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Candel Therapeutics (NASDAQ: CADL) Reports Positive Data From Phase 2 Trial Of CAN-2409 In Borderline Resectable Pancreatic Cancer

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–News Direct–

By Jeremy Golden, Benzinga

Clinical-stage biopharmaceutical company Candel Therapeutics, Inc. (NASDAQ: CADL) reported updated survival data from its randomized phase 2 clinical trial of CAN-2409 in borderline resectable pancreatic cancer. Pancreatic cancer is the fourth leading cause of cancer-related death in the U.S. The disease accounts for approximately 3% of all cancers, with an estimated 64,050 patients diagnosed in 2023.

The randomized, controlled clinical trial is specifically looking into the safety and efficacy of CAN-2409 plus valacyclovir (prodrug), together with standard of care (SoC) chemoradiation, followed by resection if possible in borderline resectable pancreatic ductal adenocarcinoma (PDAC).

Very encouraging results were recently reported by the Needham, Massachusetts-based company.

Patients reached an estimated median overall survival of 28.8 months after experimental treatment with CAN-2409 versus only 12.5 months in the control group in PDAC. At 24 months, the survival rate was 71.4% in CAN-2409 treated patients compared to only 16.7% in the control group after chemoradiation. Thus, prolonged and sustained survival was observed after experimental treatment with CAN-2409 in patients with borderline resectable PDAC. Importantly, 4 out of 7 patients who received CAN-2409 were still alive at the time of data cut-off, with 2 patients surviving more than 50.0 months from enrollment. Only 1 out of 6 patients in the randomized control SoC chemotherapy group remained alive at the data cut-off (50.6 months).

No new safety signals were observed, providing further support that multiple injections of CAN-2409 are generally well tolerated. Additionally, there were no dose-limiting toxicities or cases of pancreatitis reported.

Previous analysis of resected tumors showed dense aggregates of immune cells including CD8+, cytotoxic tumor-infiltrating lymphocytes and dendritic cells in PDAC tissue after CAN-2409 administration. This reinforces the potential of CAN-2409 to activate a robust antitumoral immune response in patients with cancer also in cold, immunosuppressive tumors like PDAC.

Given the frequent recurrence and short survival with SoC chemotherapy for non-metastatic PDAC, effective new treatment options are urgently needed, said Garrett Nichols, MD, MS, Chief Medical Officer of Candel. We are very encouraged by the improved survival associated with CAN-2409, which has been shown to be durable after prolonged follow-up based on the updated data in this randomized clinical trial. CAN-2409 was generally well tolerated without significant additional local or systemic toxicity when added to SoC chemoradiation.

Candels most advanced viral immunotherapy candidate, CAN-2409, is an investigational off-the-shelf, replication-defective adenovirus designed to induce an individualized, systemic immune response against the tumor. Because of its versatility, CAN-2409 has the potential to treat a broad range of solid tumors. More than 1,000 patients have been dosed with CAN-2409 to date, with a favorable reported tolerability profile and proof of concept in each indication that the company is currently pursuing.

CAN-2409 is injected directly into the tumor or target tissue using a localized injection method that is akin to the standard approach for in situ vaccination to elicit an immune response against the injected tumor and uninjected metastases.

Long-term survival data in PDAC was recently updated with eight months of further follow-up since the first analysis was presented at the 2023 Society for Immunotherapy (SITC) Annual Meeting. Based on the data presented at SITC, the U.S. Food and Drug Administration (FDA) granted Fast Track Designation to Candel Therapeutics for CAN-2409 in combination with valacyclovir for the treatment of patients with PDAC in December 2023. More recently, the FDA also granted Orphan Drug Designation.

The failure of conventional immunotherapy to improve outcomes in pancreatic cancer is attributed to the highly immunosuppressive tumor microenvironment, which is largely devoid of immune cells, said Paul Peter Tak, MD, PhD, FMedSci, President and Chief Executive Officer of Candel. The immunological changes induced by CAN-2409, evident in the pancreatic tissue and the peripheral blood after administration, suggest that CAN-2409 is able to change the balance between the tumor and the patients anti-tumor immune response, which can convert progressive cancer into a chronic disease associated with improved survival.

Featured photo by National Cancer Institute on Unsplash.

Candel is a clinical stage biopharmaceutical company focused on developing off-the-shelf multimodal biological immunotherapies that elicit an individualized, systemic anti-tumor immune response to help patients fight cancer. Candel has established two clinical stage multimodal biological immunotherapy platforms based on novel, genetically modified adenovirus and herpes simplex virus (HSV) gene constructs, respectively. CAN-2409 is the lead product candidate from the adenovirus platform and is currently in ongoing clinical trials in non-small cell lung cancer (NSCLC) (phase 2), borderline resectable pancreatic cancer (phase 2), and localized, non-metastatic prostate cancer (phase 2 and phase 3). CAN-3110 is the lead product candidate from the HSV platform and is currently in an ongoing investigator-sponsored phase 1 clinical trial in recurrent high-grade glioma (HGG). Finally, Candels enLIGHTEN Discovery Platform is a systematic, iterative HSV-based discovery platform leveraging human biology and advanced analytics to create new viral immunotherapies for solid tumors.

This article includes certain disclosures that contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding the timing and advancement of development programs, including the timing and availability of additional data, key data readout milestones, including CAN-3110 in HGG; expectations regarding the potential benefits conferred by Fast Track Designation; expectations regarding the therapeutic benefit of its programs, including the potential for its programs to extend patient survival; and expectations regarding cash runway and expenditures. The words may, will, could, would, should, expect, plan, anticipate, intend, believe, estimate, predict, project, potential, continue, target and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on managements current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, those risks and uncertainties related to the timing and advancement of development programs; expectations regarding the therapeutic benefit of the Companys programs; that final data from our pre-clinical studies and completed clinical trials may differ materially from reported interim data from ongoing studies and trials; the Companys ability to efficiently discover and develop product candidates; the Companys ability to obtain and maintain regulatory approval of product candidates; the Companys ability to maintain its intellectual property; the implementation of the Companys business model, and strategic plans for the Companys business and product candidates, and other risks identified in the Companys SEC filings, including the Companys most recent Quarterly Report on Form 10-Q filed with the SEC, and subsequent filings with the SEC. The Company cautions you not to place undue reliance on any forward-looking statements, which speak only as of the date they are made. The Company disclaims any obligation to publicly update or revise any such statements to reflect any change in expectations or in events, conditions or circumstances on which any such statements may be based, or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements. Any forward-looking statements contained in this press release represent the Companys views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date.

This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice.

Contact Details

Aljanae Reynolds

+1 617-916-5445

areynolds@wheelhouselsa.com

Company Website

https://www.candeltx.com/

View source version on newsdirect.com: https://newsdirect.com/news/candel-therapeutics-nasdaq-cadl-reports-positive-data-from-phase-2-trial-of-can-2409-in-borderline-resectable-pancreatic-cancer-425692953

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Dolly Varden Silver Confirms High-grade Gold System at Homestake Ridge

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Dolly Varden Silver reported a significant gold intercept from a step-out drill hole at the Homestake Silver deposit. The hole is a 45-meter step-out along strike from hole HR24-433 and 30 meters up dip from hole HR24-451

Canada, 7th Oct 2025 – Global Stocks News – Sponsored content disseminated on behalf of Dolly Varden Silver. On October 1, 2025 Dolly Varden Silver (TSXV: DV) (NYSE American: DVS) (FSE: DVQ) reported a significant gold intercept from a step-out drill hole at the Homestake Silver deposit.

Hole HR25-456 intersected 3.34 g/t Au over 120 meters, including 216 g/t Au over 0.52 meters and 166 g/t Au over 1.3 meters.

The hole is a 45-meter step-out along strike from hole HR24-433 and 30 meters up dip from hole HR24-451

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“These gold results from a step-out hole at the Homestake Silver Deposit confirm that the deposit continues to grow beyond the current mineral resource estimate,” stated Shawn Khunkhun, CEO of Dolly Varden Silver in the October 1, 2025 press release.

“These results demonstrate the strength of the high-grade gold system, potentially a separate and overlapping event from high-grade silver mineralization at the deposit; this deposit is potentially a key driver of future project development,” added Khunkhun.

“We have two lenses that are close to each other,” Rob van Egmond, VP of Exploration, told Guy Bennett, the CEO of Global Stocks News (GSN). “The second phase could overlap the silver-rich mineralization, or it could be a separate lens.”

“Any time you have overlapping events or long-lived fluid conduits, it indicates some of the precious metals may have been deposited during the Jurassic age [160 million years ago], while a second mineralizing event may have occurred in the Eocene age [40 million years ago]”.

“This duo-timeline mineralisation is one deposit is a known characteristic of the Golden Triangle. One of our neighbours has been age-dating their assays, confirming the presence of an Eocene age mineralised system.” 

“When you find a regional corridor where Jurassic mineralization has been overprinted by Eocene mineralisation,” added van Egmond, “typically the grade is augmented in that structure. Hole HR25-456 had large flakes of visible gold.”

 

 

“When we purchased this asset,” van Egmond told GSN. “Homestake Silver had a higher ratio of silver to gold than Homestake Main. But we’re thinking about changing the name, because at investor conferences Shawn and I have to explain that Homestake Silver is now primarily a gold deposit.”

“Geologists are always working to either prove or disprove a model,” said van Egmond. “You collect data, assess it, and make modifications to the model as necessary. Hole HR25-456 is adding confidence to the current model.” 

Five diamond drills are nearing completion of the 2025 drill program across the Kitsault Valley and Big Bulk Projects. At Homestake Silver, drilling has focused on expanding and infilling areas of high-grade gold mineralisation

DV is also testing outside the current resource. Additional results from the Homestake Silver gold zone, Wolf Vein silver mineralization extension, Big Bulk copper-gold porphyry system, as well as other exploration targets, will be reported as assays are received.

DV Silver is using directional drilling technology to precisely target areas for step-out and infill holes at Homestake Silver.

“Directional drilling allows you to position the drill bit exactly where you want it to be, without re-drilling hundreds of meters from the surface,” van Egmond told GSN. “It’s an ideal technique for us to explore Homestake Silver.”

This animated video by Horizontal Technology gives a technical overview of directional drilling.

“A skilled driller can direct the course of the drill bit along a pre-planned path over great distances,” confirms Horizontal Technology.

HR25-456 is one of three holes drilled from the same pad, designed to extend the wide, high-grade plunging zone and test outside the current mineral resource model. The drill hole is approximately a 45-meter step-out along strike from previous intersects.

Approximately 40% of the 2025 season’s 55,000-meter planned drill program at DV’s 100% owned Kitsault Valley Silver and Gold Project targeted the Homestake Silver Deposit to expand and infill zones of high-grade gold mineralization.

The deposit remains open for expansion, with gold mineralization vectoring to the Homestake Main Deposit, along strike to the north of the Homestake Silver Deposit.

On October 01, 2025 Dolly Varden Silver announced a $30 Million Bought-Deal Financing featuring 2,300,000 @ $6.50/share; 750,000 flow-through shares @ $9.42/share and 990,000 flow-through shares at $8.10 per share.

Flow-through shares enable public companies to transfer exploration expenditures to investors who can take advantage of the corresponding tax incentives, thereby ‘flowing their benefits through’ to the shareholder,” writes CG Wealth Management.

“Investors in a high tax bracket can use the tax credits from flow-through investments to bring down their personal tax owing,” added CG Wealth.

Pursuant to existing agreements, Hecla Canada and Fury Gold Mines will be entitled to acquire shares @ $6.50/share to maintain their respective pro rata equity interests in DV Silver.

DV’s metal inventory value is now approximately a 50/50 split between silver and gold.

“With gold selling for CND $5,400/ounce,” van Egmond told GSN, “our team is encouraged to hit 120 meters of 3.34 g/t gold.”

Rob van Egmond, P.Geo., Vice-President Exploration for Dolly Varden Silver, the “Qualified Person” as defined by NI43-101, has reviewed, validated and approved the scientific and technical information contained in this GSN release.

Disclaimer: Dolly Varden Silver paid GSN $1,750 for the research, creation and dissemination of this content.

Contact: guy.bennett@globalstocksnews.com

Full Disclaimer: Global Stocks News (GSN) researches and fact-checks diligently, but we cannot ensure our publications are free from error. Investing in publicly traded stocks is speculative and carries a high degree of risk. GSN makes no recommendation to purchase any individual stock. When compensation has been paid to GSN, the amount and nature of the compensation will be disclosed clearly. GSN publications may contain forward-looking statements such as “project,” “anticipate,” “expect,” which are based on reasonable expectations, but these statements are imperfect predictors of future events. When compensation has been paid to GSN, the amount and nature of the compensation will be disclosed clearly.

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Contact Person: guy.bennett@globalstocksnews.com

Website: https://www.globalstocksnews.com

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Matt Egyhazy on AI: The Future of Banking is Hyper-Personalized, Not Just Automated

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New York, USA, 7th October 2025, ZEX PR WIRE, In an era where digital transformation is reshaping industries, the financial services sector stands at a critical juncture. The conversation around artificial intelligence has often been dominated by its potential for automation, process optimization, and cost reduction. While these benefits are significant, Matt Egyhazy argues that this view is far too narrow. He posits that the true, transformative power of AI lies not in replacing human functions, but in profoundly enhancing them to deliver an unprecedented level of client personalization.

According to Matt Egyhazy, the ultimate goal of implementing AI should be to move banking from a transactional model to a deeply relational one. The future, he suggests, is not a world of automated, impersonal interactions. Instead, it is a future where technology empowers financial institutions to understand and anticipate the unique needs of each client, offering tailored advice, products, and support throughout their financial lives. This vision re-frames AI as the engine for hyper-personalization, a tool for building stronger, more meaningful, and more resilient client partnerships.

Redefining the Role of AI in Financial Services

For too long, the narrative has positioned AI as a tool for internal optimization. The metrics for success were often inwardly focused: reduced headcount, faster processing times, and lower operational costs. Egyhazy advocates for a fundamental shift in this perspective. The focus must turn outward, toward the client experience. The new key performance indicators should be client satisfaction, financial wellness, and long term loyalty.

This approach requires thinking of AI less like a factory assembly line, designed for uniform efficiency, and more like a master craftsman’s toolkit, capable of creating something unique for each individual. It is about using intelligent systems to understand the nuanced context of a client’s life or a business’s operational cycle.

“We must see AI as a catalyst for empathy at scale,” says Egyhazy. “The technology allows us to listen more intently to the signals our clients are giving us through their financial activities. When we harness that understanding, we can move from being reactive service providers to proactive, trusted advisors. The goal is not just to make banking faster; it is to make banking smarter, more intuitive, and more aligned with the individual aspirations of our clients.”

The Mechanics of Hyper-Personalization

Achieving this vision of hyper-personalization is a complex undertaking, built on a foundation of robust, secure, and ethically managed data. AI algorithms can analyze vast and diverse datasets far beyond human capacity, identifying patterns, predicting future needs, and flagging opportunities that might otherwise go unnoticed.

This capability translates into tangible, real world applications. For a small business owner, it could mean an AI powered system that analyzes cash flow patterns and proactively suggests a more flexible line of credit before a seasonal downturn. This prevents a potential crisis and demonstrates a deep understanding of the business’s unique rhythm.

In wealth management, it could be a platform that adjusts investment recommendations in real time, not just based on market fluctuations, but also on subtle shifts in a client’s life goals, which are inferred from their changing financial behavior. For a commercial banking client, an AI might alert a relationship manager that a company is expanding into a new international market, providing the manager with the perfect opportunity to offer tailored trade finance and foreign exchange services.

“This is about connecting the dots in a client’s financial story,” Egyhazy explains. “Predictive analytics allows us to anticipate the next chapter in that story. We can be ready with the right advice or the right product at the exact moment it becomes relevant. That is a profoundly different and more valuable interaction than simply waiting for a client to come to us with a request.”

Balancing Technology with the Human Touch

A common fear is that the rise of AI will render the human element in banking obsolete. Matt Egyhazy strongly contests this view, arguing that AI’s true value is realized when it augments, rather than replaces, human expertise. The technology should be seen as a powerful co-pilot for financial professionals.

By automating routine and data intensive tasks, AI can liberate relationship managers, financial advisors, and other specialists to focus on what they do best: building trust, providing nuanced strategic advice, and navigating complex, emotionally charged financial decisions with clients. AI can provide the data driven insights, but it is the human professional who provides the wisdom, empathy, and contextual understanding to apply those insights effectively.

“Imagine a relationship manager who is freed from hours of manual data analysis,” says Egyhazy. “Instead, they walk into a client meeting armed with a set of AI generated insights about that client’s emerging needs and potential risks. The conversation is immediately more strategic, more forward looking, and more valuable. The technology does not replace the relationship; it powers it.”

Navigating the Ethical and Practical Challenges

This forward-thinking vision is not without its challenges. The ethical implications of using client data are paramount. Egyhazy stresses that any AI-driven initiative must be built on a bedrock of trust, which requires an unwavering commitment to data privacy, security, and transparency. Clients must have confidence that their information is protected and used responsibly to their benefit.

Furthermore, the “black box” problem, where AI decision making processes are opaque, must be actively avoided. Financial institutions have a responsibility to ensure their AI models are explainable, fair, and free from bias. There is also the significant technical hurdle of integrating sophisticated AI platforms with existing legacy banking systems and the critical need to upskill the workforce to collaborate effectively with these new intelligent tools.

“We must innovate at the speed of trust,” Egyhazy notes. “Progress cannot come at the expense of our fundamental obligations to our clients and our communities. Responsible innovation means being transparent, ethical, and deliberate in how we deploy these powerful technologies.”

A Vision for the Future of Banking

Ultimately, Egyhazy’s vision is for a banking ecosystem that is more responsive, more intelligent, and more human. It is a future where a client’s interaction with their bank feels less like a series of isolated transactions and more like a continuous, supportive partnership.

This future is one where technology and humanity work in concert to help individuals, families, and businesses achieve their financial goals. By focusing AI on hyper-personalization, the banking industry has an opportunity to redefine its value proposition, fostering a new generation of client loyalty built on genuine understanding and proactive support.

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Matt Egyhazy

Orchard Park, New York, USA

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Cheap Airport Transfers: Travelers Get New Choices with Global Airport Taxi

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For international and domestic travelers, finding reliable and affordable airport transportation has always been a challenge. Today, with the launch of Global Airport Taxi, passengers worldwide now have access to cheap airport transfers, budget-friendly cabs, and premium taxi services—all within a single online booking platform.

The platform, designed for both leisure and business travelers, is transforming how people experience airport transfers. With a strong focus on low-cost pricing, safety, and convenience, Global Airport Taxi ensures that no passenger has to compromise quality for affordability.

Why Affordable Airport Transfers Matter

Travelers are becoming increasingly conscious of travel costs. Rising airfares, higher baggage fees, and fluctuating hotel rates have made affordability a priority. At the same time, passengers don’t want to sacrifice comfort and reliability when arranging airport taxis.

Global Airport Taxi bridges this gap by offering cheap airport transfers without hidden costs. From solo travelers on tight budgets to large groups seeking cost-effective minibuses or coaches, the platform covers every need.

Unlike ride-hailing apps with unpredictable surge pricing, Global Airport Taxi guarantees fixed fares, giving passengers full control over travel expenses.

Key Features of Global Airport Taxi

  1. Transparent and Low-Cost Pricing
    Passengers can see upfront rates with no hidden fees. Whether you’re booking a cheap cab to Heathrow, a minibus in Dubai, or an executive car in New York, the price remains transparent and locked in at the time of booking.

  2. Worldwide Coverage
    Operating in 150+ countries, Global Airport Taxi provides seamless airport transfers across Europe, North America, Asia, the Middle East, and beyond. Whether you land at London Heathrow, Paris Charles de Gaulle, JFK New York, or Dubai International, a reliable transfer is just a click away.

  3. Fleet Variety for All Budgets

  • Saloon cars – ideal for budget-conscious individuals and couples.

  • Estate cars & MPVs – for families needing extra luggage space.

  • Minibuses and coaches – affordable group travel for schools, sports teams, or corporate events.

  • Executive cars – premium yet cost-effective options for business travelers.

  1. Flight Tracking & Meet and Greet
    Drivers monitor real-time flight data to ensure on-time pickups, even if your flight is delayed. Meet-and-greet services are available for stress-free arrivals.

  2. Safety and Professionalism
    Every driver is licensed, insured, and vetted, ensuring passenger safety and peace of mind. Vehicles are modern, clean, and well-maintained.

  3. Eco-Friendly Options
    Travelers can also opt for electric or hybrid airport taxis, combining affordability with sustainability.

Meeting the Needs of Today’s Travelers

The demand for cheap airport transfers isn’t just about saving money—it’s about value. Travelers today want:

  • Convenience – easy online booking from mobile or desktop.

  • Flexibility – vehicles to match different passenger and luggage needs.

  • Assurance – knowing their driver is professional and punctual.

  • Support – 24/7 customer care for last-minute changes or emergencies.

Global Airport Taxi is built with these priorities in mind. The platform is user-friendly, multilingual, and accessible worldwide, ensuring smooth booking whether you are in London, Dubai, Toronto, or Karachi.

Quote from the Company

“We understand that travelers today demand both affordability and reliability. Global Airport Taxi is committed to offering cheap airport transfers without compromise—whether you need a cab, minibus, or luxury car, you’ll find a trusted option at a fair price. Our vision is to make airport transfers simple, transparent, and globally connected,” said Qazi Mumtaz Hussain spokesperson for Global Airport Taxi.

The Growing Market for Cheap Airport Transfers

The global airport transfer market is growing rapidly, with millions of passengers relying on taxis, cabs, and shuttles every day. However, most travelers face two challenges: either paying high prices for premium transfers or risking unreliable budget cabs.

Global Airport Taxi addresses both problems by combining affordability, professionalism, and international reach. With fixed pricing, multiple vehicle options, and trusted drivers, the service ensures that passengers no longer have to choose between cheap and reliable—they can have both.

About Global Airport Taxi

Global Airport Taxi is a worldwide airport transfer marketplace that connects travelers with licensed, professional taxi and cab operators across 150+ countries. From saloon cars to minibuses and executive vehicles, the platform offers affordable, transparent, and reliable airport transfers with instant online booking.

Travelers can enjoy fixed fares, professional drivers, 24/7 support, and a choice of vehicles to suit all budgets. Whether it’s a quick cab ride, a cheap airport shuttle, or a premium chauffeur-driven transfer, Global Airport Taxi makes every journey smooth and cost-effective.

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