customs review and release. Through parallel workflows and coordinated execution, all parties collectively pressed the “fast-forward button” for the Product’s commercialization, helping this urgently needed innovative therapy reach patients faster.
As the Product enters the large-scale clinical application stage, it is expected to further strengthen Dermavon’s comprehensive dermatology solutions and brand value. Building on its leadership in skin health, Dermavon will continue to improve accessibility of ruxolitinib phosphate cream to benefit more vitiligo patients and steadfastly safeguard public skin health through innovation.
About Vitiligo
Vitiligo is a chronic autoimmune disease characterized by depigmentation of the skin, which results from the loss of pigment-producing cells known as melanocytes. The discolored areas usually get bigger with time and the condition could influence skin on any part of the patients’ body. Vitiligo usually affects the appearance of patients, especially on exposed areas such as the face and neck. According to a study that involved over 1,000 diagnosed vitiligo patients, over 45% of patients have facial involvement, and over 20% of patients have neck involvement[1].The obvious presence of white patches may make patients feel that their appearance has been compromised, which in turn materially affects their social life, and is associated with a significantly higher incidence of mental health disorders; accordingly, there is an urgent need for effective treatment options for vitiligo[2].
It is estimated that there are approximately 10.3 million vitiligo patients in China and non-segmental vitiligo patients account for approximately 8.2 million[1]. Existing therapies, such as topical corticosteroids (TCS) and topical calcineurin inhibitors (TCIs), have clinical limitations, with adverse reactions or limited efficacy with long-term use. Ruxolitinib phosphate cream successfully fills the gap in targeted drug treatment for vitiligo and is of great landmark significance.
More Information About Ruxolitinib Phosphate Cream
Ruxolitinib phosphate cream (Opzelura®), a novel cream formulation of the selective JAK1/JAK2 inhibitor ruxolitinib developed by Incyte, is the first and only drug approved for the repigmentation of non-segmental vitiligo by the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA)[3,4]. In the U.S., the Product is indicated for the topical treatment of nonsegmental vitiligo in adult and pediatric patients aged 12 years and older, and for the short-term and non-continuous chronic treatment of mild to moderate atopic dermatitis (AD) in non-immunocompromised adult and pediatric patients aged 2 years and older whose disease is not well controlled with topical prescription therapies, or when those therapies are not advisable. In Europe, ruxolitinib phosphate cream is approved for the topical treatment of non-segmental vitiligo with facial involvement in adults and adolescents from 12 years of age. In China, besides vitiligo indication, the product’s NDA for the treatment of mild-to-moderate AD in adults and pediatric patients aged 2 years and older is also under regulatory review, which has been included in the Priority Review List and is expected to accelerate the Product’s AD review process for marketing approval.
The Group, through the subsidiary of Dermavon entered into a Collaboration and License Agreement with Incyte for ruxolitinib phosphate cream on 2 December 2022, obtaining an exclusive license to develop, register and commercialize the Product in Mainland China, Hong Kong Special Administrative Region, Macau Special Administrative Region, Taiwan Region and eleven Southeast Asian countries (the “Territory”) and a non-exclusive license to manufacture the Product in the Territory. The subsidiary of Dermavon has sublicensed the relevant rights for the Product outside of Mainland China to the Group (excluding Dermavon and its subsidiary).
Incyte has worldwide rights for the development and commercialization of ruxolitinib phosphate cream (excluding territories in which exclusive rights have already been licensed), marketed in the United States and Europe as Opzelura®. Opzelura® and the Opzelura® logo are registered trademarks of Incyte.
About CMS
CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.
CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.
CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development in its advantageous specialty fields, strengthening the competitiveness of the cardiovascular-kidney-metabolic/ gastroenterology/ ophthalmology/ skin health businesses, bringing economies of scale in specialty fields. Among them, the skin health business (Dermavon) has become a leading enterprise in its field, and is proposed to be listed independently on the SEHK. Meanwhile, CMS continuously promotes the operation and development of its integrated R&D, manufacturing and commercialization chain in Southeast Asia and the Middle East, capturing growth opportunities in emerging markets to support the high-quality and sustainable development of the Group.
Reference:
- China Insights Consultancy’s industrial report
- Wang G, Qiu D, Yang H, Liu W. The prevalence and odds of depression in patients with vitiligo: a meta-analysis[J]. Journal of the European Academy of Dermatology and Venereology, 2018,32(8):1343-1351. DOI:10.1111/jdv.14739.
- The U.S. FDA approval information can be found on the Incyte official website, as follows:
- The EMA approval information can be found on the Incyte official website, as follows:
CMS Disclaimer and Forward-Looking Statements
This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.
This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.
Media Contact
Brand: China Medical System Holdings Ltd.
Contact: CMS Investor Relations
Website: https://web.cms.net.cn/en/home/
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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
Karviva Wins Progressive Grocer Editor’s Pick Award as Brand Gains National Recognition and Retail Momentum
Saint Louis, Missouri, United States, 20th Apr 2026 – Karviva, the functional beverage brand founded by Dr. Angela Zeng, has been named a recipient of the 2026 Editor’s Pick Award by Progressive Grocer, one of the grocery retail industry’s leading trade publications. The recognition places Karviva among a select group of products identified for innovation, quality, and alignment with evolving consumer preferences.
The 22nd annual Editors’ Picks, announced by Progressive Grocer on April 8, 2026, highlight products shaping the future of food and beverage retail. This year’s selections emphasize functional nutrition, clean ingredients, global influences, and convenience-driven innovation. Karviva’s inclusion reflects growing demand for beverages that support everyday wellness while meeting modern lifestyle expectations.
Karviva develops plant-based functional juices designed to support hydration, digestion, energy, and metabolic balance. Founded by Dr. Zeng, the brand combines modern nutritional science with principles rooted in Traditional Chinese Medicine, focusing on whole-food ingredients and lower-sugar formulations rather than conventional juice cleanse approaches.
The recognition comes at a time when the functional beverage category is shifting toward more thoughtful formulations. Progressive Grocer noted that products incorporating adaptogens, plant-based nutrients, and functional ingredients are increasingly resonating with consumers seeking long-term wellness solutions rather than short-term trends.
Dr. Zeng has positioned Karviva within this shift by focusing on consistency, ingredient integrity, and daily usability.
“The goal is not to create extreme solutions, but to support the body in a way that fits into everyday life,” said Dr. Zeng. “Consumers are becoming more aware of what goes into their products, and they are looking for options that align with long-term health.”
The Editor’s Pick recognition follows a period of growing national visibility for Dr. Zeng and the Karviva brand. Most recently, Women’s World featured Dr. Zeng in an article titled “Dr. Angela Zeng Unites Ancient Wellness Principles and Modern Science,” highlighting her work in bridging traditional healing practices with contemporary nutritional research.
Karviva has also continued to expand its retail footprint across the United States. The brand’s products are now available in more than 1,000 retail locations, with recent launches in major grocery chains and regional markets contributing to its increasing national presence.
As consumers move toward products that prioritize function, transparency, and quality ingredients, Karviva’s recognition by Progressive Grocer reinforces its position within the next wave of functional beverage innovation.
With the Editor’s Pick award, continued media attention, and expanding retail distribution, Karviva enters 2026 with strong momentum across both industry and consumer markets.
About Karviva
Karviva is a St. Louis–based functional beverage company founded by Dr. Angela Zeng, PhD, MBA. The brand develops plant-based juices designed to support hydration, digestion, energy, and overall well-being. Rooted in both modern nutritional science and Traditional Chinese Medicine principles, Karviva focuses on clean ingredients, lower-sugar formulations, and products that fit into everyday routines. Karviva products are available through more than 1,000 retail locations across the United States and international markets.
Media Contact
Organization: Karviva
Contact Person: Dr. Angela Zeng
Website: https://karviva.com/
Email:
angela@karviva.com
City: Saint Louis
State: Missouri
Country:United States
Release id:44159
The post Karviva Wins Progressive Grocer Editor’s Pick Award as Brand Gains National Recognition and Retail Momentum appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
AetherCanvas Recently Launches Water Element Art Collection in North America
In 2026, art is taking shape in a groundbreaking new form. Asian heritage-driven art brand AetherCanvas officially announces the global launch of its 2026 Water Element Collection this April – a contemporary wall art series curated exclusively for the North American market.
The collection draws on traditional East Asian design philosophies, including the Five Elements framework, and adapts these influences into a modern visual language suited to current interior design preferences. The works focus on water-inspired forms, textures, and tonal compositions, offering an alternative to the increasingly warm and saturated color palettes seen in recent North American interiors.
AetherCanvas draws on the long-established principles of Feng Shui, which emphasize the relationship between spatial design, sensory experience, and environmental harmony.By translating these ancient ideas into modern, accessible wall art, the brand is redefining the role of art within everyday living environments in North America.
“Today’s North American homeowners seek art that does more than impress visually—they want meaning, cultural depth, and calm, balanced living spaces.” said Dennil, CEO of AetherCanvas, at the collection launch. “Eastern wisdom has long recognized the connection between our surroundings and our sense of harmony and well-being. With this Water Element Collection, AetherCanvas turns ancient spatial harmony into refined, modern art that seamlessly elevates North American homes.”
For AetherCanvas, art is an intentional presence that shapes the emotional architecture of a space. Each piece is designed to introduce balance, softness, and a refined atmospheric quality into the environments it inhabits.
In the living room, the water element artwork becomes a quiet visual anchor, softening social interactions while cultivating a sense of ease, warmth, and relaxation. In study areas, these pieces are intended to support a sense of clarity and focus, aligning with more mindful work routines. In the entryway or foyer, each piece establishes the first emotional impression of the home—subtly guiding the transition from the outside world into a more composed and intentional interior atmosphere.
The Balancing Role of the Water Element in 2026
2026 is associated with intensified “fire”, traditionally linked to heat, activity, emotional intensity, and strong outward expression.
Leading North American design authorities have described the year as a “Bold Warmth Era,” marked by the widespread use of saturated terracotta, burnt orange, and earthy tonal palettes across residential and commercial interiors. Mainstream interior styles further reinforce this shift toward warmth and saturation. Bohemian interiors embrace layered earth tones and organic warmth; Maximalism favors high-saturation contrasts and expressive color pairings; Pop-inspired spaces reintroduce bold, energetic palettes; while color-drenching trends immerse entire rooms in a single dominant hue.
Against this backdrop, AetherCanvas’s water element works provide a deliberate counterbalance, drawing from the Five Elements philosophy (the ancient Chinese system of wood, fire, earth, metal, and water that underpins Feng Shui) to offset visual intensity with calm and fluidity. They offer a strategic visual and emotional reset, bringing softness, depth, and equilibrium to otherwise high-energy environments.
AetherCanvas Integrates Water Element Design into Modern Spatial Art
AetherCanvas introduces its 2026 collection, inspired by the qualities of the water element – balance, fluidity, tranquility, and abundance – through a contemporary lens. The collection seeks to elevate residential and office spaces, not simply through aesthetic representation of water, but by creating artworks that complement and enhance the ambiance of modern interiors.
In this collection, water serves as a design motif that pairs harmoniously with other elements, particularly fire, to evoke a sense of calm and refinement. By aligning with the growing demand for thoughtfully curated living environments across North America, AetherCanvas’s pieces are designed to fit into today’s design trends, offering both beauty and a sense of calm in different settings.
These ideas are visual language suited to modern interiors, allowing the artworks to function as both refined design pieces and reflection of the spaces it inhabits.
Eastern Craftsmanship and Natural Materials in Contemporary Art
The 2026 Water Element Collection is crafted using carefully selected natural stone, handcrafted base forms, and traditional Eastern artisanal techniques. The collection will be available exclusively through AetherCanvas’s North American online store starting April 2026.
AetherCanvas draws on the heritage of Eastern craftsmanship, selecting premium materials rich in symbolic meaning. Each piece incorporates carefully chosen natural minerals, formed over millions of years, imparting a sense of permanence, stability, and tactile depth to the design. Handcrafted bisque textures add a distinctive material richness, preserving time-honored Eastern artistic techniques while infusing each work with a unique sense of craftsmanship and individuality.
These materials are valued not only for their appearance, but also for the stories they carry. Traditional craftsmanship techniques, preserved across generations, reinforce the brand’s emphasis on cultural continuity and artistic authenticity.
With the launch of its 2026 collection, AetherCanvas highlights a broader approach to how art can be incorporated into living and working environments across North America. The collection integrates personal aesthetics, cultural influences, and intentional spatial composition, reflecting a more immersive direction for wall art in 2026 and beyond.
In addition, AetherCanvas offers an optional online personalization tool designed to help users explore the relationship between personal characteristics and spatial elements, offering a reflective framework for understanding how art may influence atmosphere, mood, and spatial perception.
By combining natural materials, artisanal craftsmanship and design concepts, AetherCanvas develops pieces that bring a sense of balance and atmosphere to interior spaces.
Discover more AetherCanvas and explore its latest creations on:
Instagram(@senaura_art)
TikTok(@senaura_art)
Pinterest(@AetherCanvas).
About AetherCanvas
AetherCanvas is an art brand inspired by Feng Shui concepts, Five Elements philosophy, and contemporary wall art design. The brand is redefining the role of art in contemporary interior spaces with a forward-looking vision that establishes a new benchmark for spatial art within North American design. AetherCanvas also introduces its proprietary “Attraction Code,” a conceptual framework that translates invisible yet perceptible forces—such as energy, emotion, and atmosphere—into tangible visual expression.
Media Contact
Organization: AetherCanvas
Contact Person: Penelope Wong
Website: https://aethercanvas.art/
Email:
info@AetherCanvas.art
City: Los Angeles
State: CA
Country:United States
Release id:44083
The post AetherCanvas reinterprets spatial art through the lens of Eastern energy concepts appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
Sihoo Doro C300 Pro V2 Is Officially Available: The Next Evolution in Full-Body Adaptive Ergonomics
Featuring the revolutionary DynaCore System, Sihoo’s newest flagship chair eliminates support loss during movement and delivers truly adaptive, personalized comfort.
Shenzhen, China, 20th Apr 2026 – Sihoo, a global leader in ergonomic furniture with 15 years of design and engineering excellence, today announced the official global availability of the highly anticipated Doro C300 Pro V2. Engineered to redefine all-day comfort, this new flagship model is the market’s first ergonomic chair to deliver true, intuitive, full-body adaptive support.
The End of Support Loss During Movement
Building on the global success of the original Doro C300, the Pro V2 sets a new standard for dynamic comfort. At its core is Sihoo’s proprietary DynaCore Full-Body Support System.
Unlike traditional office chairs that lose support the moment you move—or ergonomic chairs that demand constant readjustment—the Doro C300 Pro V2’s DynaCore system seamlessly synchronizes the backrest, lumbar support, headrest, and armrests. The result is a chair that intuitively responds to your natural movements. Whether you lean forward for focused work, shift side to side, or recline to relax, the chair maintains perfect, continuous balance.
Personalized Comfort from the First Moment
The Doro C300 Pro V2 takes personalization further with the SyncroFlex Backrest. The instant you sit down, the chair automatically maps and follows the natural curvature of your spine. Its intelligent recline path adapts dynamically to your unique body size and movement patterns, delivering a highly tailored experience with zero manual adjustments.
Next-Generation Features
The Doro C300 Pro V2 is packed with upgraded technology designed for today’s professionals, gamers, and creators:
- Self-Adaptive Dynamic Lumbar Support 2.0 — Offers three levels of targeted adjustability for fatigue-reducing lower-back support that lasts all day.
- 8D Bionic Armrests — Move in eight directions to provide perfect arm support whether you’re typing, gaming with a controller, or scrolling on a mobile device.
- Ultra-Wide 3D Headrest — Delivers precise, cradle-like neck support to relieve tension during long periods of focus.
- Weight-Adaptive Mechanism 2.0 — Automatically calibrates recline tension to your body weight, providing an ultra-smooth recline of up to 135° for a seamless transition between work and rest.
Availability
The Sihoo Doro C300 Pro V2 is now officially available in major global markets, including the United States, Germany, and France.
To purchase or learn more about its groundbreaking features, visit: https://sihoooffice.com/pages/sihoo-c300-pro-v2.
About Sihoo
Founded in 2011, Sihoo is driven by a core mission: to create seating solutions that seamlessly combine comfort, robust support, and cutting-edge ergonomic innovation. With 15 years of dedicated expertise in biomechanics and engineering, Sihoo has become a globally recognized brand trusted by modern businesses, remote workers, and households in more than 100 countries.
Media Contact
Organization: Sihoo
Contact Person: Wendy Xu
Website: https://sihoooffice.com/
Email: Send Email
City: Shenzhen
Country:China
Release id:44170
The post Sihoo Doro C300 Pro V2 Is Officially Available: The Next Evolution in Full-Body Adaptive Ergonomics appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Karviva Wins Progressive Grocer Editor’s Pick Award as Brand Gains National Recognition and Retail Momentum
AetherCanvas reinterprets spatial art through the lens of Eastern energy concepts
Sihoo Doro C300 Pro V2 Is Officially Available: The Next Evolution in Full-Body Adaptive Ergonomics
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