Press Release
Scientific Anti-Aging Decoding the NAD⁺ Formula for Youthful Cells & Skin
In recent years, the anti-aging field has been abuzz with discussions about NAD⁺ (Nicotinamide Adenine Dinucleotide), a molecule central to cellular energy metabolism and DNA repair. Research indicates that NAD⁺ levels naturally decline with age, potentially dropping by as much as 50% by the age of 40. This decline is closely associated with fatigue, a slower metabolism, and increased oxidative stress, making NAD⁺ replenishment a crucial component of modern longevity strategies.
Recognizing this fundamental need, Vitanorms Reju+ O12 was scientifically formulated to replenish NAD⁺ levels, enhance cellular energy, and activate the body’s natural anti-aging mechanisms. By combining NAD⁺ precursors with potent AMPK activators, Reju+ O12 offers a comprehensive approach to longevity from within, helping People not only restore lost vitality but also sustain youthful function at the cellular level.
The Invisible Accelerator of Aging: Declining NAD⁺ Levels
What Is NAD⁺?
NAD⁺ is a vital coenzyme involved in energy metabolism, DNA repair, and gene regulation. Present in every living cell, it not only drives the redox reactions that generate energy but also serves as the essential fuel for Sirtuins, a family of proteins that regulate cellular repair, antioxidant defenses, and inflammation. In essence, NAD⁺ acts as both the cell’s energy “currency” and its “repair toolbox.”
However, research has demonstrated that NAD⁺ levels plummet with age, leading to:
Mitochondrial Dysfunction: Aging mitochondria produce less ATP. With dwindling NAD⁺, cells become “energy-starved,” resulting in fatigue and metabolic imbalances.
Weakened DNA Repair: NAD⁺ fuels longevity proteins like Sirtuins, which repair DNA damage. Lower NAD⁺ levels mean these proteins cannot keep pace, accelerating cellular aging.
Increased Inflammation: A reduced NAD⁺/NADH ratio triggers oxidative stress and chronic inflammation—often termed “inflammaging”—which has been linked to cardiovascular disease, obesity, diabetes, and neurodegenerative disorders.
To counteract this decline, it is essential to boost NAD⁺ and sustain its levels over time.
How to Boost NAD⁺? The Key Is the Internal Cycle!
Supplementing with NAD⁺ precursors, such as Niacin/Nicotinamide and NR, has emerged as a promising strategy to slow aging. However, a one-time boost is insufficient; maintaining elevated NAD⁺ levels long-term depends on an efficient internal recycling mechanism. Several pathways can increase NAD⁺:
De Novo Synthesis: Starting from tryptophan, NAD⁺ is produced through a series of biochemical reactions.
Preiss-Handler Pathway: This pathway uses niacin (NA) as a precursor, converting it to NAD⁺ via enzymatic steps.
Salvage Pathway: This pathway recycles NAD⁺ from dietary precursors (e.g., NMN, NR, niacin, nicotinamide) through key enzymes like NAMPT.
Merely replenishing NAD⁺ is not enough. The secret to long-term success lies in activating the cell’s internal recycling system:
The Role of the Internal Cycle: Orally or intravenously administered precursors only offer a temporary spike in NAD⁺. For sustained NAD⁺ levels, the body must efficiently recycle it via the salvage pathway—stimulated through AMPK activation and increased Sirtuin activity.
AMPK (5’ AMP-Activated Protein Kinase) Activation: The body’s “master switch” for metabolism and energy balance, AMPK enhances NAD⁺ recycling via NAMPT activation. It can be stimulated through exercise, caloric restriction, and AMPK activators like curcumin.
Sirtuins: These NAD⁺-dependent enzymes are crucial for cellular metabolism, DNA repair, and anti-inflammatory responses.
For long-term benefits, combining NAD⁺ precursors with AMPK activators is essential. This dual approach supports continuous NAD⁺ regeneration, optimizing energy, longevity, and cellular resilience.
NAD⁺ Precursors: The Ultimate Showdown—Who Reigns Supreme?
Today’s market offers four primary NAD⁺ precursors, each with distinct advantages and drawbacks:
1.Tryptophan: A natural dietary source (meat, dairy, fish) that contributes to NAD⁺ synthesis via the de novo pathway. However, its low conversion efficiency (requiring 10 enzymatic steps) and potential metabolic burden limit its effectiveness.
2.NMN (Nicotinamide Mononucleotide): Once hailed as a breakthrough, NMN’s direct absorption in humans is questionable, as research suggests it relies on gut bacteria to convert it into nicotinamide metabolites. Clinical trials have shown limited metabolic benefits, and concerns have been raised about its long-term safety.
3.NR (Nicotinamide Riboside): Brands like Thorne and TruHealth are incorporate this NAD⁺ precursor into their formulations. NR is a fast-absorbing vitamin B3 derivative with proven safety and NAD⁺-boosting effects. However, its rapid breakdown in the gut may reduce its bioavailability, potentially inhibiting Sirtuin activity and limiting its clinical efficacy, leading some to view it as overpriced with minimal impact on insulin sensitivity and muscle function.
4.Niacin/Nicotinamide: Clinically-backed brands like Vitanorms prioritize this NAD⁺ precursor for its efficacy. It is a potent and direct NAD⁺ booster, capable of increasing NAD⁺ levels 5–8 fold and supporting mitochondrial function, vascular health, and inflammation reduction. However, it may cause skin flushing, requires consistent use for 2–3 weeks to see benefits, and should be paired with AMPK activators to avoid potential Sirtuin suppression.
Optimal NAD⁺ restoration should balance precursor supplementation with AMPK activation to ensure sustained benefits.
The Golden Sidekicks in Anti-Aging: A List of AMPK Activators
While supplementing with NAD⁺ precursors is straightforward, activating the cell’s internal metabolic cycle with AMPK activators is equally important. Key options include:
Curcumin: Enhances NAMPT activity, supporting NAD⁺ recycling.
Resveratrol: Activates Sirt1, improving cellular repair and mitochondrial function.
Quercetin: Reduces unnecessary NAD⁺ consumption, preserving reserves.
Coenzyme Q10: Strengthens the mitochondrial respiratory chain, promoting efficient conversion of NADH back to NAD⁺.
Diet or Supplements? Bridging the Nutritional Gap
While NAD⁺ precursors and AMPK activators exist in certain foods, obtaining sufficient amounts through diet alone is nearly impossible. For example:
People would need to consume 80 kg of grapes to get a meaningful dose of Resveratrol.
People would need to eat 3 kg of sardines to obtain an optimal amount of Coenzyme Q10.
People would need to consume 1.5 kg of chicken breast or 50 eggs to get 30 mg of Niacin.
This is why a science-backed supplement like Vitanorms Reju+ O12 provides a precise and efficient solution, delivering clinically researched ingredients in optimal dosages, without the dietary burden.
How to Choose the Right Supplements?
Prioritize Quality Standards: Look for supplements certified by reputable regulatory bodies such as Canada’s NPN, Australia’s TGA, or the EU’s EFSA. These certifications ensure pharmaceutical-grade manufacturing, clinical validation, and strict scientific evaluation, guaranteeing safety and efficacy.
Avoid Common Pitfalls: Beware of single-ingredient “miracle” solutions. Their effects are often limited. Instead, choose comprehensive, multi-ingredient formulations that provide balanced dosing and synergistic benefits while minimizing the risk of ingredient conflicts.
Choosing science-backed, high-quality supplements is key to optimizing health and longevity.
About Vitanorms:
Founded in Canada, Vitanorms is a pioneering health and longevity brand dedicated to personalized, all-natural nutritional solutions. Since 2010, Vitanorms has partnered with over 30 leading private clinics across North America, providing comprehensive wellness consulting and premium supplements to nearly 20,000 high-net-worth clients and their families.
Leveraging over a decade of clinical insights, Vitanorms’ research and development team, in collaboration with experts from Stanford University School of Medicine and the University of Toronto, has developed a series of science-backed, highly performance formulations trusted by both clients and healthcare professionals. From ingredient sourcing to global distribution, every aspect of the process adheres to the strictest international quality standards, ensuring unmacthed safety, purity, and efficacy.
Today, Vitanorms products are available in North America, Europe, and Asia, setting a new benchmark for proactive health and longevity. More than just a supplement brand, Vitanorms represents a commitment to vitality, balance, and life-long well-being.
Brand Contact information：
Brand Name: Vitanorms
Country: Canada
Website: www.vitanorms.com
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Washington, London, 13th August 2025, ZEX PR WIRE, The United States has signed an executive order for the first time to include mainstream cryptocurrencies such as Bitcoin, Ethereum, and Ripple into the compliant investment scope of retirement plans like 401(k). This policy breaks the long-standing investment restrictions on cryptocurrencies in the pension sector, marking the formal entry of cryptocurrencies into the mainstream U.S. pension system and laying the institutional foundation for their long-term investment value.
Driven by policy initiatives, market focus on cryptocurrency assets is gradually shifting from short-term speculation to long-term value investing. UK-based cloud mining platform OPTO Miner has launched low-threshold, fully transparent mining contracts to help investors convert digital assets into sustainable daily returns without the need to build their own mining rigs.
Leveraging mining facilities powered by green energy and flexible contract structures, OPTO Miner has pioneered an innovative and feasible solution that addresses the investment needs of both “long-term holding” and “stable returns.”
Since its establishment in the UK in 2018, OPTO Miner has always adhered to legal and compliant operations, with complete registration qualifications and operating licenses. The platform relies on high-performance computing equipment and intelligent scheduling systems to continuously optimize energy management, effectively controlling operating costs and significantly improving mining efficiency.
For crypto asset investors seeking long-term stable returns, OPTO Miner offers a reliable solution that balances risk hedging with yield growth.
Traditional cryptocurrency mining often requires users to purchase mining equipment, configure mining pools, and conduct in-depth research on algorithms, which not only involves high technical barriers but also involves cumbersome operational processes. Now, with the launch of OPTO Miner’s cloud computing power contracts, users can embark on their mining journey with a single click without needing to master complex technologies, enjoying a simple and efficient user experience.
Automated mining, truly achieving “zero operation”
At OPTO Miner, users do not need to perform any complex settings, nor do they need to worry about coin selection or hashrate adjustments. Simply select the appropriate cloud hashrate contract, and the system will run intelligently around the clock, automatically matching the optimal mining strategy based on market conditions to help users achieve continuous and stable returns.
Multi-currency deposits and withdrawals, flexible and free
No matter which mainstream digital currency you prefer, OPTO Miner can meet your needs. The platform supports deposits and withdrawals in multiple currencies, including BTC, ETH, XRP, DOGE, SOL, LTC, BCH, USDT, USDC, and more. You can freely choose your preferred payment method based on your needs and control every step of your funds flow.
Green Energy-Powered, Eco-Friendly Mining
At OPTO Miner, mining is not just about profits—it’s also about the environment. The platform’s cloud computing infrastructure is entirely powered by renewable energy, reducing carbon emissions while ensuring stable computing power output, aligning investment with sustainable development.
Security and Transparency, Peace of Mind
Fund safety is always our top priority. OPTO Miner employs enterprise-grade security solutions, including McAfee® security protection and Cloudflare® anti-DDoS security barriers, to ensure the safety of user assets through multiple layers of technology. All revenue details, withdrawal records, and contract information can be viewed in real time on the control panel, ensuring transparency and accountability.
Daily settlement, stable returns
To help users lock in stable returns, the platform has launched a daily settlement contract model, which distributes fixed returns every 24 hours. This mechanism not only reduces the impact of market fluctuations, but also makes profit growth more sustainable and predictable.
Start OPTO Miner
1: Register now to receive a $15 bonus.
2: Contract Selection: After successful registration, select a mining contract that aligns with your revenue goals and budget. OPTO Miner offers a variety of contracts to meet your diverse needs, whether you are a newcomer or an experienced miner.
BTC Contract: $100/2 days, daily return of $4
DOGE Contract: $1,000/6 days, daily return of $12.50
DOGE/LTC Contract: $3,000/20 days, daily return of $42
BTC Contract: $10,000/37 days, daily return of $159
BTC Contract: $50,000/45 days, daily return of $885
For more contract details, visit the OPTO Miner official website: optominer.com
3: Start earning profits: After selecting and activating the mining contract, the system will automatically process the mining tasks. OPTO Miner’s advanced technology ensures an efficient mining process and maximizes potential profits.
Conclusion
Under the Trump administration’s policy easing restrictions on investing in cryptocurrency through 401(k) plans, OPTO Miner has established a low-threshold, sustainable channel for digital asset appreciation for investors, leveraging its compliant operations, energy-efficient computing power driven by green energy, and fully transparent profit model. Whether you are a newcomer to the market or a seasoned investor committed to long-term holding, you have the opportunity to achieve steady returns and continuously enhance the value of your assets on this platform.
Official website: https://optominer.com/
Click here to download the app
Disclaimer: The information provided in this press release does not constitute an investment solicitation, nor does it constitute investment advice, financial advice, or trading recommendations. Cryptocurrency mining and staking involve risks and the possibility of losing funds. It is strongly recommended that you perform due diligence before investing or trading in cryptocurrencies and securities, including consulting a professional financial advisor.
About Author
Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
ReactorTrade, a decentralized trading platform, has begun the sale of its native $REACT token, the core utility token of the ReactorTrade ecosystem. $REACT powers all value exchange between traders, liquidity providers, strategy developers, and platform participants, acting as the gateway to governance, premium features, and incentive mechanisms. This marks the start of community distribution, well before the Token Generation Event (TGE). Unlike a TGE — which unlocks token liquidity and market trading — the current public sale phase allows early supporters to secure allocations at a discounted rate ahead of exchange listings and full ecosystem activation.
The initial distribution phase begins alongside the first phase of ReactorTrade’s public rollout — the Trade Aggregation Engine — with yield aggregation vaults scheduled for Q4 2025 and dynamic perpetuals set to follow in early 2026, forming a multi-phase product roadmap designed to steadily expand user capabilities.
DeFi Market Momentum Supports $REACT’s Public Sale
The timing coincides with a surge of interest across the DeFi sector. As of June 2025, the combined market capitalization of top DeFi tokens reached $98.4 billion, representing a 38% year-over-year surge from $71.2 billion. Across the sector, the numbers show investors are once again interested in productive, infrastructure-focused crypto assets.
According to industry data, DeFi was June’s top-performing category with a roughly 10.9% increase in total value locked, even as the broader crypto market remained flat.
Meanwhile, the Coinbase COIN50 index showed a strong increase in TVL across DeFi assets. This all but confirms sustained momentum at a time when the broader market and other sectors are showing flat or even declining trends. ReactorTrade’s token sale taps into this trend, positioning $REACT amid a DeFi upswing that is valuing utility, governance power, and yield mechanics.
More About $REACT
$REACT launches with a maximum supply based on a $30M starting fully diluted valuation (FDV), with an FDV of $100M projected at TGE. The current price of the token is $0.03, increasing to $0.10 at the TGE. $REACT will be available on BNB Chain and Base.
The global token distribution follows a deflationary supply model: for every token sold to the community, an equal token is permanently burned. The token allocation is 20% LP tokens, 25% community tokens, 5% team tokens (locked for 12 months, then vested linearly over 24 months), 20% ecosystem growth, 2% KOLs, 3% advisors, and 25% burned.
Under the burn-on-sale model, the “community tokens” share is flexible — for every token sold, an equivalent token is earned for distribution, and the undistributed portion adjusts accordingly. For example, if 35% of the supply is sold, 35% will be earned for distribution and the undistributed share will drop proportionally.
In terms of utility, $REACT acts as the core economic and governance layer for ReactorTrade. Holders can vote on protocol decisions like new market listings and feature priorities, with voting power tied to holdings or staking levels. Stakers can also earn trading fee discounts, liquidity reward multipliers, and access to event-based promotions. Token holdings will determine membership tiers, to be introduced after the first stage of the sale, offering varying bonuses and perks for participants. Certain premium features, such as early market access, advanced trading bots, exclusive analytics, and alpha/beta testing participation, are token-gated and require either a minimum holding or staking commitment. This mechanism ties token scarcity directly to platform adoption — a rarity among DeFi governance models — creating a clear link between network growth and tokenholder value.
To further widen community participation, ReactorTrade is introducing its “ConvertDrop” program, allowing early supporters and partner protocol communities to swap certain assets or stake holdings in exchange for recurring $REACT airdrops, reinforcing grassroots ownership from day one.
About ReactorTrade and the $REACT Token
ReactorTrade is a decentralized trading and yield platform combining spot trading, permissionless perpetuals, and meta-governance yield aggregation in one interface. By unifying liquidity aggregation, yield strategies, and governance, it solves a core DeFi pain point — switching between multiple tools to trade, farm, and vote. Its hybrid architecture blends aggregated AMM liquidity, on-chain order book access, and automated strategy vaults for deep liquidity, fast execution, and reduced MEV risk. Built with a community-first approach and backed by seed funding, ReactorTrade is designed for progressive decentralization, with its $REACT token powering governance, incentives, and long-term value alignment across the ecosystem.
Have questions about ReactorTrade and its token? Feel free to reach out: info@reactor.trade. Want to be early? Subscribe for alpha at https://reactor.trade. $REACT token awaits you here https://www.reactor.trade/reactor-token.
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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
Migaku, a Japanese learning app, uses authentic content to help learners reach fluency and supports ten languages including Japanese.
Migaku, A Popular Japanese Learning App, Challenges Industry Leaders with a Content-Based Approach to Fluency
Migaku, a Japanese learning app with roots in immersion-based study, is expanding its reach in a market dominated by platforms like Duolingo, Lingopie, Memrise, Mondly, Babbel, and Busuu. Known for helping learners progress through authentic content, the platform offers a dedicated Learn Japanese path alongside its support for other languages.
A Different Path in the Japanese Learning App Market
The Japanese learning app space has grown quickly, driven by interest in anime, business opportunities, and Japanese culture. Many well-known services such as Duolingo, Lingopie, and Memrise have made language study more accessible. Duolingo emphasizes gamified streaks, Lingopie focuses on subtitled video immersion, and Memrise builds vocabulary through spaced repetition. Each offers strengths, but all share the challenge of moving learners from basic proficiency to advanced fluency.
Migaku began as a Japanese learning app aimed at serious learners, turning Netflix shows, YouTube videos, and web pages into interactive lessons. Users can click any word for an instant definition, AI-generated explanation, and automatic flashcard creation. While Japanese remains central to its identity, the platform now supports Cantonese, Chinese, English, French, German, Korean, Portuguese, Spanish, and Vietnamese, offering the same content-based approach across languages.
Balancing Engagement with Depth
In many Japanese learning apps, game elements encourage consistency but may prioritize daily activity over deep understanding. Migaku’s model combines engagement with in-context study, allowing learners to interact with the same materials native speakers consume. This helps bridge the gap between textbook language and real-world usage.
For example, Duolingo’s short drills can build recognition skills and Lingopie’s dual subtitles can support listening. Migaku integrates vocabulary management, grammar explanations, and context-specific reviews directly into the content. This places it within a smaller segment of Japanese learning apps that aim for advanced comprehension.
The Broader Competitive Landscape
Other competitors in the Japanese learning app market include:
Mondly: Offers AR and VR experiences for interactive practice.
Babbel: Focuses on conversation skills and structured lessons.
Busuu: Adds peer feedback from native speakers.
FluentU: Uses real-world videos with interactive captions.
Each contributes to the range of study options available. Industry observers note that different learners benefit from different methods. Migaku’s contribution is its emphasis on authentic content as the primary learning medium.
Looking Ahead
As the Japanese learning app market continues to expand, platforms are exploring AI, adaptive learning, and deeper integration with streaming media. Migaku is developing additional AI tools for grammar analysis and comprehension support, building on the content-based learning model that has defined its approach since launch.
About Migaku
Migaku is a language learning technology platform originally created as a Japanese learning app for immersion-based study. It now supports ten languages including Cantonese, Chinese, English, French, German, Japanese, Korean, Portuguese, Spanish, and Vietnamese. Through its browser extension and mobile applications, Migaku integrates with streaming services, websites, and e-books to provide interactive learning experiences.
Media Contact
Organization: Migaku Inc.
Contact Person: Matteo Sanzone
Website: https://migaku.com/
Email:
seo@migaku.com
City: Tokyo
Country:Japan
Release id:32307
The post Migaku Popular Japanese Learning App Challenges Leaders appeared first on King Newswire. This content is provided by a third-party source.. King Newswire makes no warranties or representations in connection with it. King Newswire is a press release distribution agency and does not endorse or verify the claims made in this release. If you have any complaints or copyright concerns related to this article, please contact the company listed in the ‘Media Contact’ section
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Disclaimer: The views, suggestions, and opinions expressed here are the sole responsibility of the experts. No Digi Observer journalist was involved in the writing and production of this article.
OPTO Miner generates $7,700 per day from diverse multi-currency mining operations
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