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Candel Therapeutics (NASDAQ: CADL) Reports Positive Data From Phase 2 Trial Of CAN-2409 In Borderline Resectable Pancreatic Cancer

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–News Direct–

By Jeremy Golden, Benzinga

Clinical-stage biopharmaceutical company Candel Therapeutics, Inc. (NASDAQ: CADL) reported updated survival data from its randomized phase 2 clinical trial of CAN-2409 in borderline resectable pancreatic cancer. Pancreatic cancer is the fourth leading cause of cancer-related death in the U.S. The disease accounts for approximately 3% of all cancers, with an estimated 64,050 patients diagnosed in 2023.

The randomized, controlled clinical trial is specifically looking into the safety and efficacy of CAN-2409 plus valacyclovir (prodrug), together with standard of care (SoC) chemoradiation, followed by resection if possible in borderline resectable pancreatic ductal adenocarcinoma (PDAC).

Very encouraging results were recently reported by the Needham, Massachusetts-based company.

Patients reached an estimated median overall survival of 28.8 months after experimental treatment with CAN-2409 versus only 12.5 months in the control group in PDAC. At 24 months, the survival rate was 71.4% in CAN-2409 treated patients compared to only 16.7% in the control group after chemoradiation. Thus, prolonged and sustained survival was observed after experimental treatment with CAN-2409 in patients with borderline resectable PDAC. Importantly, 4 out of 7 patients who received CAN-2409 were still alive at the time of data cut-off, with 2 patients surviving more than 50.0 months from enrollment. Only 1 out of 6 patients in the randomized control SoC chemotherapy group remained alive at the data cut-off (50.6 months).

No new safety signals were observed, providing further support that multiple injections of CAN-2409 are generally well tolerated. Additionally, there were no dose-limiting toxicities or cases of pancreatitis reported.

Previous analysis of resected tumors showed dense aggregates of immune cells including CD8+, cytotoxic tumor-infiltrating lymphocytes and dendritic cells in PDAC tissue after CAN-2409 administration. This reinforces the potential of CAN-2409 to activate a robust antitumoral immune response in patients with cancer also in cold, immunosuppressive tumors like PDAC.

Given the frequent recurrence and short survival with SoC chemotherapy for non-metastatic PDAC, effective new treatment options are urgently needed, said Garrett Nichols, MD, MS, Chief Medical Officer of Candel. We are very encouraged by the improved survival associated with CAN-2409, which has been shown to be durable after prolonged follow-up based on the updated data in this randomized clinical trial. CAN-2409 was generally well tolerated without significant additional local or systemic toxicity when added to SoC chemoradiation.

Candels most advanced viral immunotherapy candidate, CAN-2409, is an investigational off-the-shelf, replication-defective adenovirus designed to induce an individualized, systemic immune response against the tumor. Because of its versatility, CAN-2409 has the potential to treat a broad range of solid tumors. More than 1,000 patients have been dosed with CAN-2409 to date, with a favorable reported tolerability profile and proof of concept in each indication that the company is currently pursuing.

CAN-2409 is injected directly into the tumor or target tissue using a localized injection method that is akin to the standard approach for in situ vaccination to elicit an immune response against the injected tumor and uninjected metastases.

Long-term survival data in PDAC was recently updated with eight months of further follow-up since the first analysis was presented at the 2023 Society for Immunotherapy (SITC) Annual Meeting. Based on the data presented at SITC, the U.S. Food and Drug Administration (FDA) granted Fast Track Designation to Candel Therapeutics for CAN-2409 in combination with valacyclovir for the treatment of patients with PDAC in December 2023. More recently, the FDA also granted Orphan Drug Designation.

The failure of conventional immunotherapy to improve outcomes in pancreatic cancer is attributed to the highly immunosuppressive tumor microenvironment, which is largely devoid of immune cells, said Paul Peter Tak, MD, PhD, FMedSci, President and Chief Executive Officer of Candel. The immunological changes induced by CAN-2409, evident in the pancreatic tissue and the peripheral blood after administration, suggest that CAN-2409 is able to change the balance between the tumor and the patients anti-tumor immune response, which can convert progressive cancer into a chronic disease associated with improved survival.

Featured photo by National Cancer Institute on Unsplash.

Candel is a clinical stage biopharmaceutical company focused on developing off-the-shelf multimodal biological immunotherapies that elicit an individualized, systemic anti-tumor immune response to help patients fight cancer. Candel has established two clinical stage multimodal biological immunotherapy platforms based on novel, genetically modified adenovirus and herpes simplex virus (HSV) gene constructs, respectively. CAN-2409 is the lead product candidate from the adenovirus platform and is currently in ongoing clinical trials in non-small cell lung cancer (NSCLC) (phase 2), borderline resectable pancreatic cancer (phase 2), and localized, non-metastatic prostate cancer (phase 2 and phase 3). CAN-3110 is the lead product candidate from the HSV platform and is currently in an ongoing investigator-sponsored phase 1 clinical trial in recurrent high-grade glioma (HGG). Finally, Candels enLIGHTEN Discovery Platform is a systematic, iterative HSV-based discovery platform leveraging human biology and advanced analytics to create new viral immunotherapies for solid tumors.

This article includes certain disclosures that contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, express or implied statements regarding the timing and advancement of development programs, including the timing and availability of additional data, key data readout milestones, including CAN-3110 in HGG; expectations regarding the potential benefits conferred by Fast Track Designation; expectations regarding the therapeutic benefit of its programs, including the potential for its programs to extend patient survival; and expectations regarding cash runway and expenditures. The words may, will, could, would, should, expect, plan, anticipate, intend, believe, estimate, predict, project, potential, continue, target and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on managements current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, those risks and uncertainties related to the timing and advancement of development programs; expectations regarding the therapeutic benefit of the Companys programs; that final data from our pre-clinical studies and completed clinical trials may differ materially from reported interim data from ongoing studies and trials; the Companys ability to efficiently discover and develop product candidates; the Companys ability to obtain and maintain regulatory approval of product candidates; the Companys ability to maintain its intellectual property; the implementation of the Companys business model, and strategic plans for the Companys business and product candidates, and other risks identified in the Companys SEC filings, including the Companys most recent Quarterly Report on Form 10-Q filed with the SEC, and subsequent filings with the SEC. The Company cautions you not to place undue reliance on any forward-looking statements, which speak only as of the date they are made. The Company disclaims any obligation to publicly update or revise any such statements to reflect any change in expectations or in events, conditions or circumstances on which any such statements may be based, or that may affect the likelihood that actual results will differ from those set forth in the forward-looking statements. Any forward-looking statements contained in this press release represent the Companys views only as of the date hereof and should not be relied upon as representing its views as of any subsequent date.

This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice.

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Aljanae Reynolds

+1 617-916-5445

areynolds@wheelhouselsa.com

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https://www.candeltx.com/

View source version on newsdirect.com: https://newsdirect.com/news/candel-therapeutics-nasdaq-cadl-reports-positive-data-from-phase-2-trial-of-can-2409-in-borderline-resectable-pancreatic-cancer-425692953

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Press Release

Cyberforce Crypto Recovery Launches Innovative Solutions for Recovering Lost Digital Assets

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New York, NY – Cyberforce Crypto Recovery, a leader in cryptocurrency recovery, announced the launch of an innovative solution to recover lost digital assets. In the fast-evolving world of digital finance, cryptocurrency has become both a revolutionary opportunity and a growing target for cybercriminals. From phishing scams and exchange hacks to fraudulent investment schemes, billions of dollars have been siphoned from unsuspecting investors. For many, the question remains: How to get stolen crypto back?

Cyberforce Crypto Recovery, a trusted name in the crypto recovery space, is leading the charge with advanced solutions tailored to help victims of digital theft reclaim their assets. With a specialized team of cybersecurity experts, forensic analysts, and recovery specialists, the company is setting a new standard for effectiveness in the crypto recovery industry.

A Revolutionary Cryptocurrency Recovery System

Cyberforce Crypto Recovery recently unveiled its state-of-the-art cryptocurrency recovery system, designed to give individuals and businesses a fighting chance at retrieving stolen funds. Unlike traditional asset recovery firms, Cyberforce combines cutting-edge digital forensics with an international network of investigators to trace and recover misappropriated assets.

The system is built on three core pillars:

  1. Tracing Technology – leveraging blockchain analytics and advanced tracking tools to follow the digital footprint of stolen crypto.
  2. Legal and Regulatory Expertise – working alongside international law enforcement agencies and financial regulators to freeze and retrieve assets.
  3. Education and Prevention – equipping clients with the knowledge to avoid falling victim to similar scams in the future.

This holistic approach not only focuses on the immediate recovery of assets but also emphasizes long-term protection.

Support for Victims of Crypto and Forex Scams

Cryptocurrency isn’t the only area plagued by online crime. Many victims also lose funds to Forex trading scams, which often disguise themselves as legitimate investment opportunities. Cyberforce Crypto Recovery recognizes the devastating financial and emotional toll these scams take and provides tailored solutions to help victims recover their money.

Whether the theft occurred through fake trading platforms, deceptive brokers, or phishing attacks, Cyberforce’s recovery system is designed to tackle complex cases. Clients benefit from expert tracing, transparent communication, and personalized strategies for reclaiming lost assets.

If you’ve been affected, seeking a cryptocurrency recovery service to get stolen crypto back may be the most effective step toward financial restitution.

Advanced Tracing and Wallet Recovery Services

One of Cyberforce Crypto Recovery’s standout services is its crypto tracing and wallet recovery program. Stolen cryptocurrency is rarely static; thieves often move funds through multiple wallets, mixers, or exchanges in an attempt to hide their tracks.

To counter this, Cyberforce employs a blend of:

  • Blockchain analysis – identifying the transaction trail of stolen coins.
  • Digital forensics – uncovering links between anonymous wallet addresses and real-world identities.
  • Collaborations with exchanges – working with major trading platforms to freeze stolen funds before they can be cashed out.

The company also assists in recovering access to lost or compromised wallets, a service that has helped countless clients regain control over their assets.

Impressive Recovery Rate and Client-Centric Approach

Cyberforce Crypto Recovery boasts an impressive 97% recovery rate, a figure that sets it apart in an industry often plagued by false promises. This success can be attributed to the company’s meticulous process and unwavering commitment to its clients.

Some of the company’s most notable attributes include:

  • Case Management: Every client is assigned a dedicated case manager who provides ongoing updates, guidance, and emotional support throughout the recovery process.
  • Quick Reaction: Cybercrime cases require urgency. Cyberforce understands that time is of the essence and initiates recovery actions immediately.
  • Global Network: With international reach, the company can provide assistance regardless of where clients are located.
  • Cutting-Edge Tools: From digital location techniques to advanced forensic detection, the Cyberforce team utilizes the most up-to-date cybersecurity resources available.
  • Reliable Protocols: Clients’ personal and financial information is protected through strict security measures, ensuring that privacy is never compromised.

Beyond Recovery: Education and Protection

Cyberforce is not just a recovery company—it is also a hub for education and prevention. Many victims of crypto scams find themselves targeted repeatedly, especially if they don’t learn how to recognize red flags.

To combat this, Cyberforce provides its clients with:

  • Educational resources on identifying common scam tactics.
  • Workshops and webinars on digital security best practices.
  • Personalized prevention strategies tailored to each client’s digital footprint.

By investing in education, Cyberforce helps ensure that clients not only recover their money but also safeguard their future investments.

Addressing Romance and Pig Butchering Scams

One of the fastest-growing cybercrime trends is the romance scam, often linked to pig butchering schemes and fake online investments. These scams manipulate victims into sending money or investing in fraudulent platforms under the illusion of a personal or romantic connection.

Cyberforce has expanded its services to help recover funds from pig butchering and fake online investments, offering victims a chance to reclaim stolen assets while also exposing criminal networks behind these operations. Through forensic tracing and close collaboration with global financial institutions, the company has successfully helped numerous victims regain money that was lost to dishonest partners or fraudulent investment platforms.

A Commitment to Justice

What sets Cyberforce Crypto Recovery apart is its unwavering mission: to ensure that no stolen funds are left unaccounted for. The company views each case not just as a financial dispute but as a step toward restoring justice for victims of cybercrime.

With the rise of blockchain technology and digital assets, cybercrime will continue to evolve. Yet, Cyberforce remains at the forefront of innovation, constantly updating its tools and methods to stay ahead of malicious actors.

The Future of Crypto Recovery

The world of cryptocurrency is still relatively young, and with innovation comes risk. However, companies like Cyberforce Crypto Recovery are proving that victims are not powerless. By combining technology, expertise, and compassion, Cyberforce provides hope to those who believed their funds were lost forever.

For individuals and businesses alike, the message is clear: recovery is possible. And with a trusted partner like Cyberforce, the path to justice and financial restitution is closer than ever.

Cyberforce Crypto Recovery continues to set the gold standard for crypto recovery solutions, building trust, delivering results, and ensuring that the digital economy remains a place of opportunity—not exploitation.

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Company: Cyberforce Crypto Recovery

Contact: Media Team

Email: press@cyberforcegroup.com

Website: https://www.cyberforcegroup.com/

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Press Release

Dolly Varden Silver Confirms High-grade Gold System at Homestake Ridge

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Dolly Varden Silver reported a significant gold intercept from a step-out drill hole at the Homestake Silver deposit. The hole is a 45-meter step-out along strike from hole HR24-433 and 30 meters up dip from hole HR24-451

Canada, 7th Oct 2025 – Global Stocks News – Sponsored content disseminated on behalf of Dolly Varden Silver. On October 1, 2025 Dolly Varden Silver (TSXV: DV) (NYSE American: DVS) (FSE: DVQ) reported a significant gold intercept from a step-out drill hole at the Homestake Silver deposit.

Hole HR25-456 intersected 3.34 g/t Au over 120 meters, including 216 g/t Au over 0.52 meters and 166 g/t Au over 1.3 meters.

The hole is a 45-meter step-out along strike from hole HR24-433 and 30 meters up dip from hole HR24-451

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“These gold results from a step-out hole at the Homestake Silver Deposit confirm that the deposit continues to grow beyond the current mineral resource estimate,” stated Shawn Khunkhun, CEO of Dolly Varden Silver in the October 1, 2025 press release.

“These results demonstrate the strength of the high-grade gold system, potentially a separate and overlapping event from high-grade silver mineralization at the deposit; this deposit is potentially a key driver of future project development,” added Khunkhun.

“We have two lenses that are close to each other,” Rob van Egmond, VP of Exploration, told Guy Bennett, the CEO of Global Stocks News (GSN). “The second phase could overlap the silver-rich mineralization, or it could be a separate lens.”

“Any time you have overlapping events or long-lived fluid conduits, it indicates some of the precious metals may have been deposited during the Jurassic age [160 million years ago], while a second mineralizing event may have occurred in the Eocene age [40 million years ago]”.

“This duo-timeline mineralisation is one deposit is a known characteristic of the Golden Triangle. One of our neighbours has been age-dating their assays, confirming the presence of an Eocene age mineralised system.” 

“When you find a regional corridor where Jurassic mineralization has been overprinted by Eocene mineralisation,” added van Egmond, “typically the grade is augmented in that structure. Hole HR25-456 had large flakes of visible gold.”

 

 

“When we purchased this asset,” van Egmond told GSN. “Homestake Silver had a higher ratio of silver to gold than Homestake Main. But we’re thinking about changing the name, because at investor conferences Shawn and I have to explain that Homestake Silver is now primarily a gold deposit.”

“Geologists are always working to either prove or disprove a model,” said van Egmond. “You collect data, assess it, and make modifications to the model as necessary. Hole HR25-456 is adding confidence to the current model.” 

Five diamond drills are nearing completion of the 2025 drill program across the Kitsault Valley and Big Bulk Projects. At Homestake Silver, drilling has focused on expanding and infilling areas of high-grade gold mineralisation

DV is also testing outside the current resource. Additional results from the Homestake Silver gold zone, Wolf Vein silver mineralization extension, Big Bulk copper-gold porphyry system, as well as other exploration targets, will be reported as assays are received.

DV Silver is using directional drilling technology to precisely target areas for step-out and infill holes at Homestake Silver.

“Directional drilling allows you to position the drill bit exactly where you want it to be, without re-drilling hundreds of meters from the surface,” van Egmond told GSN. “It’s an ideal technique for us to explore Homestake Silver.”

This animated video by Horizontal Technology gives a technical overview of directional drilling.

“A skilled driller can direct the course of the drill bit along a pre-planned path over great distances,” confirms Horizontal Technology.

HR25-456 is one of three holes drilled from the same pad, designed to extend the wide, high-grade plunging zone and test outside the current mineral resource model. The drill hole is approximately a 45-meter step-out along strike from previous intersects.

Approximately 40% of the 2025 season’s 55,000-meter planned drill program at DV’s 100% owned Kitsault Valley Silver and Gold Project targeted the Homestake Silver Deposit to expand and infill zones of high-grade gold mineralization.

The deposit remains open for expansion, with gold mineralization vectoring to the Homestake Main Deposit, along strike to the north of the Homestake Silver Deposit.

On October 01, 2025 Dolly Varden Silver announced a $30 Million Bought-Deal Financing featuring 2,300,000 @ $6.50/share; 750,000 flow-through shares @ $9.42/share and 990,000 flow-through shares at $8.10 per share.

Flow-through shares enable public companies to transfer exploration expenditures to investors who can take advantage of the corresponding tax incentives, thereby ‘flowing their benefits through’ to the shareholder,” writes CG Wealth Management.

“Investors in a high tax bracket can use the tax credits from flow-through investments to bring down their personal tax owing,” added CG Wealth.

Pursuant to existing agreements, Hecla Canada and Fury Gold Mines will be entitled to acquire shares @ $6.50/share to maintain their respective pro rata equity interests in DV Silver.

DV’s metal inventory value is now approximately a 50/50 split between silver and gold.

“With gold selling for CND $5,400/ounce,” van Egmond told GSN, “our team is encouraged to hit 120 meters of 3.34 g/t gold.”

Rob van Egmond, P.Geo., Vice-President Exploration for Dolly Varden Silver, the “Qualified Person” as defined by NI43-101, has reviewed, validated and approved the scientific and technical information contained in this GSN release.

Disclaimer: Dolly Varden Silver paid GSN $1,750 for the research, creation and dissemination of this content.

Contact: guy.bennett@globalstocksnews.com

Full Disclaimer: Global Stocks News (GSN) researches and fact-checks diligently, but we cannot ensure our publications are free from error. Investing in publicly traded stocks is speculative and carries a high degree of risk. GSN makes no recommendation to purchase any individual stock. When compensation has been paid to GSN, the amount and nature of the compensation will be disclosed clearly. GSN publications may contain forward-looking statements such as “project,” “anticipate,” “expect,” which are based on reasonable expectations, but these statements are imperfect predictors of future events. When compensation has been paid to GSN, the amount and nature of the compensation will be disclosed clearly.

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Organization: Global Stocks News

Contact Person: guy.bennett@globalstocksnews.com

Website: https://www.globalstocksnews.com

Email: Send Email

Country:Canada

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Matt Egyhazy on AI: The Future of Banking is Hyper-Personalized, Not Just Automated

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New York, USA, 7th October 2025, ZEX PR WIRE, In an era where digital transformation is reshaping industries, the financial services sector stands at a critical juncture. The conversation around artificial intelligence has often been dominated by its potential for automation, process optimization, and cost reduction. While these benefits are significant, Matt Egyhazy argues that this view is far too narrow. He posits that the true, transformative power of AI lies not in replacing human functions, but in profoundly enhancing them to deliver an unprecedented level of client personalization.

According to Matt Egyhazy, the ultimate goal of implementing AI should be to move banking from a transactional model to a deeply relational one. The future, he suggests, is not a world of automated, impersonal interactions. Instead, it is a future where technology empowers financial institutions to understand and anticipate the unique needs of each client, offering tailored advice, products, and support throughout their financial lives. This vision re-frames AI as the engine for hyper-personalization, a tool for building stronger, more meaningful, and more resilient client partnerships.

Redefining the Role of AI in Financial Services

For too long, the narrative has positioned AI as a tool for internal optimization. The metrics for success were often inwardly focused: reduced headcount, faster processing times, and lower operational costs. Egyhazy advocates for a fundamental shift in this perspective. The focus must turn outward, toward the client experience. The new key performance indicators should be client satisfaction, financial wellness, and long term loyalty.

This approach requires thinking of AI less like a factory assembly line, designed for uniform efficiency, and more like a master craftsman’s toolkit, capable of creating something unique for each individual. It is about using intelligent systems to understand the nuanced context of a client’s life or a business’s operational cycle.

“We must see AI as a catalyst for empathy at scale,” says Egyhazy. “The technology allows us to listen more intently to the signals our clients are giving us through their financial activities. When we harness that understanding, we can move from being reactive service providers to proactive, trusted advisors. The goal is not just to make banking faster; it is to make banking smarter, more intuitive, and more aligned with the individual aspirations of our clients.”

The Mechanics of Hyper-Personalization

Achieving this vision of hyper-personalization is a complex undertaking, built on a foundation of robust, secure, and ethically managed data. AI algorithms can analyze vast and diverse datasets far beyond human capacity, identifying patterns, predicting future needs, and flagging opportunities that might otherwise go unnoticed.

This capability translates into tangible, real world applications. For a small business owner, it could mean an AI powered system that analyzes cash flow patterns and proactively suggests a more flexible line of credit before a seasonal downturn. This prevents a potential crisis and demonstrates a deep understanding of the business’s unique rhythm.

In wealth management, it could be a platform that adjusts investment recommendations in real time, not just based on market fluctuations, but also on subtle shifts in a client’s life goals, which are inferred from their changing financial behavior. For a commercial banking client, an AI might alert a relationship manager that a company is expanding into a new international market, providing the manager with the perfect opportunity to offer tailored trade finance and foreign exchange services.

“This is about connecting the dots in a client’s financial story,” Egyhazy explains. “Predictive analytics allows us to anticipate the next chapter in that story. We can be ready with the right advice or the right product at the exact moment it becomes relevant. That is a profoundly different and more valuable interaction than simply waiting for a client to come to us with a request.”

Balancing Technology with the Human Touch

A common fear is that the rise of AI will render the human element in banking obsolete. Matt Egyhazy strongly contests this view, arguing that AI’s true value is realized when it augments, rather than replaces, human expertise. The technology should be seen as a powerful co-pilot for financial professionals.

By automating routine and data intensive tasks, AI can liberate relationship managers, financial advisors, and other specialists to focus on what they do best: building trust, providing nuanced strategic advice, and navigating complex, emotionally charged financial decisions with clients. AI can provide the data driven insights, but it is the human professional who provides the wisdom, empathy, and contextual understanding to apply those insights effectively.

“Imagine a relationship manager who is freed from hours of manual data analysis,” says Egyhazy. “Instead, they walk into a client meeting armed with a set of AI generated insights about that client’s emerging needs and potential risks. The conversation is immediately more strategic, more forward looking, and more valuable. The technology does not replace the relationship; it powers it.”

Navigating the Ethical and Practical Challenges

This forward-thinking vision is not without its challenges. The ethical implications of using client data are paramount. Egyhazy stresses that any AI-driven initiative must be built on a bedrock of trust, which requires an unwavering commitment to data privacy, security, and transparency. Clients must have confidence that their information is protected and used responsibly to their benefit.

Furthermore, the “black box” problem, where AI decision making processes are opaque, must be actively avoided. Financial institutions have a responsibility to ensure their AI models are explainable, fair, and free from bias. There is also the significant technical hurdle of integrating sophisticated AI platforms with existing legacy banking systems and the critical need to upskill the workforce to collaborate effectively with these new intelligent tools.

“We must innovate at the speed of trust,” Egyhazy notes. “Progress cannot come at the expense of our fundamental obligations to our clients and our communities. Responsible innovation means being transparent, ethical, and deliberate in how we deploy these powerful technologies.”

A Vision for the Future of Banking

Ultimately, Egyhazy’s vision is for a banking ecosystem that is more responsive, more intelligent, and more human. It is a future where a client’s interaction with their bank feels less like a series of isolated transactions and more like a continuous, supportive partnership.

This future is one where technology and humanity work in concert to help individuals, families, and businesses achieve their financial goals. By focusing AI on hyper-personalization, the banking industry has an opportunity to redefine its value proposition, fostering a new generation of client loyalty built on genuine understanding and proactive support.

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Orchard Park, New York, USA

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