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CMS (867.HK; 8A8.SG) NDA for AD Indication of Long-acting Anti-IL-4Rα Humanized Monoclonal Antibody Injection MG-K10 Accepted in China

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SHENZHEN, CHINAChina Medical System Holdings Limited (“CMS”) is pleased to announce that its subsidiary, Dermavon Holdings Limited (“Dermavon”, an innovative pharmaceutical company specialized in skin health which is applying for a separate listing on the Main Board of The Stock Exchange of Hong Kong Limited, please refer to the announcement of CMS on 22 April 2025 for details) together with its subsidiaries, holds co-development rights (except for atopic dermatitis (AD)) and exclusive commercialization rights for the Class 1 innovative drug anti-IL-4Rα MG-K10 humanized monoclonal antibody injection (“MG-K10” or the “Product”). The New Drug Application (“NDA”) has been accepted by National Medical Products Administration (NMPA) on 30 October 2025. The product is intended for the treatment of adult with moderate-to-severe AD whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable.

 

MG-K10 (generic name: Comekibart Injection) is an innovative long-acting anti-IL-4Rα humanized monoclonal antibody that simultaneously blocks the signaling of key type 2 inflammatory cytokines IL-4 and IL-13. With a longer half-life, the Product enables a four-week dosing frequency (currently marketed anti-IL-4Rα drugs require biweekly dosing), which is expected to improve patient adherence. MG-K10 is expected to become the world’s first long-acting anti-IL-4Rα monoclonal antibody to be launched on the market, and has the potential to become the Best-in-Class (BIC).

 

MG-K10 has achieved positive results in a randomized, double-blind, placebo-controlled Phase III clinical study in adults with moderate-to-severe AD, meeting the primary research endpoint as designed, and at 52 weeks of treatment with MG-K10, proportion of participants with Investigator Global Assessment (IGA) score of 0 or 1, also with an improvement of 2 points from baseline is 76.6%; proportion of participants with 75% reduction in Eczema Area and Severity Index (EASI 75) from baseline is 94.3 %; proportion of participants with 90% reduction in Eczema Area and Severity Index (EASI 90) from baseline is 79.1 %. Regarding safety, most of the Treatment Emergent Adverse Event (TEAE) were Grade 1-2, with no Adverse Event of Special Interest (AESI) or fatal adverse event occurred. The incidence of common adverse reactions (conjunctivitis, injection site reactions, etc.) of drugs with the same target is relatively low for MG-K10.

 

The Product has the potential for the treatment of other type 2 inflammatory diseases, such as asthma, prurigo nodularis, seasonal allergic rhinitis, chronic obstructive pulmonary disease, chronic spontaneous urticaria, chronic rhinosinusitis with nasal polyps, and eosinophilic esophagitis. Among them, asthma, prurigo nodularis and seasonal allergic rhinitis have all entered the phase III clinical trial stage in China.

 

If MG-K10 is approved, it will provide a new, effective, and safe systemic treatment option for 14.5 million patients with moderate-to-severe AD[1]. Furthermore, MG-K10 will generate synergy with Dermavon’s ruxolitinib cream (for mild to moderate AD), the oral small molecule TYK2 inhibitor CMS-D001 (for moderate to severe AD), and dermatology-grade skincare products of Heling soothing product series, establishing a comprehensive solution for AD that covers various administration routes (injection, oral, and topical) and addresses multiple needs in “treatment + care”, benefiting a wide range of AD patients. Concurrently, it will further enrich Dermavon’s product portfolio in the field of dermatological treatment and reinforce its leading position in skin health sector.

 

On 24 January 2025, CMS through its subsidiaries entered into a Collaboration Agreement (“Agreement”) with Hunan Mabgeek Biotech Co., LTD and its subsidiaries for MG-K10. In accordance with the Agreement and supplementary agreements, CMS has obtained the co-development rights (excluding AD) and exclusive commercialization rights for the Product in Mainland China, Hong Kong Special Administrative Region, Macao Special Administrative Region, Taiwan Region and Singapore; its subsidiary Dermavon has obtained, through its subsidiary, the co-development rights (excluding AD) and exclusive commercialization rights for the Product in the field of dermatological indications in Mainland China.

 

About AD Indication

MG-K10’s first indication, AD, is a chronic inflammatory skin disease accompanied by severe itching. It is the most burdensome non-fatal skin disease worldwide and also a chronic disease with a relatively high prevalence and significant disease burden in China. It is estimated that there are over 54 million AD patients in China in 2024. Based on SCORAD scores, the proportion of moderate to severe AD in China was 27%, which means there are over 14.5 million patients[1]. Due to the limitations in efficacy and safety of traditional systemic therapies for AD, moderate to severe AD patients often experience delays in systemic treatment initiation, poor compliance, and suboptimal disease control, leaving a significant unmet need in clinical practice[2]. MG-K10, with its extended dosing interval of once every four weeks, is expected to improve patient adherence and provide a new, effective, and safe systemic treatment option for patients with moderate-to-severe AD.

 

About CMS

CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.

 

CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.

 

CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development in its advantageous specialty fields, strengthening the competitiveness of the cardio-cerebrovascular/ gastroenterology/ ophthalmology/ skin health businesses, bringing economies of scale in specialty fields. Among them, the skin health business (Dermavon) has become a leading enterprise in its field, and is proposed to be listed independently on the SEHK. Meanwhile, CMS continuously promotes the operation and development of its integrated R&D, manufacturing and commercialization chain in Southeast Asia and the Middle East, capturing growth opportunities in emerging markets to support the high-quality and sustainable development  of the Group.

 

Reference:

  1. China Insights Consultancy. Industry report on global and China Dermatology Treatment and Care Industry
  2. Chinese Society of Dermatology, China Dermatologist Association. Clinical pathway for the diagnosis and treatment of moderate to severe atopic dermatitis in China (2023): an expert consensus[J]. Chinese Journal of Dermatology, 2023, 56(11): 1000-1007. DOI: 10.35541/cjd.20230247.

 

CMS Disclaimer and Forward-Looking Statements

 

This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patients specific circumstances and in accordance with the drug package insert.

 

This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Groups market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.

 

Media Contact

Brand: China Medical System Holdings Ltd.

Contact: CMS Investor Relations

Email: ir@cms.net.cn

Website: https://web.cms.net.cn/en/home/

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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.

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AntNest $1,000,000 Genesis Airdrop is LIVE! Play games to Win Big!

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Amid the ongoing surge of the Web3 entertainment sector, AntNest — a highly anticipated fully on-chain decentralized entertainment and prediction platform — has announced a major expansion of its ecosystem. Recently, AntNest launched multiple on-chain games and introduced a joint airdrop campaign with several community partners, with a total prize pool of $1,000,000 in USDC, further boosting user participation and ecosystem growth.
The platform has now been successfully deployed on both Base and BSC (BNB Smart Chain). With its high transparency and strong product experience, AntNest has quickly gained traction across the Web3 community.
According to the latest on-chain data, since launch, AntNest has processed over 12,000 game rounds, attracted more than 3,500 unique players, and distributed over $2.4 million in total payouts. To celebrate this key milestone and accelerate community growth, AntNest has also launched its airdrop campaign. With a combination of diverse gameplay and incentive mechanisms, user engagement on the platform continues to grow.
Unlike traditional centralized gaming platforms such as Stake, AntNest is built around on-chain execution and verifiable outcomes. By integrating verifiable random functions (VRF) and smart contract-based settlement, the platform ensures fairness and transparency while creating a more direct link between gameplay and trust.

Eliminating Trust Barriers: How AntNest Defines True On-Chain Fairness
For a long time, traditional betting platforms and pseudo-decentralized games have struggled with issues such as “black-box algorithms,” “manipulated probabilities,” and “withdrawal barriers.” AntNest was created to eliminate these problems entirely through cryptographic guarantees.
As a native Web3 platform, AntNest has established four core technological pillars:
Provably Fair (Cryptographic-Level Fairness):
 By eliminating centralized random number generation, all game outcomes are determined by on-chain block hashes combined with VRF. No one — including the development team — can predict or manipulate the results.
100% Fully On-Chain Transparency:
 Every bet, every game result, and every movement of funds within the prize pool is recorded in real-time on Base and BSC. Players can verify all data via blockchain explorers, ensuring full transparency of fund flows.
Instant Payouts:
 No more delayed withdrawals. Once a game ends, smart contracts automatically execute settlements, delivering winnings directly to players’ Web3 wallets instantly — with no manual claims required.
Pure Web3 Experience (No KYC):
 Staying true to decentralization, the platform requires no email registration or identity verification. Simply connect your wallet to begin playing. The code is fully open-source and rigorously audited to ensure maximum fund security.
The platform uses VRF to generate key random outcomes, with all core data recorded on-chain. The settlement process is fully executed by smart contracts, eliminating any possibility of human intervention. Compared to traditional gaming environments, this ensures truly fair mechanics and fair reward distribution.

Six Core Game Matrix: Minimal Interaction, Maximum Upside Potential
AntNest seamlessly combines lightweight gameplay with extreme return potential. Supporting assets including USDC, USDT, BNB, ETH, cbBTC, and AWT, the platform’s six core games feature ultra-simple interactions and instant onboarding, while offering compelling upside opportunities for players across different risk preferences:
Crash:
 A split-second battle between greed and discipline, with the potential to reach 100x, 1,000x, or even higher returns. The multiplier rises in real time from 1.00x, increasing rapidly until a random “crash” occurs. Players simply need to cash out before the crash to instantly lock in substantial profits. Will you secure gains early, or chase the myth of 100x? The timing of your exit — and your ultimate upside — is entirely in your hands.
Mines:
 Customizable difficulty with the potential to reach up to 3,000,000x returns. By bringing the classic minesweeper game on-chain, players can freely adjust the number of mines to control risk and reward. The higher the difficulty, the more extreme the potential returns. Under maximum settings, even minimal input can unlock astonishing upside possibilities.
Devil’s Room:
 A reverse-thinking arena and a high-stakes playground for independent minds. In each round, the system’s “Devil” randomly eliminates a room. If the Devil enters an empty room, all players receive a full refund — effectively granting a free round. If the most crowded room is eliminated, survivors split the losers’ funds. If your judgment sets you apart as the only player in an overlooked room, you could dominate the game and claim 70% of the entire prize pool in a single sweep.
BTC Pool:
 Spend just 1 USDC for a ticket that could change your outcome. The winner claims 70% of the prize pool, with potential returns reaching nearly 50,000x. No strategy required. No experience needed. No large capital necessary. One ticket — one opportunity to redefine your outcome.
ETH Pool:
 Spend 1 USDC for a potentially life-changing opportunity. The winner claims 70% of the prize pool, with potential returns reaching nearly 1,500x. No strategy. No experience. No large capital required. Just one ticket — and the chance to turn it into something bigger.
FlipBTC:
 Simplicity at its core — predict BTC’s direction in seconds. A lightweight prediction game aligned with market movement. Choose Up or Down, get results instantly, and enjoy one of the fastest ways to generate on-chain returns in short periods of time.

$1,000,000 USDC Airdrop Now Live: Get Free Starting Capital
AntNest has partnered with communities including Fish, FomoIn, and DMDAO to launch a Genesis Airdrop campaign with a total prize pool of $1,000,000 in USDC.
Notably, the platform is directly providing starting capital to participants:
Each eligible user receives 3U (USDC/USDT) as initial capital
This capital can be used directly to participate in any on-chain game
Most importantly, once basic settlement conditions are met, all pure profits generated from this 3U can be withdrawn instantly directly to the user’s wallet

Claim Your 3U in 3 Simple Steps
Follow the official account @antnestglobal and complete basic interactions (like and repost campaign posts)
Join the official Telegram: t.me/AntNest_Official
Visit antnest.io to register and connect your Web3 wallet
After completing these steps, users become eligible for the airdrop and subsequent reward distributions.
It is worth noting that the campaign follows a FCFS (First Come, First Served) model, with limited spots available and growing interest from the community.
Users can leverage the airdrop capital to directly enter gameplay, explore different strategies, and potentially generate on-chain profits.

Final Thoughts
As on-chain technology continues to mature, gaming applications are evolving from single-mechanic systems into multi-layered ecosystems. Through its diverse game matrix and airdrop-driven onboarding model, AntNest is building a more comprehensive participation framework.
With the launch of the $1,000,000 USDC Genesis Airdrop, AntNest demonstrates both the robustness of its smart contracts and its commitment to transparency.
Spots are limited — act now. Head to AntNest’s official campaign posts, complete the tasks, claim your 3U starting capital, and begin earning real on-chain profits in a truly fair environment.
 
Stay Updated & Join the Airdrop:
Website: antnest.io
Twitter (X): https://x.com/antnestglobal
Telegram: https://t.me/AntNest_Official

 

Media Contact: 

Media Relations
Global News Online
New York
NY
United States
05391597051
https://www.globalnewsonline.info

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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.

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Floors To Your Home Encourages Buyers to Ask One Key Question Before Purchasing Flooring Online

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Lisle, IL, 25th April 2026, ZEX PR WIRE — As businesses continue to navigate an increasingly competitive and fast-paced marketplace, marketing expert Garrett Kappel is emphasizing the importance of clarity and consistency as foundational elements of effective brand development. Based in Lisle, Illinois, Kappel has built a reputation for helping organizations refine their messaging, align their strategies, and create stronger connections with their audiences through disciplined marketing practices.

Kappel believes that while marketing channels and technologies continue to evolve, the core principles of strong branding remain unchanged. Businesses that communicate clearly and maintain consistency across all touchpoints are more likely to build trust, improve recognition, and achieve long-term growth.

“Many companies invest heavily in marketing activities but overlook the importance of a clear and consistent message,” Kappel said. “Without that foundation, even the most creative campaigns can struggle to deliver meaningful results.”

The Role of Clarity in Modern Brand Development

In today’s crowded marketplace, consumers are exposed to a constant stream of information. Garrett Kappel points out that this environment makes clarity more valuable than ever. Businesses must be able to explain what they offer and why it matters in a way that is easy to understand.

Kappel works with organizations to simplify their messaging without losing depth. This often involves identifying the core value proposition and ensuring that it is communicated effectively across all platforms. When businesses achieve this level of clarity, they make it easier for customers to engage and make informed decisions.

He notes that clarity also reduces internal confusion. Teams that understand the brand’s message can execute marketing initiatives more effectively, leading to stronger and more cohesive outcomes.

“Clarity creates alignment,” Kappel explained. “When everyone understands the message, it becomes much easier to deliver it consistently.”

Consistency as a Driver of Trust and Recognition

While clarity defines what a brand communicates, consistency ensures that the message remains stable over time. Garrett Kappel emphasizes that consistent communication builds familiarity, which is essential for trust.

Businesses often struggle with consistency as they expand into new platforms or experiment with different marketing tactics. Kappel advises companies to establish clear brand guidelines that outline tone, voice, and messaging standards. These guidelines serve as a reference point for all marketing activities.

When customers encounter consistent messaging across websites, social media, and other channels, they begin to associate specific qualities with the brand. This familiarity strengthens recognition and encourages repeat engagement.

“Consistency is what turns a message into a brand,” Kappel said. “It reinforces what you stand for every time a customer interacts with your business.”

Addressing Common Branding Challenges

Garrett Kappel frequently works with businesses that face challenges related to fragmented messaging. As organizations grow, different departments may develop their own communication styles, leading to inconsistency.

Kappel addresses this issue by conducting comprehensive brand evaluations. He reviews existing materials, analyzes communication patterns, and identifies areas where messaging can be improved. This process helps businesses uncover gaps and create a more unified approach.

Another common challenge involves overcomplication. Companies sometimes attempt to communicate too many ideas at once, which can dilute their message. Kappel encourages businesses to focus on a few key points that clearly convey their value.

“Effective branding requires focus,” he said. “When you simplify your message, you make it more powerful.”

Integrating Strategy With Execution

Clarity and consistency must be supported by a strong strategic framework. Garrett Kappel works with leadership teams to align marketing initiatives with broader business objectives. This ensures that branding efforts contribute directly to growth and performance.

Kappel emphasizes the importance of setting clear goals and defining measurable outcomes. By tracking performance metrics, businesses can evaluate the effectiveness of their strategies and make informed adjustments.

This integration of strategy and execution creates a feedback loop that supports continuous improvement. Marketing efforts become more targeted, efficient, and impactful over time.

“Strategy provides direction, and execution brings it to life,” Kappel explained. “When both are aligned, businesses can achieve meaningful progress.”

The Value of a Disciplined Marketing Approach

In an environment where new trends and tools emerge regularly, Garrett Kappel advocates for a disciplined approach to marketing. He encourages businesses to evaluate opportunities carefully rather than adopting every new tactic.

Kappel believes that discipline allows organizations to maintain focus and avoid unnecessary complexity. By prioritizing clarity and consistency, businesses can build a strong foundation that supports long-term success.

This approach does not mean avoiding innovation. Instead, it involves integrating new ideas in a way that aligns with the brand’s core message and strategy.

“Marketing should evolve, but it should not lose its direction,” Kappel said. “Discipline ensures that growth remains intentional.”

Supporting Businesses Across Industries

From his base in Lisle, Illinois, Garrett Kappel works with a wide range of clients, including startups, small businesses, and established organizations. His experience spans industries such as professional services, retail, technology, and healthcare.

Despite these differences, Kappel applies the same principles of clarity and consistency to every engagement. He believes that these fundamentals are universally applicable and essential for building strong brands.

Clients value his collaborative approach and his ability to translate complex ideas into clear, actionable strategies. By focusing on practical solutions, Kappel helps businesses achieve measurable results.

Enhancing the Customer Journey Through Consistent Brand Experience

In addition to refining messaging and aligning strategy, Garrett Kappel places strong emphasis on improving the overall customer journey. He believes that brand development does not stop at communication but extends to every interaction a customer has with a business. From the first point of contact to post-purchase engagement, each step should reflect the same level of clarity and consistency. Kappel often works with businesses to identify friction points in their customer experience and address gaps that may weaken trust or reduce engagement. By ensuring that messaging, service delivery, and follow-up communication are aligned, companies can create a more seamless and reliable experience. This approach not only strengthens brand perception but also supports customer retention and long-term loyalty, which are essential for sustainable growth. 

Looking Ahead: The Future of Brand Development

As the marketing landscape continues to evolve, Garrett Kappel expects clarity and consistency to remain central to effective brand development. While new technologies will create additional opportunities, they will also increase the need for disciplined communication.

Kappel encourages businesses to invest in their brand foundations and to view marketing as a long-term commitment. By maintaining a clear message and consistent execution, organizations can navigate change with confidence.

“Strong brands are built over time,” he said. “They are the result of consistent effort and a clear understanding of what matters to customers.”

For businesses seeking to strengthen their market presence, Kappel’s perspective offers a practical and reliable approach. By focusing on clarity and consistency, organizations can build trust, improve recognition, and achieve sustainable growth in an increasingly competitive environment.

For more information, please feel free to visit https://garrettkappel.com/ 

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Dr B Palvan Recognized for Public Health Leadership and Excellence in Dermatology

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Hyderabad, India, 25th April 2026, ZEX PR WIRE — Dr B Palvan, an experienced medical professional with qualifications in MBBS and DDVL, is being recognized for his contributions to public healthcare administration and specialist services in dermatology, cosmetology, laser treatment, and hair care.

Known for his dual expertise in government healthcare leadership and clinical skin care practice, Dr B Palvan has built a strong reputation through years of dedicated service in Telangana’s health sector.

As a healthcare administrator, Dr B Palvan has received multiple honors for outstanding performance in district medical and health services. His work in implementing national health programs, strengthening public healthcare systems, and improving administrative efficiency has earned recognition from senior government officials and district leadership.

Among his major recognitions, Dr B Palvan received the Meritorious District Officer (DM&HO) Award from the Honorable Collector of Vikarabad District on 26 January 2023 for distinguished service and commitment to public healthcare.

He was again honored with the Meritorious District Officer (DM&HO) Award on 26 January 2024, reflecting continued excellence in district-level health administration and leadership.

In another major milestone, Dr B Palvan was awarded Best Performing DMHO of the Year 2023 in Overall National Health Programs on 25 January 2024. The recognition was presented by senior officials including the Honorable Secretary of the Medical and Health Department, the Commissioner of Health and Family Welfare, and the Director of Public Health and Family Welfare.

Healthcare professionals note that consistent recognition at both district and departmental levels reflects strong administrative capabilities, measurable public service outcomes, and dedication to healthcare delivery systems.

Alongside his public health accomplishments, Dr B Palvan is also respected in the field of dermatology and cosmetology. With specialization in skin treatment, laser procedures, and hair care solutions, he has helped patients seeking modern and evidence-based treatment options.

His qualifications in dermatology have supported his growing profile as a trusted medical professional for skin-related concerns, cosmetic procedures, pigmentation treatment, acne management, laser therapies, and hair restoration guidance.

Experts say doctors who combine administrative leadership with specialist medical knowledge bring unique value to the healthcare ecosystem by understanding both policy implementation and patient care needs.

Dr B Palvan’s career reflects a balance of public service, medical professionalism, and continuous dedication to improving health outcomes.

As Telangana continues to advance healthcare infrastructure and specialist services, professionals like Dr B Palvan are being recognized for contributing to both institutional progress and community well-being.

With multiple awards, strong qualifications, and growing recognition in dermatology and healthcare leadership, Dr B Palvan continues to strengthen his professional reputation as a respected name in medicine and public health.

About Dr B Palvan
Dr B Palvan is a medical professional holding MBBS and DDVL qualifications. He is recognized for achievements in healthcare administration and expertise in dermatology, cosmetology, laser treatments, and hair care services.

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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.

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