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China Medical System (867.HK, 8A8.SG) NDA for the Improved New Drug ZUNVEYL for Alzheimer’s Disease Accepted in China

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SHENZHEN, CHINA – China Medical System Holdings Limited (“CMS” or the “Group”) is pleased to announce that on 28 July 2025, the New Drug Application (NDA) for improved new drug ZUNVEYL (Benzgalantamine Gluconate Enteric-coated Tablets) (“ZUNVEYL” or the “Product”) has been accepted by the National Medical Products Administration of China (NMPA). The Product is indicated for the treatment of mild-to-moderate dementia of the Alzheimer’s type in adults.

About Product ZUNVEYL

ZUNVEYL was approved in July 2024 by the U.S. Food and Drug Administration (FDA) for the treatment of mild-to-moderate dementia of the Alzheimer’s type in adults. As a new generation of acetylcholinesterase inhibitor (AChEI), ZUNVEYL can inhibit the acetylcholinesterase from breaking down the neurotransmitter acetylcholine, increase the level of acetylcholine in the central nervous system, and therefore alleviate cognition and memory impairment in Alzheimer’s disease patients. As a prodrug of galantamine, ZUNVEYL remains inert as it passes through the stomach and the intestine, and eventually releases the active drug into the bloodstream after being metabolized by the liver. With such a mechanism of action, ZUNVEYL is expected to have equivalent efficacy as galantamine with the potential of reducing gastrointestinal (GI) side effects and addressing certain tolerability issues. Galantamine has accumulated extensive evidence of efficacy and demonstrated long-term clinical benefit in the treatment of mild-to-moderate dementia of the Alzheimer’s type since the approval of FDA in 2001[1]. Moreover, GI adverse events documented across all studies for ZUNVEYL were less than 2% and no insomnia was observed[2]. As the second oral therapy approved by FDA for the treatment of Alzheimer’s disease during the past decade, ZUNVEYL demonstrates a potentially better gastrointestinal safety profile to improve compliance of Alzheimer’s disease patients and therefore brings clinical benefits. Patent in regard to use of ZUNVEYL has already been granted in China.

About Alzheimer’s Disease

Alzheimer’s disease is a chronic, progressive neurodegenerative disease characterized by progressive decline in memory and other cognitive functions, among which some of the patients will progress to dementia. Dementia is a kind of syndrome with acquired cognitive function impairment as the core symptom, and can lead to the reduction of patients’ daily living, learning, working and social interaction ability. Alzheimer dementia accounts for 50% to 70% of all types of dementia[3,4]. According to the epidemiological study results published in the Lancet Public Health[5], there are about 9.83 million patients with Alzheimer dementia in China, of which 7.93 million are mild-to-moderate[6]. With the intensifying aging trend, the number of patients and the consequent disease burden will further increase in the future.

Currently the clinical treatment of Alzheimer’s disease can be categorized as improving cognitive symptoms and decelerating disease progression[7], and AChEI belongs to the former. According to the Research Report on the Diagnosis and Treatment of Alzheimer’s disease Patients in China[8], the high incidence of side effects is one of the major pain points for existing drugs for Alzheimer’s disease, and drug intolerance is one of the challenges in current treatment of Alzheimer’s disease. Tolerability affects therapy adherence, with data showing that 55% of Alzheimer’s disease patients discontinue their medication after one year, mainly due to GI side effects and insomnia. Medication discontinuation can cause risk to patients themselves, and dissatisfaction and burden among patient’s family, physicians, and caregivers[9]. Therefore, Alzheimer’s disease patients still have an urgent need for safer therapies.

On 8 January 2025, the Group through a wholly-owned subsidiary of the Company entered into a License, Collaboration and Distribution Agreement (the “Agreement”)  with Alpha Cognition Inc. (“Alpha”) of the improved new drug ZUNVEYL for the treatment of mild-to-moderate dementia of the Alzheimer’s type. In accordance with the Agreement, the Group is entitled to an exclusive right to develop, register, manufacture, import, export and commercialize the Product in Asia (excluding Japan and the Middle East region), Australia and New Zealand (the “Territory”), Alpha reserves the right to manufacture and supply in the Territory. The term of cooperation commences on the effective date of the Agreement and extends for twenty years (the “Initial Term”), it may be automatically renewed every five years upon the expiration of the Initial Term unless terminated by notice from either party.

Around six months after obtaining the above rights of ZUNVEYL, the Group promptly submitted the NDA in China, demonstrating its efficient allocation of resources and robust capabilities in registration promotion. ZUNVEYL will further diversify the Group’s innovative drug product matrix and enhance the Group’s comprehensive competitiveness. The Product will synergize with the Group’s various central nervous system products including the innovative drug VALTOCO (diazepam nasal spray) and the original brand drug Deanxit (flupentixol and melitracen tablets) on sale and the innovative drug Y-3 for Injection under development in terms of expert network and market resources. Relying on the Group’s successful commercialization experience and compliant and efficient commercialization system, if ZUNVEYL is approved for marketing, it will bring a new drug option for the treatment of cognitive impairment in Chinese Alzheimer’s disease patients, meeting the clinical need for drugs of both efficacy and safety, improving disease diagnosis and treatment practices, thereby benefiting patients. The Product is expected to have a positive impact on the Group’s financial results.

Reference:

  1. Xu, Hong et al. Long-term Effects of Cholinesterase Inhibitors on Cognitive Decline and Mortality. Neurology vol. 96,17 (2021): e2220-e2230. doi:10.1212/WNL.0000000000011832
  2. Safety profile of ZUNVEYL as disclosed by Alpha:  https://www.alphacognition.com/investors/news/alpha-cognitions-oral-ther…
  3. 2018 Chinese Guidelines for the Diagnosis and Treatment of Dementia and Cognitive Impairment (Chapter 1): Dementia Classification and Diagnostic Criteria [J]. National Medical Journal of China, 2018, 98 (13): 965-970. DOI: 10.3760/cma.j.issn.0376-2491.2018.1003
  4. 2018 Chinese Guidelines for the Diagnosis and Treatment of Dementia and Cognitive Impairment (Chapter 2): Guidelines For Diagnosis and Treatment of Alzheimer’s Disease [J]. National Medical Journal of China, 2018,98 (13): 971-977. DOI: 10.3760/cma.j.issn.0376-2491.2018.13.004
  5. Jia, Longfei et al. Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study. The Lancet. Public health vol. 5,12 (2020): e661-e671. doi:10.1016/S2468-2667(20)30185-7
  6. Yuan, Jing et al. Severity Distribution of Alzheimer’s Disease Dementia and Mild Cognitive Impairment in the Framingham Heart Study. 1 Jan. 2021: 807-817.
  7. Mayo Clinic. 2024. Alzheimer’s Disease: Therapies to Improve Cognitive Symptoms and Decelerate Disease Progression. https://www.mayoclinic.org/zh-hans/diseases-conditions/alzheimers-diseas…
  8. Research Report on the Diagnosis and Treatment of Alzheimer’s Disease Patients in China (2020). Alzheimer’s Disease Chinese (ADC). https://www.adc.org.cn/index.php/book/chinaadzlxzbg2020/chinaadzlxzbg2020-381.html
  9. Data on patient discontinuation as disclosed by Alpha:  https://www.alphacognition.com/investors/news/alpha-cognitions-oral-therapy-zunveyl-receives-fda-approval-to-treat-alzheimers-disease-

 

About CMS

CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs. 

CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients. 

CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development of its advantageous specialty fields and expand business boundaries, strengthening the competitiveness of the cardio-cerebrovascular/ gastroenterology/ ophthalmology/ skin health businesses. Among them, the skin health business has become a leading enterprise in its field, bringing economies of scale in specialty therapeutic fields. Meanwhile, CMS continuously deepens its business development in Southeast Asia and the Middle East regions, further escorting the sustainable and healthy development.

 

CMS Disclaimer and Forward-Looking Statements

This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.

This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.

 

Media Contact

Brand: China Medical System Holdings Ltd.

Contact: CMS Investor Relations

Email: ir@cms.net.cn

Website: https://web.cms.net.cn/en/home/

Source: China Medical System Holdings Ltd.

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From Code to Compassion: Rathi Murthy’s Journey of Mindful Leadership

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October 8, 2025

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California, US, 8th October 2025, ZEX PR WIRE, Rathi Murthy is widely recognized as one of the most visionary technology leaders of her generation, a trailblazer whose career spans some of the most influential companies in the world and whose impact continues to redefine what is possible at the intersection of artificial intelligence, financial inclusion, and mindful leadership. Named among the Top Women in Tech, Murthy’s influence stretches far beyond the boardroom. She embodies a rare blend of technical mastery, business acumen, and human-centered leadership, positioning her as a role model for the next generation of innovators.

Today, Murthy serves as the Chief Technology Officer at Varo Bank, the first nationally chartered, all-digital consumer bank in the United States. In this role, she leads Varo’s end-to-end technology strategy, advancing its mission to deliver secure, scalable, and AI-powered digital banking platforms. Her vision is bold yet deeply practical: to build real-time, inclusive, and accessible financial solutions for millions of consumers who have historically been underserved by traditional banking systems. For Murthy, AI is not just a technology, it is a tool for social transformation, a force that can dismantle barriers and create pathways for financial empowerment.

A Career Forged at the Crossroads of Innovation

Murthy’s career trajectory is as impressive as it is inspiring. Before joining Varo Bank, she held senior leadership positions at some of the most dynamic organizations in technology, media, and financial services.

As Chief Technology Officer and President of Expedia Services at Expedia Group, Murthy led critical technology pillars across artificial intelligence, e-commerce, payments, and customer experience. She played a central role in modernizing Expedia’s global platform, helping the company reimagine the infrastructure that powers millions of bookings worldwide. Her leadership was instrumental in bringing agility, personalization, and innovation to a highly competitive travel industry.

Earlier, as CTO at Verizon Media, Murthy spearheaded global technology initiatives, driving innovations in 5G, AI, and media platforms. She also served as SVP and CTO at Gap Inc., where she created the digital transformation roadmap for the company’s family of brands, ensuring that the future of retail would be as immersive and data-driven as it was customer-focused.

Her prior roles include CIO of Enterprise Growth at American Express, where she built technology capabilities to support new business models, as well as senior positions at eBay, Yahoo, Sun Microsystems, and WebMD. Each role added new dimensions to her leadership philosophy, sharpening her expertise in scaling technology platforms while keeping people and experiences at the center.

Recognition and Influence

Murthy’s contributions have not gone unnoticed. She has been consistently celebrated as a force in global technology leadership.
 • Top 100 Executive Women in Tech to Watch (2023) by WomenTech Network
 • Top Woman in Cloud Innovation (2014)
 • Most Influential Women in Payments (2015)

These honors reflect more than her accomplishments. They acknowledge her courage in breaking barriers, her commitment to mentoring other women in tech, and her determination to build a more equitable industry.

Mindful Leadership: The Art of Living

Beyond her corporate roles, Murthy is also a teacher of The Art of Living, a global movement dedicated to cultivating mindfulness, resilience, and community well-being. This practice is more than a personal pursuit, it informs her leadership style and her belief that technology must be aligned with humanity’s highest values.

For Murthy, mindful leadership is not a trend but a necessity. In a world where technology evolves at breathtaking speed, she believes that leaders must balance innovation with intention, ensuring that progress does not come at the expense of peace, well-being, or ethical responsibility. Her integration of mindfulness into her executive leadership is one of the qualities that set her apart in the tech industry. She leads with clarity, empathy, and purpose.

Board Service and Mentorship

Murthy is also deeply committed to shaping the future of education and innovation. She serves on the Board of Directors for PagerDuty, on the Board of Governors at Sri Sri University, and as an advisor to the University of San Francisco. She is also an active angel investor, supporting mission-driven startups in fintech, enterprise technology, and social impact. Through these roles, she empowers the next generation of entrepreneurs, ensuring that their ideas and innovations are nurtured with both resources and mentorship.

A Life Rooted in Purpose

Murthy’s journey is not just one of professional triumphs, it is a testament to living a life rooted in purpose. Her story reflects the power of resilience, adaptability, and continuous growth. Whether leading global teams at Fortune 500 companies, advising academic institutions, or teaching mindfulness to communities, Murthy approaches every role with the same conviction: technology must serve humanity, and leadership must serve others.

She holds a Master’s degree in Computer Engineering from Santa Clara University, where she honed the technical foundation that would fuel her ascent in the tech world. Yet her education did not end there. Her lifelong learning through corporate leadership, spiritual practice, and mentorship continues to shape her evolving vision of what technology and leadership can achieve.

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Darius McGrew Leads Frontier’s AI-Powered Push for Hurricane Preparedness Across Florida

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October 8, 2025

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Canton, Michigan, 8th October 2025, ZEX PR WIRE, As Florida braces for another turbulent hurricane season, telecommunications executive Darius McGrew is stepping into the spotlight with innovative AI-powered strategies that are redefining how businesses and communities prepare for natural disasters. As an Enterprise Account Executive with Frontier Communications, McGrew has become a trusted partner to organizations across the healthcare, government, finance, and nonprofit sectors, ensuring they remain connected when storms threaten to disrupt everything.

A Local Leader in the Eye of the Storm

Tampa sits at the heart of one of America’s most hurricane-prone regions. For McGrew, storm season is not just another quarter on the sales calendar. It is a call to safeguard critical infrastructure. By utilizing AI-driven analytics, he has developed a system that categorizes enterprise clients based on risk zone, infrastructure resilience, and historical outage patterns. This allows him to design customized readiness packages that anticipate client vulnerabilities before disaster strikes.

“Enterprise businesses are facing several challenges at this time of year, but we are too,” McGrew said. “At an internet service provider, we must identify and develop replicable systems that can be quickly implemented across particular audiences. Resilient communications are not just about uptime. They are about safety.”

Delivering Resilience in Healthcare

Healthcare organizations, where downtime can endanger lives, are at the forefront of McGrew’s work. MedFleet, a regional medical transport provider, partnered with him to implement redundant internet connectivity, a step that ensures dispatch operations remain uninterrupted throughout storm season. At CoreRX, a Clearwater-based healthcare manufacturer, previous storms had exposed weaknesses in their landline system. During Hurricane Helene, intermittent connectivity created risks for essential operations. McGrew and the Frontier team addressed the issue by introducing cost-effective landline redundancy, a solution that transformed a vulnerable system into one built for reliability and long-term safety.

Municipalities Gain Strength Through Redundancy

Local governments, often on the front lines of disaster response, are also benefiting from McGrew’s approach. The City of Zephyrhills collaborated with him to implement landline redundancy, which enhances communication during severe weather while delivering long-term cost savings. The City of Aledo made a similar investment, ensuring that municipal operations can remain stable and reliable even in the face of heavy storms. These measures allow cities to maintain essential services and communicate with residents without interruption.

Financial Institutions and Nonprofits Benefit

Financial and nonprofit organizations have also sought McGrew’s expertise. Legend Bank, which was expanding with a new branch, relied on him to provide dedicated internet access that secures and stabilizes its financial operations. Meanwhile, Champions for Children, a Tampa-based nonprofit focused on abuse prevention, partnered with McGrew to enhance its inbound call system using RingCentral’s voice solutions. The upgrade ensures that donation calls are never missed, even during periods of high demand or storm-related disruptions, protecting vital revenue streams that fund the organization’s mission.

AI Turns Sales into Safety

Rather than relying on reactive measures such as mobile failovers, McGrew has pioneered an AI-powered outreach strategy that turns storm preparedness into a proactive campaign. By predicting which clients are most vulnerable, he can initiate conversations before disaster strikes. The result is tailored packages that keep hospitals, banks, city halls, and nonprofits connected when hurricanes threaten to sever lifelines.

“Every deal I close is more than a contract,” McGrew emphasized. “It is about making sure a hospital can reach its patients, a city can update its residents, or a nonprofit can answer a critical call for help. Connectivity becomes survival in the middle of a storm.”

Frontier’s Role in Storm Preparedness

Frontier’s extensive telecommunications infrastructure is the foundation of McGrew’s work. From redundant circuits and dedicated internet to cloud-based voice platforms, Frontier offers the tools required for business continuity in storm-prone regions. McGrew’s ability to combine these services with predictive AI models has positioned him as a leader in Florida’s disaster readiness efforts.

“AI-powered outreach and predictive planning have completely reshaped our ability to serve customers,” said McGrew. “By combining Frontier’s technology with forward-thinking strategies, we are not just meeting demand. We are anticipating it.”

Looking Ahead

As climate change fuels longer and more severe storm seasons, McGrew remains focused on expanding his work with businesses and municipalities throughout Florida. His vision is to ensure that no organization has to gamble with its connectivity when disaster looms. From MedFleet ambulances and CoreRX manufacturing lines to city governments and nonprofits serving families in need, his clients share a common goal: They have the confidence that their systems will stay connected when it matters most.

As Florida heads deeper into hurricane season, McGrew stands as a reminder that resilience is not simply about recovering after a storm. With the right strategies, it is about staying connected through it.

About Frontier

Frontier Communications is a leading telecommunications provider delivering high-speed internet, advanced voice services, and enterprise-grade connectivity across the United States. With a focus on reliability, innovation, and community resilience, Frontier helps businesses, governments, and nonprofits prepare for and overcome the challenges of natural disasters.

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Dr. Khadija Lilley Crowned Moroccan Caftan Ambassador at Queen Arab Worldwide – Celebrating Heritage, Empowerment, and Global Impact

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October 8, 2025

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Morocco, 8th October 2025, ZEX PR WIRE, International model, entrepreneur, and philanthropist Dr. Khadija Lilley has once again made Morocco proud by winning the prestigious title of Moroccan Caftan Ambassador at the Queen Arab Worldwide pageant. She will soon represent Morocco on the grand stage in Egypt, wearing the iconic Moroccan caftan, a proud emblem of her country’s artistry, culture, and timeless heritage.

This honour adds to a long list of global achievements that define Dr. Lilley’s inspiring journey. Her pageant titles include:

  • Mrs. Georgia Globe 2023
  • Mrs. Morocco Universe Middle East 2024
  • Mr. South East Globe 2025
  • 1st Runner-up, Mrs. USA Curve

Beyond her beauty and grace, Dr. Khadija Lilley is celebrated for her humanitarian spirit and entrepreneurial leadership. In 2024, she was awarded an Honorary Doctorate in Construction Management, recognising her dedication to innovation and social development. That same year, she received the President’s Lifetime Achievement Award from U.S. President Joe Biden, honouring her outstanding contributions to society and service to humanity.

Deeply committed to giving back, Dr. Lilley has devoted her success to meaningful causes. She personally funded a water well in her home village, ensuring access to clean water for local families, and continues to support education, books, and healthcare initiatives for children and schools in her community. Her work reflects her lifelong belief that true success is measured not by crowns, but by compassion.

Dr. Khadija Lilley is an internationally recognised model

Speaking about her latest recognition, Dr. Lilley shared:

“Being named the Moroccan Caftan Ambassador is not just about fashion, it’s about identity, pride, and the beauty of our Moroccan heritage. The caftan represents centuries of craftsmanship and resilience, and I’m honoured to carry that legacy to an international stage.”

Today, Dr. Khadija Lilley continues to inspire as a model, influencer, entrepreneur, healthcare professional, wife, mother, and philanthropist. Her journey stands as a testament to the power of ambition rooted in purpose, embodying what it means to be both a queen on stage and a leader in life.

About Dr. Khadija Lilley

Dr. Khadija Lilley is an internationally recognised model, entrepreneur, and humanitarian leader. With a background in construction management and healthcare, she has built a diverse career dedicated to empowerment, education, and philanthropy. Her global recognition in pageantry and her commitment to community upliftment continue to inspire women worldwide to lead with heart, heritage, and hope.

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Know More @khadijalilley
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