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CMS(867.HK/8A8.SG): Self-Developed INHBE-Targeting siRNA Drug Received IND Approval for Overweight/Obesity

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SHENZHEN, CHINA China Medical System Holdings Limited (“CMS” or the “Group”) is pleased to announce that self-developed innovative drug INHBE-targeting small nucleic acid drug CMS-D008 injection (“CMS-D008”) received the Drug Clinical Trial Approval Notice issued by National Medical Products Administration (“NMPA”) on 4 March 2026. The NMPA has approved the conduct of clinical trials of CMS-D008 injection for overweight or obese individuals.

About CMS-D008

CMS-D008 is a novel siRNA therapy administered by subcutaneous injection. CMS-D008 targets and reduces the hepatic expression of the inhibin subunit beta E (INHBE) gene and lowers the level of Activin E protein encoded by INHBE, which blocks Activin E-ALK7 signaling and reduces fat accumulation effectively. Preclinical studies suggested that CMS-D008 efficiently and sustainably suppressed INHBE expression. In the diet-induced obesity model, CMS-D008 enhanced weight loss by reducing fat mass while retaining lean mass with a good safety profile. It demonstrates potentially better prospects for high-quality, long-term weight loss that boosts fat-specific loss while preserving muscle mass. In the future, it may be developed for the treatment of overweight/obesity, abdominal obesity, and related metabolic diseases.

Fat Loss, muscle preserved: a potentially better therapeutic option for overweight/obesity

Overweight or obesity is a chronic, progressive, relapsing disease characterized by excessive accumulation or abnormal distribution or function of body fat[1]. World Obesity Atlas 2025 Report projected that the global proportion of overweight and obese adults will rise to 50%, with nearly 3 billion adults impacted by high body mass index (BMI), and the population of adults who are overweight or obese in China is projected to reach 515 million by 2030[2]. Existing GLP-1RAs have been proven to be effective for the treatment of overweight and obesity. The main actions of GLP-1RAs are to suppress appetite by acting on the central nervous system and to delay gastric emptying[3]. INHBE’s novel mechanism of action differs from GLP-1RAs. INHBE is identified through genome-wide association studies. Populations with loss of function in INHBE are associated with favorable fat distribution and beneficial metabolic characteristics[4]. Targeted inhibition of INHBE might be more conducive for long-term weight management at the genetic level with precisely lower visceral fat and favorable metabolic profiles.

CMS-D008 teams up with CMS-D005: highly effective weight loss plus long-term maintenance, building a more comprehensive weight-loss solution

CMS-D008 will synergize with CMS-D005, a self-developed innovative drug currently in clinical development. CMS-D008 reduces fat without sacrificing muscle mass by precisely inhibiting INHBE gene expression; while CMS-D005, as a GLP-1R/GCGR dual agonist, can effectively reduce liver fat while losing weight. The synergy between these two drugs will achieve highly effective weight loss benefits and long-term maintenance of results, jointly enhancing the Group’s R&D capabilities and product competitiveness in the field of obesity/metabolic treatment. Furthermore, leveraging the Group’s mature network resources in the field of cardiovascular and metabolic diseases, the drug’s R&D and commercialization process will be accelerated, providing patients with more comprehensive and innovative treatment options.

The Group is actively preparing to initiate relevant clinical trials and strives to launch the Product as soon as possible.

About CMS

CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.

CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.

CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development in its advantageous specialty fields, strengthening the competitiveness of the cardiovascular-kidney-metabolic/ gastroenterology/ ophthalmology/ skin health businesses, bringing economies of scale in specialty fields. Among them, the skin health business (Dermavon) has become a leading enterprise in its field, and is proposed to be listed independently on the SEHK. Meanwhile, CMS continuously promotes the operation and development of its integrated R&D, manufacturing and commercialization chain in Southeast Asia and the Middle East, capturing growth opportunities in emerging markets to support the high-quality and sustainable development of the Group.

Reference:

  1. Chinese Society of Endocrinology. Guideline for chronic weight management and clinical practice of anti-obesity medications(2024 version). Chinese Journal of Endocrinology and Metabolism. 2024,40(7):545-564.
  2. World Obesity Federation. World Obesity Atlas 2025. London: World Obesity Federation, 2025. https://data.worldobesity.org/publications/?cat=23
  3. Zhikai Zheng, Yao Zong, Yiyang Ma, Yucheng Tian, Yidan Pang, Changqing Zhang, Junjie Gao. Glucagon-like peptide-1 receptor: mechanisms and advances in therapy. Sig Transduct Target Ther 9, 234 (2024). doi: 10.1038/s41392-024-01931-z
  4. Parsa Akbari, Olukayode A Sosina, Jonas Bovijn, et al. Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes. Nat Commun.2022 Aug 23;13(1):4844. doi: 10.1038/s41467-022-32398-7.

CMS Disclaimer and Forward-Looking Statements

This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.

This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.

Media Contact

Brand: China Medical System Holdings Ltd.

Contact: CMS Investor Relations

Email: ir@cms.net.cn

Website: https://web.cms.net.cn/en/home/

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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.

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Press Release

Event Branding Launches Budget-Friendly Pull-Up Solutions for 2026 Corporate Events

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Event Branding has announced a special offer on its Econo pull-up banner range

Meyerton, Gauteng, South Africa, 5th Mar 2026 – Event Branding has announced a special offer on its Econo pull-up banner range, providing organisations with a cost-efficient way to enhance their visual presence at events, activations, and in-store environments. The offer, structured around a bulk purchase model, is positioned to support businesses and institutions that require multiple branded displays while managing constrained marketing budgets.​

Offer overview

Event Branding is making Econo pull-up banners available at a price point of R835.00 excluding VAT per unit, with an additional volume benefit built into the structure of the promotion. For every four banners purchased, a fifth Econo pull-up banner is supplied at no additional banner charge, effectively extending the value of the package for high-usage environments such as exhibitions, trade shows, retail spaces, and corporate events.​

The Econo pull-up format is widely used in the South African market as an accessible option for organisations that need branded presence without the higher capital outlay associated with more elaborate display systems. Typical Econo pull-up banner specifications in the local industry include a size of approximately 850 mm in width by 2000 mm in height and a lightweight, portable stand with a carry bag, enabling repeated use across different venues.

Context in the South African branding landscape

In South Africa, pull-up banners form a core component of event and in-store branding, complementing other elements such as gazebos, feather flags, wall backdrops, and counter units. Agencies and print providers across the country have long treated Econo pull-up banners as a standard entry-level solution, particularly for small and medium-sized businesses that require visibility at trade shows, conferences, and community events.

Econo pull-up banners are typically chosen for their balance of print quality, durability, and portability rather than for premium hardware features. Industry offerings in this category generally emphasise a non-curl or lay-flat print material, a compact aluminium base, and a simple pull-up mechanism, allowing marketing teams and event coordinators to deploy them quickly in constrained spaces such as mall walkways, reception areas, and exhibition booths.

Role of Econo pull-up banners in event branding

Pull-up banners play a significant role in creating a coherent visual identity at events, often acting as directional markers, information points, or product-focused highlights. While larger structures such as custom stands and modular exhibition systems help define a stand’s physical footprint, vertical banners serve as repeated brand touchpoints that are visible from multiple angles.

In practice, organisations use Econo pull-up banners to:

  • Present brand identity elements such as logos, taglines, and primary colours in a consistent format across multiple locations.
  • Highlight specific campaigns, promotions, or product launches in a way that can be updated periodically by reprinting the banner skin while retaining the same category of hardware.
  • Provide supporting messaging in spaces where floor area is limited and overhead rigging is either impractical or not allowed by venue regulations.​

Because they are compact and freestanding, pull-up banners are often integrated into broader event branding programmes that include custom displays, promotional materials, and experiential activations. This integration allows marketing teams to maintain visual consistency across indoor and outdoor touchpoints while using formats that can be transported and stored between events.

Practical implications of the bulk offer

By structuring the special as “buy four, receive a fifth banner at no additional banner cost,” Event Branding has aligned the offer with typical use cases in which organisations require multiple, thematically linked visuals rather than a single display. Examples include multi-branch retailers needing standardised branding in several outlets, national campaigns rolled out across various activation sites, and corporate events that require repeated messaging in foyers, registration areas, breakaway rooms, and presentation spaces.

The per-unit price point of R835.00 excluding VAT positions the Econo banner option within the lower to mid-range of the South African market for economy pull-up solutions, where similar products often cluster around comparable pricing once print, hardware, and basic finishing are taken into account. In a bulk configuration, the effective cost per unit is reduced further when the fifth banner is factored into the overall package, which can be material for organisations planning multi-site deployments or frequent event participation.

Alignment with broader branding strategies

Event and experiential marketing in South Africa continue to prioritise tangible, in-person brand encounters, even as digital channels expand. Within this environment, portable branding hardware remains a central tool for marketers looking to reinforce their brand message at physical touchpoints such as expos, roadshows, conferences, and community-based activations.

Event-focused branding providers increasingly position their services around complete solutions that bundle design, print, and hardware into integrated packages. In that context, a structured Econo pull-up banner offering such as this one can serve as a foundational component in a broader toolkit that may also include flags, gazebos, counters, backwalls, and floor graphics, all working together to support consistent brand communication in busy event environments.

Industry perspective on economy pull-up systems

Within the signage and print industry, Econo pull-up banners are often seen as a practical starting point for organisations that are building up their physical branding assets over time. They offer an accessible way to test messaging, refine visual identity in live environments, and assess how audiences engage with different layouts and headlines before committing to larger-scale structural investments.

Standard features of Econo pull-up systems typically include:

  • A printed graphic panel produced on PVC, PET, or similar lay-flat substrate designed to minimise edge curl and maintain a smooth viewing surface.
  • An aluminium base with an integrated roller mechanism that houses and protects the print when retracted.
  • A vertical support pole or set of poles and a top clamp bar or rail that secures the banner in its extended position.
  • A soft carry bag suited for transport in passenger vehicles and for storage between uses.

These attributes make economy-class pull-up banners particularly relevant for small marketing teams, SMEs, and organisations that do not maintain permanent exhibit infrastructure but still require recurring brand presence at public-facing events.

Significance for organisations planning 2026 events

As organisations plan their 2026 calendars, including trade exhibitions, conferences, product activations, and internal events, portable branding remains a key budget line item. With physical events reasserting their role in relationship-building and brand storytelling, consistent and visible branding at venues has implications for both perception and recall among attendees.

The availability of Econo pull-up banners at R835.00 excluding VAT, with an enhanced value structure on orders of five units, intersects with this planning cycle by allowing marketing, events, and communications teams to expand or refresh their portable display inventory under defined cost parameters. In many cases, such inventory is deployed repeatedly across a year’s programme of activities, including regional roadshows, sponsorship-linked events, and internal corporate engagements.

Positioning within the broader promotional ecosystem

Portable printed displays such as Econo pull-up banners complement digital and social media campaigns by reinforcing visual identity in physical spaces. While online channels capture attention before and after an event, physical branding assets help define the on-site experience, guide foot traffic, and provide visual anchors for photography and content captured at the event itself.

In that ecosystem, Econo pull-up banners function as one of the more agile tools available to brand custodians. They can be updated through new artwork, reallocated from one campaign to another, and positioned flexibly depending on venue layout and event objectives. When acquired in sets, banners with distinct but complementary artwork can be arranged to create narrative sequences, product clusters, or zoned messaging that supports the broader communication strategy at a venue.

Conclusion

Event Branding’s current Econo pull-up banner pricing of R835.00 excluding VAT per unit, combined with a “buy four, receive a fifth banner at no additional banner cost” structure, is aligned with the ongoing role of economy pull-up systems in South Africa’s event and retail branding environment. Within an industry that continues to rely on portable display hardware to support experiential marketing, trade exhibitions, and in-store visibility, this type of structured offer provides organisations with a defined mechanism to expand their pool of reusable branding assets for the 2026 events cycle and beyond.

 

 

 

Media Contact

Organization: Event Branding

Contact Person: Bernie Burness

Website: https://eventbranding.co.za/

Email: Send Email

Contact Number: +27823216520

Address:52 The Avenue

Address 2: henley on klip

City: Meyerton

State: Gauteng

Country:South Africa

Release id:41568

The post Event Branding Launches Budget-Friendly Pull-Up Solutions for 2026 Corporate Events appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section

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Neel Somani on Infrastructure, Energy Markets, and Building the Systems of Tomorrow

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Canton, Michigan, 5th March 2026, ZEX PR WIRE — Neel Somani has built his career at the intersection of machine learning, markets, and infrastructure. A seasoned researcher and entrepreneur, he is driven by a singular fascination: how complex systems actually work beneath the surface and how to make them more efficient.

That systems-level thinking began early. At UC Berkeley, Neel pursued an unusually rigorous academic path, juggling triple majors across computer science, mathematics, and business administration. The combination wasn’t accidental. Computer science gave him the tools to build, mathematics gave him the tools to model, and business gave him the lens to understand incentives. Together, they formed the intellectual framework that would define his work.

After Berkeley, Neel Somani joined Citadel’s commodities group, where he focused heavily on power markets, one of the most structurally complex and misunderstood markets in the global economy. Electricity pricing, in particular, reveals how theory and reality often diverge.

Take New York City. Many people assume electricity there should be cheap. Upstate New York benefits from nuclear power and hydropower, including energy from Niagara Falls. Yet New York City operates as its own pricing zone, and transmission capacity between upstate and the city is limited. When those lines reach their physical limit, the city must generate power locally. That typically means natural gas plants, which are more expensive. The constraint isn’t about a lack of energy overall, it’s about infrastructure bottlenecks.

Understanding the types of natural gas generation deepens the story. At a basic level, all gas plants burn fuel to create high-pressure, high-temperature air. That energy can be extracted from pressure alone or from both pressure and heat. Simple cycle gas turbines operate much like jet engines attached to generators. They start quickly but are less efficient. Combined cycle plants, on the other hand, capture waste heat to produce steam that drives a second turbine. They are far more efficient, but slower and more expensive to start. In the winter, when natural gas is diverted to heating homes, some plants switch to oil, a less efficient fuel that can drive prices even higher.

In theory, power markets dispatch the cheapest and most efficient plants first. In practice, operational constraints complicate that ideal. Some units have high startup costs. Others incur costs when shutting down. Certain plants must run for minimum time periods once activated. Wind turbines, for example, may continue operating even when prices turn negative because it is more expensive to stop and restart. These realities, known broadly as unit commitment constraints, mean the grid does not always behave like a clean economic model. Prices reflect physics, engineering, and timing as much as supply and demand.

For Neel Somani, this insight extends beyond energy. It’s about recognizing that real-world systems operate under constraints that models often simplify away. The same principle applies to renewable energy. Solar power is abundant during the day, but demand continues after sunset. Without storage, renewables cannot fully solve the reliability problem. Batteries help, but they are not the only answer. Pumped hydro storage, moving water uphill and releasing it later, and compressed air storage both rely on the same core idea: store energy when it is cheap and release it when it is scarce. Infrastructure determines flexibility.

This systems-driven perspective ultimately shaped Neel’s transition into blockchain infrastructure. He founded Eclipse, a leading-edge Ethereum Layer 2 powered by the Solana Virtual Machine, designed to improve scalability and execution performance. The project drew $50 million in Series A funding and positioned itself at the forefront of modular blockchain architecture. Just as power grids balance generation, transmission, and storage, blockchains must balance execution, consensus, and data availability. In both cases, bottlenecks define outcomes.

Across energy markets and decentralized networks alike, Neel Somani’s work reflects a consistent philosophy: understand the constraints, respect the mechanics, and design systems that operate efficiently within reality, not just theory. Whether analyzing electricity pricing in New York City or building the next generation of blockchain infrastructure, his focus remains the same. Infrastructure is destiny. And those who understand it shape the future.

To leran more visit: https://www.linkedin.com/in/neelsomani/

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PlanetConvert.co Launches Online HEIC to JPG Converter for Fast and Secure Image Conversion

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PlanetConvertCo has launched a new online tool that allows users to quickly convert HEIC images into widely supported JPG or PNG formats. The browser-based converter is designed to be fast, simple, and privacy-focused, enabling users to convert Apple HEIC photos into compatible image formats in seconds without uploading files to external servers.

United States, 5th Mar 2026 PlanetConvert.co has announced the launch of its new online tool designed to help users quickly convert HEIC images into widely supported JPG or PNG formats. 

HEIC (High Efficiency Image Format) is commonly used on Apple devices because it provides high image quality while keeping file sizes small. Despite its advantages, many websites, apps, and software programs still do not fully support the format. This can make it difficult for users to share or edit HEIC images across different devices and platforms.

PlanetConvertCo’s new converter solves this issue by allowing users to easily transform HEIC images into JPG or PNG formats, which remain the most widely supported image types across operating systems, browsers, and editing tools.

The platform is designed to be simple and accessible. Users can upload their HEIC files directly through the website, convert them instantly, and download the converted images without complicated steps or technical setup.

The tool is intended for everyday users who need to quickly convert photos taken on Apple devices, as well as for professionals who regularly work with images that need universal compatibility for sharing, editing, or publishing online.

By offering a straightforward solution for HEIC conversion, PlanetConvertCo aims to make it easier for users to ensure their images can be opened and used on virtually any device or platform.

The new HEIC converter is now available online and can be accessed directly through their website. 

About PlanetConvertCo

PlanetConvertCo provides a simple online HEIC to JPG converter that allows users to quickly convert images into widely compatible formats. The tool is designed for speed, ease of use, and privacy, with the image conversion operating entirely within the user’s browser. 

Media Contact

Organization: PlanetConvertCo

Contact Person: Danny Gilles

Website: https://planetconvert.co/

Email: Send Email

Country:United States

Release id:42227

The post PlanetConvert.co Launches Online HEIC to JPG Converter for Fast and Secure Image Conversion appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section

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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.

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