Press Release
Park Hotel Tokyo’s Artist in Hotel: Immerse Yourself in the Beauty of Transience
Artist Room Fireworks — An Interview with Japanese Artist Ayaïro— Painting the Beauty of Transience: the Creation of an immersive art experience —
Tokyo, Japan, 5th Aug 2026 – At Park Hotel Tokyo (Operated by Shiba Park Hotel Co., Ltd. / Minato-ku, Tokyo / President: Noriyoshi Tanaka), artists paint directly onto the walls and ceilings of our guest rooms, shaping each space in its entirety into a single art installation. We call them Artist Rooms.
Taking Japanese culture and Japanese aesthetics as its themes, the project works hand in hand with Japanese artists to create stay experiences found nowhere else.
Here we introduce the Artist Room “Fireworks” (available from September 2025) by Ayaïro. In this interview she speaks about the background to her work and the thoughts she carried into the room.
Ayairo shares the inspiration and creative story behind her artwork.
From English to Art: How Ayaïro Became a Japanese Artist
Q1. You graduated from Tokyo University of Foreign Studies with a degree in English before taking the path of an artist. Could you tell us about your background, and what first drew you to art?
It may look as though I have moved between unrelated things, but within me it all connects in a single line. I loved to draw from the time I was small, and a fascination with Hollywood actors led me to study English; then, through studying abroad, I came into contact with other cultures. As I did, I began to look more closely at my own identity, and it was the sense that drawing let me understand something about myself that led me to start painting works themed on childhood.
Satoyama and Childhood: The Origins of Her Japanese Art
Q2. Your works depicting Japan’s satoyama landscapes and the children who live in them have a distinctive world of their own, one that carries a sense of nostalgia. Could you tell us how memories of childhood shape the way you paint today, and what thoughts you bring to your work?
The way I see my own work has changed a great deal since I began. I no longer feel a strong awareness of “painting in order to convey something”; the work begins from an impulse — something moves me. As I go, I select and discard, over and over, and only afterwards do I realize what drew me. That process itself has become the axis of my practice.
What I am expressing, as a result, is not the landscape itself but the sensation it gives rise to. To me, exploring that sensation is what creation is. I am strongly drawn to what rises up suddenly out of light and shadow, out of dusk, out of the ripple of water — beautiful, yet unable to hold its form; present, yet impossible to grasp. Childhood as a theme holds that same transience: it stays vivid in memory, and yet you can never return to it. I feel that I keep painting in order to understand “the beauty of transience” — the thread that has drawn me all along.
Motifs that layer memories of childhood over satoyama scenes give the space its sense of story.
An Entire Room as Canvas: Creating an Immersive Art Experience
Q3. This project treated an entire guest room as a canvas, which must have made it a special experience, different from your previous work. Could you tell us how ideas differ when the expression takes in the space itself, what new challenges you took on, and where you found ingenuity — or difficulty?
I usually paint on a flat canvas, and this was my first time working across a full 360-degree space. I approached it not as a work to be “looked at” but as a space to be “experienced” — designing everything from the scale and placement of the fireworks to the open space and the flow from the corridor, all in pursuit of a sense of immersion. Because this is a hotel, I felt the work had to stay close to the stay experience itself, and I was particularly conscious of using open space to create a room where guests can spend their time in comfort. What changed most in this project was not the motif but the perspective — seeing the entire space as a single experience.
The Story and the Colors Behind the “Fireworks” Art Installation
Q4. Seeing the room in person, we were struck by its warmth — a space that opens into a world only you could create. Could you tell us about the story and the concept behind it?
I chose fireworks as a motif for their Japanese character. The fireworks painted on the window glass catch their own reflection, creating a sense of unity in which outside and inside seem to run continuously into one another, so that the space feels all the more expansive. Fireworks are brilliant and exhilarating in the moment you see them, and yet they carry a fleetingness — gone in an instant. They are also a motif that symbolizes “the beauty of transience,” and I layered their brilliance with that transience in my expression.
Color is an element of great importance to me. The gradation of dusk expresses the very sensation of shifting — not distinctly, but hazily, wavering — and it is one of the expressions I hold most dear. By bringing black into the upper part of the room, I let the flow of time and a sense of depth come through, and I was conscious of the balance that draws the whole together. I painted with care for expression rooted in my own sensations.
Artist Room: a live-in studio where artists create during their residency. The entire space is designed as an “experience.”
A Message to Guests from Overseas: Touching Japanese Culture
Q5. Park Hotel Tokyo welcomes many guests from overseas. What kind of experience would you like them to have in this room? And do you have a message for the guests who stay here?
Fundamentally, I hold no set intention of “this is how I want you to feel”; more than anything, I would be happy if you would simply enjoy the space freely. If I had to name one thing: how people feel about fireworks differs greatly from culture to culture, country to country. In Japan, I think many people share a sense of them as something not only beautiful, but attended by the fleetingness and the ache of a summer that vanishes in an instant. That delicate aesthetic sense is, I feel, one of the things that makes Japan Japan. So for guests visiting from overseas, I would be very glad if a stay in this room became an occasion to touch Japanese sensibility.
The Artist Room “Fireworks,” painted in delicate hues, embodies the theme of the beauty found in impermanence and subtle fluctuations.
Media Contact
Organization: Shiba Park Hotel Co., Ltd
Contact Person: Fumiko Kitao
Website: https://parkhoteltokyo.com/
Email: Send Email
Address:1-5-10 Shiba Koen, Minato-ku,
City: Tokyo
Country:Japan
Release id:47904
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Press Release
Quoin Pharmaceuticals Announces FDA Fast Track Designation for QRX003 for the Treatment of Peeling Skin Syndrome
Ashburn, Virginia, September 22nd, 2026, FinanceWire
– First-Ever Fast Track Designation Granted for a Peeling Skin Syndrome Therapy
– Second Fast Track Designation Granted to QRX003, in Addition to Netherton Syndrome
– Fast Track Designation Facilitates Development and Expedites Regulatory Review of Therapies Addressing Serious Conditions with Significant Unmet Medical Need
– Follows July 2026 FDA Clearance of the First-Ever IND Submitted for Peeling Skin Syndrome
– Phase 2/3 Study Expected to Initiate in 2H 2026, Enrolling up to 12 Pediatric and Adult Patients in the U.S. and Europe
– Peeling Skin Syndrome Currently Has No Approved Treatment
Quoin Pharmaceuticals Ltd. (NASDAQ: QNRX) (“Quoin” or the “Company”), a late clinical-stage specialty pharmaceutical company focused on rare and orphan diseases, today announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track Designation to QRX003 for the treatment of Peeling Skin Syndrome (PSS). QRX003 is an investigational topical serine protease inhibitor lotion. Peeling Skin Syndrome is a rare genetic skin disease for which there is currently no approved treatment.
Key Facts
- Fast Track Designation applies to QRX003 for the treatment of Peeling Skin Syndrome.
- This is the first ever Fast Track Designation granted for a Peeling Skin Syndrome therapy.
- Peeling Skin Syndrome is the second indication for which QRX003 has received Fast Track Designation. The FDA granted Fast Track Designation to QRX003 lotion (4%) for the treatment of Netherton Syndrome on March 11, 2026.
- The designation follows FDA clearance in July 2026 of Quoin’s Investigational New Drug (IND) application for QRX003 in Peeling Skin Syndrome. Quoin submitted that IND on June 2, 2026, and it was the first IND ever submitted to the FDA for the disease.
- Quoin expects to initiate a Phase 2/3 clinical study of QRX003 in Peeling Skin Syndrome in the second half of 2026.
- The IND submission was supported by clinical observations from an ongoing investigator-led pediatric study in a single subject. Significant improvements in skin appearance along with positive changes in pruritus and a number of quality-of-life measures have been recorded. Treatment is ongoing and has continued for more than 15 months, with no adverse events reported.
- There is currently no approved treatment for Peeling Skin Syndrome.
“This is an important regulatory milestone for QRX003 and for a community that today has no approved treatment,” said Dr. Michael Myers, CEO and Co-Founder of Quoin Pharmaceuticals. “Quoin submitted the first IND ever filed with the FDA for Peeling Skin Syndrome, that IND was cleared in July, and QRX003 has now been granted Fast Track Designation for the disease. We expect to initiate our Phase 2/3 study in the second half of 2026, and we believe Fast Track status will allow us to work closely with the agency as we advance the first company-sponsored clinical study in this disease.”
Peeling Skin Syndrome Development Program
The planned Phase 2/3 study is expected to enroll up to 12 pediatric and adult patients with Peeling Skin Syndrome in the United States and Europe. In the study, QRX003 will be applied twice-daily to greater than 80% of patients’ body surface area (BSA) over a 48-week period, with an interim data review at 24 weeks. Quoin is targeting approval of QRX003 as a potential treatment for Peeling Skin Syndrome in 2028.
The IND submission was supported by clinical observations from an ongoing investigator-led pediatric study. The subject has achieved improvements across key objective severity endpoints, including the Modified Ichthyosis Area Severity Index (M-IASI), Investigator’s Global Assessment (IGA) as well as pruritus and a pediatric dermatology-specific quality-of-life measure (CDLQI). Treatment is ongoing, and after continued dosing with QRX003 for over 15 months, no adverse events have been reported.
About Fast Track Designation
The FDA’s Fast Track program is designed to facilitate the development and expedite the review of drugs that treat serious conditions and fill an unmet medical need. A therapy granted Fast Track Designation may benefit from more frequent interactions with the FDA, eligibility for rolling review of regulatory submissions, and potential qualification for Accelerated Approval and Priority Review, if relevant criteria are met.
About Peeling Skin Syndrome (PSS)
Generalized inflammatory peeling skin syndrome (PSS) is a rare autosomal recessive genodermatosis caused by loss-of-function disease-causing variants of the corneodesmosin gene (CDSN), resulting in excessive shedding of the superficial layers of the epidermis. Patients generally suffer from a variety of conditions including severe pain and chronic pruritus (itch). There is currently no approved treatment for PSS.
About QRX003
QRX003 is an investigational topical serine protease inhibitor lotion in late-stage development for Netherton Syndrome and other orphan skin diseases. QRX003 has been granted Orphan Drug, Rare Pediatric Disease, and Fast Track designations by the U.S. Food and Drug Administration, and Orphan Drug Designation in the European Union and Japan for Netherton Syndrome. QRX003 has also been granted Rare Pediatric Disease and Fast Track Designation by the FDA for Peeling Skin Syndrome. QRX003 lotion (4%) is currently being evaluated in Phase 2/3 whole-body clinical trials in patients with Netherton Syndrome. Quoin expects to initiate a Phase 2/3 clinical study of QRX003 in Peeling Skin Syndrome in the second half of 2026.
About Quoin Pharmaceuticals Ltd
Quoin Pharmaceuticals Ltd. is a late clinical-stage specialty pharmaceutical company focused on developing and commercializing therapeutic products that treat rare and orphan diseases. We are committed to addressing unmet medical needs for patients, their families, communities, and care teams. Quoin’s innovative pipeline is focused on two key platform products, QRX003 and QRX009, that collectively have the potential to target a broad number of rare and orphan indications, including Netherton Syndrome, Peeling Skin Syndrome, Palmoplantar Keratoderma, Pachyonychia Congenita, Gorlin Syndrome and Tuberous Sclerosis Complex, Microcystic Lymphatic Malformations, Venous Malformations, Angiofibromas and others.
For more information, visit: www.quoinpharma.com or LinkedIn for updates.
Forward-Looking Statements
The Company cautions that statements in this press release that are not descriptions of historical facts are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements may be identified by the use of words referencing future events or circumstances, such as “expect,” “intend,” “hope,” “plan,” “potential,” “anticipate,” “look forward,” “believe,” “may,” and “will,” among others. This press release contains forward-looking statements. All statements that reflect the Company’s expectations, assumptions, projections, beliefs, or opinions about the future, other than statements of historical fact, are forward-looking statements, including, without limitation, statements relating to: Fast Track Designation facilitating development and expediting regulatory review of therapies addressing serious conditions with significant unmet medical need; plans to initiate a Phase 2/3 clinical study of QRX003 in Peeling Skin Syndrome in the second half of 2026; Fast Track status allowing Quoin to work closely with the FDA to advance the first company-sponsored clinical study in Peeling Skin Syndrome; the study expecting to enroll up to 12 pediatric and adult patients with Peeling Skin Syndrome in the United States and Europe; QRX003 expected to be applied twice-daily to greater than 80% of a patients’ body surface area over a 48-week period, with an interim data review at 24 weeks; targeting approval of QRX003 as a potential treatment for Peeling Skin Syndrome in 2028; therapies granted Fast Track Designation benefiting from more frequent interactions with the FDA, eligibility for rolling review of regulatory submissions, and potential qualification for Accelerated Approval and Priority Review, if relevant criteria are met; and Quoin’s products in development collectively having the potential to target a broad number of rare and orphan indications, including Netherton Syndrome, Peeling Skin Syndrome, Palmoplantar Keratoderma, Pachyonychia Congenita, Gorlin Syndrome, Tuberous Sclerosis Complex, Microcystic Lymphatic Malformations, Venous Malformations, Angiofibroma and others. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based upon the Company’s current expectations and involve assumptions that may never materialize or may prove to be incorrect. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties including, but not limited to, the Company’s ability to pursue its regulatory strategy; the Company’s ability to obtain regulatory approvals for commercialization of product candidates or to comply with ongoing regulatory requirements; the Company’s ability to complete clinical trials on time and achieve desired results and benefits as expected; and other factors discussed in the Company’s Annual Report on Form 10-K for the year ended December 31, 2025 and in other filings the Company has made and may make with the SEC in the future. One should not place undue reliance on these forward-looking statements, which speak only as of the date on which they were made. The Company undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as may be required by law.
Contacts
Jeff Ramson
jramson@pcgadvisory.com
Michael Myers
mmyers@quoinpharma.com
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
Why Starting Work at 14 Prepared William Stapleton to Sell a Company for $300 Million
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William Stapleton, President and CEO of Iron Rock Payments in Frisco, Texas, shares how early work shaped his path from private banking to entrepreneurship.
How did working from age 14 influence your career?
Texas, USA, Sep 22, 2026, ZEX PR WIRE — “I have worked since I was 14 years old to support myself and used this work ethic into college,” Stapleton says. He grew up in a working-class household in Long Beach, California. His mother is from Ecuador and his father is of German and Polish descent. Starting work young built financial responsibility and shaped his approach to business.
He played varsity baseball and water polo while working through high school. He graduated with honors from Long Beach Wilson Classical High School near the top of his class. In college, he took an unpaid internship at Salomon Brothers while balancing his studies. “I graduated college with full honors, top of my class academically,” he says. He earned a double major in Rhetorical Theory and Global Economics from California State University, Long Beach in 2006.
What did you learn in private banking that helped you as an entrepreneur?
After graduation, Morgan Stanley Private Bank recruited Stapleton to work in New York. He later joined JPMorgan Chase, where he contributed to building what is now known as the Chase Private Client program. He spent approximately seven years in private banking and advisory roles.
Working with high-net-worth clients taught him how to manage relationships, assess risk, and structure solutions. Those skills transferred directly to running a business. Understanding client needs and delivering value became the foundation of his entrepreneurial approach.
How did you transition from banking to payments?
Stapleton founded PayFacto, a credit card processing company based in Montreal. He built the company from the ground up and grew it until Visa acquired it in 2019. The sale carried an estimated valuation of $300 million.
He did not wait long to start again. In 2012, he founded Iron Rock Payments, a credit card processing company based in Frisco, Texas. The company has been recognized as an Inc. 5000 company and employs 15 people. Stapleton serves as President and CEO.
What do businesses get wrong about payment processing?
Many businesses treat payment processing as a commodity. They focus only on rates and miss the bigger picture. The right processor can improve cash flow, reduce chargebacks, and provide data that drives decisions.
Stapleton emphasizes that service matters as much as price. Businesses need a partner who understands their industry and responds quickly when issues arise. A few basis points saved on fees mean nothing if downtime costs thousands in lost sales.
What lessons from your first exit did you apply to Iron Rock Payments?
Selling PayFacto taught Stapleton the importance of building systems that scale. He learned to hire people who are better than him in specific areas and to trust them. He also realized that culture drives retention and retention drives growth.
At Iron Rock Payments, he focused on creating processes that work whether the company has 5 employees or 50. He invests in technology that automates repetitive tasks so his team can focus on client relationships. He also prioritizes transparency with clients and employees.
What advice do you give to people thinking about starting a business?
Start before you feel ready. Waiting for the perfect moment means you will never start. Stapleton began working at 14 and took an unpaid internship in college because he wanted experience more than money.
He also advises entrepreneurs to stay close to their customers. The best product ideas come from listening to what clients actually need, not from guessing. Finally, he says to protect your reputation. Trust takes years to build and seconds to destroy.
If you do nothing else
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Start working as early as you can to build a strong work ethic and financial discipline.
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Take internships or entry-level roles that teach you skills, even if the pay is low or nonexistent.
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Spend time in an industry before you try to disrupt it so you understand how it really works.
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Build systems and processes that can scale as your business grows.
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Hire people who are stronger than you in areas where you are weak and trust them to do their jobs.
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Listen to your clients and let their needs guide your product and service decisions.
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Protect your reputation by delivering on promises and treating people with respect.
Share this Q&A with someone who is thinking about making the leap from employee to entrepreneur or who wants to understand how early work experience shapes long-term success.
About William Stapleton
William Stapleton is President and CEO of Iron Rock Payments, a credit card processing company based in Frisco, Texas. He founded the company in 2012 after selling his previous venture, PayFacto, to Visa in 2019 at an estimated valuation of $300 million. Before entering entrepreneurship, he worked in private banking at Morgan Stanley and JPMorgan Chase, where he contributed to creating the Chase Private Client program. He graduated with full honors from California State University, Long Beach with a double major in Rhetorical Theory and Global Economics.
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
David Wayne Fish makes a personal pledge: one season, one sport, no missed games
California, USA, Sep 22, 2026, ZEX PR WIRE — David Wayne Fish is putting a specific commitment on the record. With six kids moving through baseball, football, and tennis across overlapping seasons, he says the easiest thing to let slip is presence. So he is naming the standard out loud.
“If one of my kids has a game or a practice, someone from this family is there,” Fish says. “That’s the whole pledge. It sounds simple because it should be simple. The hard part is building a life where you can actually keep it.”
Fish runs healthcare and wellness companies as a consultant and CEO, work that does not pause for a Tuesday scrimmage. He is not pretending otherwise. The pledge is not about having endless free time. It is about deciding in advance what wins when a calendar conflict shows up.
Why he is saying it publicly
Fish has coached football, baseball, and helped organize tennis for years. He says most parents do not fail their kids through some dramatic absence. They fail them through a hundred small ones that never get flagged as decisions at all.
“Nobody skips a game and thinks of it as a broken promise,” he says. “It just looks like a scheduling problem. I wanted to write my own rule down so it stops being negotiable case by case.”
He credits his own father, and the model of family life he grew up with in Michigan, for the instinct behind this. Fish says he was raised around the idea that a father’s job includes showing up, not just providing.
What the commitment actually covers
The pledge Fish is making has a few concrete parts:
Every game gets a family face in the stands. Not every game gets David personally, with six kids and overlapping seasons that is not realistic, but every game gets someone: him, his wife, or another family member who can stand in.
Coaching commitments get finished, not started. Fish says he does not sign up to coach a season and then quietly hand it off when work gets busy. If he takes a team, he finishes the season.
Conflicts get resolved before the week starts, not during it. Fish says he sits down weekly and maps which kid has what, so trade-offs get made on a Sunday with a clear head instead of on a Wednesday in a parking lot.
“I’d rather lose an hour on Sunday mapping the week than lose a moment at my kid’s game because I’m distracted by something I should have planned around,” he says.
What he is asking of himself, not other parents
Fish is careful to frame this as his own standard, not a lecture. He is not telling other families how to run their weeks.
“I’m not in a position to tell another parent what their life allows,” he says. “I know what mine allows, and I know where I’ve cut corners before without meaning to. This is me closing that gap for myself.”
He says the pledge will get tested immediately, since his kids’ seasons rarely line up cleanly. Two games at the same hour, in two different towns, is not a hypothetical for his family. It happens.
“When that comes up, the answer isn’t ‘we’ll figure it out.’ The answer is already written down: someone from this family goes to each one,” Fish says. “I’d rather have made that call in October than try to make it in the car in March.”
Holding himself to it
Fish says he plans to track the pledge the same plain way he tracks anything else he takes seriously: a simple log of games, and who from the family was there. No app, no public scoreboard, just a habit he intends to keep himself honest about.
“If I say I’m going to do something for my kids, I want a way to check whether I actually did it,” he says. “That’s the only accountability that’s ever mattered to me.”
To read more, visit the website here.
About David Wayne Fish
David Wayne Fish is an entrepreneur based in Laguna Niguel, California. He works as a CEO and consultant to healthcare and wellness companies. Outside that work, he coaches youth football and baseball, helps organize tennis programs, and is the father of six children active in sports.
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
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