Press Release
Candel Therapeutics (NASDAQ: CADL) Reports Positive Data From Phase 2 Trial Of CAN-2409 In Borderline Resectable Pancreatic Cancer
–News Direct–
By Jeremy Golden, Benzinga
Clinical-stage biopharmaceutical company Candel Therapeutics, Inc. (NASDAQ: CADL) reported updated survival data from its randomized phase 2 clinical trial of CAN-2409 in borderline resectable pancreatic cancer. Pancreatic cancer is the fourth leading cause of cancer-related death in the U.S. The disease accounts for approximately 3% of all cancers, with an estimated 64,050 patients diagnosed in 2023.
The randomized, controlled clinical trial is specifically looking into the safety and efficacy of CAN-2409 plus valacyclovir (prodrug), together with standard of care (SoC) chemoradiation, followed by resection if possible in borderline resectable pancreatic ductal adenocarcinoma (PDAC).
Very encouraging results were recently reported by the Needham, Massachusetts-based company.
Patients reached an estimated median overall survival of 28.8 months after experimental treatment with CAN-2409 versus only 12.5 months in the control group in PDAC. At 24 months, the survival rate was 71.4% in CAN-2409 treated patients compared to only 16.7% in the control group after chemoradiation. Thus, prolonged and sustained survival was observed after experimental treatment with CAN-2409 in patients with borderline resectable PDAC. Importantly, 4 out of 7 patients who received CAN-2409 were still alive at the time of data cut-off, with 2 patients surviving more than 50.0 months from enrollment. Only 1 out of 6 patients in the randomized control SoC chemotherapy group remained alive at the data cut-off (50.6 months).
No new safety signals were observed, providing further support that multiple injections of CAN-2409 are generally well tolerated. Additionally, there were no dose-limiting toxicities or cases of pancreatitis reported.
Previous analysis of resected tumors showed dense aggregates of immune cells including CD8+, cytotoxic tumor-infiltrating lymphocytes and dendritic cells in PDAC tissue after CAN-2409 administration. This reinforces the potential of CAN-2409 to activate a robust antitumoral immune response in patients with cancer also in cold, immunosuppressive tumors like PDAC.
Given the frequent recurrence and short survival with SoC chemotherapy for non-metastatic PDAC, effective new treatment options are urgently needed, said Garrett Nichols, MD, MS, Chief Medical Officer of Candel. We are very encouraged by the improved survival associated with CAN-2409, which has been shown to be durable after prolonged follow-up based on the updated data in this randomized clinical trial. CAN-2409 was generally well tolerated without significant additional local or systemic toxicity when added to SoC chemoradiation.
Candels most advanced viral immunotherapy candidate, CAN-2409, is an investigational off-the-shelf, replication-defective adenovirus designed to induce an individualized, systemic immune response against the tumor. Because of its versatility, CAN-2409 has the potential to treat a broad range of solid tumors. More than 1,000 patients have been dosed with CAN-2409 to date, with a favorable reported tolerability profile and proof of concept in each indication that the company is currently pursuing.
CAN-2409 is injected directly into the tumor or target tissue using a localized injection method that is akin to the standard approach for in situ vaccination to elicit an immune response against the injected tumor and uninjected metastases.
Long-term survival data in PDAC was recently updated with eight months of further follow-up since the first analysis was presented at the 2023 Society for Immunotherapy (SITC) Annual Meeting. Based on the data presented at SITC, the U.S. Food and Drug Administration (FDA) granted Fast Track Designation to Candel Therapeutics for CAN-2409 in combination with valacyclovir for the treatment of patients with PDAC in December 2023. More recently, the FDA also granted Orphan Drug Designation.
The failure of conventional immunotherapy to improve outcomes in pancreatic cancer is attributed to the highly immunosuppressive tumor microenvironment, which is largely devoid of immune cells, said Paul Peter Tak, MD, PhD, FMedSci, President and Chief Executive Officer of Candel. The immunological changes induced by CAN-2409, evident in the pancreatic tissue and the peripheral blood after administration, suggest that CAN-2409 is able to change the balance between the tumor and the patients anti-tumor immune response, which can convert progressive cancer into a chronic disease associated with improved survival.
Featured photo by National Cancer Institute on Unsplash.
Candel is a clinical stage biopharmaceutical company focused on developing off-the-shelf multimodal biological immunotherapies that elicit an individualized, systemic anti-tumor immune response to help patients fight cancer. Candel has established two clinical stage multimodal biological immunotherapy platforms based on novel, genetically modified adenovirus and herpes simplex virus (HSV) gene constructs, respectively. CAN-2409 is the lead product candidate from the adenovirus platform and is currently in ongoing clinical trials in non-small cell lung cancer (NSCLC) (phase 2), borderline resectable pancreatic cancer (phase 2), and localized, non-metastatic prostate cancer (phase 2 and phase 3). CAN-3110 is the lead product candidate from the HSV platform and is currently in an ongoing investigator-sponsored phase 1 clinical trial in recurrent high-grade glioma (HGG). Finally, Candels enLIGHTEN Discovery Platform is a systematic, iterative HSV-based discovery platform leveraging human biology and advanced analytics to create new viral immunotherapies for solid tumors.
This article includes certain disclosures that contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding the timing and advancement of development programs, including the timing and availability of additional data, key data readout milestones, including CAN-3110 in HGG; expectations regarding the potential benefits conferred by Fast Track Designation; expectations regarding the therapeutic benefit of its programs, including the potential for its programs to extend patient survival; and expectations regarding cash runway and expenditures. The words may, will, could, would, should, expect, plan, anticipate, intend, believe, estimate, predict, project, potential, continue, target and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on managements current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, those risks and uncertainties related to the timing and advancement of development programs; expectations regarding the therapeutic benefit of the Companys programs; that final data from our pre-clinical studies and completed clinical trials may differ materially from reported interim data from ongoing studies and trials; the Companys ability to efficiently discover and develop product candidates; the Companys ability to obtain and maintain regulatory approval of product candidates; the Companys ability to maintain its intellectual property; the implementation of the Companys business model, and strategic plans for the Companys business and product candidates, and other risks identified in the Companys SEC filings, including the Companys most recent Quarterly Report on Form 10-Q filed with the SEC, and subsequent filings with the SEC. The Company cautions you not to place undue reliance on any forward-looking statements, which speak only as of the date they are made. The Company disclaims any obligation to publicly update or revise any such statements to reflect any change in expectations or in events, conditions or circumstances on which any such statements may be based, or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements. Any forward-looking statements contained in this press release represent the Companys views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date.
This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice.
Contact Details
Aljanae Reynolds
+1 617-916-5445
Company Website
View source version on newsdirect.com: https://newsdirect.com/news/candel-therapeutics-nasdaq-cadl-reports-positive-data-from-phase-2-trial-of-can-2409-in-borderline-resectable-pancreatic-cancer-425692953
Candel Therapeutics
COMTEX_453283087/2655/2024-06-03T08:31:08
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Bulgarian tour operator Belprego Travel has announced its own charter programs to Doha, Qatar, for the New Year 2026, Valentine’s Day, and spring, featuring direct flights from Sofia and accommodation in five-star hotels.
Sofia, Bulgaria, 10th Dec 2025 – Belprego Travel, a licensed Bulgarian tour operator established in 2010, has announced its own charter programs to Qatar for the 2026 tourism season. The new offerings include direct charter flights from Sofia to Doha for the New Year holidays, a romantic Valentine’s Day package, and multiple spring departures with Qatar Airways.
New Year 2026 program
The flagship New Year program runs from December 27, 2025, to January 3, 2026, featuring an 8-day itinerary with 7 nights. Travelers can choose from a variety of hotels in Doha.
Package prices start from €818 per person for standard accommodation, with premium options reaching up to €3,433 per person at select luxury hotels. All packages include round-trip charter flights with BH Air with 20 kg checked and 7 kg carry-on luggage, airport transfers, and medical insurance with €10,000 coverage.
The premium All-Inclusive option at Rixos Gulf Doha 5-star includes a New Year’s gala dinner, priced from €2,392 per person.
An alternative New Year program with Qatar Airways runs from December 27, 2025, to January 2, 2026, offering 7 days and 6 nights at JW Marriott Marquis City Center Doha, priced from €1,713 per person.
Valentine’s Day and spring programs
The Valentine’s Day program runs from February 9–16, 2026, featuring 8 days and 7 nights at a five-star hotel in Doha. Prices start from €920 per person, including direct Qatar Airways flights, transfers, and bed & breakfast accommodation.
Spring 2026 dates are scheduled for February 27, March 13, March 20, and March 28, all operating with direct Qatar Airways flights. The eight-day program includes five-star hotel accommodation with breakfast, with prices from €997 per person.
Optional excursions
Belprego offers a variety of optional excursions for all Qatar programs. Available options include a 4-hour Doha city tour visiting the Museum of Islamic Art, Katara Cultural Village, The Pearl Island, and Souq Waqif market for €75. Desert safari and beach from €100. Evening cruises on a traditional dhow boat start from €50, and a full-day excursion to Zekreet in Western Qatar, including a visit to Richard Serra’s East-West/West-East sculpture installation, is offered for €100.
Visa information
Bulgarian citizens with valid passports can enter Qatar without a pre-issued visa. A free visa is issued upon arrival at Hamad International Airport in Doha. Passports must be valid for at least six months after the date of departure from Qatar.
Company statement
“Qatar represents an exciting new destination for Bulgarian tourists seeking a unique combination of modern luxury and traditional Arab culture. Direct charter flights from Sofia make Doha more accessible than ever, and the diverse selection of hotels ensures options for every budget,” said Radoslava Beleganska, Managing Director of Belprego Travel.
About Qatar
Qatar is a peninsular nation on the Persian Gulf, known for its futuristic skyline, world-class museums, traditional markets, and unique desert landscapes where sand dunes meet the sea at the Inland Sea nature reserve. The capital Doha hosted the 2022 FIFA World Cup and has established itself as a leading tourist destination in the Middle East.
About Belprego Travel
Belprego Travel is a licensed Bulgarian tour operator established in 2010, with a nationwide presence through offices in Sofia, Plovdiv, Pazardzhik, Asenovgrad, Peshtera, and Mezdra. The company specializes in organizing charter programs and package holidays to exotic destinations worldwide, including Turkey, the Middle East, and beyond. With a dedicated team committed to long-term partnerships and personalized service, Belprego has built a strong reputation for delivering quality travel experiences at competitive prices.
Media Contact
Organization: Belprego Travel
Contact Person: Marketing
Website: https://www.belprego.com
Email: Send Email
Contact Number: +359883570057
City: Sofia
Country:Bulgaria
Release id:38808
The post Belprego Travel launches exclusive charter programs to Qatar for 2026 appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
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Press Release
Asia’s First Drama-Asset Blockchain System Goes Live: Star Xun Redefines Film Investment
The Star Xun Studio today launched Asia’s first blockchain-based asset system designed specifically for micro-dramas, introducing on-chain copyright registration, NFT-based rights certification, and automated royalty distribution. The system enables transparent, real-time royalty settlement and secure investment participation, marking a structural transformation in how short-form content is financed, owned, and monetized. Industry observers note that the launch could redefine film and micro-drama investment models across the region.
United States, 10th Dec 2025 – Star Xun Studio has announced the launch of a blockchain-supported framework designed to help creators and production teams manage copyright documentation, track usage, and streamline royalty allocation for micro-drama content. The initiative reflects ongoing developments in the short-form entertainment sector, where production volume has increased and digital rights management has become more complex.
The new framework allows each micro-drama project to record key information—such as copyright registration details, contributor agreements, and performance data—on a verifiable ledger. Star Xun Studio states that this approach aims to reduce inconsistencies in documentation and strengthen transparency for participating creators. The system also uses digital identifiers to certify ownership data, helping to address common issues such as attribution disputes or unauthorized redistribution.
A core component of the framework is an automated royalty-allocation module. According to the development team, this module applies predefined distribution rules to calculate and disburse royalties associated with content performance or licensed usage. Participants may view activity logs, usage indicators, and other non-sensitive data through a dashboard intended to simplify accounting workflows.
Industry observers note that the rapid growth of short-form video platforms has increased demand for more structured rights-management tools. The micro-drama category has expanded quickly in several regions, including Southeast Asia, North America, and parts of China, prompting creators and production groups to explore new models for organizing and documenting digital assets. Analysts say blockchain-based systems are one possible method for improving record-keeping efficiency, though adoption varies across markets.
Members of the Star Xun Studio technical team explained that the framework was developed in response to feedback from creators who sought clearer visibility into revenue-sharing processes and usage patterns. They emphasized that the system is intended as an operational tool rather than a financial product, and that the focus remains on accurate record-tracking through a standardized digital infrastructure.
Star Xun Studio plans to continue refining the framework and may explore additional features—such as support for licensing workflows, expanded metadata tagging, and analytical tools that help creators understand content performance trends. The studio described these efforts as part of its long-term objective to strengthen transparency and collaboration within the micro-drama production ecosystem.
About Star Xun Studio
Star Xun Studio is a creative and technology-focused collective involved in micro-drama development and digital rights solutions. The studio works with creators in multiple regions to explore new approaches to content management, copyright documentation, and workflow transparency within the short-form entertainment sector.
Media Contact
Organization: Star Xun Studio
Contact Person: Star Xun drama studio
Website: http://starxun.net
Email: Send Email
Country:United States
Release id:38712
The post Asia’s First Drama-Asset Blockchain System Goes Live: Star Xun Redefines Film Investment appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
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Press Release
Thrive Financial Announces New Initiative to Expand Real-World Financial Education and Client Support
Through expertise and ecosystem integration, explore how Thrive Financial helps communities achieve lasting economic growth and generate Real-World Impact.
United States, 10th Dec 2025 – The impact of Thrive Financial has long transcended cold numbers. Our goal is to create a Thrive Financial Ecosystem that generates a positive chain reaction, with the core driving force coming from Thrive Financial Academy Expert Training. We will provide an in-depth look at Thrive Financial Real-World Impact, proving that we are actively changing the financial future of thousands of individuals and bringing lasting economic benefits to the wider community. Our business model seeks not only profitability but also active contribution to society.
Thrive Financial firmly believes that financial education is the most effective tool for empowering individuals and narrowing the social wealth gap. We invest significant resources in promoting financial literacy. This extends beyond paid courses to include regularly held free online seminars, publishing educational white papers for the public, and sharing easy-to-understand financial knowledge on major social media platforms. Through these efforts, we are opening a door to knowledge for communities that traditionally have limited access to high-quality financial education, thereby greatly improving overall financial literacy in society. This is a critical step in fulfilling our Thrive Financial Mission and Vision.
The rapid development of the Thrive Financial Ecosystem is, in itself, a huge contribution to socio-economic growth. As the Academy and the trading platform expand their operations, we continuously create a large number of high-quality employment opportunities, covering fields such as financial analysts, software engineers, customer service specialists, and professional mentors. Furthermore, we actively establish mutually beneficial partnerships with technology suppliers and service providers globally. This open collaborative model not only drives innovation but also injects vitality into the broader business community, ensuring that Thrive Financial can continuously realize its Real-World Impact.
In addition to our contributions in business and education, Thrive Financial is also committed to giving back to society. We actively participate in Corporate Social Responsibility (CSR) activities, such as establishing educational funds to sponsor students in underprivileged areas to access basic financial courses, or organizing volunteer teams to provide pro-bono financial planning consultation for non-profit organizations. These actions demonstrate our long-term commitment to the overall well-being of society and emphasize our stance as a responsible corporate citizen. We believe that the value of a true leading enterprise should be measured by its contribution to society.
Thrive Financial is continuously generating profound Thrive Financial Real-World Impact through its unique Thrive Financial Ecosystem. From providing top-tier Thrive Financial Academy Expert Training to promoting community economic growth, we stand by our commitment to society. Choosing to partner with us is not just choosing quality financial services; it is choosing to support an honest enterprise dedicated to working toward a better future.
About Thrive Financial / TLN Exchange
Thrive Financial is dedicated to empowering individuals to achieve financial independence through its integrated ecosystem. The ecosystem includes the Thrive Financial Academy, a leading educational institution offering practical Expert Training and structured Thrive Financial Academy Programs; and TLN Exchange, an efficient and secure financial trading platform based on TLN Exchange Trusted Services and TLN VAULT Security Features. Under the leadership of Noah Larson, Thrive Financial Leader, the company upholds Thrive Financial Integrity and transparency, committed to delivering Thrive Financial Verified Results and creating a positive Thrive Financial Real-World Impact globally.
Media Contact
Organization: Thrive Financial LTD
Contact Person: Noah Larson
Website: https://thrivefin.ai/
Email: Send Email
Country:United States
Release id:37888
The post Thrive Financial Announces New Initiative to Expand Real-World Financial Education and Client Support appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Belprego Travel launches exclusive charter programs to Qatar for 2026
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