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Candel Therapeutics (NASDAQ: CADL) Reports Positive Data From Phase 2 Trial Of CAN-2409 In Borderline Resectable Pancreatic Cancer

Published

1 year ago

on

–News Direct–

By Jeremy Golden, Benzinga

Clinical-stage biopharmaceutical company Candel Therapeutics, Inc. (NASDAQ: CADL) reported updated survival data from its randomized phase 2 clinical trial of CAN-2409 in borderline resectable pancreatic cancer. Pancreatic cancer is the fourth leading cause of cancer-related death in the U.S. The disease accounts for approximately 3% of all cancers, with an estimated 64,050 patients diagnosed in 2023.

The randomized, controlled clinical trial is specifically looking into the safety and efficacy of CAN-2409 plus valacyclovir (prodrug), together with standard of care (SoC) chemoradiation, followed by resection if possible in borderline resectable pancreatic ductal adenocarcinoma (PDAC).

Very encouraging results were recently reported by the Needham, Massachusetts-based company.

Patients reached an estimated median overall survival of 28.8 months after experimental treatment with CAN-2409 versus only 12.5 months in the control group in PDAC. At 24 months, the survival rate was 71.4% in CAN-2409 treated patients compared to only 16.7% in the control group after chemoradiation. Thus, prolonged and sustained survival was observed after experimental treatment with CAN-2409 in patients with borderline resectable PDAC. Importantly, 4 out of 7 patients who received CAN-2409 were still alive at the time of data cut-off, with 2 patients surviving more than 50.0 months from enrollment. Only 1 out of 6 patients in the randomized control SoC chemotherapy group remained alive at the data cut-off (50.6 months).

No new safety signals were observed, providing further support that multiple injections of CAN-2409 are generally well tolerated. Additionally, there were no dose-limiting toxicities or cases of pancreatitis reported.

Previous analysis of resected tumors showed dense aggregates of immune cells including CD8+, cytotoxic tumor-infiltrating lymphocytes and dendritic cells in PDAC tissue after CAN-2409 administration. This reinforces the potential of CAN-2409 to activate a robust antitumoral immune response in patients with cancer also in cold, immunosuppressive tumors like PDAC.

Given the frequent recurrence and short survival with SoC chemotherapy for non-metastatic PDAC, effective new treatment options are urgently needed, said Garrett Nichols, MD, MS, Chief Medical Officer of Candel. We are very encouraged by the improved survival associated with CAN-2409, which has been shown to be durable after prolonged follow-up based on the updated data in this randomized clinical trial. CAN-2409 was generally well tolerated without significant additional local or systemic toxicity when added to SoC chemoradiation.

Candels most advanced viral immunotherapy candidate, CAN-2409, is an investigational off-the-shelf, replication-defective adenovirus designed to induce an individualized, systemic immune response against the tumor. Because of its versatility, CAN-2409 has the potential to treat a broad range of solid tumors. More than 1,000 patients have been dosed with CAN-2409 to date, with a favorable reported tolerability profile and proof of concept in each indication that the company is currently pursuing.

CAN-2409 is injected directly into the tumor or target tissue using a localized injection method that is akin to the standard approach for in situ vaccination to elicit an immune response against the injected tumor and uninjected metastases.

Long-term survival data in PDAC was recently updated with eight months of further follow-up since the first analysis was presented at the 2023 Society for Immunotherapy (SITC) Annual Meeting. Based on the data presented at SITC, the U.S. Food and Drug Administration (FDA) granted Fast Track Designation to Candel Therapeutics for CAN-2409 in combination with valacyclovir for the treatment of patients with PDAC in December 2023. More recently, the FDA also granted Orphan Drug Designation.

The failure of conventional immunotherapy to improve outcomes in pancreatic cancer is attributed to the highly immunosuppressive tumor microenvironment, which is largely devoid of immune cells, said Paul Peter Tak, MD, PhD, FMedSci, President and Chief Executive Officer of Candel. The immunological changes induced by CAN-2409, evident in the pancreatic tissue and the peripheral blood after administration, suggest that CAN-2409 is able to change the balance between the tumor and the patients anti-tumor immune response, which can convert progressive cancer into a chronic disease associated with improved survival.

Featured photo by National Cancer Institute on Unsplash.

Candel is a clinical stage biopharmaceutical company focused on developing off-the-shelf multimodal biological immunotherapies that elicit an individualized, systemic anti-tumor immune response to help patients fight cancer. Candel has established two clinical stage multimodal biological immunotherapy platforms based on novel, genetically modified adenovirus and herpes simplex virus (HSV) gene constructs, respectively. CAN-2409 is the lead product candidate from the adenovirus platform and is currently in ongoing clinical trials in non-small cell lung cancer (NSCLC) (phase 2), borderline resectable pancreatic cancer (phase 2), and localized, non-metastatic prostate cancer (phase 2 and phase 3). CAN-3110 is the lead product candidate from the HSV platform and is currently in an ongoing investigator-sponsored phase 1 clinical trial in recurrent high-grade glioma (HGG). Finally, Candels enLIGHTEN Discovery Platform is a systematic, iterative HSV-based discovery platform leveraging human biology and advanced analytics to create new viral immunotherapies for solid tumors.

This article includes certain disclosures that contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding the timing and advancement of development programs, including the timing and availability of additional data, key data readout milestones, including CAN-3110 in HGG; expectations regarding the potential benefits conferred by Fast Track Designation; expectations regarding the therapeutic benefit of its programs, including the potential for its programs to extend patient survival; and expectations regarding cash runway and expenditures. The words may, will, could, would, should, expect, plan, anticipate, intend, believe, estimate, predict, project, potential, continue, target and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on managements current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, those risks and uncertainties related to the timing and advancement of development programs; expectations regarding the therapeutic benefit of the Companys programs; that final data from our pre-clinical studies and completed clinical trials may differ materially from reported interim data from ongoing studies and trials; the Companys ability to efficiently discover and develop product candidates; the Companys ability to obtain and maintain regulatory approval of product candidates; the Companys ability to maintain its intellectual property; the implementation of the Companys business model, and strategic plans for the Companys business and product candidates, and other risks identified in the Companys SEC filings, including the Companys most recent Quarterly Report on Form 10-Q filed with the SEC, and subsequent filings with the SEC. The Company cautions you not to place undue reliance on any forward-looking statements, which speak only as of the date they are made. The Company disclaims any obligation to publicly update or revise any such statements to reflect any change in expectations or in events, conditions or circumstances on which any such statements may be based, or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements. Any forward-looking statements contained in this press release represent the Companys views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date.

This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice.

Contact Details

Aljanae Reynolds

+1 617-916-5445

areynolds@wheelhouselsa.com

Company Website

https://www.candeltx.com/

View source version on newsdirect.com: https://newsdirect.com/news/candel-therapeutics-nasdaq-cadl-reports-positive-data-from-phase-2-trial-of-can-2409-in-borderline-resectable-pancreatic-cancer-425692953

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Googolplex Smiles Party Billionaires Club Unveils Global Peace and Prosperity Initiative to Launch October 12, 2025

Published

4 hours ago

on

August 3, 2025

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On October 12, 2025, a new global movement led by Dr. Narendra Singh Khurana and the Googolplex Smiles Party Billionaires Club will launch a multi-dimensional initiative to foster ethical entrepreneurship, digital empowerment, and world peace through innovative technologies and service-led economic models.

In an era defined by rapid technological change and widespread social challenges, a groundbreaking international initiative is set to launch on October 12, 2025, under the leadership of Dr. Narendra Singh Khurana. The initiative, developed by the Googolplex Smiles Party Billionaires Club (GSPBC), integrates ethical entrepreneurship, spiritual values, and advanced technologies to empower communities and promote sustainable prosperity worldwide.

Titled the “Googolplex Sikok Eirene Peace Initiative,” this global framework draws upon a diverse set of programs aimed at uniting 200+ countries through blockchain transparency, artificial intelligence, and service-based economies. The launch will coincide with India’s 78th Independence Day celebrations and is being positioned as a milestone in the alignment of innovation with peace and universal purpose.

Central to the initiative is the Googolplex AI PowerBox—an advanced tool suite designed to democratize access to artificial intelligence and digital entrepreneurship. This toolkit is intended to provide users with resources for education, content creation, business development, and personal growth, all within an ethical ecosystem guided by the principles of seva (selfless service).

Complementing the digital infrastructure is the proposed launch of the Googolplex Prayer Bank and Seva Credits platform—a novel spiritual-financial system that rewards positive community contributions and verified acts of service. These credits can be used to access educational tools, health and wellness services, and entrepreneurial resources. The ecosystem seeks to redefine traditional measures of success by introducing Gross Global Good (GGG) as a new index of societal impact.

SIKOK Punjabi – From GSP Wallet to Wealth: Unlocking Global Potential Googolplex AI Powerbox Toolkit

https://www.youtube.com/watch?v=9oGzXGxgNs0&feature=youtu.be

 Justice Khadak Singh Global SIKOK Peace and Business Excellence Award

The Peace and Business Excellence Award 2025  will also be unveiled during the initiative’s global summit in Dubai. This award aims to honour individuals and organisations that demonstrate outstanding contributions to ethical enterprise, inclusive innovation, and cross-cultural peacebuilding. Recognising leadership that integrates spiritual principles with business excellence, the award reflects the broader mission of fostering conscious capitalism.

October 12 holds additional historical and symbolic importance. The date marks Columbus Day in the United States, Día de la Raza in Spanish-speaking countries, and the birthday of Dr. Khurana’s mother—adding personal, cultural, and spiritual resonance to the event. The initiative also draws inspiration from historical peacebuilders such as Guru Ram Das Ji and Mother Teresa, whose legacies underscore the values of compassion, service, and visionary leadership.

Among the ten transformative programs included in the initiative are:

  • The City of Peace Franchise Model: A global rollout of ethically run, spiritually aligned business and wellness hubs supported by AI and blockchain technology.
  • The Googolplex Universal Curriculum (GUC): An innovative education platform blending wisdom, entrepreneurship, and emotional intelligence.
  • SEPC (Sikok Eirene Peace Coin): A blockchain-based digital currency rewarding peacebuilding and community contributions.
  • Googolplex Genius Clubs: Training hubs for future peace leaders and ethical entrepreneurs.
  • Global Wisdom Vault: A decentralized archive to preserve and share sacred knowledge and traditional practices from indigenous and faith-based communities worldwide.

Dr. Khurana’s vision is also closely aligned with international peace movements and the objectives of the United Nations. The initiative includes proposals for AI-led peace councils, youth and elder mediation forums, and decentralised governance structures based on values of transparency, inclusion, and nonviolence.

Another prominent element is the Googolplex Travel for Free Project, which leverages AI optimization, tokenised rewards, and global partnerships to facilitate zero-cost global travel. Designed to promote intercultural exchange and economic accessibility, the program offers members credits redeemable for flights, accommodations, and cultural experiences.

By fostering cross-cultural collaboration, ethical business practices, and grassroots community engagement, the Googolplex initiative seeks to create a new global standard for innovation rooted in compassion and equity. Its long-term goals include the empowerment of 10 million peace entrepreneurs, the recognition of 1,000 ethical billionaires, and the establishment of decentralized City of Peace franchises in every participating nation.

The official unveiling of the initiative is scheduled for October 12, 2025, in Dubai, where global leaders, innovators, spiritual representatives, and peacebuilders will gather at the Googolplex Smiles Global Summit. The event will also serve as the launch platform for several key components, including the Billionaire of Peace Certification Program and the Sikok Meta Tech Gala Dinner.

The movement is supported by a diverse coalition of thinkers, entrepreneurs, and global citizens committed to reimagining prosperity in terms of purpose, transparency, and collective well-being. The initiative’s blueprint presents a vision where technology and spirituality converge to create a world governed not merely by profit, but by peace, progress, and moral integrity.

Contact Information:

Email: 

press@gspbillionaires.club

Sikokmedia@gmail.com  

LinkedIn: Dr. Narendra Singh Khurana

Media Contact:

Company Name: Googolplex Smiles Party Billionaires Club – USA 

Contact: Team Sikok Dubai, India

Email: Sikok@gspbillionaires.club, Sikokmedia@gmail.com

Website: https://www.linkedin.com/in/dr-narendra-pal-singh-khurana-96387a67

Country: United States of America

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Dr. Shreyank Educare Expands Math Tutoring Services in Burnaby with Flexible In-Person and Online Support

Published

7 hours ago

on

August 3, 2025

By

In a move that brings tailored academic support closer to home, Dr. Shreyank Educare has expanded its in-person and online options for students searching for a reliable “math tutor near me.” The center now offers full support for both high school and university-level math, including UBC and Langara courses, all under one roof in Burnaby.

With many students struggling to find qualified math tutors near them who can explain complex concepts clearly, this initiative bridges a critical gap in local education. Dr. Shreyank Educare’s new offerings cater to a wide spectrum of learners—from students tackling Pre-Calculus 11 to those enrolled in UBC’s STAT 200 or MATH 152.

“Students today need targeted, flexible support that fits their course content and exam goals,” said Dr. Shreyank Gupta, the center’s founder. “This is why we created structured programs that go beyond traditional tutoring and focus on real results.”

What’s Included in the Math Tutoring Program?

High school courses: Mathematics 8 and 9, Foundations of Math 10–12, Pre-Calculus 11 & 12

College/university support: Statistics and Linear Algebra, aligned with UBC and Langara curriculums

Test prep: Help with Math Diagnostic Tests (MDTs), Math Proficiency Tests (MPTs), and Basic Skills Tests (BSTs)

Students can choose from:

  • 1-on-1 sessions for personalized instruction and homework help by qualified math tutor in Burnaby
  • A Drop-In Program for quick, focused tutoring when needed
  • A Tutor on Call service for immediate access to expert help—perfect for busy schedules or late-night studying

This flexible format is ideal for students across Burnaby and other cities looking for a reliable online math tutor. Learners outside Burnaby can benefit from the same quality instruction via virtual sessions that mirror the in-person experience.

Enrollment Now Open

The program is currently accepting new students. To learn more or schedule a consultation, visit www.drshreyankeducare.com or call +1 672-514-7587. In-person sessions are held at the learning centre on 2088 Madison Avenue, Burnaby, with online options available across Canada.

About Dr. Shreyank Educare:

Founded by Dr. Shreyank Gupta (PhD), Dr. Shreyank Educare is a student-focused academic center offering tutoring in mathematics, science, finance, computer programming, and test preparation. With a mix of in-person and online tutoring in Canada, the center empowers students from high school to university with personalized, expert-led support that drives real academic progress.

 

 

Media Contact:

Email: info@drshreyankeducare.com

Phone: +1 672-514-7587

Website: https://drshreyankeducare.com/

Person Contact Name : DR Shreyank Gupta

Location City State: Burnaby

Company Name: Dr. Shreyank Educare

 

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Press Release

Covert Currency Launched: Pepe Dollar ($PEPD) Mobilizes for Meme-Based Economic Rebellion

Published

8 hours ago

on

August 3, 2025

By

 

 

 

In a world awash with fiat instability and centralized financial control, a new digital currency has emerged not just as a joke, but as a layered social commentary: Pepe Dollar ($PEPD). This tongue-in-cheek financial revolution is now live with its presale and invites meme lovers, digital rebels, and decentralized dreamers to join its movement.

Website: https://pepedollar.io

DApp Platform: https://app.pepedollar.io

Telegram Community: https://t.me/pepedollarcommunity

Pepe Dollar News: https://coinmarketcap.com/currencies/pepe-dollar/

The Meme Economy’s Weapon of Choice

Pepe Dollar is no ordinary meme coin. It’s a Layer-2 payment infrastructure built specifically for the meme economy, engineered to empower users with real, usable value amid the chaos of valueless fiat currencies. With a fixed max supply of 3.695 billion tokens, a satirical nod to the $36.95 trillion U.S. national debt, $PEPD is a direct critique of inflationary practices and centralized monetary policies.

But satire aside, the project is technologically serious.

“Pepe Dollar is a punchline, but also a platform,” says the development team. “It’s for everyone tired of being rugged, restricted, and regulated by outdated systems.”

A Decentralized Joke with Real Purpose

Built on Ethereum with cross-chain compatibility planned for Arbitrum, Polygon, Optimism, and BNB Chain, Pepe Dollar is pushing the boundaries of what meme coins can represent. Its backbone lies in the PepeDollar.fun platform, a no-code, decentralized environment where anyone can launch meme tokens with transparency and community-first economics.

Using smart contract automation and a mandatory bonding curve, the platform minimizes price manipulation and pump-and-dump risk. Each project launched via Pepedollar.fun comes with:

  • A tokenomics dashboard for real-time transparency
  • Locked liquidity features
  • Developer wallet tracking
  • A built-in community chat
  • A creator bio section
  • A meme gallery

This isn’t your average meme coin playground, this is meme capitalism with ethics.

Accessible for All, Built for the Future

PepeDollar.fun democratizes token creation. No coding skills? No problem. Users can mint coins effortlessly while the system handles everything from deployment to exchange integration.

It’s a hub for creators, communities, and culture. The development roadmap includes:

  • Cross-chain deployments
  • Governance mechanisms
  • Creator verification system
  • NFT integrations for meme branding

“We’re building the infrastructure for meme economies of the future,” the developers emphasize. “If fiat fails the people, memes will fund the resistance.”

The $PEPD Token: Currency of Culture

$PEPD is more than a meme coin; it’s the native token powering the entire Pepedollar.fun ecosystem. Whether it’s used to pay minting fees, unlock platform features, or reward community members, $PEPD is the financial fuel for this cultural economy.

Key token utilities include:

  • Minting and launching meme tokens
  • Access to premium features on Pepedollar.fun
  • Staking and liquidity rewards
  • Governance and voting rights for platform evolution

Join the Rebellion: Presale Now Live

The presale of $PEPD is your chance to be part of a movement before it goes viral. The team is offering exclusive early access with bonuses for early supporters. As the community grows, $PEPD aims to become the most recognized and respected meme coin infrastructure token on the market.

Website: https://pepedollar.io

dApp (Mint Platform): https://app.pepedollar.io

Telegram Community: https://t.me/pepedollarcommunity

Pepe Dollar News: https://coinmarketcap.com/currencies/pepe-dollar/

About Pepe Dollar

Pepe Dollar ($PEPD) is a decentralized digital asset designed as both satire and solution, a humorous yet functional take on fiat money. Created for the meme economy, $PEPD enables users to create, fund, and manage decentralized meme coins using intuitive tools and fair pricing models. With community at its core and innovation in its DNA, Pepe Dollar is pioneering a new era where memes meet money, and every token tells a story.

For Media Inquiries or Collaborations:

Email: Info@pepedollar.io

TG: https://t.me/pepedollarcommunity

 X: https://x.com/PepeDollarETH

Company Name: Pepe Dollar Labs

Contact Name: Community Media Team

Website: https://pepedollar.io

country: Ajeltake, Marshall Islands

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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.

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