Press Release
Candel Therapeutics (NASDAQ: CADL) Reports Positive Data From Phase 2 Trial Of CAN-2409 In Borderline Resectable Pancreatic Cancer
–News Direct–
By Jeremy Golden, Benzinga
Clinical-stage biopharmaceutical company Candel Therapeutics, Inc. (NASDAQ: CADL) reported updated survival data from its randomized phase 2 clinical trial of CAN-2409 in borderline resectable pancreatic cancer. Pancreatic cancer is the fourth leading cause of cancer-related death in the U.S. The disease accounts for approximately 3% of all cancers, with an estimated 64,050 patients diagnosed in 2023.
The randomized, controlled clinical trial is specifically looking into the safety and efficacy of CAN-2409 plus valacyclovir (prodrug), together with standard of care (SoC) chemoradiation, followed by resection if possible in borderline resectable pancreatic ductal adenocarcinoma (PDAC).
Very encouraging results were recently reported by the Needham, Massachusetts-based company.
Patients reached an estimated median overall survival of 28.8 months after experimental treatment with CAN-2409 versus only 12.5 months in the control group in PDAC. At 24 months, the survival rate was 71.4% in CAN-2409 treated patients compared to only 16.7% in the control group after chemoradiation. Thus, prolonged and sustained survival was observed after experimental treatment with CAN-2409 in patients with borderline resectable PDAC. Importantly, 4 out of 7 patients who received CAN-2409 were still alive at the time of data cut-off, with 2 patients surviving more than 50.0 months from enrollment. Only 1 out of 6 patients in the randomized control SoC chemotherapy group remained alive at the data cut-off (50.6 months).
No new safety signals were observed, providing further support that multiple injections of CAN-2409 are generally well tolerated. Additionally, there were no dose-limiting toxicities or cases of pancreatitis reported.
Previous analysis of resected tumors showed dense aggregates of immune cells including CD8+, cytotoxic tumor-infiltrating lymphocytes and dendritic cells in PDAC tissue after CAN-2409 administration. This reinforces the potential of CAN-2409 to activate a robust antitumoral immune response in patients with cancer also in cold, immunosuppressive tumors like PDAC.
Given the frequent recurrence and short survival with SoC chemotherapy for non-metastatic PDAC, effective new treatment options are urgently needed, said Garrett Nichols, MD, MS, Chief Medical Officer of Candel. We are very encouraged by the improved survival associated with CAN-2409, which has been shown to be durable after prolonged follow-up based on the updated data in this randomized clinical trial. CAN-2409 was generally well tolerated without significant additional local or systemic toxicity when added to SoC chemoradiation.
Candels most advanced viral immunotherapy candidate, CAN-2409, is an investigational off-the-shelf, replication-defective adenovirus designed to induce an individualized, systemic immune response against the tumor. Because of its versatility, CAN-2409 has the potential to treat a broad range of solid tumors. More than 1,000 patients have been dosed with CAN-2409 to date, with a favorable reported tolerability profile and proof of concept in each indication that the company is currently pursuing.
CAN-2409 is injected directly into the tumor or target tissue using a localized injection method that is akin to the standard approach for in situ vaccination to elicit an immune response against the injected tumor and uninjected metastases.
Long-term survival data in PDAC was recently updated with eight months of further follow-up since the first analysis was presented at the 2023 Society for Immunotherapy (SITC) Annual Meeting. Based on the data presented at SITC, the U.S. Food and Drug Administration (FDA) granted Fast Track Designation to Candel Therapeutics for CAN-2409 in combination with valacyclovir for the treatment of patients with PDAC in December 2023. More recently, the FDA also granted Orphan Drug Designation.
The failure of conventional immunotherapy to improve outcomes in pancreatic cancer is attributed to the highly immunosuppressive tumor microenvironment, which is largely devoid of immune cells, said Paul Peter Tak, MD, PhD, FMedSci, President and Chief Executive Officer of Candel. The immunological changes induced by CAN-2409, evident in the pancreatic tissue and the peripheral blood after administration, suggest that CAN-2409 is able to change the balance between the tumor and the patients anti-tumor immune response, which can convert progressive cancer into a chronic disease associated with improved survival.
Featured photo by National Cancer Institute on Unsplash.
Candel is a clinical stage biopharmaceutical company focused on developing off-the-shelf multimodal biological immunotherapies that elicit an individualized, systemic anti-tumor immune response to help patients fight cancer. Candel has established two clinical stage multimodal biological immunotherapy platforms based on novel, genetically modified adenovirus and herpes simplex virus (HSV) gene constructs, respectively. CAN-2409 is the lead product candidate from the adenovirus platform and is currently in ongoing clinical trials in non-small cell lung cancer (NSCLC) (phase 2), borderline resectable pancreatic cancer (phase 2), and localized, non-metastatic prostate cancer (phase 2 and phase 3). CAN-3110 is the lead product candidate from the HSV platform and is currently in an ongoing investigator-sponsored phase 1 clinical trial in recurrent high-grade glioma (HGG). Finally, Candels enLIGHTEN Discovery Platform is a systematic, iterative HSV-based discovery platform leveraging human biology and advanced analytics to create new viral immunotherapies for solid tumors.
This article includes certain disclosures that contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding the timing and advancement of development programs, including the timing and availability of additional data, key data readout milestones, including CAN-3110 in HGG; expectations regarding the potential benefits conferred by Fast Track Designation; expectations regarding the therapeutic benefit of its programs, including the potential for its programs to extend patient survival; and expectations regarding cash runway and expenditures. The words may, will, could, would, should, expect, plan, anticipate, intend, believe, estimate, predict, project, potential, continue, target and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on managements current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, those risks and uncertainties related to the timing and advancement of development programs; expectations regarding the therapeutic benefit of the Companys programs; that final data from our pre-clinical studies and completed clinical trials may differ materially from reported interim data from ongoing studies and trials; the Companys ability to efficiently discover and develop product candidates; the Companys ability to obtain and maintain regulatory approval of product candidates; the Companys ability to maintain its intellectual property; the implementation of the Companys business model, and strategic plans for the Companys business and product candidates, and other risks identified in the Companys SEC filings, including the Companys most recent Quarterly Report on Form 10-Q filed with the SEC, and subsequent filings with the SEC. The Company cautions you not to place undue reliance on any forward-looking statements, which speak only as of the date they are made. The Company disclaims any obligation to publicly update or revise any such statements to reflect any change in expectations or in events, conditions or circumstances on which any such statements may be based, or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements. Any forward-looking statements contained in this press release represent the Companys views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date.
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View source version on newsdirect.com: https://newsdirect.com/news/candel-therapeutics-nasdaq-cadl-reports-positive-data-from-phase-2-trial-of-can-2409-in-borderline-resectable-pancreatic-cancer-425692953
Candel Therapeutics
COMTEX_453283087/2655/2024-06-03T08:31:08
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Press Release
Epic Deals Nook Revolutionizes Online Shopping with Daily Steals Across All Product Categories
United States, 16th Jun 2025 – In the ever-growing world of eCommerce, Epic Deals Nook is making waves by delivering an unmatched shopping experience through its wide variety of high-quality products, unbeatable prices, and daily deals that cater to every shopper’s needs. As an all-in-one online shopping destination, Epic Deals Nook is redefining how consumers shop by combining convenience, value, and variety—all on a single platform.
Epic Deals Nook offers a diverse product lineup across categories like home & kitchen, electronics, fashion, beauty, fitness, accessories, pet supplies, gadgets, and more. Whether customers are searching for the latest tech gadgets, trendy clothing, or practical household items, the platform ensures there’s something for everyone—and always at a discounted rate.
“Our goal is simple,” said a spokesperson for Epic Deals Nook. “We want to help our customers save more every single day, without compromising on quality. That’s why we’re committed to offering daily deals and special promotions that rival even the biggest eCommerce giants.”
Why Epic Deals Nook Stands Out
Unlike many eCommerce platforms that only run major promotions during the holidays or peak seasons, Epic Deals Nook brings shoppers new deals daily. These limited-time offers encourage customers to check back regularly, ensuring a dynamic and exciting shopping experience. Shoppers can expect:
- Massive discounts on select products every day
- A user-friendly website that makes browsing and buying seamless
- Secure checkout and multiple payment options
- Fast and reliable shipping with tracking
- Responsive customer service to handle inquiries or concerns
Moreover, the platform prioritizes product quality and authenticity by carefully curating items from trusted vendors. This commitment to excellence has helped Epic Deals Nook grow a loyal customer base across various age groups and demographics.
Perfect for Bargain Hunters and Everyday Shoppers Alike
What truly sets Epic Deals Nook apart is its “Something for Everyone” approach. Whether you’re a college student looking for affordable tech accessories, a busy parent seeking household essentials, or a fashion-forward shopper on the hunt for the latest trends, Epic Deals Nook serves as the ideal destination.
In addition to providing great deals, the company also runs seasonal sales and exclusive member discounts, giving returning customers even more reasons to keep shopping. The website is optimized for both desktop and mobile use, ensuring shoppers can take advantage of deals on-the-go.
Customer-Centric Vision
Epic Deals Nook isn’t just about affordability—it’s about creating a community of happy, satisfied customers. From its hassle-free return policy to its regular customer engagement campaigns on social media, the brand focuses on building trust and long-term relationships.
The company has also introduced a newsletter and rewards program, allowing subscribers to get early access to flash sales, new arrivals, and members-only discounts. This personalized approach to eCommerce is part of Epic Deals Nook’s broader mission to make quality products accessible to everyone, regardless of budget.
About Epic Deals Nook
Epic Deals Nook is a fast-growing online shopping store committed to offering a vast range of high-quality products at affordable prices. With daily deals, exclusive offers, and a user-friendly platform, the company has become a go-to destination for budget-conscious shoppers worldwide. Epic Deals Nook continues to innovate in the eCommerce space with customer satisfaction at the core of its operations.
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Epic Deals Nook Revolutionizes Online Shopping with Daily Steals Across All Product Categories
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Press Release
Aristara Launches Modern eCommerce Store Featuring a Handpicked Mix of Stylish and Practical Products
United States, 16th Jun 2025 – Aristara, a new name in the world of online shopping, proudly announces the official launch of its modern eCommerce store, aristara.co. With a thoughtfully curated collection of everyday essentials, statement pieces, and lifestyle-enhancing products, Aristara is redefining the online shopping experience for discerning customers who value both style and substance.
Designed to meet the diverse needs of modern consumers, Aristara offers a wide range of high-quality items across multiple categories, including home goods, beauty and wellness, electronics, accessories, and more. What sets Aristara apart is its commitment to offering products that are not just trendy, but also practical—making everyday life easier, more beautiful, and more enjoyable.
A Shopping Experience Tailored for the Modern Consumer
In an age where online shopping can often feel overwhelming or impersonal, Aristara takes a fresh, customer-first approach. The platform is clean, user-friendly, and optimized for both desktop and mobile shopping, ensuring that users can browse and purchase with ease from anywhere.
“We built Aristara with one goal in mind: to offer a reliable and stylish destination for everyday shoppers who want the best without the stress,” said a spokesperson for Aristara. “Every product we feature has been handpicked by our team based on quality, value, and design. Whether you’re upgrading your home, gifting something special, or just treating yourself, we want every experience on Aristara.co to feel rewarding.”
A Curated Collection of High-Quality Products
Aristara’s catalog emphasizes balance—between trendiness and usability, between aesthetics and function. Among the store’s standout items are elegant home décor accents, personal care gadgets, smart storage solutions, wellness products, and kitchen tools that combine innovation with charm. By blending form and function, Aristara ensures that customers don’t have to choose between beauty and utility.
In addition to general products, Aristara plans to introduce a seasonal collection and exclusive limited-time offers to give customers fresh reasons to return.
Focused on Customer Satisfaction
With fast, reliable shipping and a responsive customer service team, Aristara ensures that every shopper is treated like a VIP. The store also features secure checkout processes and a straightforward return policy, offering customers complete peace of mind when shopping.
Aristara’s platform is equipped with customer reviews and detailed product descriptions to help buyers make informed choices. The store’s growing loyal customer base is already praising the easy-to-navigate interface and the premium feel of the products.
Expanding Reach and Community
While Aristara is currently focused on serving the U.S. market, international shipping options are in the pipeline. The brand is also committed to building a strong online community through regular content updates, lifestyle tips, social media engagement, and newsletters with exclusive deals.
The company invites customers to stay connected via Instagram, Facebook, and TikTok, where Aristara shares styling ideas, product demos, and behind-the-scenes stories that bring the brand to life.
About Aristara
Aristara is a modern eCommerce platform committed to offering a curated collection of stylish and practical products that elevate everyday living. From must-have household tools to chic personal accessories, Aristara aims to be the go-to destination for quality, function, and fashion—all in one place. With a focus on customer satisfaction and smart product curation, Aristara is more than a store—it’s a lifestyle brand for modern living.
To learn more or start shopping, visit https://aristara.co.
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Aristara Launches Modern eCommerce Store Featuring a Handpicked Mix of Stylish and Practical Products
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Press Release
Adorielle Emerges as a Chic Online Marketplace Blending Style Utility and Affordability
United States, 16th Jun 2025 – Adorielle, the new name in online shopping, is capturing attention for all the right reasons—style, convenience, and budget-friendly pricing. As an emerging eCommerce destination, Adorielle is committed to reshaping how modern consumers shop by offering a seamless digital experience and a carefully curated product selection that combines everyday functionality with elegant design.
From fashion-forward wardrobe essentials and home improvement tools to gadgets, wellness products, and lifestyle accessories, Adorielle positions itself as a one-stop online marketplace for today’s style-conscious and practical shoppers. Every item in the Adorielle catalog is selected with a core philosophy in mind: beauty meets utility without the premium price tag.
A New Standard for eCommerce Shopping
Founded by a team of passionate retail and digital commerce experts, Adorielle was launched to fill a gap in the market: a need for a curated platform that offers trendy, practical, and reliable products that won’t break the bank.
“Shoppers today want more than just cheap prices—they want value, aesthetics, and an enjoyable shopping experience,” says a company spokesperson at Adorielle. “We built Adorielle to be exactly that—a digital boutique where design meets everyday practicality.”
At a time when countless online stores flood the internet, Adorielle stands out by staying away from mass-produced, generic products. Instead, the brand emphasizes quality, customer satisfaction, and affordable luxury, ensuring each visitor finds something that fits both their needs and their personal style.
Product Categories That Fit Modern Lifestyles
Whether you’re a professional upgrading your workspace, a parent looking for smart home solutions, or a fashion enthusiast chasing the latest looks, Adorielle offers a rich and diverse shopping experience across multiple categories, including:
- Home & Kitchen: From minimalist décor to smart cooking gadgets, shoppers can find elegant pieces to enhance their living spaces.
- Fashion & Accessories: Trendy apparel and accessories that blend seasonal styles with lasting quality.
- Electronics & Gadgets: Practical tech for everyday use, curated for affordability and durability.
- Health & Wellness: Essential self-care and fitness products that encourage healthier lifestyles.
- Travel & Outdoor: Handy and stylish gear for adventurers, travelers, and commuters.
Each product listing is paired with detailed descriptions, user-friendly images, and competitive pricing, offering peace of mind to every customer. With secure payment options and swift shipping, Adorielle ensures convenience from cart to doorstep.
Customer-Centric Experience
One of Adorielle’s core strengths is its commitment to customer satisfaction. The brand features 24/7 customer support, easy returns, and a transparent shipping policy. With a growing base of loyal shoppers, Adorielle is quickly earning a reputation for reliability, responsiveness, and quality assurance.
The platform also runs regular promotions, flash sales, and seasonal discounts—helping shoppers make the most of their money while discovering new favorites.
Looking Ahead
As eCommerce continues to evolve, Adorielle is planning to scale up by expanding product categories, forming new supplier partnerships, and introducing sustainable and eco-conscious product lines. The brand also aims to integrate AI-powered recommendation systems and mobile app shopping to enhance user experience.
About Adorielle
Adorielle is an online shopping destination offering a curated selection of fashion, home, tech, and lifestyle products. Founded on the belief that shopping should be both stylish and affordable, Adorielle is dedicated to providing a seamless and enjoyable customer experience for global shoppers. The brand combines function and elegance across every product category while maintaining competitive pricing and reliable service.
Visit https://adorielle.com to explore the latest in stylish, affordable living.
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Adorielle Emerges as a Chic Online Marketplace Blending Style Utility and Affordability
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