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China Medical System (867.HK, 8A8.SG) NDA for the Improved New Drug ZUNVEYL for Alzheimer’s Disease Accepted in China

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4 months ago

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SHENZHEN, CHINA – China Medical System Holdings Limited (“CMS” or the “Group”) is pleased to announce that on 28 July 2025, the New Drug Application (NDA) for improved new drug ZUNVEYL (Benzgalantamine Gluconate Enteric-coated Tablets) (“ZUNVEYL” or the “Product”) has been accepted by the National Medical Products Administration of China (NMPA). The Product is indicated for the treatment of mild-to-moderate dementia of the Alzheimer’s type in adults.

About Product ZUNVEYL

ZUNVEYL was approved in July 2024 by the U.S. Food and Drug Administration (FDA) for the treatment of mild-to-moderate dementia of the Alzheimer’s type in adults. As a new generation of acetylcholinesterase inhibitor (AChEI), ZUNVEYL can inhibit the acetylcholinesterase from breaking down the neurotransmitter acetylcholine, increase the level of acetylcholine in the central nervous system, and therefore alleviate cognition and memory impairment in Alzheimer’s disease patients. As a prodrug of galantamine, ZUNVEYL remains inert as it passes through the stomach and the intestine, and eventually releases the active drug into the bloodstream after being metabolized by the liver. With such a mechanism of action, ZUNVEYL is expected to have equivalent efficacy as galantamine with the potential of reducing gastrointestinal (GI) side effects and addressing certain tolerability issues. Galantamine has accumulated extensive evidence of efficacy and demonstrated long-term clinical benefit in the treatment of mild-to-moderate dementia of the Alzheimer’s type since the approval of FDA in 2001[1]. Moreover, GI adverse events documented across all studies for ZUNVEYL were less than 2% and no insomnia was observed[2]. As the second oral therapy approved by FDA for the treatment of Alzheimer’s disease during the past decade, ZUNVEYL demonstrates a potentially better gastrointestinal safety profile to improve compliance of Alzheimer’s disease patients and therefore brings clinical benefits. Patent in regard to use of ZUNVEYL has already been granted in China.

About Alzheimer’s Disease

Alzheimer’s disease is a chronic, progressive neurodegenerative disease characterized by progressive decline in memory and other cognitive functions, among which some of the patients will progress to dementia. Dementia is a kind of syndrome with acquired cognitive function impairment as the core symptom, and can lead to the reduction of patients’ daily living, learning, working and social interaction ability. Alzheimer dementia accounts for 50% to 70% of all types of dementia[3,4]. According to the epidemiological study results published in the Lancet Public Health[5], there are about 9.83 million patients with Alzheimer dementia in China, of which 7.93 million are mild-to-moderate[6]. With the intensifying aging trend, the number of patients and the consequent disease burden will further increase in the future.

Currently the clinical treatment of Alzheimer’s disease can be categorized as improving cognitive symptoms and decelerating disease progression[7], and AChEI belongs to the former. According to the Research Report on the Diagnosis and Treatment of Alzheimer’s disease Patients in China[8], the high incidence of side effects is one of the major pain points for existing drugs for Alzheimer’s disease, and drug intolerance is one of the challenges in current treatment of Alzheimer’s disease. Tolerability affects therapy adherence, with data showing that 55% of Alzheimer’s disease patients discontinue their medication after one year, mainly due to GI side effects and insomnia. Medication discontinuation can cause risk to patients themselves, and dissatisfaction and burden among patient’s family, physicians, and caregivers[9]. Therefore, Alzheimer’s disease patients still have an urgent need for safer therapies.

On 8 January 2025, the Group through a wholly-owned subsidiary of the Company entered into a License, Collaboration and Distribution Agreement (the “Agreement”)  with Alpha Cognition Inc. (“Alpha”) of the improved new drug ZUNVEYL for the treatment of mild-to-moderate dementia of the Alzheimer’s type. In accordance with the Agreement, the Group is entitled to an exclusive right to develop, register, manufacture, import, export and commercialize the Product in Asia (excluding Japan and the Middle East region), Australia and New Zealand (the “Territory”), Alpha reserves the right to manufacture and supply in the Territory. The term of cooperation commences on the effective date of the Agreement and extends for twenty years (the “Initial Term”), it may be automatically renewed every five years upon the expiration of the Initial Term unless terminated by notice from either party.

Around six months after obtaining the above rights of ZUNVEYL, the Group promptly submitted the NDA in China, demonstrating its efficient allocation of resources and robust capabilities in registration promotion. ZUNVEYL will further diversify the Group’s innovative drug product matrix and enhance the Group’s comprehensive competitiveness. The Product will synergize with the Group’s various central nervous system products including the innovative drug VALTOCO (diazepam nasal spray) and the original brand drug Deanxit (flupentixol and melitracen tablets) on sale and the innovative drug Y-3 for Injection under development in terms of expert network and market resources. Relying on the Group’s successful commercialization experience and compliant and efficient commercialization system, if ZUNVEYL is approved for marketing, it will bring a new drug option for the treatment of cognitive impairment in Chinese Alzheimer’s disease patients, meeting the clinical need for drugs of both efficacy and safety, improving disease diagnosis and treatment practices, thereby benefiting patients. The Product is expected to have a positive impact on the Group’s financial results.

Reference:

  1. Xu, Hong et al. Long-term Effects of Cholinesterase Inhibitors on Cognitive Decline and Mortality. Neurology vol. 96,17 (2021): e2220-e2230. doi:10.1212/WNL.0000000000011832
  2. Safety profile of ZUNVEYL as disclosed by Alpha:  https://www.alphacognition.com/investors/news/alpha-cognitions-oral-ther…
  3. 2018 Chinese Guidelines for the Diagnosis and Treatment of Dementia and Cognitive Impairment (Chapter 1): Dementia Classification and Diagnostic Criteria [J]. National Medical Journal of China, 2018, 98 (13): 965-970. DOI: 10.3760/cma.j.issn.0376-2491.2018.1003
  4. 2018 Chinese Guidelines for the Diagnosis and Treatment of Dementia and Cognitive Impairment (Chapter 2): Guidelines For Diagnosis and Treatment of Alzheimer’s Disease [J]. National Medical Journal of China, 2018,98 (13): 971-977. DOI: 10.3760/cma.j.issn.0376-2491.2018.13.004
  5. Jia, Longfei et al. Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study. The Lancet. Public health vol. 5,12 (2020): e661-e671. doi:10.1016/S2468-2667(20)30185-7
  6. Yuan, Jing et al. Severity Distribution of Alzheimer’s Disease Dementia and Mild Cognitive Impairment in the Framingham Heart Study. 1 Jan. 2021: 807-817.
  7. Mayo Clinic. 2024. Alzheimer’s Disease: Therapies to Improve Cognitive Symptoms and Decelerate Disease Progression. https://www.mayoclinic.org/zh-hans/diseases-conditions/alzheimers-diseas…
  8. Research Report on the Diagnosis and Treatment of Alzheimer’s Disease Patients in China (2020). Alzheimer’s Disease Chinese (ADC). https://www.adc.org.cn/index.php/book/chinaadzlxzbg2020/chinaadzlxzbg2020-381.html
  9. Data on patient discontinuation as disclosed by Alpha:  https://www.alphacognition.com/investors/news/alpha-cognitions-oral-therapy-zunveyl-receives-fda-approval-to-treat-alzheimers-disease-

 

About CMS

CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs. 

CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients. 

CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development of its advantageous specialty fields and expand business boundaries, strengthening the competitiveness of the cardio-cerebrovascular/ gastroenterology/ ophthalmology/ skin health businesses. Among them, the skin health business has become a leading enterprise in its field, bringing economies of scale in specialty therapeutic fields. Meanwhile, CMS continuously deepens its business development in Southeast Asia and the Middle East regions, further escorting the sustainable and healthy development.

 

CMS Disclaimer and Forward-Looking Statements

This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.

This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.

 

Media Contact

Brand: China Medical System Holdings Ltd.

Contact: CMS Investor Relations

Email: ir@cms.net.cn

Website: https://web.cms.net.cn/en/home/

Source: China Medical System Holdings Ltd.

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Press Release

Vanswe Fitness Strengthens Position as a Trusted Provider of Accessible Cardio and Strength Home Gym Equipment in the U.S.

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2 hours ago

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November 22, 2025

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United States, 22nd Nov 2025 – Vanswe Fitness, a direct-to-consumer home fitness brand, today announced the continued expansion of its cardio and strength equipment lineup, reinforcing its commitment to making safe, effective, and affordable home workouts accessible to households across America. With a focus on user-friendly designs and long-lasting equipment, Vanswe Fitness is emerging as a leading choice for seniors, rehabilitation users, and home gym enthusiasts seeking dependable solutions without the premium price tag.

Vanswe Fitness specializes in low-impact recumbent exercise bikes, known for their comfort-focused engineering and ease of use, particularly for older adults, individuals recovering from injury, or anyone seeking joint-friendly cardio. These recumbent bikes—one of the brand’s best-selling product categories—provide a safe and supportive way to stay active at home. Customers can explore the full line of recumbent bikes at https://www.vanswefitness.com/.

In addition to cardio equipment, Vanswe Fitness offers a growing range of strength training machines, including power racks and Smith machines designed for stability, safety, and long-term durability. These products enable full-body strength development at home while minimizing common safety risks associated with traditional free-weight training. The full cardio and strength lineup can be viewed here: https://www.vanswefitness.com/.

“We design every piece of equipment with real people in mind,” said a Vanswe Fitness spokesperson. “Our focus has always been on products that are approachable—easy to assemble, comfortable to use, stable, and built to last. We are especially passionate about supporting seniors and rehabilitation users, who are often underserved in the home fitness market.”

A Trusted Alternative to Established Fitness Brands

With the rising demand for at-home workout solutions, Vanswe Fitness competes with several well-known fitness equipment brands . However, Vanswe sets itself apart through its direct-to-consumer model, which allows it to offer premium-grade equipment at more affordable prices, avoiding the typical retail markups found in big-box stores.

Key Benefits of Vanswe Fitness Equipment Include:

  • Low-impact cardio options designed for seniors and rehabilitation
  • Stable and secure strength systems for safer home workouts
  • Adjustable features to accommodate a wide range of body types and fitness levels
  • Direct-to-consumer affordability without compromising build quality
  • Long-lasting performance, backed by strong customer reviews and repeat buyers

Built for Accessibility and Safety

At the core of Vanswe Fitness is a philosophy of accessible fitness. The brand emphasizes low joint strain, ergonomic support, and user-friendly assembly—making exercise achievable for people who may struggle with high-impact or technically complex gym routines.

Each product undergoes rigorous testing to ensure stability and durability, offering customers confidence in building their personal fitness routines at home.

Strengthening Brand Authority Through Education & Support

As part of its growth strategy, Vanswe Fitness is enhancing community and educational outreach to help customers select the right equipment and training approach for their needs. The brand is also expanding user support resources and expert insights to empower healthier, safer home exercise practices.

“Our mission is to ensure that anyone—regardless of age or fitness level—feels confident working out at home,” the spokesperson added.

To explore Vanswe Fitness products and learn more about home gym solutions, visit the official site:
 https://www.vanswefitness.com/

About Vanswe Fitness
Vanswe Fitness is a U.S.-based home fitness brand specializing in reliable and affordable cardio and strength equipment. With a focus on recumbent bikes for low-impact exercise and heavy-duty home gym systems like Smith machines and power racks, Vanswe Fitness is committed to making safe fitness accessible to households nationwide.

Media Contact

Organization: Vanswe Fitness

Contact Person: Tony Shen

Website: https://www.vanswefitness.com/

Email: Send Email

Country:United States

Release id:37533

The post Vanswe Fitness Strengthens Position as a Trusted Provider of Accessible Cardio and Strength Home Gym Equipment in the U.S. appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section

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Press Release

Get AI-Driven, Result-Oriented SEO Campaigns by SEOServicesInIndia.CO.IN

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3 hours ago

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November 22, 2025

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SEOServicesInIndia.CO.IN has introduced AI SEO, Geo SEO, and ChatGPT SEO Services to help Indian businesses stand out online. These tools make SEO smarter, faster, and easier through AI-driven optimisation, hyper-local visibility, and quick, high-quality content creation. With flexible plans and a results-focused approach, the company aims to help startups and local businesses grow steadily. Founder Anubhav Garg says the goal is simple: give Indian businesses practical tools that actually work in today’s competitive digital space.

Delhi, 22 November 2025 – Okay, business owners in India, listen up. This is worth your attention. SEOServicesInIndia.CO.IN, a trusted SEO Company India, has just launched its latest SEO Services: AI SEO Services, Geo SEO Services, and ChatGPT SEO Services. Yes—all three. And they’re designed for businesses that want to be found online, without pulling their hair out over complicated strategies.

Let’s be honest. India’s digital space is crowded. Overcrowded, even. If you run a small shop, a local service, or a growing online brand, being visible on Google isn’t optional anymore. It’s essential. And that’s exactly why we decided to offer something smarter. Something simpler. Something that actually works.

Here’s what’s new

  • AI SEO Services – Imagine giving your website a brain upgrade. That’s what AI SEO Services is. Your site learns, adapts, and improves with every update. Keywords, meta tags, content ideas—everything becomes faster, smarter, and more likely to push you up the search rankings.
  • Geo SEO Services – Local businesses, this one’s for you. Want to be found in your city? Or maybe just your neighbourhood? Geo SEO Services make it happen. City-level searches, hyper-local results—your business shows up exactly where it matters most.
  • ChatGPT SEO Services – Content is king. No debate there. But creating it can be a headache. That’s where ChatGPT SEO Services step in. Blogs, landing pages, product descriptions—SEO-optimised, high-quality, and fast. Less stress, more results.

Why are these services going to make a difference?

  • Work smarter, not harder – AI SEO Services guide your strategy with real insights.
  • Reach the right audience – Geo SEO Services help local customers find you without guesswork.
  • No more content headaches – ChatGPT SEO Services produce SEO-friendly content quickly.
  • Flexible plans – Pick the SEO Package India that fits your business perfectly.
  • All-in-one SEO Services – AI SEO Services, Geo SEO Services, and ChatGPT SEO Services together.
  • Focus on real results – Not just rankings. Traffic. Leads. Conversions.

Why SEOServicesInIndia.CO.IN?

We’re not just any SEO company. As a reputed SEO Company india, we’ve helped hundreds of businesses grow online. Now, with AI SEO Services, Geo SEO Services, and ChatGPT SEO Services, Indian businesses have access to smarter, faster, and more practical tools to reach their goals.

Startups in Bengaluru, small businesses in Pune, online stores in Delhi—whatever the size or type, we’ve got you covered. No jargon. No over-promises. Just tools that help your business get found, connect with the right audience, and grow steadily.

Looking ahead

Digital marketing in India is moving at lightning speed. Search engines are smarter. Audiences are more selective. Competition? Fiercer than ever. Modern SEO isn’t optional anymore—it’s mandatory.

“Our vision is simple,” says Anubhav Garg, Founder & CEO of SEOServicesInIndia.CO.IN. “We want Indian businesses to grow online using tools that actually work. AI SEO Services, Geo SEO Services, and ChatGPT SEO Services help businesses reach the right audience, improve rankings, and save time. That’s it. Simple, practical, and effective.”

Contact us 

Call or WhatsApp –  +919717686168

Email – Anubhav@Mysticdigi.com 

Media Contact

Organization: SEOServiceinIndia.co.in

Contact Person: SEOServiceinIndia.co.in

Website: https://seoserviceinindia.co.in/

Email: Send Email

Contact Number: +919717686168

Address:J-57, Ramesh Nagar

City: Delhi

State: Delhi

Country:India

Release id:37617

The post Get AI-Driven, Result-Oriented SEO Campaigns by SEOServicesInIndia.CO.IN appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section

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Press Release

OpenDroids Beats 1X’s Neo in Real-World Dishwashing Test — at Twice the Speed and a Fraction of the Funding

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3 hours ago

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November 22, 2025

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San Francisco, CA – Nov, 2025 – OpenDroids, a robotics startup focused on practical home and workplace automation, today announced that its humanoid robot has completed a full dishwasher-loading task roughly twice as fast as 1X Technologies’ Neo robot, despite operating on around 1/100 of the capital raised by its better-funded competitor.

In a recent side-by-side kitchen demonstration, OpenDroids’ robot and Neo were each tasked with loading a standard dishwasher with dishes from a countertop and sink. Under comparable conditions, the OpenDroids unit finished the job in approximately half the time, showcasing what the company calls “capital-efficient automation” doing more with dramatically less money.

“Everyone talks about billion-dollar robots. We wanted to prove you don’t need a billion dollars to get real work done,” said Jack Jesionowski, Founder at OpenDroids. “With about one-hundredth of Neo’s funding, our robot loaded the dishwasher twice as fast. It’s not just a flex, it’s proof that scrappy engineering and tight focus can beat raw capital.”

Proving That Speed and Scrappiness Still Matter

While much of the industry is focused on glossy demos and mega-rounds, OpenDroids intentionally chose a boring, unavoidable household chore, doing the dishes, to illustrate a bigger point:

  • Real task, real environment – No lab tricks. A standard kitchen, real dishes, and a common home appliance.
  • Direct comparison – Same core task: identify dishes, grasp them, and load them into the appropriate racks.
  • Capital efficiency – OpenDroids claims to have spent 1/100 of Neo’s funding and still delivered faster real-world performance in this test.

“We respect what teams like 1X are building. But this demo shows something important,” added Sebastian Paredes, CMO of OpenDroids. “The future won’t be won just by whoever raises the biggest round. It’ll be won by whoever can turn every dollar into actual, repeatable tasks in the real world.”

More With Less: A Different Robotics Playbook

Instead of chasing sci-fi perfection, OpenDroids is focused on nailing a narrow set of high-frequency tasks that matter most to households and businesses: cleaning, organizing, and basic handling.

The dishwasher demo is the first in a series of public benchmarks the company plans to release, all centered around one idea: “Show, don’t tell.”

  • Task-first, not hype-first – Every demo is chosen around economic value: chores people hate, time businesses can’t afford to waste.
  • Capital discipline – Lean teams, smaller budgets, and faster iteration cycles.
  • Execution over aesthetics – If it gets the job done faster and reliably, it wins.

Watch the Demo

The full side-by-side dishwasher run featuring OpenDroids and Neo is available at:

Video Link

Businesses, investors, and partners interested in pilot programs or collaborations can reach the team at contact@opendroids.com or visit the website.

About OpenDroids

OpenDroids is a robotics company building practical humanoid robots for real-world chores, starting with cleaning, organizing, and basic handling tasks in homes and businesses. Operating with a fraction of the capital of legacy robotics players, OpenDroids focuses on capital-efficient engineering, fast iteration, and real-world performance, proving that you don’t need billions to automate the work people least want to do.

Learn more at website.

Media Contact

Organization: Open Droids

Contact Person: Jack Jesionowski

Website: https://www.opendroids.com/

Email: Send Email

Country:United States

Release id:37605

The post OpenDroids Beats 1X’s Neo in Real-World Dishwashing Test — at Twice the Speed and a Fraction of the Funding appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section

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