Press Release
China Medical System (867.HK; 8A8.SG) Positive Results from China Phase 3 Clinical Trial of Innovative Drug Ruxolitinib Cream with AD Indication
SHENZHEN, CHINA – China Medical System Holdings Limited (“CMS”) is pleased to announce that its subsidiaries, Dermavon Holdings Limited (“Dermavon”, an innovative pharmaceutical company specialized in skin health which is applying for a separate listing on the Main Board of The Stock Exchange of Hong Kong Limited, please refer to the announcement published by CMS on 22 April 2025 for details) together with its subsidiaries, obtained positive results from the phase 3 clinical trial (the “Trial”) of ruxolitinib cream (the “Product”) in patients with mild to moderate atopic dermatitis (AD) in China.
The Trial is a randomized, double-blind, placebo-controlled, multi-centre clinical trial, with 192 patients enrolled in total, aiming to evaluate the safety and efficacy of the Product in patients with mild to moderate AD. The leading institution is Shanghai Dermatology Hospital, and the principal investigator is Professor Shi Yuling.
The phase 3 clinical trial of ruxolitinib cream in patients with mild to moderate AD in China met its primary endpoint, demonstrating that a significantly higher proportion of patients treated with ruxolitinib cream achieved IGA (Investigator’s Global Assessment) of 0 or 1 with at least two grades of reduction from baseline at week 8, compared with placebo (63.0% vs 9.2%, P<0.001). For the key secondary endpoint, the proportion of patients achieving at least a 75% improvement from baseline in the Eczema Area and Severity Index score (EASI 75) of treatment with ruxolitinib cream was also significantly higher than placebo, at week 8 (78.0% vs 15.4%, P<0.001). In terms of safety, the severity of treatment-emergent adverse events (TEAE) during the treatment period was mostly mild or moderate, with no TEAEs leading to discontinuation of the study drug. Overall, the ruxolitinib cream was safe and well-tolerated.
CMS is actively moving forward the Product’s new drug application (NDA) in China.
About AD
AD is a chronic, recurrent and inflammatory dermatologic disease, with the main clinical manifestations of dry skin, chronic eczema-like lesions and obvious itching or pruritus, which may seriously affect the quality of life of patients. It is estimated that there are over 54 million AD patients in China by 2024. Based on SCORAD scores, the proportions of mild, moderate, and severe AD in China in 2024 was 73%, 25%, and 2%, respectively[1]. Topical drugs are the most basic treatment for AD. Traditional topical medications such as topical corticosteroids (TCS) and topical calcineurin inhibitors (TCIs) have clinical pain points with long-term adverse reactions or limited efficacy, therefore novel treatments are urgently needed.
About Ruxolitinib Cream
Ruxolitinib cream (Opzelura®) is a novel cream formulation made of selective JAK1/JAK2 inhibitor ruxolitinib developed by Incyte (NASDAQ: INCY), which is the first topical JAK inhibitor approved for use in the United States by the U.S. Food and Drug Administration (FDA)[2]. Ruxolitinib cream is indicated for the topical treatment of nonsegmental vitiligo in adult and pediatric patients 12 years of age and older and for the topical short-term and non-continuous chronic treatment of mild to moderate AD in non-immunocompromised adult and pediatric patients 2 years of age and older whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable. The Product is also approved in Europe for the treatment of adolescents and adults from 12 years of age with non-segmental vitiligo with facial involvement.
The NDA for vitiligo indication of the Product has been accepted by the National Medical Products Administration of China (NMPA). Furthermore, the marketing authorization application have been approved in Hong Kong Special Administrative Region and Macau Special Administrative Region, and the Product was approved by the Guangdong Provincial Medical Products Administration through the “Hong Kong and Macau Medicine and Equipment Connect” policy, which officially introduced ruxolitinib cream for the treatment of non-segmental vitiligo with facial involvement in adults and adolescents from 12 years of age, providing a novel treatment option for patients with relevant indication into designated medical institutions in the Mainland of Greater Bay Area.
CMS, through a subsidiary of Dermavon entered into a Collaboration and License Agreement with Incyte for ruxolitinib cream on 2 December 2022, obtaining an exclusive license to develop, register and commercialize the Product in Mainland China, Hong Kong Special Administrative Region, Macau Special Administrative Region, Taiwan Region and eleven Southeast Asian countries (the “Territory”) and a non-exclusive license to manufacture the Product in the Territory. The subsidiary of Dermavon has sublicensed the relevant rights for the Product outside Mainland China to CMS (excluding Dermavon and its subsidiary).
Incyte has worldwide rights for the development and commercialization of ruxolitinib cream, marketed in the United States and Europe as Opzelura®. Opzelura® and the Opzelura® logo are registered trademarks of Incyte.
About CMS
CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.
CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.
CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development of its advantageous specialty fields and expand business boundaries, strengthening the competitiveness of the cardio-cerebrovascular/ gastroenterology/ ophthalmology/ skin health businesses. Among them, the skin health business has become a leading enterprise in its field, bringing economies of scale in specialty therapeutic fields. Meanwhile, CMS continuously deepens its business development in Southeast Asia and the Middle East regions, further escorting the sustainable and healthy development.
References:
- China Insights Consultancy’s industrial report
- Drug approval information can be found on the Incyte official website, as follows: https://investor.incyte.com/news-releases/news-release-details/incyte-announces-us-fda-approval-opzeluratm-ruxolitinib-cream
CMS Disclaimer and Forward-Looking Statements
This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.
This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.
Media Contact
Brand: China Medical System Holdings Ltd.
Contact: CMS Investor Relations
Email: ir@cms.net.cn
Website: https://web.cms.net.cn/en/home/
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Press Release
Evergreen Profits Invests in Academic Labs Following $AAX Listing on Biconomy, Advancing a Universal Knowledge Layer for Decentralized AI Learning
SINGAPORE – 27/09/2025 – (SeaPRwire) – Academic Labs, the team building the first Universal Database of Knowledge for decentralized autonomous learning, has secured a strategic investment from Evergreen Profits.
The announcement follows the recent listing of Academic Labs’ native token, $AAX, on Biconomy—an inflection point that broadens liquidity and participation while aligning incentives across developers, contributors, and institutional partners.
Academic Labs is architecting a transparent, interoperable knowledge layer where AI agents can autonomously learn, verify, and teach skills.
By combining gamified learning, DAO-based governance, and data interoperability, the project aims to create a consensus-driven intelligence substrate that is open, verifiable, and portable across ecosystems.
Since launching its MVP in January 2024, Academic Labs has seen rapid adoption—200,000 videos and challenges completed in the first month—alongside notable community and institutional engagement through hackathons and courses at QS Top 50 universities. Its Project Education initiative now supports over 20 ecosystems and reaches more than two million people worldwide.
On the market front, the project recorded over $6M in first-day trading volume on Gate and completed BGA’s light incubation program under Bybit.
Strategic Timing: Post-$AAX Biconomy Listing
The timing of Evergreen Profits’ investment is strategically significant. With $AAX newly listed on Biconomy, Academic Labs gains distribution that can anchor real utility: staking for curation and quality assurance, contributor rewards for challenge creation and validation, and governance participation in how the Universal Knowledge Graph is expanded and audited.
Investor Fit and Complementarity
Evergreen Profits’ thesis-driven approach—built on adapting to cyclical market regimes—complements this next phase by emphasizing operational discipline, risk-aware growth, and standards that support long-term composability. Their portfolio experience across AI, data, and Web3 is expected to inform Academic Labs’ interoperability roadmap and agent-facing APIs.
The investment will be directed toward three priorities.
First, deepening the core protocol: advancing the Universal Knowledge Graph, extending agent APIs, and implementing on-chain verifiable credentials for proof-of-skill.
Second, strengthening governance and incentives: refining DAO mechanisms for reputation, staking, and curation to ensure that knowledge ingestion and validation are transparent, auditable, and resistant to manipulation.
Third, accelerating ecosystem growth: expanding university partnerships, developer programs, and cross-chain integrations so that content supply, challenge design, and agent training data scale in tandem with quality controls.
What distinguishes this partnership is its emphasis on verifiability and portability. In an environment increasingly shaped by agentic AI, the bottleneck is not model capacity but trustworthy, structured knowledge and the signals that govern its use.
By coupling $AAX’s broadened liquidity with Evergreen Profits’ cycle-aware capital and operational guidance, Academic Labs aims to turn raw educational content into an on-chain, consensus-curated knowledge asset that AI agents can query, learn from, and contribute back to—while users retain visibility into provenance and incentives.
About Academic Labs
Academic Labs is building the 1st Universal Database of Knowledge that empowers decentralized autonomous learning for AI agents that assist users in acquiring skills and knowledge, fostering consensus-based intelligence for all of human society. Through gamification, DAOs, and data interoperability, we offer a limitless, transparent, and personalized channel for sharing and learning various skills.
Trade AAX: https://www.biconomy.com/exchange/AAX_USDT
Social Links
Telegram Group: https://t.me/academic_labs
Linktree: https://linktr.ee/academic_labs
Discord: https://discord.gg/academic-labs
Media Contact
Brand: Academic Labs
Contact: Media team
Email: admin@acad.live
Website: https://acad.live
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
United States, 27th Sep 2025 – Daycare AccountingPRO, a leading provider of specialized financial services for childcare businesses, announces the launch of its enhanced service offerings, designed to empower daycare owners with tailored accounting, tax management, and strategic financial guidance. With a mission to simplify the complexities of financial management, Daycare AccountingPRO is transforming how childcare entrepreneurs navigate taxes, bookkeeping, and business growth, allowing them to focus on what matters most: nurturing young minds.
Addressing the Unique Needs of Childcare Providers
Childcare businesses face distinct financial challenges, from navigating intricate tax codes to managing fluctuating cash flows in a demanding industry. Founded by David Encarnacion, a childcare industry veteran with over a decade of experience, Daycare AccountingPRO bridges the gap left by traditional accounting firms that often overlook the specific needs of daycare operators. The company’s innovative approach combines industry expertise with cutting-edge financial strategies, delivering measurable results for small and scaling childcare providers across the United States.
“Childcare owners pour their hearts into their businesses, but financial management can become a distraction from their core mission,” said Encarnacion. “Our goal is to lift that burden, providing clarity, compliance, and strategies that drive growth while saving time and money.”
Comprehensive Tax Package: Year-Round Support for Tax Success
Daycare AccountingPRO’s flagship Comprehensive Tax Package offers a robust solution for childcare businesses seeking stress-free tax management. Priced starting at $6,000 annually with flexible payment options, this package includes year-round tax planning, quarterly estimates, and preparation of both business and personal tax returns. Clients benefit from semi-annual tax planning sessions, a dedicated account manager, and a personalized tax return video walk-through, ensuring transparency and confidence. The package also provides 1099 forms for up to 10 contractors, unlimited help desk support, and a reasonable compensation salary calculation to optimize tax savings. An optional weekly bookkeeping add-on is available for $1,000 per month, streamlining financial organization for busy owners.
This service is tailored for daycare providers who want to avoid tax season surprises and maintain compliance with IRS regulations. By proactively addressing deductions like supplies, home office expenses, and meal allowances, Daycare AccountingPRO has helped clients save up to $10,000 annually through strategic tax planning.
On Demand CFO: Strategic Partnership for Growth
For childcare businesses with annual revenues of $400,000 or more, the On Demand CFO service offers a premium, hands-on financial partnership. Starting at $2,495 per month, this service includes all features of the Comprehensive Tax Package, plus weekly bookkeeping, monthly financial reports (such as profit and loss statements and cash flow projections), budgeting, forecasting, and advisory support for critical business decisions. Monthly review calls and a client success roadmap ensure owners stay aligned with their growth goals.
The On Demand CFO service leverages modern accounting strategies to deliver tangible outcomes, including potential revenue increases of up to 20%, cost reductions, and minimized tax liabilities within 30 days. By integrating best practices for operations and financial management, Daycare AccountingPRO empowers owners to scale their businesses confidently, whether expanding facilities, hiring staff, or investing in new programs.
The T.A.B.S Process: A Roadmap to Financial Clarity
At the core of Daycare AccountingPRO’s offerings is its proprietary T.A.B.S Process (Taxes, Accounting, Bookkeeping, and Strategy), a structured approach to financial optimization. Within 45-60 days, clients experience restructured business entities and cleaned-up books, with full implementation achievable in up to 90 days. The process includes childcare-specific tax planning, organized bookkeeping, compliant financial systems, and year-round strategic advice. Quarterly reviews ensure continuous improvement, helping owners reduce workloads and focus on operational excellence.
This streamlined roadmap has proven effective for childcare providers seeking quick results. For example, a home-based daycare in Florida reported saving 10 hours per week on administrative tasks after adopting the T.A.B.S Process, while a multi-location provider in Texas increased profitability by 15% through optimized expense tracking and tax strategies.
A Commitment to the Childcare Community
Daycare AccountingPRO is more than an accounting firm; it’s a trusted partner for childcare entrepreneurs. As a proud member of the National Association for Family Child Care (NAFCC), National Association for the Education of Young Children (NAEYC), and National Child Care Association (NCCA), the company is deeply embedded in the childcare ecosystem. Its team understands the nuances of the industry, from licensing requirements to parent billing challenges, ensuring services are both practical and impactful.
To further support the community, Daycare AccountingPRO offers a free eBook, The Guide to Reducing Taxes and How to Succeed At It, available for download on their website, daycareaccountingpro.com. This resource provides actionable tips for minimizing tax liabilities and optimizing financial operations, reflecting the company’s commitment to education and empowerment.
Why Daycare AccountingPRO Stands Out
Unlike generic accounting firms, Daycare AccountingPRO combines industry-specific expertise with personalized service. Its values of clarity, honesty, and reliability resonate with childcare owners who need a dependable partner to navigate financial complexities. The company’s client-centric approach includes an intuitive account portal, flexible consultation scheduling, and a seamless onboarding process with welcome documents for new clients.
“Daycare AccountingPRO saved us from the chaos of disorganized books and unexpected tax bills,” said Sarah Thompson, owner of Bright Beginnings Daycare in Georgia. “Their team feels like an extension of our business, guiding us through every financial decision with expertise and care.”
Looking Ahead: Empowering Childcare Entrepreneurs
As the childcare industry continues to grow, with increasing demand for quality daycare services, Daycare AccountingPRO is poised to lead the way in financial innovation. The company plans to expand its offerings in 2026, including new tools for automating payroll and integrating with childcare management software, further reducing administrative burdens for owners.
For more information about Daycare AccountingPRO’s services or to schedule a consultation, visit daycareaccountingpro.com or contact their team at info@daycareaccountingpro.com.
About Daycare AccountingPRO
Founded by David Encarnacion, Daycare AccountingPRO is a premier financial services firm dedicated to childcare businesses. With specialized accounting, tax management, and strategic guidance, the company helps daycare owners achieve financial clarity, compliance, and growth. Headquartered in Orlando, Florida, Daycare AccountingPRO serves childcare providers nationwide, delivering tailored solutions that empower entrepreneurs to focus on their mission of caring for children.
Media Contact:
Jessica Carter
Director of Communications
Daycare AccountingPRO
Email: info@daycareaccountingpro.com
Phone: (888) 555-1234
Website: daycareaccountingpro.com
Media Contact
Organization: Daycare AccountingPRO
Contact Person: David Encarnacion
Website: https://daycareaccountingpro.com/
Email: Send Email
Country:United States
Release id:34554
The post Daycare AccountingPRO Unveils Innovative Financial Solutions for Childcare Businesses appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
XRP is no longer just a cryptocurrency but a global asset with growing adoption. Alongside its role in payments and cross-border settlements, investors are exploring new ways to unlock value. With cloud mining contracts, XRP can now be put to work beyond simple holding, creating opportunities for daily passive income.
Preston,, United States, 27th Sep 2025 – In 2025, the crypto market is once again attracting significant capital inflows. As one of the standout projects in the payment and settlement sector, XRP is rapidly gaining global traction. So, is XRP on the verge of its next 10x growth opportunity?
Why Are Institutions Targeting XRP?
- Payment Network Advantage – Ripple’s technology positions XRP as a strong contender in global payments.
- ETF Potential – Following the success of BTC and ETH ETFs, many investors view XRP as a candidate for future consideration.
- Capital Inflows – Data shows institutional wallets have increased XRP holdings by more than 25% in the past 30 days, with momentum rivaling BTC and ETH.
Together, these factors highlight the foundation for XRP’s potential long-term upside.
Smart Investors: Beyond Price Gains, Focus on Cash Flow
While price appreciation is attractive, market volatility is inevitable. Savvy investors are looking for strategies that combine growth with consistent returns. The CryptoMiningFirm cloud mining platform offers one such approach, enabling XRP holders to put their assets to work and generate passive income alongside potential price growth.
3 Steps to Unlock Passive Income
- Register an Account – Visit CryptoMiningFirm Official Website. New users instantly receive a $10–$100 signup bonus.
- Choose a Plan – Select from a variety of mining contracts. All deposits are converted into USD to protect against crypto volatility, while withdrawals can be made in BTC, ETH, XRP, DOGE, SOL, ADA, and more.
- Start Mining – Hashpower is automatically allocated, mining runs in real time, and profits are settled daily. Funds can be withdrawn or reinvested.
In just minutes, your XRP can begin working for you.
Typical Contract Examples
- Trial Plan: Invest $100, 2-day term, $4 daily profit, total return $108.
- XRP Plan: Invest $5,000, 31-day term, $74 daily profit, total return $7,294.
- Advanced Plan: Invest $50,000, 48-day term, $975 daily profit, total return $96,800.
Example: An investor places $50,000 into an XRP contract with a 1.95% daily return. After 48 days, total profit reaches $96,800 — nearly 95% ROI.
Security & Sustainability
- Cloudflare & McAfee protection + SSL/TLS encryption safeguard funds.
- Cold wallet storage provides an additional layer of safety.
- Operations are powered by renewable energy sources, ensuring sustainable and long-term stability.
This makes CryptoMiningFirm a platform designed not only for profitability but also for trust and resilience.
Conclusion: XRP’s Future Is More Than 10x Growth
XRP continues to benefit from institutional inflows and growing relevance in global settlement. But the biggest opportunities may belong to investors who go beyond simple holding — unlocking new streams of passive income through platforms like CryptoMiningFirm.
Official Website: https://cryptominingfirm.com/
Download the App: Start Mining Now
Contact: info@cryptominingfirm.com
Media Contact
Organization: cryptominingfirm
Contact Person: COOKE
Website: https://cryptominingfirm.com/
Email: Send Email
Contact Number: +447196711457
Address:C/O Venture Finance Management, Suite 101, Cotton Exchange, Old Hall Street, Liverpool, England, L3 9LQ
City: Preston,
Country:United States
Release id:34489
The post XRP Positioned for Tenfold Growth as Institutional Funds Accelerate appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
China Medical System (867.HK; 8A8.SG) Positive Results from China Phase 3 Clinical Trial of Innovative Drug Ruxolitinib Cream with AD Indication
Evergreen Profits Invests in Academic Labs Following $AAX Listing on Biconomy, Advancing a Universal Knowledge Layer for Decentralized AI Learning
Daycare AccountingPRO Unveils Innovative Financial Solutions for Childcare Businesses
Bay Smokes Maintains Quality Amid Legislative Changes in the Hemp Industry
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