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Candel Therapeutics (NASDAQ: CADL) Reports Positive Data From Phase 2 Trial Of CAN-2409 In Borderline Resectable Pancreatic Cancer

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–News Direct–

By Jeremy Golden, Benzinga

Clinical-stage biopharmaceutical company Candel Therapeutics, Inc. (NASDAQ: CADL) reported updated survival data from its randomized phase 2 clinical trial of CAN-2409 in borderline resectable pancreatic cancer. Pancreatic cancer is the fourth leading cause of cancer-related death in the U.S. The disease accounts for approximately 3% of all cancers, with an estimated 64,050 patients diagnosed in 2023.

The randomized, controlled clinical trial is specifically looking into the safety and efficacy of CAN-2409 plus valacyclovir (prodrug), together with standard of care (SoC) chemoradiation, followed by resection if possible in borderline resectable pancreatic ductal adenocarcinoma (PDAC).

Very encouraging results were recently reported by the Needham, Massachusetts-based company.

Patients reached an estimated median overall survival of 28.8 months after experimental treatment with CAN-2409 versus only 12.5 months in the control group in PDAC. At 24 months, the survival rate was 71.4% in CAN-2409 treated patients compared to only 16.7% in the control group after chemoradiation. Thus, prolonged and sustained survival was observed after experimental treatment with CAN-2409 in patients with borderline resectable PDAC. Importantly, 4 out of 7 patients who received CAN-2409 were still alive at the time of data cut-off, with 2 patients surviving more than 50.0 months from enrollment. Only 1 out of 6 patients in the randomized control SoC chemotherapy group remained alive at the data cut-off (50.6 months).

No new safety signals were observed, providing further support that multiple injections of CAN-2409 are generally well tolerated. Additionally, there were no dose-limiting toxicities or cases of pancreatitis reported.

Previous analysis of resected tumors showed dense aggregates of immune cells including CD8+, cytotoxic tumor-infiltrating lymphocytes and dendritic cells in PDAC tissue after CAN-2409 administration. This reinforces the potential of CAN-2409 to activate a robust antitumoral immune response in patients with cancer also in cold, immunosuppressive tumors like PDAC.

Given the frequent recurrence and short survival with SoC chemotherapy for non-metastatic PDAC, effective new treatment options are urgently needed, said Garrett Nichols, MD, MS, Chief Medical Officer of Candel. We are very encouraged by the improved survival associated with CAN-2409, which has been shown to be durable after prolonged follow-up based on the updated data in this randomized clinical trial. CAN-2409 was generally well tolerated without significant additional local or systemic toxicity when added to SoC chemoradiation.

Candels most advanced viral immunotherapy candidate, CAN-2409, is an investigational off-the-shelf, replication-defective adenovirus designed to induce an individualized, systemic immune response against the tumor. Because of its versatility, CAN-2409 has the potential to treat a broad range of solid tumors. More than 1,000 patients have been dosed with CAN-2409 to date, with a favorable reported tolerability profile and proof of concept in each indication that the company is currently pursuing.

CAN-2409 is injected directly into the tumor or target tissue using a localized injection method that is akin to the standard approach for in situ vaccination to elicit an immune response against the injected tumor and uninjected metastases.

Long-term survival data in PDAC was recently updated with eight months of further follow-up since the first analysis was presented at the 2023 Society for Immunotherapy (SITC) Annual Meeting. Based on the data presented at SITC, the U.S. Food and Drug Administration (FDA) granted Fast Track Designation to Candel Therapeutics for CAN-2409 in combination with valacyclovir for the treatment of patients with PDAC in December 2023. More recently, the FDA also granted Orphan Drug Designation.

The failure of conventional immunotherapy to improve outcomes in pancreatic cancer is attributed to the highly immunosuppressive tumor microenvironment, which is largely devoid of immune cells, said Paul Peter Tak, MD, PhD, FMedSci, President and Chief Executive Officer of Candel. The immunological changes induced by CAN-2409, evident in the pancreatic tissue and the peripheral blood after administration, suggest that CAN-2409 is able to change the balance between the tumor and the patients anti-tumor immune response, which can convert progressive cancer into a chronic disease associated with improved survival.

Featured photo by National Cancer Institute on Unsplash.

Candel is a clinical stage biopharmaceutical company focused on developing off-the-shelf multimodal biological immunotherapies that elicit an individualized, systemic anti-tumor immune response to help patients fight cancer. Candel has established two clinical stage multimodal biological immunotherapy platforms based on novel, genetically modified adenovirus and herpes simplex virus (HSV) gene constructs, respectively. CAN-2409 is the lead product candidate from the adenovirus platform and is currently in ongoing clinical trials in non-small cell lung cancer (NSCLC) (phase 2), borderline resectable pancreatic cancer (phase 2), and localized, non-metastatic prostate cancer (phase 2 and phase 3). CAN-3110 is the lead product candidate from the HSV platform and is currently in an ongoing investigator-sponsored phase 1 clinical trial in recurrent high-grade glioma (HGG). Finally, Candels enLIGHTEN Discovery Platform is a systematic, iterative HSV-based discovery platform leveraging human biology and advanced analytics to create new viral immunotherapies for solid tumors.

This article includes certain disclosures that contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding the timing and advancement of development programs, including the timing and availability of additional data, key data readout milestones, including CAN-3110 in HGG; expectations regarding the potential benefits conferred by Fast Track Designation; expectations regarding the therapeutic benefit of its programs, including the potential for its programs to extend patient survival; and expectations regarding cash runway and expenditures. The words may, will, could, would, should, expect, plan, anticipate, intend, believe, estimate, predict, project, potential, continue, target and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on managements current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, those risks and uncertainties related to the timing and advancement of development programs; expectations regarding the therapeutic benefit of the Companys programs; that final data from our pre-clinical studies and completed clinical trials may differ materially from reported interim data from ongoing studies and trials; the Companys ability to efficiently discover and develop product candidates; the Companys ability to obtain and maintain regulatory approval of product candidates; the Companys ability to maintain its intellectual property; the implementation of the Companys business model, and strategic plans for the Companys business and product candidates, and other risks identified in the Companys SEC filings, including the Companys most recent Quarterly Report on Form 10-Q filed with the SEC, and subsequent filings with the SEC. The Company cautions you not to place undue reliance on any forward-looking statements, which speak only as of the date they are made. The Company disclaims any obligation to publicly update or revise any such statements to reflect any change in expectations or in events, conditions or circumstances on which any such statements may be based, or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements. Any forward-looking statements contained in this press release represent the Companys views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date.

This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice.

Contact Details

Aljanae Reynolds

+1 617-916-5445

areynolds@wheelhouselsa.com

Company Website

https://www.candeltx.com/

View source version on newsdirect.com: https://newsdirect.com/news/candel-therapeutics-nasdaq-cadl-reports-positive-data-from-phase-2-trial-of-can-2409-in-borderline-resectable-pancreatic-cancer-425692953

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ST Chain & WFC Foundation Make Landmark Debut on Nasdaq Tower, Signaling Entry into Global Digital Finance Infrastructure

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New York, March 15, 2026, 09:00 AM (ET) —Amid the morning traffic signals and the rhythm of a city coming to life in Times Square, a new chapter in the evolution of digital finance quietly unfolded. A next-generation infrastructure designed to reshape global value flow stepped onto the world’s financial stage.

ST Chain, in collaboration with the WFC Foundation (Wheat Field Financial Technology Inc.), officially appeared on the Nasdaq Tower in Times Square—widely regarded as the “World’s First Screen” and a symbolic landmark of global capital markets.

As the iconic blue visuals illuminated the entire façade,“ST CHAIN · THE GLOBAL VALUE NETWORK”“WFC FOUNDATION · BUILDING THE INFRASTRUCTURE OF GLOBAL DIGITAL FINANCE”were prominently displayed, marking a symbolic moment for ST Chain’s entry into the mainstream narrative of global finance. The Nasdaq Tower, as one of the most recognized visibility platforms in capital markets, represents a key milestone for projects seeking global positioning.

From Transaction Tool to Global Value Network

Unlike early blockchain projects that focused primarily on digital asset transactions, ST Chain is positioned around a broader ambition: redefining how value flows globally.

As a high-performance public blockchain designed for global settlement and digital financial systems, ST Chain aims to build a decentralized global value network where assets can move freely, settle instantly, and remain under user control.

Its core capabilities include:

Ultra-high throughput at million-level TPS

Millisecond-level transaction confirmation

Extremely low transaction costs

In practical terms, processes that traditionally take days in legacy financial systems can be reduced to near-instant execution.

WFC Foundation: Bridging Compliance and Web3 Infrastructure

In the Web3 landscape, technology drives efficiency—but compliance determines scalability.

ST Chain is backed by the WFC Foundation(Wheat Field Financial Technology Inc.), which operates within a multi-layered U.S. regulatory framework, including SEC filings, MSB registration, and SEC RIA credentials.

This combination reflects a broader strategic intent:

To move Web3 beyond experimentation and into infrastructure capable of integration with global capital systems.

Why Nasdaq? Why Times Square?

Times Square is often referred to as the “Crossroads of the World,” attracting hundreds of thousands of visitors daily and serving as a global hub of commerce and culture. The Nasdaq Tower, in particular, stands as one of its most iconic and influential digital displays.

More than an advertising space, it functions as a modern “signal tower” of global finance.

Appearing on this screen is less about visibility, and more about signaling:

A project’s intention to engage with the global capital ecosystem.

It is not merely a place of high foot traffic—it is a point where capital, media, and global narratives converge.

From this perspective, ST Chain’s appearance can be seen as a public declaration:a transition from the blockchain-native world into the broader global financial system.

From Centralized Settlement to Borderless Value Flow

For decades, global finance has relied on:Multi-layered intermediaries/Cross-border restrictions/Inefficient settlement systems

ST Chain proposes an alternative model:Value moves like information.

Through blockchain infrastructure:

Cross-border payments → executed instantly

Asset transfers → without intermediaries

Transaction records → fully transparent and on-chain

This represents not only a technological upgrade, but a structural shift in how financial systems operate.

An Integrated Ecosystem: Circulation · Settlement · DeFi · DAO

ST Chain is not just a network—it is a comprehensive financial system composed of four core layers:

Real-world circulation — connecting RWA to physical economies

Global settlement network — redefining cross-border capital flow

DeFi ecosystem — enabling transparent and fair on-chain finance

DAO governance — transitioning toward community-driven decision-making

In essence, it seeks to address three fundamental questions of finance:

Where value originates, how it flows, and who governs the system.

New York, 9AM: A Moment Where Value Was Seen

At 9:00 AM in New York, as the city awakened and global financial systems began their daily cycle, the Nasdaq Tower lit up. A reporter delivered a live narration of ST Chain’s core narrative—bringing a Web3-born value network into the heart of traditional finance.

The significance of this moment lies not in the screen itself, but in the convergence it represents:

When a decentralized narrative enters the world’s most concentrated financial arena, it transitions from a digital experiment into a tangible infrastructure for real-world finance.Strictly speaking, the Nasdaq Tower cannot change the world.But it can determine one thing: Who gets seen by the world.

ST Chain and the WFC Foundation’s appearance is not merely about exposure—it signals a deeper shift:the gradual acceptance of a new underlying logic within global financial systems.

If traditional finance is built upon account-based systems,then Web3 is moving toward becoming an operating system for value.

And ST Chain is positioning itself as a foundational component of that system.

Conclusion

This is not just a display.It is a glimpse of a future, brought forward in time.

Media Contact

Organization: Wheat Field Financial Technology Inc.

Contact Person: Robby

Website: https://wfcglobal.com/

Email: Send Email

Contact Number: +17194250874

City: Denver, Colorado

Country:United States

Release id:42790

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Mahadevi Ayahuasca Retreats Introduces Authentic Amazonian Ceremonies and Educational Resources in Colombia

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Colombia, 18th Mar 2026 — Mahadevi Ayahuasca Retreats, a plant medicine retreat center located in the Colombian Amazon near Mocoa, is offering immersive and responsibly guided ayahuasca experiences designed for individuals seeking personal insight, healing, and spiritual exploration. Founded by Yasha Shah, the retreat combines traditional Yagé ceremonies with a rare preparation known as Crudo ayahuasca, creating a carefully structured environment for participants interested in experiencing the medicine with guidance, safety, and respect for Indigenous traditions.

Situated in the lush Putumayo region, Mahadevi Ayahuasca Retreats provides a tranquil natural setting where guests can participate in small group ceremonies while receiving comprehensive preparation and integration support. The retreat aims to create a supportive atmosphere where participants can explore the transformative potential of ayahuasca while being guided through each step of the process.

Ayahuasca, a traditional plant medicine used for centuries by Indigenous communities in the Amazon basin, has gained increasing international attention for its potential role in self-discovery and personal growth. However, with growing global interest has come a wide range of retreat options, making it important for participants to choose programs that emphasize safety, cultural respect, and informed preparation.

Mahadevi Ayahuasca Retreats was founded with the goal of providing a more thoughtful and responsible retreat experience. According to founder Yasha Shah, the focus is not only on the ceremonies themselves but also on proper preparation and integration afterward.

“Our approach is about helping people engage with the experience in a grounded and respectful way,” Shah said. “Preparation, guidance, and integration are just as important as the ceremonies themselves. We want participants to feel supported throughout the entire process.”

One distinctive aspect of the retreat is its use of Crudo ayahuasca, a raw preparation of the medicine that many participants report as being gentler on the body compared to traditional brewed preparations. This variation has attracted individuals who are new to ayahuasca and may be seeking a more accessible introduction to the practice.

Ceremonies are held in small groups to ensure personalized guidance and a calm, focused environment. Participants stay in a premium natural setting near Mocoa, surrounded by the biodiversity and serenity of the Colombian Amazon.

In addition to hosting retreats, Mahadevi Ayahuasca Retreats is also committed to education and responsible awareness about plant medicine. The organization has launched The Ayahuasca Framework, a comprehensive free educational video course designed to provide clear and balanced information about ayahuasca.

The program explores topics such as Indigenous traditions, neuroscience insights related to altered states of consciousness, safety considerations, and practical guidance for those considering attending an ayahuasca retreat. The course aims to help individuals make informed decisions about whether a retreat experience aligns with their personal goals.

“The Ayahuasca Framework was created to provide clarity in a space where information can sometimes be confusing or incomplete,” Shah explained. “We wanted to create a resource that blends Indigenous perspectives with modern scientific understanding while prioritizing safety and responsible engagement.”

Through its ceremonies and educational initiatives, Mahadevi Ayahuasca Retreats seeks to contribute to a more informed and respectful conversation around plant medicine experiences.

As interest in ayahuasca retreats continues to grow worldwide, the organization believes that responsible preparation, transparent education, and culturally respectful practices are essential elements of a meaningful retreat experience.

More information about Mahadevi Ayahuasca Retreats and upcoming programs can be found at https://mahadeviayahuasca.com/. Individuals interested in learning more about ayahuasca preparation and safety can access the free educational course at https://mahadeviayahuasca.com/education/.

About Mahadevi Ayahuasca Retreats

Mahadevi Ayahuasca Retreats is a plant medicine retreat center based in Putumayo, Colombia, near Mocoa. Founded by Yasha Shah, the retreat offers authentic Yagé ceremonies and Crudo ayahuasca experiences within small group settings. The organization emphasizes responsible preparation, integration support, and education through initiatives such as The Ayahuasca Framework, a free course designed to help individuals better understand ayahuasca and make informed decisions about participating in retreats.

Media Contact

Organization: Mahadevi Ayahuasca Retreats

Contact Person: Yasha Shah

Website: https://mahadeviayahuasca.com/

Email: Send Email

Country:Colombia

Release id:42758

Disclaimer: This content is provided for informational and educational purposes only and does not constitute medical, legal, or therapeutic advice. Ayahuasca and related ceremonial practices may be subject to legal restrictions depending on jurisdiction. Individuals should ensure compliance with local laws and consult qualified professionals before participating in any such activities.

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Pac-Man and Lazy Fatalism: Why Global Education’s Acquisition Frenzy Is Colliding With Economic Reality

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As student demand tightens and affordability pressures rise, education strategist warns that scale without discipline may amplify risk rather than reduce it

United States, 18th Mar 2026 — The global education sector is entering a more competitive and economically complex phase as student demand tightens, affordability pressures increase, and capital continues to pursue aggressive expansion across international education markets.

Education strategist Elaina Cohen warns that many institutional growth strategies still reflect assumptions from a previous era—one characterized by expanding student mobility, rising middle classes, and steadily growing enrollment pipelines.

“Institutional brand alone is no longer sufficient,” Cohen said. “The global education market is becoming far more competitive, and strategies built for expansion cycles will not necessarily sustain institutions in the decade ahead.”

Across many developed economies, the number of school-age students is beginning to level off or decline as birth rates fall below replacement levels in numerous countries. While demographic change is only one factor shaping the education market, it is tightening the overall pipeline of potential students.

“We are all fishing in the same pool,” Cohen said. “And the pool is not expanding the way many institutions assumed it would.”

Yet capital continues to move aggressively through the sector.

Cohen argues that the pattern increasingly resembles a Pac-Man dynamic, with institutions rapidly acquiring schools across markets under the assumption that scale itself guarantees stability.

“That mindset can become a form of lazy fatalism,” she said. “It assumes that if you acquire enough schools, demand will somehow materialize.”

“But unlike the arcade game, the board does not refill.”

Demand Is Redistributing Rather Than Expanding

While traditional education markets across Europe, East Asia, and parts of North America face slowing student growth, youth populations are expanding elsewhere.

Sub-Saharan Africa and South Asia—particularly India—are poised to become some of the most significant education growth markets in the coming decades.

According to United Nations population projections, Sub-Saharan Africa’s population could nearly double by 2050, reaching more than 2 billion people. The region already has the youngest population globally, with a median age of roughly 19 years.

Countries including Nigeria, Ethiopia, Kenya, Tanzania, and Ghana are expected to experience substantial youth population growth.

India represents another powerful demographic center of gravity. With more than 250 million people between the ages of 15 and 24, the country holds the largest youth population in the world.

Economic growth is also reshaping these markets. Several African economies—including Rwanda, Kenya, Ghana, and Ethiopia—have recorded GDP growth rates frequently ranging between 5% and 8% annually, while India has maintained growth often exceeding 6% per year in recent years.

These trends are expanding demand for private schooling, international curricula, and global university pathways.

However, Cohen cautions that demographic expansion alone does not guarantee stable education markets.

“Demand ultimately follows purchasing power,” she said. “Population growth without income growth produces a very different market dynamic.”

When Capital Moves Faster Than Affordability

In many emerging markets, international school tuition can exceed several multiples of average household income. As a result, demand is often limited to expatriate communities or a narrow domestic elite.

This creates a structural tension between investor expectations and economic capacity.

“GDP growth headlines can be misleading,” Cohen said. “The real question is how quickly household income and middle-class purchasing power are expanding.”

Without that alignment, institutions expanding rapidly into emerging markets may encounter volatile enrollment cycles and persistent pricing pressure.

“Capital often moves faster than household income,” Cohen said. “When that happens, institutions end up competing for the same small segment of families.”

The Risk of Leap-Frog Investment

As global investors pursue growth opportunities in education, some institutions have adopted what Cohen describes as “leap-frog investment.”

Leap-frog investment occurs when premium schools are built or acquired in anticipation of future wealth expansion before the underlying middle class has fully developed.

“Infrastructure investment is essential,” Cohen said. “But leap-frogging the income curve can create fragile markets.”

If middle-class purchasing power expands more slowly than expected, institutions may face under-enrollment, heavy discounting, or persistent competition for a limited pool of affluent families.

The Limits of Tuition Inflation

For decades, many institutions relied on annual tuition increases as a predictable revenue strategy. In numerous private education markets, tuition has risen five to seven percent year over year for extended periods.

However, that model is becoming increasingly difficult to sustain.

Across many developed economies, household income growth has not kept pace with tuition inflation. In the United States, median household income has grown roughly three to four percent annually over the past decade, while private school and university tuition has often increased at significantly higher rates.

Rising costs for housing, healthcare, childcare, and transportation are also placing increasing pressure on family budgets.

“Tuition increases of seven percent year over year are simply not digestible for many families anymore,” Cohen said. “When pricing consistently outpaces income growth, institutions eventually reach a ceiling.”

Evidence of this pressure is already visible across the sector. Tuition discounting has expanded significantly, with average discount rates at U.S. private colleges now exceeding 50 percent for first-time students, according to enrollment industry reports.

“Increasing sticker price while expanding discounts creates the illusion of growth,” Cohen said. “But in many cases the net yield is deteriorating.”

Structural Misalignment in the Education Economy

What is emerging across global education markets is a growing structural misalignment. Tuition models in many premium institutions were built during decades of demographic expansion and rising middle-class purchasing power. Today, however, student populations are tightening in many developed economies while household income growth has slowed relative to tuition inflation. At the same time, capital continues to pursue expansion strategies through acquisitions and international market entry. The result is an unusual tension: institutions attempting to scale supply while the affordability foundation that once supported demand is becoming less predictable. In economic terms, the education sector is transitioning from a demand-expansion environment to a competition-for-share environment—a shift that requires far greater discipline in pricing, portfolio strategy, and revenue governance.

Capital Markets Are Becoming More Selective

These pressures are increasingly intersecting with capital market expectations.

Investors who once rewarded rapid expansion are now placing greater emphasis on predictable revenue, disciplined pricing strategies, and sustainable margins.

“In expansion periods, demographic growth masked many operational inefficiencies,” Cohen said.

“In tighter markets, those inefficiencies become visible very quickly.”

Revenue Governance Becomes the Strategic Advantage

Cohen has directed multinational revenue systems within education enterprises operating across more than twenty-five countries, overseeing revenue strategy, enrollment operations, marketing, and technology teams.

Her work has included revenue forecasting tied to demographic modeling, pricing architecture redesign, acquisition diligence, and institutional portfolio strategy.

Under tightening conditions she implemented structural changes that reduced tuition discount exposure, improved net tuition yield, rationalized underperforming programs, and converted previously non-performing initiatives into recurring revenue streams.

“These were not simply enrollment gains,” Cohen said. “They were structural protections for long-term financial stability.”

According to Cohen, institutions that succeed in the next phase of global education will treat revenue as a governed system aligned with demographic and economic realities.

“The era of passive enrollment is over,” she said.
“In competitive markets, precision replaces optimism.”

Media Contact

Education Without Borders
info@edwb.org
https://edwb.org

About Elaina Cohen

Elaina Cohen is a global education strategist specializing in enrollment systems, revenue governance, and institutional growth strategy across multinational education enterprises. Her work focuses on aligning demographic trends, economic conditions, and operational strategy to build resilient education institutions in evolving global markets.

 

Media Contact

Organization: Education Without Borders

Contact Person: Elaine Jackson

Website: http://www.edwb.org/

Email: Send Email

Country:United States

Release id:42746

The post Pac-Man and Lazy Fatalism: Why Global Education’s Acquisition Frenzy Is Colliding With Economic Reality appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section

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