Press Release
CMS (867.HK/8A8.SG): Innovative Drug Oral JAK1 Inhibitor Povorcitinib Has Been Included in the List of Breakthrough Therapeutic Drugs in China
SHENZHEN, CHINA – China Medical System Holdings Limited (“CMS”, or the “Group”) is pleased to announce that its subsidiary, Dermavon Holdings Limited (“Dermavon”, an innovative pharmaceutical company specialized in skin health which is applying for an independent listing on the Main Board of The Stock Exchange of Hong Kong Limited, please refer to the announcement of the Company dated 22 April 2025 for details), has obtained the relevant licensing rights to the innovative oral JAK1 inhibitor povorcitinib (proposed English generic name: Povorcitinib Phosphate Tablets) (“povorcitinib” or the “Product”), which has been included in the list of Breakthrough Therapeutic Drugs by the Center for Drug Evaluation of the National Medical Products Administration of the People’s Republic of China (“NMPA”), with a proposed indication for adult patients with non-segmental vitiligo. This certification has the potential to accelerate the development and review process of the Product.
Povorcitinib is a selective oral small-molecule JAK1 inhibitor, with compound and use patents in certain countries/regions in the Territory. Currently, povorcitinib is in Phase 3 clinical trials for non-segmental vitiligo, moderate to severe hidradenitis suppurativa (HS) and prurigo nodularis in several countries outside China. A Phase 2 clinical trial for the treatment of asthma is also ongoing.
In March 2023, Incyte announced that povorcitinib met the primary endpoint in a global multi-center Phase 2b clinical trial for non-segmental vitiligo. Results showed that after 24 weeks of treatment, compared with vehicle, total body repigmentation of patients treated with povorcitinib once daily was significantly improved. Furthermore, according to the extended Phase 2b trial, longer-term use of povorcitinib demonstrated further improvement in total body and facial repigmentation with a favorable tolerability profile[1].
In August 2025, Dermavon received the drug clinical trial approval notice issued by NMPA to conduct clinical trials of povorcitinib for the treatment of non-segmental vitiligo and other indications. Dermavon has initiated the clinical development of the Product in China and may consider further initiating clinical development of povorcitinib in China for the treatment of skin-related diseases such as HS and prurigo nodularis in the future.
Vitiligo is a chronic autoimmune disease characterized by depigmentation of the skin, which results from the loss of pigment-producing cells known as melanocytes. It is estimated that there are approximately 10.3 million vitiligo patients in China and non-segmental vitiligo patients account for approximately 8.2 million[2]. Currently, therapeutic options for vitiligo are limited, and the condition is difficult to treat, especially for patients with moderate to severe extensive vitiligo. If approved in China, povorcitinib could provide a differentiated treatment option for patients with non-segmental vitiligo.
The Product’s inclusion in the list of Breakthrough Therapeutic Drugs is expected to accelerate its development and review process in mainland China. If approved for marketing in China, the Product has the potential to synergize with Dermavon’s commercialized innovative drug ILUMETRI (tildrakizumab injection), commercialized exclusive drug Hirudoid (mucopolysaccharide polysulfate cream) and the innovative drug currently under New Drug Application (NDA) review ruxolitinib phosphate cream, helping the product to quickly realize its clinical and commercial value and benefit more patients with skin diseases. Furthermore, if approved, the Product, together with topical ruxolitinib phosphate cream, will provide vitiligo patients with differentiated and comprehensive treatment options.
The Group, through a subsidiary of Dermavon entered into a Collaboration and License Agreement (the “License Agreement”) for povorcitinib on 31 March 2024 with Incyte, obtaining an exclusive license to research, develop, register and commercialize the Product in Mainland China, Hong Kong Special Administrative Region, Macao Special Administrative Region, Taiwan Region and eleven Southeast Asian countries (the “Territory”) and a non-exclusive license to manufacture the Product in the Territory. The subsidiary of Dermavon has sublicensed the relevant rights of povorcitinib in the Territory other than Mainland China to the Group (excluding Dermavon and its subsidiaries).
About CMS
CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.
CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.
CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development in its advantageous specialty fields, strengthening the competitiveness of the cardio-cerebrovascular/ gastroenterology/ ophthalmology/ skin health businesses, bringing economies of scale in specialty fields. Among them, the skin health business (Dermavon) has become a leading enterprise in its field, and is proposed to be listed independently on the SEHK. Meanwhile, CMS continuously promotes the operation and development of its integrated R&D, manufacturing and commercialization chain in Southeast Asia and the Middle East, capturing growth opportunities in emerging markets to support the high-quality and sustainable development of the Group.
Reference:
- Results from a global multi-center Phase 2b clinical trial of the product for non-segmental vitiligo indication can be found on the Incyte official website: https://investor.incyte.com/news-releases/news-release-details/incyte-an…
- Datas are from the China Insights Consultancy (CIC) report
CMS Disclaimer and Forward-Looking Statements
This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.
This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.
Media Contact
Brand: China Medical System Holdings Ltd.
Contact: CMS Investor Relations
Email: ir@cms.net.cn
Website: https://web.cms.net.cn/en/home/
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
Sunshine Jewelries Emphasizes Thoughtful Design With Jewelry Made for Real Life, Real Wear, and Everyday Confidence
-
A continued focus on pieces designed for lasting comfort and meaningful personal use
California, USA, 2nd March 2026, ZEX PR WIRE — Sunshine Jewelries highlights its ongoing commitment to thoughtful design and jewelry created for real wear. The brand’s current direction centers on pieces that support daily life, personal milestones, and long-term use rather than short-lived trends or single-occasion styling.
“We focus on creating pieces people reach for instinctively, whether they are dressing for work, meeting friends, or marking a meaningful moment.”
The brand’s latest emphasis reflects a growing shift toward jewelry that feels natural in everyday settings. Rather than treating jewelry as something reserved for events alone, Sunshine Jewelries approaches design as part of a person’s routine. Necklaces, earrings, bracelets, and rings are developed with balance, proportion, and comfort in mind, allowing each piece to move easily from morning to evening without feeling overstated or impractical.
“Jewelry should feel dependable, not limit how often it gets worn,” said a representative from Sunshine Jewelries. “Our designs are meant to fit into real wardrobes and real lives, while still holding meaning and presence.”
Materials across current collections include sterling silver, 10K and 14K gold, and carefully selected stones set with secure construction. Each design prioritizes wearability, accurate sizing, and thoughtful finishes that hold up to repeated use. Attention to comfort plays a central role, from smooth edges to reliable closures that support confidence during daily wear.
Sunshine Jewelries also continues to place importance on emotional connection. Many pieces are created with gifting in mind, offering options suitable for birthdays, anniversaries, career milestones, and personal celebrations. Clean silhouettes and versatile designs allow jewelry to feel personal without being tied to a single moment or trend cycle.
Alongside design philosophy, Sunshine Jewelries maintains a customer-focused shopping experience through its online store. The brand offers secure checkout, clear product information, fast delivery, and real-time order tracking to support a smooth purchasing process. This operational consistency reflects the same care applied to product design.
By reinforcing its commitment to jewelry made for real life, Sunshine Jewelries continues to position itself as a brand grounded in intention, wearability, and emotional relevance. The focus remains on pieces that stay present in daily routines, becoming part of personal stories rather than background accessories.
Current collections are available through the Sunshine Jewelries online store.
About Sunshine Jewelries
Sunshine Jewelries is a handcrafted jewelry brand dedicated to creating meaningful pieces designed for everyday wear and life’s important moments. With a focus on quality materials, thoughtful design, and careful craftsmanship, the brand creates jewelry meant to be worn often, gifted with purpose, and remembered over time.
Contact Information
Email: sunshinejewelry25@gmail.com
Website: https://sunshinejewelleries.com
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
Sunshine Jewelries Launches a Line Featuring Everyday Staples for Work, Events, and Gifting
-
A new collection focused on refined essentials designed to move effortlessly from daily wear to meaningful occasions
California, USA, 2nd March 2026, ZEX PR WIRE — Sunshine Jewelries has announced the launch of a new jewelry line centered on everyday staples created for work settings, special events, and thoughtful gifting. The release reflects the brand’s continued focus on jewelry that feels composed, wearable, and intentional from the moment it is worn, while maintaining the craftsmanship and material standards the brand is known for.
“We think of jewelry as part of someone’s routine, not just an accessory for rare occasions. This collection was shaped around real life, where a bracelet might be worn to work, to dinner, and then gifted later as something remembered.”
The new line brings together earrings, necklaces, rings, and bracelets designed with proportion, comfort, and longevity in mind. Rather than focusing on statement-only pieces, the collection prioritizes refined designs that integrate easily into daily routines, professional wardrobes, and personal milestones. Each piece is crafted to feel balanced on the body, offering a sense of polish without excess.
This launch responds to a growing demand for jewelry that can transition smoothly across different moments of life. From meetings and formal events to celebrations and gifting, the collection is structured to support versatility while retaining visual presence. Materials include sterling silver, 10K and 14K gold, and carefully selected stones set with attention to detail and secure construction.
“Our goal with this line was to create pieces people could rely on, not just admire,” said a representative from Sunshine Jewelries. “These are designs meant to be worn repeatedly, paired easily, and trusted for both everyday settings and moments that matter.”
The collection also reflects Sunshine Jewelries’ emphasis on thoughtful gifting. Many pieces are positioned as meaningful options for birthdays, anniversaries, weddings, and professional milestones. With clean silhouettes, dependable closures, and accurate sizing, the jewelry is designed to feel personal while remaining universally wearable.
In keeping with the brand’s customer-first approach, Sunshine Jewelries continues to offer fast delivery, secure checkout, and real-time order tracking across its online store.
By focusing on everyday staples, Sunshine Jewelries reinforces its belief that jewelry should feel natural, expressive, and lasting. The new line stands as a continuation of the brand’s philosophy that each piece carries meaning, shaped not only by design but by how and when it is worn.
The collection is now available through the Sunshine Jewelries online store.
About Sunshine Jewelries
Sunshine Jewelries is a handcrafted jewelry brand dedicated to creating refined, meaningful pieces for everyday wear and special occasions. With a focus on quality materials, thoughtful design, and careful craftsmanship, the brand creates jewelry meant to be worn, gifted, and remembered.
Contact Information
Email: sunshinejewelry25@gmail.com
Website: https://sunshinejewelries.com
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
Context Releases 2025 Luxury Fashion Sustainability Benchmark on ESG Disclosures
London, United Kingdom, 2nd Mar 2026 — A new 2025 Luxury Fashion Sustainability Benchmark released by sustainability consultancy Context reveals a growing divide between the depth of environmental disclosures and social transparency. The benchmark analyses the public sustainability and ESG reporting of 10 of the world’s largest luxury fashion companies, including Burberry, Chanel, LVMH, and Kering.
Social Sustainability: Placing People at the Centre
The benchmark assesses how effectively luxury fashion companies identify, manage, and report on key sustainability issues across five categories. It evaluates reporting maturity and transparency, rather than actual sustainability performance. The findings highlight the growing importance of developing a more holistic sustainability strategy that places people at the centre. While companies are integrating actionable targets and goals related to their material issues, such as climate, transparency doesn’t yet extend far enough to the people behind the products.
“As regulatory scrutiny increases and expectations rise, credible leadership will depend on companies being as open about social impacts, risks and opportunities as they are about emissions and other environmental topics,” said Helen Fisher, Managing Director at Context.
Key findings from the 2025 Luxury Fashion Sustainability Benchmark include:
- Communicating a strategy: All luxury fashion companies provided updates on their sustainability strategy, but the extent to which it covered the company’s most material environmental, social, and governance issues varied.
- Double materiality: 40% had communicated their impacts on planet and society, and the financial implications of those impacts, by reporting the results of a double materiality assessment.
- Governance: Sustainability governance is well-established at both the Board and executive levels, but detailed ESG risk management disclosures are sparse.
- Climate metrics: Luxury fashion companies tend to report more extensive climate-related data, but transparent communication on setbacks or underperformance is limited.
- Nature: Nature reporting is slowly rising, with half following science-backed guidance from the Science Based Targets Network (SBTN). Only one company has SBTN validated freshwater and land targets.
+1 - Social impact: Reporting on social issues is weaker than on environmental and governance topics, indicating potential blind spots in supply chain risk.
- Reporting frameworks: Most luxury fashion companies report against at least one sustainability reporting framework, such as the Global Reporting Initiative Standards, commonly used by companies to publicly report their impacts on the planet, economy, and society.
Download the full 2025 Luxury Fashion Sustainability Benchmark.
About Context
Context is a consultancy specialising in corporate sustainability strategy, reporting, and communications. For more than 25 years, it has helped over 250 clients across a wide range of sectors and markets to navigate the evolving sustainability landscape.
Media Contact
Organization: Context
Contact Person: Helen Fisher, Managing Director
Website: https://contextsustainability.com/
Email: Send Email
City: London
Country:United Kingdom
Release id:41950
The post Context Releases 2025 Luxury Fashion Sustainability Benchmark on ESG Disclosures appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
-
Press Release3 days ago
SPL VPN Leverages AI to Eliminate Manual Server Selection; Surpasses 2 Million Downloads in Connectivity Pivot
-
Press Release6 days ago
Erb Hub Showcases New Jersey’s Evolving Cannabis Culture Through Innovative Digital Art
-
Press Release5 days ago
Lake Worth Beach Bail Bonds Services Expanded with County-Focused Release Strategy
-
Press Release1 week ago
UAE Institutional Leaders Convene in Abu Dhabi as Digital Asset Strategy Accelerates Across Global Finance
-
Press Release5 days ago
Cabinet Paint Color Trends Shape Tampa Bay Kitchens in 2026
-
Press Release6 days ago
Ernie’s Wagon Junk Removal Expands Operations Across Greater Hillsboro to Meet Surging Demand
-
Press Release3 days ago
ZentoraReach Leads Client Acquisition & Revenue Growth for Contractors
-
Press Release1 week ago
Nermine Al Hossary: Bold Dreamer Inspiring Lives Through Influence and Authenticity
