Press Release
Esteban Merlo Brings a Strategic Vision of Real Estate Development to English-Speaking Readers
The Real Estate Developer’s Journey by Esteban Merlo offers professionals a broader understanding of the decisions, leadership, and long-term thinking behind successful development projects
Miami, Florida, United States, 5th Aug 2026 – Real estate developer, business consultant, and author Esteban Merlo has released the English edition of The Real Estate Developer’s Journey, making his professional perspective on real estate development available to a wider international audience.
The book is designed for developers, investors, entrepreneurs, consultants, and real estate professionals who want to understand what happens behind the visible results of a completed project. Rather than treating development as a process centered exclusively on construction, Esteban Merlo examines the strategic decisions, financial considerations, leadership responsibilities, and long-term vision required to transform an opportunity into a viable real estate asset.
The English-language release expands the reach of Esteban Merlo’s work and introduces his approach to readers operating in increasingly connected and competitive property markets.
Understanding What Comes Before Construction
Buildings may be the most visible result of real estate development, but every project begins with a series of less visible decisions.
Before construction starts, developers must evaluate the market, study the location, understand the intended users, assess financial feasibility, identify potential risks, and determine whether the concept can create sustainable value.
The Real Estate Developer’s Journey focuses on this critical stage of the process.
Through the book, Esteban Merlo presents development as a discipline that begins with clarity. A promising property or an ambitious idea is not enough on its own. The project must be supported by research, preparation, realistic financial expectations, and a strategy that responds to actual market conditions.
The book encourages professionals to ask essential questions before committing resources: Who will use the project? What problem will it solve? How will it compete? What risks could affect its execution? How will it remain relevant after completion?
These questions reflect the strategic foundation of Esteban Merlo’s professional philosophy.
A Book About Decisions, Not Only Properties
One of the central ideas in The Real Estate Developer’s Journey is that the quality of a development project is closely connected to the quality of the decisions made throughout its life cycle.
Real estate projects involve multiple variables, and not all of them can be controlled. Financing conditions may change. Construction costs may rise. Market demand may shift. Regulatory requirements may affect a timeline. Partnerships may evolve, and unexpected challenges may force a team to reconsider its original plan.
For Esteban Merlo, successful development does not depend on avoiding every difficulty. It depends on creating a disciplined process for evaluating information, adapting responsibly, and protecting the project’s long-term purpose.
The book explores how developers can approach uncertainty without losing direction. It also emphasizes the importance of understanding the relationship between financial performance, market needs, execution capacity, and the wider impact of a development.
This makes the book relevant not only to experienced real estate professionals but also to entrepreneurs and investors considering their first development opportunity.
Leadership at the Center of Development
Real estate development requires the coordination of many professionals and institutions.
Architects, engineers, contractors, lenders, investors, consultants, attorneys, public agencies, and community stakeholders may all influence the outcome of a project. Each group brings its own priorities, responsibilities, and expectations.
The developer must create alignment among those interests.
In The Real Estate Developer’s Journey, Esteban Merlo explains that this responsibility turns development into a significant leadership challenge. Technical knowledge is essential, but it must be supported by communication, judgment, resilience, negotiation, and the ability to make decisions under pressure.
A developer must protect the financial viability of the project while also maintaining its strategic purpose. This requires an understanding of both the details and the broader vision.
The book presents leadership as an essential part of the development process, particularly when circumstances change or difficult decisions must be made.
Turning Professional Experience Into a Resource for Others
The release of the English edition allows Esteban Merlo to share his experience with professionals across a broader range of markets.
Instead of presenting real estate development as a rigid formula, the book offers a framework for thinking more strategically about opportunities, risks, partnerships, execution, and long-term value.
Every market is different, and every project presents its own challenges. However, the principles behind responsible development remain consistent: preparation, discipline, market awareness, clear communication, and the ability to connect immediate decisions with future results.
By organizing those principles into a structured publication, Esteban Merlo provides readers with a resource they can use to examine their own professional decisions and development strategies.
The book also reflects the importance of learning from the complete journey of a project, including the adjustments, setbacks, negotiations, and lessons that are rarely visible once construction has been completed.
Real Estate Development With a Long-Term Perspective
Another defining element of the book is its emphasis on lasting value.
Short-term performance is important, but Esteban Merlo encourages readers to consider how a project will function and remain relevant over time. This includes its financial sustainability, adaptability, relationship with the surrounding area, and ability to respond to the needs of its users.
This long-term perspective is increasingly important as real estate professionals face changing consumer expectations, evolving cities, new investment models, and greater demand for responsible development.
The Real Estate Developer’s Journey invites readers to move beyond transactional thinking and consider the broader consequences of each development decision.
The objective is not simply to complete a project. It is to create an asset that has a clear purpose, a realistic strategy, and the potential to generate meaningful value.
Expanding Esteban Merlo’s International Professional Platform
The English edition of The Real Estate Developer’s Journey represents an important development in Esteban Merlo’s work as an author, consultant, and real estate professional.
By introducing the book to English-speaking readers, Esteban Merlo expands the international reach of a professional platform built around real estate strategy, leadership, responsible execution, and sustainable growth.
The release also creates a stronger connection between his practical experience and his role as an educator and thought leader within the real estate industry.
For professionals seeking a deeper understanding of development, The Real Estate Developer’s Journey offers more than a description of how projects are built. It provides a strategic view of how opportunities are evaluated, how challenges are managed, and how leadership influences the creation of successful real estate assets.
About Esteban Merlo
Esteban Merlo is a real estate developer, business consultant, and author whose work focuses on real estate development, strategic planning, investment analysis, leadership, and long-term value creation. Through his professional projects and publications, Esteban Merlo shares practical perspectives for developers, investors, entrepreneurs, and real estate professionals seeking to make more informed and sustainable decisions.
For more information, visit: https://www.estebanmerlo.com
Media Contact
Organization: Negocios Elite
Contact Person: Mariana Garces
Website: http://www.negocioselite.com
Email: Send Email
Contact Number: +13052446025
Address 2: Miami, Florida 33130
City: Miami
State: Florida
Country:United States
Release id:47883
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About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
Quoin Pharmaceuticals Announces FDA Fast Track Designation for QRX003 for the Treatment of Peeling Skin Syndrome
Ashburn, Virginia, September 22nd, 2026, FinanceWire
– First-Ever Fast Track Designation Granted for a Peeling Skin Syndrome Therapy
– Second Fast Track Designation Granted to QRX003, in Addition to Netherton Syndrome
– Fast Track Designation Facilitates Development and Expedites Regulatory Review of Therapies Addressing Serious Conditions with Significant Unmet Medical Need
– Follows July 2026 FDA Clearance of the First-Ever IND Submitted for Peeling Skin Syndrome
– Phase 2/3 Study Expected to Initiate in 2H 2026, Enrolling up to 12 Pediatric and Adult Patients in the U.S. and Europe
– Peeling Skin Syndrome Currently Has No Approved Treatment
Quoin Pharmaceuticals Ltd. (NASDAQ: QNRX) (“Quoin” or the “Company”), a late clinical-stage specialty pharmaceutical company focused on rare and orphan diseases, today announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track Designation to QRX003 for the treatment of Peeling Skin Syndrome (PSS). QRX003 is an investigational topical serine protease inhibitor lotion. Peeling Skin Syndrome is a rare genetic skin disease for which there is currently no approved treatment.
Key Facts
- Fast Track Designation applies to QRX003 for the treatment of Peeling Skin Syndrome.
- This is the first ever Fast Track Designation granted for a Peeling Skin Syndrome therapy.
- Peeling Skin Syndrome is the second indication for which QRX003 has received Fast Track Designation. The FDA granted Fast Track Designation to QRX003 lotion (4%) for the treatment of Netherton Syndrome on March 11, 2026.
- The designation follows FDA clearance in July 2026 of Quoin’s Investigational New Drug (IND) application for QRX003 in Peeling Skin Syndrome. Quoin submitted that IND on June 2, 2026, and it was the first IND ever submitted to the FDA for the disease.
- Quoin expects to initiate a Phase 2/3 clinical study of QRX003 in Peeling Skin Syndrome in the second half of 2026.
- The IND submission was supported by clinical observations from an ongoing investigator-led pediatric study in a single subject. Significant improvements in skin appearance along with positive changes in pruritus and a number of quality-of-life measures have been recorded. Treatment is ongoing and has continued for more than 15 months, with no adverse events reported.
- There is currently no approved treatment for Peeling Skin Syndrome.
“This is an important regulatory milestone for QRX003 and for a community that today has no approved treatment,” said Dr. Michael Myers, CEO and Co-Founder of Quoin Pharmaceuticals. “Quoin submitted the first IND ever filed with the FDA for Peeling Skin Syndrome, that IND was cleared in July, and QRX003 has now been granted Fast Track Designation for the disease. We expect to initiate our Phase 2/3 study in the second half of 2026, and we believe Fast Track status will allow us to work closely with the agency as we advance the first company-sponsored clinical study in this disease.”
Peeling Skin Syndrome Development Program
The planned Phase 2/3 study is expected to enroll up to 12 pediatric and adult patients with Peeling Skin Syndrome in the United States and Europe. In the study, QRX003 will be applied twice-daily to greater than 80% of patients’ body surface area (BSA) over a 48-week period, with an interim data review at 24 weeks. Quoin is targeting approval of QRX003 as a potential treatment for Peeling Skin Syndrome in 2028.
The IND submission was supported by clinical observations from an ongoing investigator-led pediatric study. The subject has achieved improvements across key objective severity endpoints, including the Modified Ichthyosis Area Severity Index (M-IASI), Investigator’s Global Assessment (IGA) as well as pruritus and a pediatric dermatology-specific quality-of-life measure (CDLQI). Treatment is ongoing, and after continued dosing with QRX003 for over 15 months, no adverse events have been reported.
About Fast Track Designation
The FDA’s Fast Track program is designed to facilitate the development and expedite the review of drugs that treat serious conditions and fill an unmet medical need. A therapy granted Fast Track Designation may benefit from more frequent interactions with the FDA, eligibility for rolling review of regulatory submissions, and potential qualification for Accelerated Approval and Priority Review, if relevant criteria are met.
About Peeling Skin Syndrome (PSS)
Generalized inflammatory peeling skin syndrome (PSS) is a rare autosomal recessive genodermatosis caused by loss-of-function disease-causing variants of the corneodesmosin gene (CDSN), resulting in excessive shedding of the superficial layers of the epidermis. Patients generally suffer from a variety of conditions including severe pain and chronic pruritus (itch). There is currently no approved treatment for PSS.
About QRX003
QRX003 is an investigational topical serine protease inhibitor lotion in late-stage development for Netherton Syndrome and other orphan skin diseases. QRX003 has been granted Orphan Drug, Rare Pediatric Disease, and Fast Track designations by the U.S. Food and Drug Administration, and Orphan Drug Designation in the European Union and Japan for Netherton Syndrome. QRX003 has also been granted Rare Pediatric Disease and Fast Track Designation by the FDA for Peeling Skin Syndrome. QRX003 lotion (4%) is currently being evaluated in Phase 2/3 whole-body clinical trials in patients with Netherton Syndrome. Quoin expects to initiate a Phase 2/3 clinical study of QRX003 in Peeling Skin Syndrome in the second half of 2026.
About Quoin Pharmaceuticals Ltd
Quoin Pharmaceuticals Ltd. is a late clinical-stage specialty pharmaceutical company focused on developing and commercializing therapeutic products that treat rare and orphan diseases. We are committed to addressing unmet medical needs for patients, their families, communities, and care teams. Quoin’s innovative pipeline is focused on two key platform products, QRX003 and QRX009, that collectively have the potential to target a broad number of rare and orphan indications, including Netherton Syndrome, Peeling Skin Syndrome, Palmoplantar Keratoderma, Pachyonychia Congenita, Gorlin Syndrome and Tuberous Sclerosis Complex, Microcystic Lymphatic Malformations, Venous Malformations, Angiofibromas and others.
For more information, visit: www.quoinpharma.com or LinkedIn for updates.
Forward-Looking Statements
The Company cautions that statements in this press release that are not descriptions of historical facts are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements may be identified by the use of words referencing future events or circumstances, such as “expect,” “intend,” “hope,” “plan,” “potential,” “anticipate,” “look forward,” “believe,” “may,” and “will,” among others. This press release contains forward-looking statements. All statements that reflect the Company’s expectations, assumptions, projections, beliefs, or opinions about the future, other than statements of historical fact, are forward-looking statements, including, without limitation, statements relating to: Fast Track Designation facilitating development and expediting regulatory review of therapies addressing serious conditions with significant unmet medical need; plans to initiate a Phase 2/3 clinical study of QRX003 in Peeling Skin Syndrome in the second half of 2026; Fast Track status allowing Quoin to work closely with the FDA to advance the first company-sponsored clinical study in Peeling Skin Syndrome; the study expecting to enroll up to 12 pediatric and adult patients with Peeling Skin Syndrome in the United States and Europe; QRX003 expected to be applied twice-daily to greater than 80% of a patients’ body surface area over a 48-week period, with an interim data review at 24 weeks; targeting approval of QRX003 as a potential treatment for Peeling Skin Syndrome in 2028; therapies granted Fast Track Designation benefiting from more frequent interactions with the FDA, eligibility for rolling review of regulatory submissions, and potential qualification for Accelerated Approval and Priority Review, if relevant criteria are met; and Quoin’s products in development collectively having the potential to target a broad number of rare and orphan indications, including Netherton Syndrome, Peeling Skin Syndrome, Palmoplantar Keratoderma, Pachyonychia Congenita, Gorlin Syndrome, Tuberous Sclerosis Complex, Microcystic Lymphatic Malformations, Venous Malformations, Angiofibroma and others. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based upon the Company’s current expectations and involve assumptions that may never materialize or may prove to be incorrect. Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties including, but not limited to, the Company’s ability to pursue its regulatory strategy; the Company’s ability to obtain regulatory approvals for commercialization of product candidates or to comply with ongoing regulatory requirements; the Company’s ability to complete clinical trials on time and achieve desired results and benefits as expected; and other factors discussed in the Company’s Annual Report on Form 10-K for the year ended December 31, 2025 and in other filings the Company has made and may make with the SEC in the future. One should not place undue reliance on these forward-looking statements, which speak only as of the date on which they were made. The Company undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as may be required by law.
Contacts
Jeff Ramson
jramson@pcgadvisory.com
Michael Myers
mmyers@quoinpharma.com
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
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William Stapleton, President and CEO of Iron Rock Payments in Frisco, Texas, shares how early work shaped his path from private banking to entrepreneurship.
How did working from age 14 influence your career?
Texas, USA, Sep 22, 2026, ZEX PR WIRE — “I have worked since I was 14 years old to support myself and used this work ethic into college,” Stapleton says. He grew up in a working-class household in Long Beach, California. His mother is from Ecuador and his father is of German and Polish descent. Starting work young built financial responsibility and shaped his approach to business.
He played varsity baseball and water polo while working through high school. He graduated with honors from Long Beach Wilson Classical High School near the top of his class. In college, he took an unpaid internship at Salomon Brothers while balancing his studies. “I graduated college with full honors, top of my class academically,” he says. He earned a double major in Rhetorical Theory and Global Economics from California State University, Long Beach in 2006.
What did you learn in private banking that helped you as an entrepreneur?
After graduation, Morgan Stanley Private Bank recruited Stapleton to work in New York. He later joined JPMorgan Chase, where he contributed to building what is now known as the Chase Private Client program. He spent approximately seven years in private banking and advisory roles.
Working with high-net-worth clients taught him how to manage relationships, assess risk, and structure solutions. Those skills transferred directly to running a business. Understanding client needs and delivering value became the foundation of his entrepreneurial approach.
How did you transition from banking to payments?
Stapleton founded PayFacto, a credit card processing company based in Montreal. He built the company from the ground up and grew it until Visa acquired it in 2019. The sale carried an estimated valuation of $300 million.
He did not wait long to start again. In 2012, he founded Iron Rock Payments, a credit card processing company based in Frisco, Texas. The company has been recognized as an Inc. 5000 company and employs 15 people. Stapleton serves as President and CEO.
What do businesses get wrong about payment processing?
Many businesses treat payment processing as a commodity. They focus only on rates and miss the bigger picture. The right processor can improve cash flow, reduce chargebacks, and provide data that drives decisions.
Stapleton emphasizes that service matters as much as price. Businesses need a partner who understands their industry and responds quickly when issues arise. A few basis points saved on fees mean nothing if downtime costs thousands in lost sales.
What lessons from your first exit did you apply to Iron Rock Payments?
Selling PayFacto taught Stapleton the importance of building systems that scale. He learned to hire people who are better than him in specific areas and to trust them. He also realized that culture drives retention and retention drives growth.
At Iron Rock Payments, he focused on creating processes that work whether the company has 5 employees or 50. He invests in technology that automates repetitive tasks so his team can focus on client relationships. He also prioritizes transparency with clients and employees.
What advice do you give to people thinking about starting a business?
Start before you feel ready. Waiting for the perfect moment means you will never start. Stapleton began working at 14 and took an unpaid internship in college because he wanted experience more than money.
He also advises entrepreneurs to stay close to their customers. The best product ideas come from listening to what clients actually need, not from guessing. Finally, he says to protect your reputation. Trust takes years to build and seconds to destroy.
If you do nothing else
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Start working as early as you can to build a strong work ethic and financial discipline.
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Take internships or entry-level roles that teach you skills, even if the pay is low or nonexistent.
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Spend time in an industry before you try to disrupt it so you understand how it really works.
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Build systems and processes that can scale as your business grows.
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Hire people who are stronger than you in areas where you are weak and trust them to do their jobs.
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Listen to your clients and let their needs guide your product and service decisions.
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Protect your reputation by delivering on promises and treating people with respect.
Share this Q&A with someone who is thinking about making the leap from employee to entrepreneur or who wants to understand how early work experience shapes long-term success.
About William Stapleton
William Stapleton is President and CEO of Iron Rock Payments, a credit card processing company based in Frisco, Texas. He founded the company in 2012 after selling his previous venture, PayFacto, to Visa in 2019 at an estimated valuation of $300 million. Before entering entrepreneurship, he worked in private banking at Morgan Stanley and JPMorgan Chase, where he contributed to creating the Chase Private Client program. He graduated with full honors from California State University, Long Beach with a double major in Rhetorical Theory and Global Economics.
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
California, USA, Sep 22, 2026, ZEX PR WIRE — David Wayne Fish is putting a specific commitment on the record. With six kids moving through baseball, football, and tennis across overlapping seasons, he says the easiest thing to let slip is presence. So he is naming the standard out loud.
“If one of my kids has a game or a practice, someone from this family is there,” Fish says. “That’s the whole pledge. It sounds simple because it should be simple. The hard part is building a life where you can actually keep it.”
Fish runs healthcare and wellness companies as a consultant and CEO, work that does not pause for a Tuesday scrimmage. He is not pretending otherwise. The pledge is not about having endless free time. It is about deciding in advance what wins when a calendar conflict shows up.
Why he is saying it publicly
Fish has coached football, baseball, and helped organize tennis for years. He says most parents do not fail their kids through some dramatic absence. They fail them through a hundred small ones that never get flagged as decisions at all.
“Nobody skips a game and thinks of it as a broken promise,” he says. “It just looks like a scheduling problem. I wanted to write my own rule down so it stops being negotiable case by case.”
He credits his own father, and the model of family life he grew up with in Michigan, for the instinct behind this. Fish says he was raised around the idea that a father’s job includes showing up, not just providing.
What the commitment actually covers
The pledge Fish is making has a few concrete parts:
Every game gets a family face in the stands. Not every game gets David personally, with six kids and overlapping seasons that is not realistic, but every game gets someone: him, his wife, or another family member who can stand in.
Coaching commitments get finished, not started. Fish says he does not sign up to coach a season and then quietly hand it off when work gets busy. If he takes a team, he finishes the season.
Conflicts get resolved before the week starts, not during it. Fish says he sits down weekly and maps which kid has what, so trade-offs get made on a Sunday with a clear head instead of on a Wednesday in a parking lot.
“I’d rather lose an hour on Sunday mapping the week than lose a moment at my kid’s game because I’m distracted by something I should have planned around,” he says.
What he is asking of himself, not other parents
Fish is careful to frame this as his own standard, not a lecture. He is not telling other families how to run their weeks.
“I’m not in a position to tell another parent what their life allows,” he says. “I know what mine allows, and I know where I’ve cut corners before without meaning to. This is me closing that gap for myself.”
He says the pledge will get tested immediately, since his kids’ seasons rarely line up cleanly. Two games at the same hour, in two different towns, is not a hypothetical for his family. It happens.
“When that comes up, the answer isn’t ‘we’ll figure it out.’ The answer is already written down: someone from this family goes to each one,” Fish says. “I’d rather have made that call in October than try to make it in the car in March.”
Holding himself to it
Fish says he plans to track the pledge the same plain way he tracks anything else he takes seriously: a simple log of games, and who from the family was there. No app, no public scoreboard, just a habit he intends to keep himself honest about.
“If I say I’m going to do something for my kids, I want a way to check whether I actually did it,” he says. “That’s the only accountability that’s ever mattered to me.”
To read more, visit the website here.
About David Wayne Fish
David Wayne Fish is an entrepreneur based in Laguna Niguel, California. He works as a CEO and consultant to healthcare and wellness companies. Outside that work, he coaches youth football and baseball, helps organize tennis programs, and is the father of six children active in sports.
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
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